SK286912B6 - Imidazoimidazoly a triazoly, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty - Google Patents
Imidazoimidazoly a triazoly, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty Download PDFInfo
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- SK286912B6 SK286912B6 SK256-2002A SK2562002A SK286912B6 SK 286912 B6 SK286912 B6 SK 286912B6 SK 2562002 A SK2562002 A SK 2562002A SK 286912 B6 SK286912 B6 SK 286912B6
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- CQQJSOXDEFZGFG-UHFFFAOYSA-N imidazo[4,5-d]imidazole Chemical class C1=NC2=NC=NC2=N1 CQQJSOXDEFZGFG-UHFFFAOYSA-N 0.000 title claims abstract description 16
- 150000003852 triazoles Chemical class 0.000 title claims abstract description 15
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 4
- 239000000543 intermediate Substances 0.000 title abstract description 19
- 150000001875 compounds Chemical class 0.000 claims abstract description 81
- 201000010099 disease Diseases 0.000 claims abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 10
- 230000002757 inflammatory effect Effects 0.000 claims abstract description 6
- 230000001404 mediated effect Effects 0.000 claims abstract description 5
- 210000002865 immune cell Anatomy 0.000 claims abstract description 4
- 210000004969 inflammatory cell Anatomy 0.000 claims abstract description 4
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims description 957
- 125000004432 carbon atom Chemical group C* 0.000 claims description 946
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 308
- -1 firyl Chemical group 0.000 claims description 268
- 125000000623 heterocyclic group Chemical group 0.000 claims description 244
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 236
- 125000002252 acyl group Chemical group 0.000 claims description 215
- 239000001257 hydrogen Substances 0.000 claims description 185
- 229910052739 hydrogen Inorganic materials 0.000 claims description 185
- 125000005843 halogen group Chemical group 0.000 claims description 156
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 156
- 125000003118 aryl group Chemical group 0.000 claims description 134
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 125
- 125000001072 heteroaryl group Chemical group 0.000 claims description 122
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 118
- 229930195734 saturated hydrocarbon Natural products 0.000 claims description 113
- 125000004429 atom Chemical group 0.000 claims description 109
- 229910052799 carbon Inorganic materials 0.000 claims description 103
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 94
- 229910052736 halogen Inorganic materials 0.000 claims description 91
- 125000004076 pyridyl group Chemical group 0.000 claims description 78
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 78
- 125000001544 thienyl group Chemical group 0.000 claims description 75
- 150000001721 carbon Chemical group 0.000 claims description 73
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 72
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 72
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 70
- 239000004215 Carbon black (E152) Substances 0.000 claims description 69
- 229930195733 hydrocarbon Natural products 0.000 claims description 69
- 229910052757 nitrogen Inorganic materials 0.000 claims description 68
- 125000002541 furyl group Chemical group 0.000 claims description 66
- 150000002431 hydrogen Chemical class 0.000 claims description 65
- 125000002757 morpholinyl group Chemical group 0.000 claims description 65
- 125000004193 piperazinyl group Chemical group 0.000 claims description 65
- 125000003386 piperidinyl group Chemical group 0.000 claims description 65
- 125000002971 oxazolyl group Chemical group 0.000 claims description 58
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 52
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 51
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims description 51
