NL8001693A - Werkwijze voor de bereiding van orgaanextracten met een groot heparinegehalte. - Google Patents
Werkwijze voor de bereiding van orgaanextracten met een groot heparinegehalte. Download PDFInfo
- Publication number
- NL8001693A NL8001693A NL8001693A NL8001693A NL8001693A NL 8001693 A NL8001693 A NL 8001693A NL 8001693 A NL8001693 A NL 8001693A NL 8001693 A NL8001693 A NL 8001693A NL 8001693 A NL8001693 A NL 8001693A
- Authority
- NL
- Netherlands
- Prior art keywords
- extraction
- heparin
- countercurrent
- carried out
- process according
- Prior art date
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims description 80
- 229920000669 heparin Polymers 0.000 title claims description 79
- 229960002897 heparin Drugs 0.000 title claims description 79
- 238000000034 method Methods 0.000 title claims description 68
- 239000000284 extract Substances 0.000 title claims description 27
- 238000000605 extraction Methods 0.000 claims description 85
- 239000000203 mixture Substances 0.000 claims description 25
- 239000007858 starting material Substances 0.000 claims description 24
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000003792 electrolyte Substances 0.000 claims description 4
- 239000003637 basic solution Substances 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 239000003344 environmental pollutant Substances 0.000 claims 1
- 235000004213 low-fat Nutrition 0.000 claims 1
- 231100000719 pollutant Toxicity 0.000 claims 1
- 210000000056 organ Anatomy 0.000 description 35
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 33
- 208000035404 Autolysis Diseases 0.000 description 17
- 206010057248 Cell death Diseases 0.000 description 17
- 230000028043 self proteolysis Effects 0.000 description 17
- 239000000243 solution Substances 0.000 description 15
- 230000017854 proteolysis Effects 0.000 description 12
- 239000000126 substance Substances 0.000 description 12
- 235000011121 sodium hydroxide Nutrition 0.000 description 11
- 108090000790 Enzymes Proteins 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 8
- 229940088598 enzyme Drugs 0.000 description 8
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 210000001557 animal structure Anatomy 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 230000002411 adverse Effects 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 3
- 239000003925 fat Substances 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 239000006286 aqueous extract Substances 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229920001499 Heparinoid Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 150000001449 anionic compounds Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 229940021013 electrolyte solution Drugs 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000002554 heparinoid Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910001412 inorganic anion Inorganic materials 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 239000000082 organ preservation Substances 0.000 description 1
- 150000002891 organic anions Chemical class 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Extraction Or Liquid Replacement (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HURI000705 | 1979-03-21 | ||
| HU79RI705A HU177887B (en) | 1979-03-21 | 1979-03-21 | Process for preparing a raw material containing heparin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8001693A true NL8001693A (nl) | 1980-09-23 |
Family
ID=11001090
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8001693A NL8001693A (nl) | 1979-03-21 | 1980-03-21 | Werkwijze voor de bereiding van orgaanextracten met een groot heparinegehalte. |
