SK47099A3 - Benzimidazole-2-carbamates for the treatment of viral infections and cancer - Google Patents
Benzimidazole-2-carbamates for the treatment of viral infections and cancer Download PDFInfo
- Publication number
- SK47099A3 SK47099A3 SK470-99A SK47099A SK47099A3 SK 47099 A3 SK47099 A3 SK 47099A3 SK 47099 A SK47099 A SK 47099A SK 47099 A3 SK47099 A3 SK 47099A3
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- pharmaceutical composition
- cancer
- viral infections
- tumors
- treatment
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US08/857,811 US6506783B1 (en) | 1997-05-16 | 1997-05-16 | Cancer treatments and pharmaceutical compositions therefor |
| PCT/US1997/021565 WO1998051304A1 (en) | 1997-05-16 | 1997-11-26 | Benzimidazole-2-carbamates for the treatment of viral infections and cancer |
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| SK47099A3 true SK47099A3 (en) | 2000-05-16 |
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| SK470-99A SK47099A3 (en) | 1997-05-16 | 1997-11-26 | Benzimidazole-2-carbamates for the treatment of viral infections and cancer |
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| BR (1) | BR9714634A (https=) |
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| CZ (1) | CZ125299A3 (https=) |
| DE (1) | DE69737793D1 (https=) |
| HU (1) | HUP0001170A3 (https=) |
| IL (1) | IL129352A0 (https=) |
| NO (1) | NO991700L (https=) |
| NZ (1) | NZ335159A (https=) |
| PE (1) | PE11099A1 (https=) |
| PL (1) | PL335541A1 (https=) |
| SK (1) | SK47099A3 (https=) |
| TR (1) | TR199901528T2 (https=) |
| WO (1) | WO1998051304A1 (https=) |
| ZA (1) | ZA979096B (https=) |
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| US6262093B1 (en) | 1995-04-12 | 2001-07-17 | The Proctor & Gamble Company | Methods of treating cancer with benzimidazoles |
| US6479526B1 (en) | 1995-04-12 | 2002-11-12 | The Procter & Gamble Company | Pharmaceutical composition for inhibiting the growth of viruses and cancers |
| US6177460B1 (en) | 1995-04-12 | 2001-01-23 | The Procter & Gamble Company | Method of treatment for cancer or viral infections |
| US6265427B1 (en) | 1995-06-07 | 2001-07-24 | The Proctor & Gamble Company | Pharmaceutical composition for the method of treating leukemia |
| US5770616A (en) | 1995-06-07 | 1998-06-23 | The Procter & Gamble Company | Pharmaceutical composition for inhibiting the growth of cancers |
| US6686391B2 (en) | 1995-08-04 | 2004-02-03 | University Of Arizona Foundation | N-chlorophenylcarbamate and N-chlorophenylthiocarbamate compositions |
| US5900429A (en) | 1997-01-28 | 1999-05-04 | The Procter & Gamble Company | Method for inhibiting the growth of cancers |
| US6506783B1 (en) | 1997-05-16 | 2003-01-14 | The Procter & Gamble Company | Cancer treatments and pharmaceutical compositions therefor |
| US6245789B1 (en) | 1998-05-19 | 2001-06-12 | The Procter & Gamble Company | HIV and viral treatment |
| US6423734B1 (en) * | 1999-08-13 | 2002-07-23 | The Procter & Gamble Company | Method of preventing cancer |
| US6384049B1 (en) * | 2000-05-25 | 2002-05-07 | The Procter & Gamble Company | Cancer treatment |
| US6407105B1 (en) * | 2000-09-26 | 2002-06-18 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6608096B1 (en) | 2000-09-26 | 2003-08-19 | University Of Arizona Foundation | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6462062B1 (en) | 2000-09-26 | 2002-10-08 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6380232B1 (en) | 2000-09-26 | 2002-04-30 | The Procter & Gamble Company | Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof |
