NO322707B1 - Imidazoimidazoler og -triazoler, anvenselse av disse for fremstilling av prparater for behandling eller forebygging av inflammatoriske eller immuncelle-medierte sykdommer samt farmasoytiske preparater omfattende slike forbindelser. - Google Patents
Imidazoimidazoler og -triazoler, anvenselse av disse for fremstilling av prparater for behandling eller forebygging av inflammatoriske eller immuncelle-medierte sykdommer samt farmasoytiske preparater omfattende slike forbindelser. Download PDFInfo
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- NO322707B1 NO322707B1 NO20020275A NO20020275A NO322707B1 NO 322707 B1 NO322707 B1 NO 322707B1 NO 20020275 A NO20020275 A NO 20020275A NO 20020275 A NO20020275 A NO 20020275A NO 322707 B1 NO322707 B1 NO 322707B1
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- 239000003381 stabilizer Substances 0.000 description 1
- KXCAEQNNTZANTK-UHFFFAOYSA-N stannane Chemical compound [SnH4] KXCAEQNNTZANTK-UHFFFAOYSA-N 0.000 description 1
- 229910000080 stannane Inorganic materials 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
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- 229940095064 tartrate Drugs 0.000 description 1
- CWXPZXBSDSIRCS-UHFFFAOYSA-N tert-butyl piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCNCC1 CWXPZXBSDSIRCS-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- QNMBSXGYAQZCTN-UHFFFAOYSA-N thiophen-3-ylboronic acid Chemical compound OB(O)C=1C=CSC=1 QNMBSXGYAQZCTN-UHFFFAOYSA-N 0.000 description 1
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
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- 230000035897 transcription Effects 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14490599P | 1999-07-21 | 1999-07-21 | |
US15093999P | 1999-08-26 | 1999-08-26 | |
PCT/US2000/018884 WO2001007440A1 (fr) | 1999-07-21 | 2000-07-12 | Anti-inflammatoires a base d'imidazoimidazoles et de triazoles |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20020275D0 NO20020275D0 (no) | 2002-01-18 |
NO20020275L NO20020275L (no) | 2002-02-04 |
NO322707B1 true NO322707B1 (no) | 2006-11-27 |
Family
ID=26842483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20020275A NO322707B1 (no) | 1999-07-21 | 2002-01-18 | Imidazoimidazoler og -triazoler, anvenselse av disse for fremstilling av prparater for behandling eller forebygging av inflammatoriske eller immuncelle-medierte sykdommer samt farmasoytiske preparater omfattende slike forbindelser. |
Country Status (33)
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US (3) | US6492408B1 (fr) |
EP (1) | EP1216247B1 (fr) |
JP (1) | JP2003505460A (fr) |
KR (2) | KR20070053363A (fr) |
CN (1) | CN1166667C (fr) |
AR (1) | AR029383A1 (fr) |
AT (1) | ATE413402T1 (fr) |
AU (1) | AU776496B2 (fr) |
BG (1) | BG65865B1 (fr) |
BR (1) | BR0012666A (fr) |
CA (1) | CA2383017A1 (fr) |
CO (1) | CO5180640A1 (fr) |
CZ (1) | CZ2002191A3 (fr) |
DE (1) | DE60040751D1 (fr) |
DK (1) | DK1216247T3 (fr) |
EA (1) | EA004932B1 (fr) |
EE (1) | EE04965B1 (fr) |
ES (1) | ES2316374T3 (fr) |
HK (1) | HK1048637B (fr) |
HR (1) | HRP20020051A2 (fr) |
HU (1) | HUP0203971A3 (fr) |
IL (2) | IL147296A0 (fr) |
MX (1) | MXPA02000540A (fr) |
MY (1) | MY155218A (fr) |
NO (1) | NO322707B1 (fr) |
NZ (1) | NZ517217A (fr) |
PL (1) | PL352755A1 (fr) |
RS (1) | RS50260B (fr) |
SK (1) | SK286912B6 (fr) |
TR (1) | TR200200160T2 (fr) |
TW (1) | TWI261591B (fr) |
UY (1) | UY26249A1 (fr) |
WO (1) | WO2001007440A1 (fr) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
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US6492408B1 (en) * | 1999-07-21 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
WO2002012243A2 (fr) | 2000-08-09 | 2002-02-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Synthese de (r)-3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo--3-methyl-1-h-imidazo[1,2-a]imidazol-2-one |
US20030008848A1 (en) * | 2000-12-19 | 2003-01-09 | Fleck Roman Wolfgang | Small molecules useful in the treatment of inflammatory disease |
IL156813A0 (en) * | 2001-01-26 | 2004-02-08 | Bristol Myers Squibb Co | Imidazolyl derivatives and pharmaceutical compositions containing the same |
