SK822003A3 - Medicament for the immunotherapy of malignant tumours - Google Patents
Medicament for the immunotherapy of malignant tumours Download PDFInfo
- Publication number
- SK822003A3 SK822003A3 SK82-2003A SK822003A SK822003A3 SK 822003 A3 SK822003 A3 SK 822003A3 SK 822003 A SK822003 A SK 822003A SK 822003 A3 SK822003 A3 SK 822003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- tumor
- cells
- dendritic cells
- medicament
- monocytes
- Prior art date
Links
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- 238000009169 immunotherapy Methods 0.000 title abstract description 8
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- 201000003741 Gastrointestinal carcinoma Diseases 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
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- 239000012979 RPMI medium Substances 0.000 description 2
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- 210000000612 antigen-presenting cell Anatomy 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
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- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 208000009849 Female Genital Neoplasms Diseases 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
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- 238000002512 chemotherapy Methods 0.000 description 1
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- 230000004041 dendritic cell maturation Effects 0.000 description 1
- 229960002986 dinoprostone Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
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- 230000001338 necrotic effect Effects 0.000 description 1
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- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000011470 radical surgery Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- YEENEYXBHNNNGV-XEHWZWQGSA-M sodium;3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoate;(2r,3r,4s,5s,6r)-2-[(2r,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound [Na+].CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I.O[C@H]1[C@H](O)[C@@H](CO)O[C@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 YEENEYXBHNNNGV-XEHWZWQGSA-M 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000005909 tumor killing Effects 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00116362 | 2000-07-28 | ||
| PCT/EP2001/008455 WO2002009745A1 (de) | 2000-07-28 | 2001-07-21 | Arzneimittel zur immuntherapie maligner tumoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK822003A3 true SK822003A3 (en) | 2004-05-04 |
Family
ID=8169380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK82-2003A SK822003A3 (en) | 2000-07-28 | 2001-07-21 | Medicament for the immunotherapy of malignant tumours |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20030129206A1 (cs) |
| EP (1) | EP1305041B1 (cs) |
| JP (1) | JP2004505058A (cs) |
| AT (1) | ATE330626T1 (cs) |
| AU (1) | AU2001279775A1 (cs) |
| BG (1) | BG107482A (cs) |
| CA (1) | CA2417374A1 (cs) |
| CY (1) | CY1105179T1 (cs) |
| CZ (1) | CZ299669B6 (cs) |
| DE (1) | DE50110274D1 (cs) |
| DK (1) | DK1305041T3 (cs) |
| ES (1) | ES2267800T3 (cs) |
| HK (1) | HK1055562A1 (cs) |
| HU (1) | HUP0300772A3 (cs) |
| NO (1) | NO20030420L (cs) |
| PL (1) | PL358675A1 (cs) |
| PT (1) | PT1305041E (cs) |
| SI (1) | SI1305041T1 (cs) |
| SK (1) | SK822003A3 (cs) |
| WO (1) | WO2002009745A1 (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030211971A1 (en) * | 2001-09-17 | 2003-11-13 | Srivastava Pramod K. | Compositions and methods for prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with compositions comprising unfractionated cellular proteins |
| EP1603391A4 (en) * | 2003-02-20 | 2009-06-24 | Univ Connecticut Health Ct | METHOD OF USE OF COMPOSITIONS COMPRISING HIGH SHOCK PROTEINS OR ALPHA-2-MACROGLOBULIN IN THE TREATMENT OF CANCER AND INFECTION DISEASES |
| US7674456B2 (en) * | 2004-06-14 | 2010-03-09 | Charles Wiseman | Breast cancer cell lines and uses thereof |
| MY160857A (en) * | 2006-02-03 | 2017-03-31 | Malaysian Palm Oil Board | A cancer vaccine |
