KR101923367B1 - 이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드 - Google Patents

이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드 Download PDF

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KR101923367B1
KR101923367B1 KR1020137023136A KR20137023136A KR101923367B1 KR 101923367 B1 KR101923367 B1 KR 101923367B1 KR 1020137023136 A KR1020137023136 A KR 1020137023136A KR 20137023136 A KR20137023136 A KR 20137023136A KR 101923367 B1 KR101923367 B1 KR 101923367B1
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pain
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ring
alkyl
mmol
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KR20140014162A (ko
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루아 사라 에스. 하디다
에드워드 아담 칼렐
마크 토마스 밀러
비제이알라크스미 아루무감
제이슨 매카트니
코리 앤더슨
페터르 디더릭 얀 흐로텐하위스
리충 장
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버텍스 파마슈티칼스 인코포레이티드
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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KR1020137023136A 2011-02-02 2012-02-02 이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드 Active KR101923367B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161438685P 2011-02-02 2011-02-02
US61/438,685 2011-02-02
US201161440987P 2011-02-09 2011-02-09
US61/440,987 2011-02-09
US201161495538P 2011-06-10 2011-06-10
US61/495,538 2011-06-10
PCT/US2012/023593 WO2012106499A1 (en) 2011-02-02 2012-02-02 Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels

Publications (2)

Publication Number Publication Date
KR20140014162A KR20140014162A (ko) 2014-02-05
KR101923367B1 true KR101923367B1 (ko) 2018-12-04

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US (3) US8916565B2 (enExample)
EP (2) EP3056495A1 (enExample)
JP (2) JP6021824B2 (enExample)
KR (1) KR101923367B1 (enExample)
CN (2) CN103403004B (enExample)
AR (1) AR085893A1 (enExample)
AU (1) AU2012212196B2 (enExample)
BR (1) BR112013019211A2 (enExample)
CA (1) CA2825204C (enExample)
CY (1) CY1117471T1 (enExample)
DK (1) DK2670752T3 (enExample)
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HU (1) HUE028789T2 (enExample)
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SI (1) SI2670752T1 (enExample)
SM (1) SMT201600162B (enExample)
TW (2) TW201604196A (enExample)
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TW201604196A (zh) * 2011-02-02 2016-02-01 維泰克斯製藥公司 作為離子通道調節劑之吡咯并吡-螺環哌啶醯胺
US10385070B2 (en) 2011-02-18 2019-08-20 Vertex Pharmaceuticals Incorporated Chroman-spirocyclic piperidine amides as modulators of ion channels
EP2686325B1 (en) 2011-03-14 2016-12-14 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
JP6014155B2 (ja) 2011-10-31 2016-10-25 ゼノン・ファーマシューティカルズ・インコーポレイテッドXenon Pharmaceuticals Inc. ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用
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KR101719893B1 (ko) 2012-05-22 2017-03-24 제넨테크, 인크. N-치환된 벤즈아미드 및 통증의 치료에서 이들의 용도
JP6309519B2 (ja) 2012-07-06 2018-04-11 ジェネンテック, インコーポレイテッド N置換ベンズアミド及びその使用方法
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KR102226587B1 (ko) 2013-01-31 2021-03-11 버텍스 파마슈티칼스 인코포레이티드 나트륨 채널의 조절제로서의 퀴놀린 및 퀴나졸린 아미드
PL2953931T3 (pl) 2013-01-31 2017-09-29 Vertex Pharmaceuticals Incorporated Pirydonoamidy jako modulatory kanałów sodowych
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
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