- 125000000335 thiazolyl group Chemical group 0.000 claims description 50
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- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims description 47
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 47
- 125000002883 imidazolyl group Chemical group 0.000 claims description 44
- 125000000842 isoxazolyl group Chemical group 0.000 claims description 44
- 125000001113 thiadiazolyl group Chemical group 0.000 claims description 44
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims description 43
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims description 42
- 125000001425 triazolyl group Chemical group 0.000 claims description 40
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 39
- 125000001041 indolyl group Chemical group 0.000 claims description 39
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 39
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 38
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- 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 claims description 38
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 38
- 125000001715 oxadiazolyl group Chemical group 0.000 claims description 38
- 125000004306 triazinyl group Chemical group 0.000 claims description 38
- 125000001786 isothiazolyl group Chemical group 0.000 claims description 37
- 125000001624 naphthyl group Chemical group 0.000 claims description 37
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 36
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 36
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 34
- 125000001422 pyrrolinyl group Chemical group 0.000 claims description 32
- 125000002785 azepinyl group Chemical group 0.000 claims description 28
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims description 28
- 125000002632 imidazolidinyl group Chemical group 0.000 claims description 28
- 125000002636 imidazolinyl group Chemical group 0.000 claims description 28
- 229920006395 saturated elastomer Polymers 0.000 claims description 28
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 28
- 125000001984 thiazolidinyl group Chemical group 0.000 claims description 28
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 27
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 claims description 27
- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 claims description 26
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims description 25
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 25
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims description 25
- 125000000304 alkynyl group Chemical group 0.000 claims description 24
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 24
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
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- 125000005605 benzo group Chemical group 0.000 claims description 13
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- 238000011282 treatment Methods 0.000 claims description 12
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 10
- 125000001246 bromo group Chemical group Br* 0.000 claims description 10
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims description 10
- 150000002500 ions Chemical class 0.000 claims description 9
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- 125000006413 ring segment Chemical group 0.000 claims description 8
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- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 4
- 125000002843 carboxylic acid group Chemical group 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 125000004434 sulfur atom Chemical group 0.000 claims description 4
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 claims description 3
- QPFYXYFORQJZEC-FOCLMDBBSA-N Phenazopyridine Chemical compound NC1=NC(N)=CC=C1\N=N\C1=CC=CC=C1 QPFYXYFORQJZEC-FOCLMDBBSA-N 0.000 claims description 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 3