| WO2002041891A2 (en) * | 2000-11-01 | 2002-05-30 | The Procter & Gamble Company | Hiv treatment with benzimidazoles |
| CA2430897C (en) * | 2000-12-07 | 2010-11-16 | Universiteit Utrecht Holding B.V. | Liposomal composition comprising water-soluble corticosteroids for the treatment of inflammatory disorders |
| WO2002067932A1 (en) * | 2001-01-11 | 2002-09-06 | Board Of Regents, The University Of Texas System | Antihelminthic drugs as a treatment for hyperproliferative diseases |
| US6515074B2 (en) * | 2001-01-22 | 2003-02-04 | Delphi Technologies, Inc. | Thermoplastic polymer alloy compositions and process for manufacture thereof |
| US6693125B2 (en) * | 2001-01-24 | 2004-02-17 | Combinatorx Incorporated | Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders |
| AUPR626001A0 (en) * | 2001-07-10 | 2001-08-02 | Mcgregor, Neil | A method of treatment and/or prophylaxis |
| AU2002330088B2 (en) * | 2001-09-24 | 2009-09-03 | Jessie L.-S. Au | Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy |
| JP2005521712A (ja) * | 2002-03-26 | 2005-07-21 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ | 弱塩基の可溶化 |
| US20050152962A1 (en) * | 2002-06-12 | 2005-07-14 | Metselaar Josbert M. | Composition for treatment of inflammatory disorders |
| US8492443B2 (en) * | 2002-07-08 | 2013-07-23 | Joe S. Wilkins, Jr. | Treatment for herpes simplex virus and other infectious diseases |
| EP1393720A1 (en) * | 2002-08-27 | 2004-03-03 | Universiteit Utrecht | Vesicle-encapsulated corticosteroids for treatment of cancer |
| AU2003900064A0 (en) * | 2003-01-09 | 2003-01-23 | Penam Investments Pty. Ltd. | A method of treatment or prophylaxis of viral infection. |
| CA2518318A1 (en) * | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP1598353A1 (en) * | 2004-05-17 | 2005-11-23 | Boehringer Ingelheim International GmbH | Pyrrolobenzimidazolones and their use as antiproliferative agents |
| WO2006040329A1 (en) * | 2004-10-12 | 2006-04-20 | Novo Nordisk A/S | 1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds |
| US7193254B2 (en) * | 2004-11-30 | 2007-03-20 | International Business Machines Corporation | Structure and method of applying stresses to PFET and NFET transistor channels for improved performance |
| US20090286838A1 (en) * | 2004-12-06 | 2009-11-19 | Newsouth Innovations Pty Limited | Treatment for cancer |
| CN103143004A (zh) | 2005-02-04 | 2013-06-12 | 萨瓦克公司 | 存活蛋白肽疫苗 |
| US7265248B1 (en) | 2005-04-29 | 2007-09-04 | Technology Innovations, Llc | Compositions and methods for the treatment of malaria |
| BRPI0618051A2 (pt) * | 2005-11-01 | 2011-08-16 | Transtech Pharma Inc | uso farmacêutico de amidas substituìdas |
| KR20080076916A (ko) * | 2005-11-01 | 2008-08-20 | 트랜스테크 파르마, 인크. | 치환된 아미드의 약학적 사용 |
| CA2883060C (en) * | 2005-11-09 | 2019-01-08 | Philera New Zealand Limited | Treatment of mitochondria-related diseases and improvement of age-related metabolic deficits |
| JP2009528354A (ja) * | 2006-02-28 | 2009-08-06 | メルク エンド カムパニー インコーポレーテッド | ヒストン脱アセチル化酵素のインヒビター |
| EP2007722A1 (en) * | 2006-03-21 | 2008-12-31 | High Point Pharmaceuticals, LLC | Adamantane derivatives for the treatment of the metabolic syndrome |
| KR20090014347A (ko) | 2006-04-07 | 2009-02-10 | 하이 포인트 파마슈티칼스, 엘엘씨 | 11β-히드록시스테로이드 탈수소효소 타입 1 활성 화합물 |
| US20100003679A1 (en) * | 2006-06-09 | 2010-01-07 | University Of Miami | Assessment of cellular composition and fractional viability and uses thereof |
| EP2038255A2 (en) * | 2006-06-16 | 2009-03-25 | High Point Pharmaceuticals, LLC | Pharmaceutical use of substituted piperidine carboxamides |
