SK287784B6 - Fotosenzitizér a spôsob jeho prípravy - Google Patents

Fotosenzitizér a spôsob jeho prípravy Download PDF

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Publication number
SK287784B6
SK287784B6 SK1348-2003A SK13482003A SK287784B6 SK 287784 B6 SK287784 B6 SK 287784B6 SK 13482003 A SK13482003 A SK 13482003A SK 287784 B6 SK287784 B6 SK 287784B6
Authority
SK
Slovakia
Prior art keywords
solution
chlorine
photosensitizer
filtered
extract
Prior art date
Application number
SK1348-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK13482003A3 (sk
Inventor
Andrei Valentinovich Reshetnikov
Igor Dmitrievich Zalevsky
Jury Viktorovich Kemov
Andrei Valentinovich Ivanov
Artashes Vacheevich Karmenyan
Alexandr Tikhonovich Gradjushko
Vladimir Petrovich Laptev
Nataliya Petrovna Neugodova
Olga Yurievna Abakumova
Valery Alexeevich Privalov
Alexandr Vladimirovich Lappa
Vladimir Alexandrovich Romanov
Original Assignee
Rada-Pharma International B. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rada-Pharma International B. V. filed Critical Rada-Pharma International B. V.
Publication of SK13482003A3 publication Critical patent/SK13482003A3/sk
Publication of SK287784B6 publication Critical patent/SK287784B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Light Receiving Elements (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SK1348-2003A 2001-03-30 2001-10-04 Fotosenzitizér a spôsob jeho prípravy SK287784B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2001108397/14A RU2183956C1 (ru) 2001-03-30 2001-03-30 Фотосенсибилизатор и способ его получения
PCT/RU2001/000399 WO2002078694A1 (fr) 2001-03-30 2001-10-04 Photosensibilisateur et procede pour produire ledit photosensibilisateur

Publications (2)

Publication Number Publication Date
SK13482003A3 SK13482003A3 (sk) 2004-05-04
SK287784B6 true SK287784B6 (sk) 2011-09-05

Family

ID=20247772

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1348-2003A SK287784B6 (sk) 2001-03-30 2001-10-04 Fotosenzitizér a spôsob jeho prípravy

Country Status (23)

Country Link
US (2) US6969765B2 (bg)
EP (1) EP1380295B1 (bg)
KR (1) KR100628548B1 (bg)
CN (1) CN1250294C (bg)
AT (1) ATE426403T1 (bg)
AU (1) AU2002212867B2 (bg)
BG (1) BG108534A (bg)
BR (1) BR0116952A (bg)
CA (1) CA2440650C (bg)
CZ (1) CZ304591B6 (bg)
DE (1) DE60138141D1 (bg)
GB (1) GB2389531B (bg)
HR (1) HRP20030876B1 (bg)
HU (1) HU227756B1 (bg)
MX (1) MXPA03008925A (bg)
NO (1) NO327751B1 (bg)
NZ (1) NZ528237A (bg)
PL (1) PL206902B1 (bg)
RU (1) RU2183956C1 (bg)
SI (1) SI1380295T1 (bg)
SK (1) SK287784B6 (bg)
WO (1) WO2002078694A1 (bg)
ZA (1) ZA200308407B (bg)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004110438A1 (fr) * 2003-06-17 2004-12-23 Peter Timofeevich Petrov Agent de diagnostic et de therapie photodynamiques de maladies oncologiques
CA2437638A1 (en) * 2003-08-20 2005-02-20 John Robert North Photodynamic therapy
GB0323358D0 (en) * 2003-10-06 2003-11-05 Green Grass Design Ltd Novel compounds and processes
PL368213A1 (en) * 2004-05-25 2005-11-28 ADAMED Sp.z o.o. New coupling, method for its fabrication and its application
JP5172851B2 (ja) * 2006-11-03 2013-03-27 クワンジュ インスティチュート オブ サイエンス アンド テクノロジー クロロフィルａ及びクロリンｅ６の製造方法
KR100808630B1 (ko) * 2006-12-28 2008-02-29 광주과학기술원 클로린 화합물을 포함하는 경구투여용 항종양 조성물
CN100496516C (zh) * 2007-12-03 2009-06-10 贵州圣济堂制药有限公司 一种螺旋藻组合物及其制备方法与应用
RU2367434C1 (ru) * 2008-04-22 2009-09-20 Виктор Александрович Борисов Фотосенсибилизатор и способ его получения
KR100896327B1 (ko) * 2008-09-09 2009-05-07 다이아텍코리아 주식회사 스피루리나로부터 클로로필 ａ 및 클로린을 제조하는 방법
US8735439B2 (en) 2009-04-29 2014-05-27 Diatech Korea Co., Ltd. Chlorin e6-folic acid conjugate, preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same
KR100918810B1 (ko) 2009-04-29 2009-09-25 다이아텍코리아 주식회사 클로린 ｅ６-엽산 결합 화합물을 함유하는 암 치료용 약학적 조성물
ES2354096B1 (es) * 2009-07-27 2012-02-23 Nuevas Tecnologias Cientificas, S.A. Procedimiento para la obtencion de un fotosensibilizante para ser empleado en terapia fotodinamica y fotosensibilizante.
KR100950441B1 (ko) * 2009-09-30 2010-04-02 주식회사 아큐텍 스피루리나로부터 클로로필 ａ 및 포토디타진을 제조하는 방법
RU2490273C1 (ru) * 2012-02-27 2013-08-20 Оскар Иосифович Койфман Способ получения метилфеофорбида (а)
SG11201504595UA (en) * 2012-12-14 2015-07-30 Rmw Cho Group Ltd Chlorin derivative useful in photodynamic therapy and diagnosis
RU2523380C1 (ru) * 2013-05-21 2014-07-20 Общество с ограниченной ответственностью "ГЕЛИОХЛОРИН" Фотосенсибилизатор и способ его получения
CN105777760A (zh) * 2014-12-23 2016-07-20 深圳市中兴扬帆生物工程有限公司 四间-羟基苯基二氢卟酚原料药的保存方法
CN106349736A (zh) * 2016-08-05 2017-01-25 雷春生 一种纯有机光敏染料的制备方法
KR102357787B1 (ko) * 2016-12-14 2022-02-03 동성제약주식회사 고순도 트리소듐 클로린 e6(trisodium Chlorin e6)와 PVP (polyvinylpyrrolidone)의 복합체 제조 방법과 Chlorin e6의 제조 방법
RU2670087C1 (ru) * 2018-01-29 2018-10-18 Михаил Александрович Грин Фотосенсибилизатор для лечения рака предстательной железы и способ его получения
RU2691754C1 (ru) * 2018-11-15 2019-06-18 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Нижегородский государственный университет им. Н.И. Лобачевского" ПРОИЗВОДНОЕ ЦИНКОВОГО МЕТАЛЛОКОМПЛЕКСА ХЛОРИНА-e6 И ЕГО ПРИМЕНЕНИЕ
CN112521392A (zh) * 2019-09-18 2021-03-19 康俄(上海)医疗科技有限公司 一种二氢卟吩e6的纯化方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3102891A (en) 1959-11-16 1963-09-03 Elmer A Allen New porphyrinic and chlorophyllic compositions and process therefor
US4977177A (en) 1985-04-30 1990-12-11 Nippon Petrochemicals Company, Ltd. Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents
US5216012A (en) * 1986-01-02 1993-06-01 University Of Toledo Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions
US5002962A (en) 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
JP2963178B2 (ja) 1990-09-27 1999-10-12 株式会社エス・エル・ティ・ジャパン 水溶性フェオホーバイドａの製造方法
US5330741A (en) * 1992-02-24 1994-07-19 The Regents Of The University Of California Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors
RU2054476C1 (ru) * 1993-07-14 1996-02-20 Мещерякова Аделия Леонидовна Способ получения 18-карбокси-20-(карбоксиметил)-8-этенил-13-этил-2,3-дигидро-3,7-12,17-тетраметил-21н, 23нпорфин-2-пропионовой кислоты или ее солей
IL116126A0 (en) * 1995-11-24 1996-01-31 Yeda Res & Dev Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them
RU2152790C1 (ru) * 1999-05-12 2000-07-20 Мещерякова Аделия Леонидовна Средство для фотодинамической диагностики и терапии онкологических заболеваний