- 229940070891 pyridium Drugs 0.000 claims description 3
- 125000001424 substituent group Chemical group 0.000 claims description 3
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- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
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- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Veterinary Medicine (AREA)
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- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US14490599P | 1999-07-21 | 1999-07-21 | |
US15093999P | 1999-08-26 | 1999-08-26 | |
PCT/US2000/018884 WO2001007440A1 (fr) | 1999-07-21 | 2000-07-12 | Anti-inflammatoires a base d'imidazoimidazoles et de triazoles |
Publications (2)
Publication Number | Publication Date |
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SK2562002A3 SK2562002A3 (en) | 2002-07-02 |
SK286912B6 true SK286912B6 (sk) | 2009-07-06 |
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Application Number | Title | Priority Date | Filing Date |
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SK256-2002A SK286912B6 (sk) | 1999-07-21 | 2000-07-12 | Imidazoimidazoly a triazoly, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty |
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US (3) | US6492408B1 (fr) |
EP (1) | EP1216247B1 (fr) |
JP (1) | JP2003505460A (fr) |
KR (2) | KR20070053363A (fr) |
CN (1) | CN1166667C (fr) |
AR (1) | AR029383A1 (fr) |
AT (1) | ATE413402T1 (fr) |
AU (1) | AU776496B2 (fr) |
BG (1) | BG65865B1 (fr) |
BR (1) | BR0012666A (fr) |
CA (1) | CA2383017A1 (fr) |
CO (1) | CO5180640A1 (fr) |
CZ (1) | CZ2002191A3 (fr) |
DE (1) | DE60040751D1 (fr) |
DK (1) | DK1216247T3 (fr) |
EA (1) | EA004932B1 (fr) |
EE (1) | EE04965B1 (fr) |
ES (1) | ES2316374T3 (fr) |
HK (1) | HK1048637B (fr) |
HR (1) | HRP20020051A2 (fr) |
HU (1) | HUP0203971A3 (fr) |
IL (2) | IL147296A0 (fr) |
MX (1) | MXPA02000540A (fr) |
MY (1) | MY155218A (fr) |
NO (1) | NO322707B1 (fr) |
NZ (1) | NZ517217A (fr) |
PL (1) | PL352755A1 (fr) |
RS (1) | RS50260B (fr) |
SK (1) | SK286912B6 (fr) |
TR (1) | TR200200160T2 (fr) |
TW (1) | TWI261591B (fr) |
UY (1) | UY26249A1 (fr) |
WO (1) | WO2001007440A1 (fr) |
Families Citing this family (58)
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US6492408B1 (en) * | 1999-07-21 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
WO2002012243A2 (fr) | 2000-08-09 | 2002-02-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Synthese de (r)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo--3-methyl-1-h-imidazo[1,2-a]imidazol-2-one |
US20030008848A1 (en) * | 2000-12-19 | 2003-01-09 | Fleck Roman Wolfgang | Small molecules useful in the treatment of inflammatory disease |
IL156813A0 (en) * | 2001-01-26 | 2004-02-08 | Bristol Myers Squibb Co | Imidazolyl derivatives and pharmaceutical compositions containing the same |
US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
CA2451605C (fr) * | 2001-06-20 | 2010-08-10 | Daiichi Pharmaceutical Co., Ltd. | Derives de diamine |
PL368402A1 (en) * | 2001-08-09 | 2005-03-21 | Daiichi Pharmaceutical Co, Ltd. | Diamine derivatives |
FR2829766A1 (fr) * | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
WO2004032861A2 (fr) | 2002-10-11 | 2004-04-22 | Bristol-Myers Squibb Company | Composes hexahydro-benzimidazolones utiles en tant qu'agents anti-inflammatoires |
US6852748B1 (en) * | 2002-10-30 | 2005-02-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide |
US6844360B2 (en) * | 2002-10-30 | 2005-01-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide |
EP1712553A3 (fr) * | 2002-10-30 | 2006-11-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | Dérivés de [6, 7-dihydro-5h-imidazo[1,2 - a]imidazole -3-sulfonylamino]-propionamide et leur utilisation comme inhibiteurs de l'interaction des molécules d'adhésion cellulaire et des leucointégrines |
US7199125B2 (en) | 2003-10-02 | 2007-04-03 | Bristol-Myers Squibb Company | Spiro-cyclic compounds useful as anti-inflammatory agents |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
