SU1366042A3 - Способ получения гепарина - Google Patents
Способ получения гепарина Download PDFInfo
- Publication number
- SU1366042A3 SU1366042A3 SU802897057A SU2897057A SU1366042A3 SU 1366042 A3 SU1366042 A3 SU 1366042A3 SU 802897057 A SU802897057 A SU 802897057A SU 2897057 A SU2897057 A SU 2897057A SU 1366042 A3 SU1366042 A3 SU 1366042A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- heparin
- dry matter
- sample
- content
- temperature
- Prior art date
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 35
- 229960002897 heparin Drugs 0.000 title claims abstract description 35
- 229920000669 heparin Polymers 0.000 title claims abstract description 35
- 238000000034 method Methods 0.000 title abstract description 8
- 210000000056 organ Anatomy 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000000725 suspension Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 208000035404 Autolysis Diseases 0.000 claims description 6
- 206010057248 Cell death Diseases 0.000 claims description 6
- 230000028043 self proteolysis Effects 0.000 claims description 6
- 230000004071 biological effect Effects 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 15
- 210000001557 animal structure Anatomy 0.000 abstract description 3
- 150000003839 salts Chemical class 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000012266 salt solution Substances 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 description 12
- 210000000813 small intestine Anatomy 0.000 description 8
- 239000012141 concentrate Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 238000001035 drying Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 208000031888 Mycoses Diseases 0.000 description 5
- 239000003925 fat Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 210000004400 mucous membrane Anatomy 0.000 description 5
- 239000007900 aqueous suspension Substances 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000013049 sediment Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000004925 denaturation Methods 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000008399 tap water Substances 0.000 description 2
- 235000020679 tap water Nutrition 0.000 description 2
- 238000010793 Steam injection (oil industry) Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 102000022382 heparin binding proteins Human genes 0.000 description 1
- 108091012216 heparin binding proteins Proteins 0.000 description 1
- 229940060367 inert ingredients Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Extraction Or Liquid Replacement (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LV930043A LV5184A3 (lv) | 1979-03-21 | 1993-01-18 | Heparina iegusanas panemiens |
| LTRP750A LT2279B (lt) | 1979-03-21 | 1993-07-01 | Geparino gavimo budas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU79RI705A HU177887B (en) | 1979-03-21 | 1979-03-21 | Process for preparing a raw material containing heparin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1366042A3 true SU1366042A3 (ru) | 1988-01-07 |
Family
ID=11001090
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU802897057A SU1366042A3 (ru) | 1979-03-21 | 1980-03-20 | Способ получения гепарина |
| SU802897802A SU1375115A3 (ru) | 1979-03-21 | 1980-03-20 | Способ получени гепарина |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU802897802A SU1375115A3 (ru) | 1979-03-21 | 1980-03-20 | Способ получени гепарина |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4315923A (enExample) |