Also Published As

Publication number Publication date
ZA200308407B (en) 2005-02-23
HU227756B1 (en) 2012-02-28
CA2440650A1 (en) 2002-10-10
ATE426403T1 (de) 2009-04-15
PL206902B1 (pl) 2010-10-29
EP1380295B1 (en) 2009-03-25
EP1380295A1 (en) 2004-01-14
CA2440650C (en) 2009-09-15
SI1380295T1 (sl) 2009-10-31
KR20040025911A (ko) 2004-03-26
HUP0400298A3 (en) 2007-05-29
US20060003983A1 (en) 2006-01-05
HUP0400298A2 (hu) 2004-07-28
GB2389531B (en) 2005-03-16
GB0321726D0 (en) 2003-10-15
PL365102A1 (en) 2004-12-27
US6969765B2 (en) 2005-11-29
HRP20030876A2 (en) 2005-08-31
NZ528237A (en) 2006-09-29
NO327751B1 (no) 2009-09-14
CN1250294C (zh) 2006-04-12
EP1380295A4 (en) 2005-11-30
CN1512881A (zh) 2004-07-14
RU2183956C1 (ru) 2002-06-27
DE60138141D1 (de) 2009-05-07
EP1380295A9 (en) 2004-04-14
NO20034344D0 (no) 2003-09-29
CZ20032940A3 (cs) 2004-04-14
HRP20030876B1 (en) 2011-10-31
SK13482003A3 (sk) 2004-05-04
NO20034344L (no) 2003-11-21
AU2002212867B2 (en) 2007-07-12
WO2002078694A1 (fr) 2002-10-10
GB2389531A (en) 2003-12-17
CZ304591B6 (cs) 2014-07-23
BR0116952A (pt) 2004-06-01
MXPA03008925A (es) 2005-03-07
US7550587B2 (en) 2009-06-23
US20040147499A1 (en) 2004-07-29
BG108534A (bg) 2005-02-28
KR100628548B1 (ko) 2006-09-26

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Legal Events

Date Code Title Description
PC4A Assignment and transfer of rights

Owner name: RADA-PHARMA INTERNATIONAL B. V., PV, STEENBERG, NL

Free format text: FORMER OWNER: "RADA-PHARMA" OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIJU, MOSCOW, RU

Effective date: 20100412

MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20131004