RU2006144075A (ru) * | 2004-06-16 | 2008-07-27 | Вайет (Us) | ДИФЕНИЛИМИДАЗОПИРИМИДИН И -ИМИДАЗОЛАМИНЫ КАК ИНГИБИТОРЫ β-СЕКРЕТАЗЫ |
ATE444962T1 (de) * | 2004-06-16 | 2009-10-15 | Wyeth Corp | Amino-5,5-diphenylimidazolon-derivate zur beta- sekretase-hemmung |
WO2006014828A1 (fr) * | 2004-07-27 | 2006-02-09 | Boehringer Ingelheim International, Gmbh | Synthese d'amides d'acide 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonique |
TW200616634A (en) | 2004-10-01 | 2006-06-01 | Bristol Myers Squibb Co | Crystalline forms and process for preparing spiro-hydantoin compounds |
AU2005295821A1 (en) * | 2004-10-12 | 2006-04-27 | Decode Genetics Ehf | Carboxylic acid peri - substituted bicyclics for occlusive artery disease |
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CA2593515A1 (fr) * | 2005-01-14 | 2006-07-20 | Wyeth | Amino-imidazolones destines a l'inhibition de la .beta.-secretase |
CN101111489A (zh) * | 2005-02-01 | 2008-01-23 | 惠氏公司 | 作为β-分泌酶的抑制剂的氨基-吡啶 |
EP1848692A1 (fr) | 2005-02-14 | 2007-10-31 | Wyeth | AZOLYLACYLGUANIDINES UTILISEES COMME INHIBITEURS DE LA ß-SECRETASE |
US7572921B2 (en) * | 2005-04-05 | 2009-08-11 | Boehringer Ingelheim International Gmbh | Substituted benzylimidazoles useful for the treatment of inflammatory diseases |
CA2603214A1 (fr) * | 2005-04-06 | 2006-10-12 | Steven Richard Brunette | Derives d'amides, esters et acides[6,7-dihydro-5h-imidazo[1,2-alpha]imidazole-3-sulfonyl]-azetedino-carboxyliques et leur utilisation comme anti-inflammatoires |
EP1888591A2 (fr) * | 2005-05-19 | 2008-02-20 | Boehringer Ingelheim International GmbH | Derives d'acide 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonique |
EP1896478B1 (fr) | 2005-06-14 | 2014-05-21 | Merck Sharp & Dohme Corp. | Inhibiteurs d'aspartyl protéase |
MX2008000212A (es) * | 2005-06-30 | 2008-03-24 | Wyeth Corp | Compuestos amino-5-(6 miembros)heteroarilimidazolona y el uso de estos para la modulacion de la (-secretasa. |
TW200730523A (en) * | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
CN101273018A (zh) * | 2005-09-26 | 2008-09-24 | 惠氏公司 | 用于β分泌酶(BACE)抑制剂的氨基-5-[4-(二氟甲氧基)苯基]-5-苯基咪唑酮化合物 |
BRPI0620025A2 (pt) * | 2005-12-19 | 2011-10-25 | Wyeth Corp | composto, método para o tratamento de uma doença ou transtorno associado a atividade excessiva de bace, método para modular a atividade de bace, composição farmacêutica e uso do composto |
EP1979309A2 (fr) * | 2006-01-20 | 2008-10-15 | Boehringer Ingelheim International GmbH | Synthese d amides d acide 6,7-dihydro-5h-imidazoý1,2-a¨imidazole-3-sulfonique |
WO2007100536A1 (fr) * | 2006-02-24 | 2007-09-07 | Wyeth | COMPOSES DE DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] POUR L'INHIBITION DE LA β-SECRETASE |
EP2032542A2 (fr) | 2006-06-12 | 2009-03-11 | Schering Corporation | Inhibiteurs d'aspartyl protéase hétérocycliques |
US7700606B2 (en) * | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
BRPI0716539A2 (pt) | 2006-09-07 | 2016-11-01 | Emisphere Tech Inc | métodos para sintetização de ácido n-(8-[2-hidroxibenzoil]amino) caprílico e de sal de sódio deste |
CA2662348A1 (fr) * | 2006-09-21 | 2008-03-27 | Wyeth | Indolylalkylpyridin-2-amines pour l'inhibition de la .beta.-secretase |
US8093254B2 (en) | 2006-12-12 | 2012-01-10 | Schering Corporation | Aspartyl protease inhibitors |
CL2008000784A1 (es) * | 2007-03-20 | 2008-05-30 | Wyeth Corp | Compuestos amino-5-[-4-(diflourometoxi) fenil sustituido]-5-fenilmidazolona, inhibidores de b-secretasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar alzheimer, deterioro cognitivo, sindrome de down, disminucion co |
CL2008000791A1 (es) * | 2007-03-23 | 2008-05-30 | Wyeth Corp | Compuestos derivados de 2-amino-5-(4-difluorometoxi-fenil)-5-fenil-imidazolidin-4-ona; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de una enfermedad asociada con la actividad bace excesiva, tales como enferm |