| JP (2) | JPS55164202A (enExample) |
| AR (2) | AR219226A1 (enExample) |
| AT (2) | AT368004B (enExample) |
| AU (2) | AU533021B2 (enExample) |
| BE (2) | BE882369A (enExample) |
| BR (2) | BR8001717A (enExample) |
| CA (2) | CA1152894A (enExample) |
| CS (2) | CS248011B2 (enExample) |
| DD (2) | DD149532A5 (enExample) |
| DE (2) | DE3010972A1 (enExample) |
| DK (2) | DK166504C (enExample) |
| ES (2) | ES8102580A1 (enExample) |
| FR (2) | FR2451744A1 (enExample) |
| GB (2) | GB2045271B (enExample) |
| GR (2) | GR67682B (enExample) |
| HU (1) | HU177887B (enExample) |
| IN (1) | IN153527B (enExample) |
| IT (2) | IT1133074B (enExample) |
| NL (2) | NL8001695A (enExample) |
| NZ (2) | NZ193188A (enExample) |
| PL (2) | PL134709B1 (enExample) |
| SE (2) | SE451297B (enExample) |
| SU (2) | SU1366042A3 (enExample) |
| YU (2) | YU76580A (enExample) |
| ZA (2) | ZA801480B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4692435A (en) * | 1978-11-06 | 1987-09-08 | Choay, S.A. | Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation |
| SE449753B (sv) * | 1978-11-06 | 1987-05-18 | Choay Sa | Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav |
| US4826600A (en) * | 1987-06-24 | 1989-05-02 | Amoco Corporation | Process for treatment of wastewater |
| FR2704226B1 (fr) * | 1993-04-22 | 1995-07-21 | Sanofi Elf | 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| DE69833205T2 (de) * | 1997-07-16 | 2006-07-20 | Akzo Nobel N.V. | Verfahren zur herstellung von heparin |
| US7326424B2 (en) * | 2002-06-19 | 2008-02-05 | Can Technologies, Inc. | Animal feed composition |
| JP2025509347A (ja) * | 2022-03-08 | 2025-04-11 | ホライズン アイピー，エス．エル | 屠殺された動物の廃棄組織からのヘパリンならびに未変性タンパク質およびペプチドの混合物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2410084A (en) * | 1943-12-09 | 1946-10-29 | Upjohn Co | Recovery of heparin |
| US2587924A (en) * | 1948-05-27 | 1952-03-04 | Univ Alberta | Methods of producing heparin |
| US2571679A (en) * | 1948-07-08 | 1951-10-16 | Carlo Erba S A | Process for preparing purified heparin |
| DE950594C (de) * | 1953-07-01 | 1956-10-11 | Upjohn Co | Verfahren zur Gewinnung von Heparin |
| GB872214A (en) * | 1957-09-23 | 1961-07-05 | Upjohn Co | Extraction process for the recovery of heparin |
| US2989438A (en) * | 1958-12-29 | 1961-06-20 | Roussel Uclaf | Process of purifying heparin, and product produced therefrom |
| GB1221784A (en) * | 1967-04-07 | 1971-02-10 | John Ernest Scott | Precipitation of heparin from aqueous solution |
| US3451996A (en) * | 1968-02-12 | 1969-06-24 | Thompson Farms Co | Method for the preparation of heparin |
| IT1019525B (it) * | 1972-03-21 | 1977-11-30 | Ferdinando D | Metodo apparecchio e prodotto per formare complessi stabili di polia nioni |
| DE2646678C2 (de) * | 1975-10-31 | 1985-11-28 | A. H. Robins Co. Inc., Richmond, Va. | Verfahren zur Herstellung eines entfetteten Heparin-Gewebes |
| DE2646677C2 (de) * | 1975-10-31 | 1985-11-07 | A. H. Robins Co. Inc., Richmond, Va. | Verfahren zum Tempern von gefrorenem, Heparin führendem tierischem Gewebe |
| US4188467A (en) * | 1975-10-31 | 1980-02-12 | A. H. Robins Company, Incorporated | Process for tempering tissue for heparin production |
| US4192916A (en) * | 1975-10-31 | 1980-03-11 | A. H. Robins Company, Incorporated | Process for producing defatted heparin tissue for heparin production |
| DE2652272C2 (de) * | 1976-11-12 | 1979-02-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Heparin |
