SMT201600162B - Pirrolopirazina-ammidi piperidin spirocicliche come modulatori dei canali ionici - Google Patents

Pirrolopirazina-ammidi piperidin spirocicliche come modulatori dei canali ionici

Info

Publication number
SMT201600162B
SMT201600162B SM201600162T SM201600162T SMT201600162B SM T201600162 B SMT201600162 B SM T201600162B SM 201600162 T SM201600162 T SM 201600162T SM 201600162 T SM201600162 T SM 201600162T SM T201600162 B SMT201600162 B SM T201600162B
Authority
SM
San Marino
Prior art keywords
pyrrolopyrazine
spirocyclic
piperidin
modulators
amides
Prior art date
Application number
SM201600162T
Other languages
English (en)
Italian (it)
Inventor
Ruah Sara S Hadida
Edward Adam Kallel
Mark Thomas Miller
Vijayalaksmi Arumugam
Jason Mccartney
Corey Anderson
Peter Diederik Jan Grootenhuis
Licong Jiang
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of SMT201600162B publication Critical patent/SMT201600162B/it

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Orthopedic Medicine & Surgery (AREA)
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  • Diabetes (AREA)
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  • Otolaryngology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SM201600162T 2011-02-02 2016-06-08 Pirrolopirazina-ammidi piperidin spirocicliche come modulatori dei canali ionici SMT201600162B (it)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161438685P 2011-02-02 2011-02-02
US201161440987P 2011-02-09 2011-02-09
US201161495538P 2011-06-10 2011-06-10
PCT/US2012/023593 WO2012106499A1 (en) 2011-02-02 2012-02-02 Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels

Publications (1)

Publication Number Publication Date
SMT201600162B true SMT201600162B (it) 2016-07-01

Family

ID=45689011

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201600162T SMT201600162B (it) 2011-02-02 2016-06-08 Pirrolopirazina-ammidi piperidin spirocicliche come modulatori dei canali ionici

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US (3) US8916565B2 (enExample)
EP (2) EP2670752B1 (enExample)
JP (2) JP6021824B2 (enExample)
KR (1) KR101923367B1 (enExample)
CN (2) CN103403004B (enExample)
AR (1) AR085893A1 (enExample)
AU (1) AU2012212196B2 (enExample)
BR (1) BR112013019211A2 (enExample)
CA (1) CA2825204C (enExample)
CY (1) CY1117471T1 (enExample)
DK (1) DK2670752T3 (enExample)
ES (1) ES2573497T3 (enExample)
HR (1) HRP20160382T8 (enExample)
HU (1) HUE028789T2 (enExample)
IL (1) IL227815B (enExample)
MX (1) MX355907B (enExample)
NZ (1) NZ613028A (enExample)
PL (1) PL2670752T3 (enExample)
PT (1) PT2670752E (enExample)
RS (1) RS54785B1 (enExample)
RU (1) RU2634900C2 (enExample)
SG (1) SG192248A1 (enExample)
SI (1) SI2670752T1 (enExample)
SM (1) SMT201600162B (enExample)
TW (2) TW201604196A (enExample)
WO (1) WO2012106499A1 (enExample)
ZA (1) ZA201305152B (enExample)

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SG192248A1 (en) 2011-02-02 2013-09-30 Vertex Pharma Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
MX2013009393A (es) 2011-02-18 2013-08-29 Vertex Pharma Piperidinamidas cromano-espirociclicas como moduladores de canales de iones.
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CN104024251B (zh) 2011-10-31 2017-08-11 克赛农制药股份有限公司 苯磺酰胺化合物及其作为治疗剂的用途
KR20140105445A (ko) 2011-10-31 2014-09-01 제논 파마슈티칼스 인크. 비아릴 에테르 술폰아미드 및 치료제로서의 그의 용도
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WO2014022639A1 (en) 2012-08-01 2014-02-06 Vertex Pharmaceuticals Incorporated Solid forms of (4-isopropoxy-3-methoxyphenyl)(2'-methyl-6'-(trifluoromethyl)-3',4'-dihydro-2'h-spiro[piperidine-4,1'-pyrrolo[1,2-a]pyrazine]-1-yl)methanone
US9139529B2 (en) 2013-01-31 2015-09-22 Vertex Pharmaceuticals Incorporated Substituted quinoxalines as sodium channel modulators
IL269964B1 (en) 2013-01-31 2025-09-01 Vertex Pharma Pyridone amide compounds, compositions containing them and uses thereof
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CN105263490B (zh) 2013-03-14 2018-05-22 基因泰克公司 取代的三唑并吡啶及其使用方法
JP6227112B2 (ja) 2013-03-15 2017-11-08 ジェネンテック， インコーポレイテッド 置換ベンゾオキサゾールとその使用方法
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CN106715418A (zh) 2014-07-07 2017-05-24 基因泰克公司 治疗化合物及其使用方法
PE20180575A1 (es) 2015-05-22 2018-04-04 Genentech Inc Benzamidas sustituidas y metodos para utilizarlas
CN108137477A (zh) 2015-08-27 2018-06-08 基因泰克公司 治疗化合物及其使用方法
CR20180242A (es) 2015-09-28 2018-08-10 Genentech Inc Compuestos terapéuticos y sus métodos de uso
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