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RU2561132C2 (ru) | 2009-06-29 | 2015-08-20 | Аджиос Фармасьютикалз, Инк. | Производные хинолинсульфонамидов и их применение для модулирования пкм2 активности |
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US6492408B1 (en) * | 1999-07-21 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
US6852748B1 (en) | 2002-10-30 | 2005-02-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide |
US6844360B2 (en) | 2002-10-30 | 2005-01-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide |
CA2603214A1 (fr) | 2005-04-06 | 2006-10-12 | Steven Richard Brunette | Derives d'amides, esters et acides[6,7-dihydro-5h-imidazo[1,2-alpha]imidazole-3-sulfonyl]-azetedino-carboxyliques et leur utilisation comme anti-inflammatoires |
EP1888591A2 (fr) | 2005-05-19 | 2008-02-20 | Boehringer Ingelheim International GmbH | Derives d'acide 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonique |
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2000
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- 2000-07-12 JP JP2001512524A patent/JP2003505460A/ja active Pending
- 2000-07-12 NZ NZ517217A patent/NZ517217A/en unknown
- 2000-07-12 EE EEP200200028A patent/EE04965B1/xx not_active IP Right Cessation
- 2000-07-12 KR KR1020077009773A patent/KR20070053363A/ko not_active Application Discontinuation
- 2000-07-12 CZ CZ2002191A patent/CZ2002191A3/cs unknown
- 2000-07-12 CN CNB008125066A patent/CN1166667C/zh not_active Expired - Fee Related
- 2000-07-12 CA CA002383017A patent/CA2383017A1/fr not_active Abandoned
- 2000-07-12 AU AU62091/00A patent/AU776496B2/en not_active Ceased
- 2000-07-12 MX MXPA02000540A patent/MXPA02000540A/es active IP Right Grant
- 2000-07-12 HU HU0203971A patent/HUP0203971A3/hu unknown
- 2000-07-12 RS YU3902A patent/RS50260B/sr unknown
- 2000-07-12 SK SK256-2002A patent/SK286912B6/sk not_active IP Right Cessation
- 2000-07-12 TR TR2002/00160T patent/TR200200160T2/xx unknown
- 2000-07-12 EA EA200200097A patent/EA004932B1/ru not_active IP Right Cessation
- 2000-07-12 AT AT00948618T patent/ATE413402T1/de not_active IP Right Cessation
- 2000-07-12 BR BR0012666-7A patent/BR0012666A/pt active Pending
- 2000-07-12 ES ES00948618T patent/ES2316374T3/es not_active Expired - Lifetime
- 2000-07-12 KR KR1020027000782A patent/KR100767200B1/ko not_active IP Right Cessation
- 2000-07-12 EP EP00948618A patent/EP1216247B1/fr not_active Expired - Lifetime
- 2000-07-12 WO PCT/US2000/018884 patent/WO2001007440A1/fr active IP Right Grant
- 2000-07-12 DK DK00948618T patent/DK1216247T3/da active
- 2000-07-12 DE DE60040751T patent/DE60040751D1/de not_active Expired - Fee Related
- 2000-07-12 PL PL00352755A patent/PL352755A1/xx not_active Application Discontinuation
- 2000-07-12 IL IL14729600A patent/IL147296A0/xx active IP Right Grant
- 2000-07-19 CO CO00054510A patent/CO5180640A1/es not_active Application Discontinuation
- 2000-07-19 UY UY26249A patent/UY26249A1/es not_active Application Discontinuation
- 2000-07-19 MY MYPI20003311A patent/MY155218A/en unknown
- 2000-07-20 TW TW089114536A patent/TWI261591B/zh not_active IP Right Cessation
- 2000-07-21 AR ARP000103772A patent/AR029383A1/es not_active Suspension/Interruption
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2001
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2002
- 2002-01-16 BG BG106312A patent/BG65865B1/bg active Active
- 2002-01-18 NO NO20020275A patent/NO322707B1/no not_active IP Right Cessation
- 2002-01-18 HR HR20020051A patent/HRP20020051A2/hr not_active Application Discontinuation
- 2002-07-16 US US10/195,973 patent/US6689804B2/en not_active Expired - Lifetime
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- 2003-02-06 HK HK03100839.2A patent/HK1048637B/zh not_active IP Right Cessation
- 2003-09-25 US US10/672,412 patent/US7550494B2/en not_active Expired - Lifetime
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MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20100712 |