| NL8001695A NL8001695A (nl) | 1979-03-21 | 1980-03-21 | Werkwijze ter bereiding van een nieuw type heparine bevattende grondstof. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8001695A NL8001695A (nl) | 1979-03-21 | 1980-03-21 | Werkwijze ter bereiding van een nieuw type heparine bevattende grondstof. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4315923A (enExample) |
| JP (2) | JPS55164202A (enExample) |
| AR (2) | AR222215A1 (enExample) |
| AT (2) | AT368004B (enExample) |
| AU (2) | AU533021B2 (enExample) |
| BE (2) | BE882370A (enExample) |
| BR (2) | BR8001717A (enExample) |
| CA (2) | CA1152894A (enExample) |
| CS (2) | CS248012B2 (enExample) |
| DD (2) | DD149467A5 (enExample) |
| DE (2) | DE3010972A1 (enExample) |
| DK (2) | DK166504C (enExample) |
| ES (2) | ES490537A0 (enExample) |
| FR (2) | FR2451744A1 (enExample) |
| GB (2) | GB2045271B (enExample) |
| GR (2) | GR67682B (enExample) |
| HU (1) | HU177887B (enExample) |
| IN (1) | IN153527B (enExample) |
| IT (2) | IT1133074B (enExample) |
| NL (2) | NL8001693A (enExample) |
| NZ (2) | NZ193188A (enExample) |
| PL (2) | PL134709B1 (enExample) |
| SE (2) | SE453725B (enExample) |
| SU (2) | SU1375115A3 (enExample) |
| YU (2) | YU76580A (enExample) |
| ZA (2) | ZA801480B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4692435A (en) * | 1978-11-06 | 1987-09-08 | Choay, S.A. | Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation |
| SE449753B (sv) * | 1978-11-06 | 1987-05-18 | Choay Sa | Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav |
| US4826600A (en) * | 1987-06-24 | 1989-05-02 | Amoco Corporation | Process for treatment of wastewater |
| FR2704226B1 (fr) * | 1993-04-22 | 1995-07-21 | Sanofi Elf | 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| JP4455680B2 (ja) * | 1997-07-16 | 2010-04-21 | ナームローゼ・フエンノートチヤツプ・オルガノン | ヘパリンの製造方法 |
| BR0311904A (pt) * | 2002-06-19 | 2007-05-08 | Can Technologies Inc | composição de ração de animal compreendendo subproduto mucoso |
| JP2025509347A (ja) * | 2022-03-08 | 2025-04-11 | ホライズン アイピー，エス．エル | 屠殺された動物の廃棄組織からのヘパリンならびに未変性タンパク質およびペプチドの混合物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2410084A (en) * | 1943-12-09 | 1946-10-29 | Upjohn Co | Recovery of heparin |
| US2587924A (en) * | 1948-05-27 | 1952-03-04 | Univ Alberta | Methods of producing heparin |
| US2571679A (en) * | 1948-07-08 | 1951-10-16 | Carlo Erba S A | Process for preparing purified heparin |
| DE950594C (de) * | 1953-07-01 | 1956-10-11 | Upjohn Co | Verfahren zur Gewinnung von Heparin |
| GB872214A (en) * | 1957-09-23 | 1961-07-05 | Upjohn Co | Extraction process for the recovery of heparin |
| US2989438A (en) * | 1958-12-29 | 1961-06-20 | Roussel Uclaf | Process of purifying heparin, and product produced therefrom |
| GB1221784A (en) * | 1967-04-07 | 1971-02-10 | John Ernest Scott | Precipitation of heparin from aqueous solution |
| US3451996A (en) * | 1968-02-12 | 1969-06-24 | Thompson Farms Co | Method for the preparation of heparin |
| IT1019525B (it) * | 1972-03-21 | 1977-11-30 | Ferdinando D | Metodo apparecchio e prodotto per formare complessi stabili di polia nioni |
| US4188467A (en) * | 1975-10-31 | 1980-02-12 | A. H. Robins Company, Incorporated | Process for tempering tissue for heparin production |
| DE2646678C2 (de) * | 1975-10-31 | 1985-11-28 | A. H. Robins Co. Inc., Richmond, Va. | Verfahren zur Herstellung eines entfetteten Heparin-Gewebes |
| US4192916A (en) * | 1975-10-31 | 1980-03-11 | A. H. Robins Company, Incorporated | Process for producing defatted heparin tissue for heparin production |
| DE2646677C2 (de) * | 1975-10-31 | 1985-11-07 | A. H. Robins Co. Inc., Richmond, Va. | Verfahren zum Tempern von gefrorenem, Heparin führendem tierischem Gewebe |