| DE2660052A1 (de) * | 1976-11-12 | 1979-01-25 | Schering Ag | Verfahren zur herstellung von heparin |
| US4175182A (en) * | 1978-07-03 | 1979-11-20 | Research Corporation | Separation of high-activity heparin by affinity chromatography on supported protamine |
-
1979
- 1979-03-21 HU HU79RI705A patent/HU177887B/hu unknown
-
1980
- 1980-03-11 AT AT0134880A patent/AT368004B/de not_active IP Right Cessation
- 1980-03-13 ZA ZA00801480A patent/ZA801480B/xx unknown
- 1980-03-17 AT AT0144280A patent/AT365927B/de not_active IP Right Cessation
- 1980-03-18 ZA ZA00801564A patent/ZA801564B/xx unknown
- 1980-03-18 SE SE8002125A patent/SE451297B/sv not_active IP Right Cessation
- 1980-03-18 SE SE8002126A patent/SE453725B/sv not_active IP Right Cessation
- 1980-03-18 PL PL1980222794A patent/PL134709B1/pl unknown
- 1980-03-19 GR GR61493A patent/GR67682B/el unknown
- 1980-03-19 CS CS801897A patent/CS248011B2/cs unknown
- 1980-03-19 GR GR61492A patent/GR67681B/el unknown
- 1980-03-19 US US06/131,824 patent/US4315923A/en not_active Expired - Lifetime
- 1980-03-19 YU YU00765/80A patent/YU76580A/xx unknown
- 1980-03-19 CS CS801898A patent/CS248012B2/cs unknown
- 1980-03-20 SU SU802897057A patent/SU1366042A3/ru active
- 1980-03-20 SU SU802897802A patent/SU1375115A3/ru active
- 1980-03-20 DK DK119780A patent/DK166504C/da not_active IP Right Cessation
- 1980-03-20 DD DD80219786A patent/DD149532A5/de not_active IP Right Cessation
- 1980-03-20 YU YU00769/80A patent/YU76980A/xx unknown
- 1980-03-20 DK DK119480A patent/DK166393C/da not_active IP Right Cessation
- 1980-03-20 AU AU56636/80A patent/AU533021B2/en not_active Ceased
- 1980-03-20 NZ NZ193188A patent/NZ193188A/en unknown
- 1980-03-20 CA CA000348222A patent/CA1152894A/en not_active Expired
- 1980-03-20 FR FR8006267A patent/FR2451744A1/fr active Granted
- 1980-03-20 CA CA000348224A patent/CA1137081A/en not_active Expired
- 1980-03-20 FR FR8006266A patent/FR2451743A1/fr active Granted
- 1980-03-20 AU AU56637/80A patent/AU529809B2/en not_active Ceased
- 1980-03-20 DD DD80219787A patent/DD149467A5/de unknown
- 1980-03-21 ES ES490537A patent/ES8102580A1/es not_active Expired
- 1980-03-21 AR AR280392A patent/AR219226A1/es active
- 1980-03-21 BE BE0/199894A patent/BE882369A/fr not_active IP Right Cessation
- 1980-03-21 NZ NZ193215A patent/NZ193215A/en unknown
- 1980-03-21 IT IT67444/80A patent/IT1133074B/it active
- 1980-03-21 NL NL8001695A patent/NL8001695A/nl not_active Application Discontinuation
- 1980-03-21 BR BR8001717A patent/BR8001717A/pt unknown
- 1980-03-21 JP JP3601280A patent/JPS55164202A/ja active Granted
- 1980-03-21 PL PL1980222906A patent/PL128250B1/pl unknown
- 1980-03-21 IT IT67438/80A patent/IT1133068B/it active
- 1980-03-21 JP JP3600680A patent/JPS55164201A/ja active Granted
- 1980-03-21 ES ES490538A patent/ES490538A0/es active Granted
- 1980-03-21 AR AR280393A patent/AR222215A1/es active
- 1980-03-21 GB GB8009608A patent/GB2045271B/en not_active Expired
- 1980-03-21 DE DE19803010972 patent/DE3010972A1/de active Granted
- 1980-03-21 DE DE19803011062 patent/DE3011062A1/de not_active Withdrawn
- 1980-03-21 BE BE0/199895A patent/BE882370A/fr not_active IP Right Cessation
- 1980-03-21 BR BR8001711A patent/BR8001711A/pt unknown
- 1980-03-21 GB GB8009611A patent/GB2045272B/en not_active Expired
- 1980-03-21 NL NL8001693A patent/NL8001693A/nl not_active Application Discontinuation
- 1980-08-21 IN IN952/CAL/80A patent/IN153527B/en unknown
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