CN106943432B - 一种脐带间充质干细胞来源的外泌体及其在制备治疗肝癌药物中的应用 - Google Patents
一种脐带间充质干细胞来源的外泌体及其在制备治疗肝癌药物中的应用 Download PDFInfo
- Publication number
- CN106943432B CN106943432B CN201710241765.8A CN201710241765A CN106943432B CN 106943432 B CN106943432 B CN 106943432B CN 201710241765 A CN201710241765 A CN 201710241765A CN 106943432 B CN106943432 B CN 106943432B
- Authority
- CN
- China
- Prior art keywords
- exosome
- liver cancer
- umbilical cord
- compound
- mesenchymal stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710241765.8A CN106943432B (zh) | 2017-04-14 | 2017-04-14 | 一种脐带间充质干细胞来源的外泌体及其在制备治疗肝癌药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710241765.8A CN106943432B (zh) | 2017-04-14 | 2017-04-14 | 一种脐带间充质干细胞来源的外泌体及其在制备治疗肝癌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106943432A CN106943432A (zh) | 2017-07-14 |
CN106943432B true CN106943432B (zh) | 2020-06-05 |
Family
ID=59477223
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710241765.8A Active CN106943432B (zh) | 2017-04-14 | 2017-04-14 | 一种脐带间充质干细胞来源的外泌体及其在制备治疗肝癌药物中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106943432B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110151726A (zh) * | 2018-02-11 | 2019-08-23 | 上海市第六人民医院 | 负载白藜芦醇的人多能干细胞外泌体在制备治疗骨与关节退行性疾病药物上的用途 |
CN108354947A (zh) * | 2018-03-29 | 2018-08-03 | 汪洪 | 负载白藜芦醇的人多能干细胞外泌体在制备治疗难愈性皮肤创面相关疾病药物上的用途 |
CN110876734A (zh) * | 2018-09-06 | 2020-03-13 | 杨昆德 | 包含胞外囊泡的制剂、用以制备该制剂的方法及其用途 |
CN109568269B (zh) * | 2018-10-19 | 2021-12-21 | 广州医科大学 | 一种具有诊疗功能外泌体及其制备方法 |
CN113209135B (zh) * | 2021-04-23 | 2023-06-13 | 奥启(深圳)生物科技有限公司 | 一种用于延缓皮肤衰老的间充质干细胞外泌体制剂 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101239978A (zh) * | 2008-03-05 | 2008-08-13 | 南方医科大学 | 一种咪唑并吡啶类化合物 |
CN104434915A (zh) * | 2014-11-17 | 2015-03-25 | 中国药科大学 | 咪唑并吡啶类化合物的用途 |
CN105968111A (zh) * | 2016-07-14 | 2016-09-28 | 华润赛科药业有限责任公司 | 吡啶并咪唑类衍生物、其制备方法和应用 |
CN106083847A (zh) * | 2016-08-03 | 2016-11-09 | 山东大学 | 一种咪唑并吡啶巯乙酸类衍生物及其制备方法与应用 |
-
2017
- 2017-04-14 CN CN201710241765.8A patent/CN106943432B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101239978A (zh) * | 2008-03-05 | 2008-08-13 | 南方医科大学 | 一种咪唑并吡啶类化合物 |
CN104434915A (zh) * | 2014-11-17 | 2015-03-25 | 中国药科大学 | 咪唑并吡啶类化合物的用途 |
CN105968111A (zh) * | 2016-07-14 | 2016-09-28 | 华润赛科药业有限责任公司 | 吡啶并咪唑类衍生物、其制备方法和应用 |
CN106083847A (zh) * | 2016-08-03 | 2016-11-09 | 山东大学 | 一种咪唑并吡啶巯乙酸类衍生物及其制备方法与应用 |
Non-Patent Citations (2)
Title |
---|
Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis.;Zhang H等;《Nature communications》;20170410;第8卷;全文 * |