| EP1878721A1 (en) * | 2006-07-13 | 2008-01-16 | Novo Nordisk A/S | 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors |
| US8048908B2 (en) * | 2006-07-13 | 2011-11-01 | High Point Pharmaceuticals, Llc | 11β-hydroxysteroid dehydrogenase type 1 active compounds |
| EP2125704A1 (en) * | 2007-02-23 | 2009-12-02 | High Point Pharmaceuticals, LLC | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| WO2008101907A2 (en) * | 2007-02-23 | 2008-08-28 | High Point Pharmaceuticals, Llc | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| ZA200904916B (en) | 2007-02-23 | 2010-09-29 | High Point Pharmaceuticals Llc | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
| JP2010519239A (ja) * | 2007-02-23 | 2010-06-03 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | １１−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害因子としてのｎ−アドマンチルベンザミド |
| CN101652359A (zh) * | 2007-03-09 | 2010-02-17 | 高点制药有限责任公司 | 作为羟类固醇脱氢酶抑制剂的吲哚-和苯并咪唑酰胺类 |
| EP2141990A4 (en) * | 2007-03-28 | 2011-07-06 | High Point Pharmaceuticals Llc | ACTIVE COMPOUNDS ON 11BETA-HSD1 |
| CN101677562A (zh) * | 2007-04-11 | 2010-03-24 | 高点制药有限责任公司 | 新化合物 |
| JP2010526777A (ja) * | 2007-04-24 | 2010-08-05 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | 置換アミドの医薬用途 |
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| WO2009005638A2 (en) * | 2007-06-27 | 2009-01-08 | Merck & Co., Inc. | Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors |
| US8835506B2 (en) | 2008-06-05 | 2014-09-16 | Stc.Unm | Methods and related compositions for the treatment of cancer |
| WO2011056561A1 (en) | 2009-10-27 | 2011-05-12 | Beth Israel Deaconess Medical Center | Methods and compositions for the generation and use of conformation-specific antibodies |
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| WO2012149334A2 (en) | 2011-04-27 | 2012-11-01 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
| CN104780914B (zh) | 2012-05-09 | 2018-02-09 | 健康科学西部大学 | 前体脂质体睾酮制剂 |
| US9649313B2 (en) * | 2012-11-26 | 2017-05-16 | The University Of North Carolina At Chapel Hill | Use of ITK inhibitors for the treatment of cancer |
| WO2016077648A1 (en) * | 2014-11-11 | 2016-05-19 | Neymeyer Calvin E | Method of treating pre-cancerous lesion with glyphosate, and compositions thereof |
| WO2016187767A1 (en) * | 2015-05-25 | 2016-12-01 | Hutchison Medipharma Limited | Pharmaceutical compositions and use thereof |
| US11547696B2 (en) | 2016-10-28 | 2023-01-10 | Children's Hospital Medical Center | Methods and compositions for treatment of myelodysplastic syndromes and/or acute myeloid leukemias |
| CN109633026A (zh) * | 2019-01-03 | 2019-04-16 | 上海市农业科学院 | 一种液相色谱-串联质谱检测多菌灵及其代谢物的方法 |
| KR102583547B1 (ko) | 2020-03-30 | 2023-10-06 | (주)바이오메트릭스 테크놀로지 | 신규한 벤지미다졸 유도체, 이의 제조방법 및 이의 항암제 용도 |
| EP3907230B1 (en) | 2020-03-30 | 2024-08-28 | Biometrix Technology Inc. | Novel benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent comprising the same |
| US12043644B2 (en) | 2020-06-23 | 2024-07-23 | Biometrix Technology Inc | Benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent or anti-virus agent comprising the same |
| KR102449266B1 (ko) | 2020-06-23 | 2022-09-30 | (주)바이오메트릭스 테크놀로지 | 항암 활성 그리고 항바이러스 활성을 갖는 신규한 벤지미다졸-탄수화물 결합체 화합물(Benzimidazole carbohydrate conjugate compound) 및 이의 제조 방법 |
| KR102342313B1 (ko) | 2021-08-27 | 2021-12-24 | (주)바이오메트릭스 테크놀로지 | 벤지미다졸-탄수화물 결합체 화합물을 포함하는 미셀, 이의 제조방법, 이의 항암제 또는 항바이러스제로서의 용도 |
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| DE136499C (https=) | ||||