US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
CA2451605C (fr) * | 2001-06-20 | 2010-08-10 | Daiichi Pharmaceutical Co., Ltd. | Derives de diamine |
PL368402A1 (en) * | 2001-08-09 | 2005-03-21 | Daiichi Pharmaceutical Co, Ltd. | Diamine derivatives |
FR2829766A1 (fr) * | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
WO2004032861A2 (fr) | 2002-10-11 | 2004-04-22 | Bristol-Myers Squibb Company | Composes hexahydro-benzimidazolones utiles en tant qu'agents anti-inflammatoires |
US6852748B1 (en) * | 2002-10-30 | 2005-02-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide |
US6844360B2 (en) * | 2002-10-30 | 2005-01-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide |
EP1712553A3 (fr) * | 2002-10-30 | 2006-11-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | Dérivés de [6, 7-dihydro-5h-imidazo[1,2 - a]imidazole -3-sulfonylamino]-propionamide et leur utilisation comme inhibiteurs de l'interaction des molécules d'adhésion cellulaire et des leucointégrines |
US7199125B2 (en) | 2003-10-02 | 2007-04-03 | Bristol-Myers Squibb Company | Spiro-cyclic compounds useful as anti-inflammatory agents |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
RU2006144075A (ru) * | 2004-06-16 | 2008-07-27 | Вайет (Us) | ДИФЕНИЛИМИДАЗОПИРИМИДИН И -ИМИДАЗОЛАМИНЫ КАК ИНГИБИТОРЫ β-СЕКРЕТАЗЫ |
ATE444962T1 (de) * | 2004-06-16 | 2009-10-15 | Wyeth Corp | Amino-5,5-diphenylimidazolon-derivate zur beta- sekretase-hemmung |
WO2006014828A1 (fr) * | 2004-07-27 | 2006-02-09 | Boehringer Ingelheim International, Gmbh | Synthese d'amides d'acide 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonique |
TW200616634A (en) | 2004-10-01 | 2006-06-01 | Bristol Myers Squibb Co | Crystalline forms and process for preparing spiro-hydantoin compounds |
AU2005295821A1 (en) * | 2004-10-12 | 2006-04-27 | Decode Genetics Ehf | Carboxylic acid peri - substituted bicyclics for occlusive artery disease |
US7186727B2 (en) | 2004-12-14 | 2007-03-06 | Bristol-Myers Squibb Company | Pyridyl-substituted spiro-hydantoin compounds and use thereof |
CA2593515A1 (fr) * | 2005-01-14 | 2006-07-20 | Wyeth | Amino-imidazolones destines a l'inhibition de la .beta.-secretase |
CN101111489A (zh) * | 2005-02-01 | 2008-01-23 | 惠氏公司 | 作为β-分泌酶的抑制剂的氨基-吡啶 |
EP1848692A1 (fr) | 2005-02-14 | 2007-10-31 | Wyeth | AZOLYLACYLGUANIDINES UTILISEES COMME INHIBITEURS DE LA ß-SECRETASE |
US7572921B2 (en) * | 2005-04-05 | 2009-08-11 | Boehringer Ingelheim International Gmbh | Substituted benzylimidazoles useful for the treatment of inflammatory diseases |
CA2603214A1 (fr) * | 2005-04-06 | 2006-10-12 | Steven Richard Brunette | Derives d'amides, esters et acides[6,7-dihydro-5h-imidazo[1,2-alpha]imidazole-3-sulfonyl]-azetedino-carboxyliques et leur utilisation comme anti-inflammatoires |
EP1888591A2 (fr) * | 2005-05-19 | 2008-02-20 | Boehringer Ingelheim International GmbH | Derives d'acide 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonique |
EP1896478B1 (fr) | 2005-06-14 | 2014-05-21 | Merck Sharp & Dohme Corp. | Inhibiteurs d'aspartyl protéase |
MX2008000212A (es) * | 2005-06-30 | 2008-03-24 | Wyeth Corp | Compuestos amino-5-(6 miembros)heteroarilimidazolona y el uso de estos para la modulacion de la (-secretasa. |
TW200730523A (en) * | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
CN101273018A (zh) * | 2005-09-26 | 2008-09-24 | 惠氏公司 | 用于β分泌酶(BACE)抑制剂的氨基-5-[4-(二氟甲氧基)苯基]-5-苯基咪唑酮化合物 |
BRPI0620025A2 (pt) * | 2005-12-19 | 2011-10-25 | Wyeth Corp | composto, método para o tratamento de uma doença ou transtorno associado a atividade excessiva de bace, método para modular a atividade de bace, composição farmacêutica e uso do composto |
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WO2007100536A1 (fr) * | 2006-02-24 | 2007-09-07 | Wyeth | COMPOSES DE DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] POUR L'INHIBITION DE LA β-SECRETASE |
EP2032542A2 (fr) | 2006-06-12 | 2009-03-11 | Schering Corporation | Inhibiteurs d'aspartyl protéase hétérocycliques |
US7700606B2 (en) * | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
BRPI0716539A2 (pt) | 2006-09-07 | 2016-11-01 | Emisphere Tech Inc | métodos para sintetização de ácido n-(8-[2-hidroxibenzoil]amino) caprílico e de sal de sódio deste |