Murine bone marrow stromal cells pulsed with homologous tumor-derived exosomes inhibit proliferation of liver cancer cells.;Bo Ma等;《Clinical and translational oncology》;20121030;第14卷(第10期);全文 * |
Also Published As
Publication number | Publication date |
---|---|
CN106943432A (zh) | 2017-07-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106943432B (zh) | 一种脐带间充质干细胞来源的外泌体及其在制备治疗肝癌药物中的应用 | |
CN106974938B (zh) | 一种具有抗肝癌作用的骨髓间充质干细胞来源的外泌体及其药物制剂 | |
KR20100051032A (ko) | 산삼 또는 인삼을 포함한 인삼류의 형성층 유래 식물줄기세포주를 유효성분으로 함유하는 암의 예방 또는 치료용 조성물 | |
US20070134275A1 (en) | Medicaments for the immunotherapy of malignant tumors | |
KR100874613B1 (ko) | 줄기세포 배양액을 이용한 암세포 성장 저해 방법 | |
CN115400216B (zh) | 一种用于甲状腺未分化癌的药物组合物和应用 | |
JP2014224085A (ja) | 抗癌幹細胞剤 | |
TW201132342A (en) | Antrocin containing pharmaceutical compositions for inhibiting cancer cells | |
CN115282143A (zh) | α-倒捻子素在制备治疗黑色素瘤药物中的应用及药物 | |
KR102152659B1 (ko) | 편도 유래 중간엽 줄기세포의 조정 배지를 포함하는 암 전이 억제용 조성물 | |
CN106265619A (zh) | Dfmo或dfmo和姜提取物在制备食管癌和肝癌的预防及临床治疗的药物中的应用 | |
CN113304141A (zh) | 银杏双黄酮在制备抗肿瘤药物及肿瘤化疗增敏剂中的应用 | |
CN107281177B (zh) | 促进造血干细胞归巢和植入的方法 | |
CN105284786B (zh) | 一种细胞保存液及其在保护巨核祖细胞活力中的应用 | |
KR20030067275A (ko) | 니트로이미다졸 및 위상 이성질화 효소 저해제를유효성분으로 포함하는 항암제 | |
CN113181166B (zh) | 莪术烯醇在制备抗肺癌药物中的应用 | |
CN110856717A (zh) | 一种肿瘤免疫调节剂及其用途 | |
CN112370444B (zh) | 一种pd-1/pd-l1抑制剂及其应用 | |
CN114712393B (zh) | Hnf-1α基因修饰的间充质干细胞在防治肝癌中的用途 | |
KR20010101065A (ko) | 표고버섯 균사체 추출물 유래의 lak 활성증강물질 및이를 함유하는 lak 활성증강용 제제 | |
KR20130067037A (ko) | 산삼 또는 인삼을 포함한 인삼류의 형성층 유래 식물줄기세포주를 유효성분으로 함유하는 암의 예방 또는 치료용 조성물 | |
KR102526447B1 (ko) | 편도 유래 중간엽 줄기세포의 조정 배지를 포함하는 간질환 예방 또는 치료용 조성물 | |
CN104873513B (zh) | 一种抑制肺癌细胞转移的药物组合物以及检测方法 | |
CN105999245A (zh) | 含乌司他丁的药物组合物在制备治疗胆囊癌药物中的用途 | |
CN115554317A (zh) | 一种用于治疗肿瘤的药物组合物、试剂盒及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20200508 Address after: 510630 5202, building D, No. 100, Village North Ring Road, Tianhe District, Guangzhou City, Guangdong Province Applicant after: Guangzhou Zeus Biotechnology Co.,Ltd. Address before: 211198 No. 18 Zhilan Road, Science Park, Jiangning District, Nanjing City, Jiangsu Province Applicant before: NANJING GAISIFU MEDICAL TECHNOLOGY Co.,Ltd. |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20230817 Address after: 3rd and 4th floors of the main building, No. 883 Shenzhou Road, Science City, Guangzhou High tech Industrial Development Zone, Guangdong Province, 510670 Patentee after: Guangzhou Ruiting Cosmetics Manufacturing Co.,Ltd. Address before: 5202, Building D, No. 100, Village North Ring Road, Tianhe District, Guangzhou City, Guangdong Province, 510630 Patentee before: Guangzhou Zeus Biotechnology Co.,Ltd. |
|
TR01 | Transfer of patent right |