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| US2933502A (en) | 1958-02-12 | 1960-04-19 | Du Pont | Benzimidazolone derivatives |
| US3010968A (en) | 1959-11-25 | 1961-11-28 | Du Pont | Process for manufacture of certain alkyl esters of benzimidazole carbamic acids |
| NL134354C (https=) | 1963-05-23 | |||
| US3499761A (en) | 1964-07-20 | 1970-03-10 | Gaf Corp | Silver halide emulsions containing alkyl esters of benzimidazole carbamic acid antifogging agents |
| BE666795A (https=) | 1964-08-04 | 1966-01-13 | ||
| USRE28403E (en) | 1964-08-04 | 1975-04-29 | Butyl and n-propoxy-z-carbo- methoxyaminobenzimidazoles | |
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-
1997
- 1997-05-16 US US08/857,811 patent/US6506783B1/en not_active Expired - Fee Related
- 1997-10-10 PE PE1997000897A patent/PE11099A1/es not_active Application Discontinuation
- 1997-10-10 ZA ZA979096A patent/ZA979096B/xx unknown
- 1997-10-17 AR ARP970104815A patent/AR010008A1/es unknown
- 1997-11-26 AT AT97949600T patent/ATE363904T1/de not_active IP Right Cessation
- 1997-11-26 PL PL97335541A patent/PL335541A1/xx unknown
- 1997-11-26 DE DE69737793T patent/DE69737793D1/de not_active Expired - Lifetime
- 1997-11-26 WO PCT/US1997/021565 patent/WO1998051304A1/en not_active Ceased
- 1997-11-26 CA CA002268840A patent/CA2268840C/en not_active Expired - Fee Related
- 1997-11-26 TR TR1999/01528T patent/TR199901528T2/xx unknown
- 1997-11-26 CZ CZ991252A patent/CZ125299A3/cs unknown
- 1997-11-26 SK SK470-99A patent/SK47099A3/sk unknown
- 1997-11-26 JP JP52193098A patent/JP2001527523A/ja not_active Ceased
- 1997-11-26 AU AU74027/98A patent/AU728690B2/en not_active Ceased
- 1997-11-26 IL IL12935297A patent/IL129352A0/xx unknown
- 1997-11-26 CN CN97182190A patent/CN1254282A/zh active Pending
- 1997-11-26 BR BR9714634-0A patent/BR9714634A/pt unknown
- 1997-11-26 NZ NZ335159A patent/NZ335159A/xx unknown
- 1997-11-26 HU HU0001170A patent/HUP0001170A3/hu unknown
- 1997-11-26 KR KR1019990703138A patent/KR20000049065A/ko not_active Ceased
- 1997-11-26 EP EP97949600A patent/EP0956017B1/en not_active Expired - Lifetime
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1999
- 1999-03-01 US US09/259,969 patent/US6077862A/en not_active Expired - Fee Related
- 1999-04-09 NO NO991700A patent/NO991700L/no not_active Application Discontinuation
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2000
- 2000-09-29 US US09/676,032 patent/US6900235B1/en not_active Expired - Fee Related
- 2000-09-29 US US09/676,202 patent/US6420411B1/en not_active Expired - Fee Related
- 2000-09-29 US US09/676,407 patent/US6482843B1/en not_active Expired - Fee Related
- 2000-09-29 US US09/676,409 patent/US6423736B1/en not_active Expired - Fee Related
- 2000-09-29 US US09/676,031 patent/US6710065B1/en not_active Expired - Fee Related
- 2000-09-29 US US09/676,030 patent/US6407131B1/en not_active Expired - Fee Related
- 2000-09-29 US US09/676,034 patent/US6864275B1/en not_active Expired - Fee Related
- 2000-09-29 US US09/676,029 patent/US6423735B1/en not_active Expired - Fee Related
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2003
- 2003-01-13 US US10/340,945 patent/US6984654B2/en not_active Expired - Fee Related
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2004
- 2004-10-21 US US10/970,346 patent/US20050192328A1/en not_active Abandoned
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2005
- 2005-08-26 US US11/212,300 patent/US20050288349A1/en not_active Abandoned
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