| DE2660052A1 (de) * | 1976-11-12 | 1979-01-25 | Schering Ag | Verfahren zur herstellung von heparin |
| DE2652272C2 (de) * | 1976-11-12 | 1979-02-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Heparin |
| US4175182A (en) * | 1978-07-03 | 1979-11-20 | Research Corporation | Separation of high-activity heparin by affinity chromatography on supported protamine |
-
1979
- 1979-03-21 HU HU79RI705A patent/HU177887B/hu unknown
-
1980
- 1980-03-11 AT AT0134880A patent/AT368004B/de not_active IP Right Cessation
- 1980-03-13 ZA ZA00801480A patent/ZA801480B/xx unknown
- 1980-03-17 AT AT0144280A patent/AT365927B/de not_active IP Right Cessation
- 1980-03-18 SE SE8002126A patent/SE453725B/sv not_active IP Right Cessation
- 1980-03-18 PL PL1980222794A patent/PL134709B1/pl unknown
- 1980-03-18 ZA ZA00801564A patent/ZA801564B/xx unknown
- 1980-03-18 SE SE8002125A patent/SE451297B/sv not_active IP Right Cessation
- 1980-03-19 US US06/131,824 patent/US4315923A/en not_active Expired - Lifetime
- 1980-03-19 CS CS801898A patent/CS248012B2/cs unknown
- 1980-03-19 GR GR61493A patent/GR67682B/el unknown
- 1980-03-19 GR GR61492A patent/GR67681B/el unknown
- 1980-03-19 YU YU00765/80A patent/YU76580A/xx unknown
- 1980-03-19 CS CS801897A patent/CS248011B2/cs unknown
- 1980-03-20 SU SU802897802A patent/SU1375115A3/ru active
- 1980-03-20 DD DD80219787A patent/DD149467A5/de unknown
- 1980-03-20 AU AU56636/80A patent/AU533021B2/en not_active Ceased
- 1980-03-20 FR FR8006267A patent/FR2451744A1/fr active Granted
- 1980-03-20 CA CA000348222A patent/CA1152894A/en not_active Expired
- 1980-03-20 FR FR8006266A patent/FR2451743A1/fr active Granted
- 1980-03-20 AU AU56637/80A patent/AU529809B2/en not_active Ceased
- 1980-03-20 NZ NZ193188A patent/NZ193188A/en unknown
- 1980-03-20 YU YU00769/80A patent/YU76980A/xx unknown
- 1980-03-20 DK DK119780A patent/DK166504C/da not_active IP Right Cessation
- 1980-03-20 DD DD80219786A patent/DD149532A5/de not_active IP Right Cessation
- 1980-03-20 DK DK119480A patent/DK166393C/da not_active IP Right Cessation
- 1980-03-20 SU SU802897057A patent/SU1366042A3/ru active
- 1980-03-20 CA CA000348224A patent/CA1137081A/en not_active Expired
- 1980-03-21 ES ES490537A patent/ES490537A0/es active Granted
- 1980-03-21 AR AR280393A patent/AR222215A1/es active
- 1980-03-21 BE BE0/199895A patent/BE882370A/fr not_active IP Right Cessation
- 1980-03-21 NZ NZ193215A patent/NZ193215A/en unknown
- 1980-03-21 AR AR280392A patent/AR219226A1/es active
- 1980-03-21 JP JP3601280A patent/JPS55164202A/ja active Granted
- 1980-03-21 NL NL8001693A patent/NL8001693A/nl not_active Application Discontinuation
- 1980-03-21 IT IT67444/80A patent/IT1133074B/it active
- 1980-03-21 NL NL8001695A patent/NL8001695A/nl not_active Application Discontinuation
- 1980-03-21 IT IT67438/80A patent/IT1133068B/it active
- 1980-03-21 GB GB8009608A patent/GB2045271B/en not_active Expired
- 1980-03-21 BR BR8001717A patent/BR8001717A/pt unknown
- 1980-03-21 BE BE0/199894A patent/BE882369A/fr not_active IP Right Cessation
- 1980-03-21 GB GB8009611A patent/GB2045272B/en not_active Expired
- 1980-03-21 JP JP3600680A patent/JPS55164201A/ja active Granted
- 1980-03-21 PL PL1980222906A patent/PL128250B1/pl unknown
- 1980-03-21 ES ES490538A patent/ES8102581A1/es not_active Expired
- 1980-03-21 BR BR8001711A patent/BR8001711A/pt unknown
- 1980-03-21 DE DE19803010972 patent/DE3010972A1/de active Granted
- 1980-03-21 DE DE19803011062 patent/DE3011062A1/de not_active Withdrawn
- 1980-08-21 IN IN952/CAL/80A patent/IN153527B/en unknown
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