| EP1974742A1 (en) * | 2007-03-29 | 2008-10-01 | LipoNova AG | A method for improving the manufacturing process of a tumour vaccine |
| JP2012531391A (ja) | 2009-07-02 | 2012-12-10 | アイティーエイチ イミュン セラピー ホールディングス エービー | ガンのエキソソーム−ベースの治療 |
| CN105807053B (zh) | 2016-04-15 | 2019-04-02 | 苏州药明康德新药开发股份有限公司 | 一种肿瘤解离试剂在流式细胞检测中的应用 |
| ES2908885T3 (es) | 2017-07-05 | 2022-05-04 | Vcc Medical Deutschland Gmbh | Método para fabricar una vacuna tumoral |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077519A (en) * | 1993-01-29 | 2000-06-20 | University Of Pittsburgh | Methods for isolation and use of T cell epitopes eluted from viable cells in vaccines for treating cancer patients |
| DE19633731A1 (de) * | 1996-08-21 | 1998-02-26 | Johann Hinrich Prof Dr Peters | Hybridzellen zur Steigerung der Immunogenität von Tumorzellen |
| CA2321093A1 (en) * | 1998-02-20 | 1999-08-26 | The Rockefeller University | Apoptotic cell-mediated antigen presentation to dendritic cells |
| DE19812004A1 (de) * | 1998-03-19 | 1999-09-30 | Forschungszentrum Juelich Gmbh | Dehydrogenasen mit verbesserter NAD-Abhängigkeit, deren Herstellung und Verwendung |
| AU3102799A (en) * | 1998-03-20 | 1999-10-11 | Genzyme Corporation | Enhanced anti-tumor immunity |
| CA2326739A1 (en) * | 1998-04-02 | 1999-10-14 | The Regents Of The University Of California | Methods for enhancing antigen-presenting cells and anti-tumor responses in a human patient |
| US6045990A (en) * | 1998-07-09 | 2000-04-04 | Baust; John M. | Inclusion of apoptotic regulators in solutions for cell storage at low temperature |
-
2001
- 2001-07-21 CZ CZ20030179A patent/CZ299669B6/cs not_active IP Right Cessation
- 2001-07-21 WO PCT/EP2001/008455 patent/WO2002009745A1/de active IP Right Grant
- 2001-07-21 CA CA002417374A patent/CA2417374A1/en not_active Abandoned
- 2001-07-21 JP JP2002515298A patent/JP2004505058A/ja not_active Abandoned
- 2001-07-21 ES ES01958002T patent/ES2267800T3/es not_active Expired - Lifetime
- 2001-07-21 PT PT01958002T patent/PT1305041E/pt unknown
- 2001-07-21 HU HU0300772A patent/HUP0300772A3/hu unknown
- 2001-07-21 SI SI200130618T patent/SI1305041T1/sl unknown
- 2001-07-21 US US09/926,630 patent/US20030129206A1/en not_active Abandoned
- 2001-07-21 DE DE50110274T patent/DE50110274D1/de not_active Expired - Fee Related
- 2001-07-21 AT AT01958002T patent/ATE330626T1/de not_active IP Right Cessation
- 2001-07-21 DK DK01958002T patent/DK1305041T3/da active
- 2001-07-21 PL PL01358675A patent/PL358675A1/xx unknown
- 2001-07-21 SK SK82-2003A patent/SK822003A3/sk unknown
- 2001-07-21 EP EP01958002A patent/EP1305041B1/de not_active Expired - Lifetime
- 2001-07-21 AU AU2001279775A patent/AU2001279775A1/en not_active Abandoned
-
2003
- 2003-01-21 BG BG107482A patent/BG107482A/bg active Pending
- 2003-01-27 NO NO20030420A patent/NO20030420L/no not_active Application Discontinuation
- 2003-10-27 HK HK03107742A patent/HK1055562A1/xx not_active IP Right Cessation
-
2006
- 2006-08-29 CY CY20061101216T patent/CY1105179T1/el unknown
- 2006-11-06 US US11/593,132 patent/US20070134275A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CZ2003179A3 (cs) | 2004-01-14 |
| CY1105179T1 (el) | 2010-03-03 |
| SI1305041T1 (sl) | 2006-12-31 |
| DE50110274D1 (de) | 2006-08-03 |
| AU2001279775A1 (en) | 2002-02-13 |
| CA2417374A1 (en) | 2003-01-27 |
| BG107482A (bg) | 2003-11-28 |
| US20070134275A1 (en) | 2007-06-14 |
| WO2002009745A1 (de) | 2002-02-07 |
| HUP0300772A2 (en) | 2003-08-28 |
| NO20030420D0 (no) | 2003-01-27 |
| PT1305041E (pt) | 2006-09-29 |
| EP1305041B1 (de) | 2006-06-21 |
| EP1305041A1 (de) | 2003-05-02 |
| ATE330626T1 (de) | 2006-07-15 |
| HK1055562A1 (en) | 2004-01-16 |
| CZ299669B6 (cs) | 2008-10-08 |
| US20030129206A1 (en) | 2003-07-10 |
| NO20030420L (no) | 2003-01-27 |
| HUP0300772A3 (en) | 2005-11-28 |
| DK1305041T3 (da) | 2006-10-23 |
| JP2004505058A (ja) | 2004-02-19 |
| ES2267800T3 (es) | 2007-03-16 |
| PL358675A1 (en) | 2004-08-09 |
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