CA2662348A1 (fr) * | 2006-09-21 | 2008-03-27 | Wyeth | Indolylalkylpyridin-2-amines pour l'inhibition de la .beta.-secretase |
US8093254B2 (en) | 2006-12-12 | 2012-01-10 | Schering Corporation | Aspartyl protease inhibitors |
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LT3307271T (lt) | 2015-06-11 | 2023-10-25 | Agios Pharmaceuticals, Inc. | Piruvatkinazės aktyvatorių panaudojimo būdai |
GB2560713A (en) * | 2017-03-20 | 2018-09-26 | Eternygen Gmbh | Inhibitor of citrate transporter |
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DE2100800A1 (de) | 1970-01-12 | 1971-07-15 | Sumitomo Chemical Co Ltd , Osaka (Japan) | Verfahren zur Herstellung von cycli sehen Arylimiden |
JPS5136332B1 (fr) | 1970-12-09 | 1976-10-07 | ||
JPS5188631A (en) | 1975-01-31 | 1976-08-03 | Hiiryoyosatsukinzai oyobi sonoseizoho | |
DE3382406D1 (de) | 1982-04-08 | 1991-10-17 | Shell Int Research | Neue hydantoine, ihre herstellung und verwendung. |
JPS60246374A (ja) | 1984-05-18 | 1985-12-06 | Daicel Chem Ind Ltd | 2−アミノイミダゾリン化合物の製造方法 |
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US5208250A (en) | 1988-05-25 | 1993-05-04 | Warner-Lambert Company | Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents |
IE62214B1 (en) | 1988-05-25 | 1995-01-11 | Warner Lambert Co | Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents |
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JPH04273877A (ja) * | 1991-02-28 | 1992-09-30 | Sumitomo Pharmaceut Co Ltd | 新規なイミダゾール誘導体 |
CA2083891A1 (fr) | 1991-12-03 | 1993-06-04 | Angus Murray Macleod | Composes heterocycliques, compositions et utilisation therapeutique |
TW521073B (en) | 1994-01-05 | 2003-02-21 | Hoechst Marion Roussel Inc | New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them |
WO1998039303A1 (fr) * | 1997-03-03 | 1998-09-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Petites molecules convenant au traitement d'une maladie inflammatoire |
US6630492B1 (en) | 1997-08-28 | 2003-10-07 | Novartis Ag | Lymphocyte function antigen-1 antagonists |
WO1999049856A2 (fr) | 1998-03-27 | 1999-10-07 | Genentech, Inc. | Antagonistes destines au traitement de troubles induits par le recepteur d'adhesion de cd11/cd18 |
WO2001006984A2 (fr) * | 1999-07-21 | 2001-02-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Petites particules utiles pour le traitement de maladies inflammatoires |
US6492408B1 (en) * | 1999-07-21 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
US6852748B1 (en) | 2002-10-30 | 2005-02-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide |
US6844360B2 (en) | 2002-10-30 | 2005-01-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide |
CA2603214A1 (fr) | 2005-04-06 | 2006-10-12 | Steven Richard Brunette | Derives d'amides, esters et acides[6,7-dihydro-5h-imidazo[1,2-alpha]imidazole-3-sulfonyl]-azetedino-carboxyliques et leur utilisation comme anti-inflammatoires |
EP1888591A2 (fr) | 2005-05-19 | 2008-02-20 | Boehringer Ingelheim International GmbH | Derives d'acide 6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonique |
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2000
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- 2000-07-12 BR BR0012666-7A patent/BR0012666A/pt active Pending
- 2000-07-12 ES ES00948618T patent/ES2316374T3/es not_active Expired - Lifetime
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- 2000-07-12 EP EP00948618A patent/EP1216247B1/fr not_active Expired - Lifetime
- 2000-07-12 WO PCT/US2000/018884 patent/WO2001007440A1/fr active IP Right Grant
- 2000-07-12 DK DK00948618T patent/DK1216247T3/da active
- 2000-07-12 DE DE60040751T patent/DE60040751D1/de not_active Expired - Fee Related
- 2000-07-12 PL PL00352755A patent/PL352755A1/xx not_active Application Discontinuation
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- 2000-07-20 TW TW089114536A patent/TWI261591B/zh not_active IP Right Cessation
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- 2002-07-16 US US10/195,973 patent/US6689804B2/en not_active Expired - Lifetime
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