SK285990B6 - Kombinácia nesedatívnych antihistaminík so substanciami, ktoré ovplyvňujú pôsobenie leukotriénu, naošetrovanie rinitídy/konjunktivitídy - Google Patents
Kombinácia nesedatívnych antihistaminík so substanciami, ktoré ovplyvňujú pôsobenie leukotriénu, naošetrovanie rinitídy/konjunktivitídy Download PDFInfo
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- SK285990B6 SK285990B6 SK1175-2002A SK11752002A SK285990B6 SK 285990 B6 SK285990 B6 SK 285990B6 SK 11752002 A SK11752002 A SK 11752002A SK 285990 B6 SK285990 B6 SK 285990B6
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- SK
- Slovakia
- Prior art keywords
- antagonist
- leukotriene
- pharmaceutical composition
- allergic
- azelastine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Landscapes
- Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10007203A DE10007203A1 (de) | 2000-02-17 | 2000-02-17 | Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis |
| PCT/EP2001/001190 WO2001060407A2 (de) | 2000-02-17 | 2001-02-05 | Neue kombination nichtsedierender antihistaminika mit substanzen, die die leukotrienwirkung beeinflussen, zur behandlung der rhinitis/konjunktivitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK11752002A3 SK11752002A3 (sk) | 2002-11-06 |
| SK285990B6 true SK285990B6 (sk) | 2008-01-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1175-2002A SK285990B6 (sk) | 2000-02-17 | 2001-02-05 | Kombinácia nesedatívnych antihistaminík so substanciami, ktoré ovplyvňujú pôsobenie leukotriénu, naošetrovanie rinitídy/konjunktivitídy |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6436924B2 (ja) |
| EP (1) | EP1265615B1 (ja) |
| JP (1) | JP5529362B2 (ja) |
| KR (1) | KR100764329B1 (ja) |
| CN (1) | CN1241569C (ja) |
| AR (1) | AR027528A1 (ja) |
| AT (1) | ATE287266T1 (ja) |
| AU (1) | AU781177B2 (ja) |
| BR (1) | BR0108445A (ja) |
| CZ (1) | CZ296395B6 (ja) |
| DE (2) | DE10007203A1 (ja) |
| DK (1) | DK1265615T3 (ja) |
| ES (1) | ES2236189T3 (ja) |
| HK (1) | HK1053792A1 (ja) |
| HU (1) | HU228927B1 (ja) |
| IL (2) | IL151106A0 (ja) |
| MX (1) | MXPA02008064A (ja) |
| NO (1) | NO328153B1 (ja) |
| NZ (1) | NZ520470A (ja) |
| PL (1) | PL198357B1 (ja) |
| PT (1) | PT1265615E (ja) |
| RU (1) | RU2292208C2 (ja) |
| SK (1) | SK285990B6 (ja) |
| TW (1) | TWI296525B (ja) |
| UA (1) | UA72587C2 (ja) |
| WO (1) | WO2001060407A2 (ja) |
| ZA (1) | ZA200206575B (ja) |
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| GB2373186A (en) * | 2001-02-23 | 2002-09-18 | Astrazeneca Ab | Pharmaceutical combinations of a CCR3 antagonist and a compound which is usefulreatment of asthma, allergic disease or inflammation |
| FR2833493B1 (fr) * | 2001-12-18 | 2005-09-23 | Ioltechnologie Production | Forme galenique solide et soluble pour l'administration occulaire de principes actifs et procede de fabrication d'un insert ophtalmique solide et soluble |
| AU2003264859A1 (en) * | 2001-12-21 | 2003-12-19 | Sampad Bhattacharya | Intranasal pharmaceutical compositions comprising an antihistamine and a leukotriene inhibitor |
| GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| AU2003301305A1 (en) * | 2002-10-17 | 2004-05-04 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction; methods of treatment |
| US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
| US7507531B2 (en) | 2002-10-17 | 2009-03-24 | Decode Genetics Chf. | Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction |
| US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
| US7851486B2 (en) | 2002-10-17 | 2010-12-14 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment |
| US20040198743A1 (en) * | 2003-01-31 | 2004-10-07 | Schering Corporation | Methods for treating allergic skin and allergic ocular conditions using combinations of histamine receptor antagonists |
| US20040235807A1 (en) * | 2003-05-21 | 2004-11-25 | Weinrich Karl P. | Formulations including a topical decongestant and a topical corticosteroid suitable for nasal administration and method for treating obstructive sleep apnea |
| CA2539276A1 (en) * | 2003-09-17 | 2005-03-31 | Decode Genetics Ehf. | Methods of preventing or treating recurrence of myocardial infarction |
| US20060263350A1 (en) * | 2003-09-26 | 2006-11-23 | Fairfield Clinical Trials Llc | Combination antihistamine medication |
| WO2005030331A1 (en) * | 2003-09-26 | 2005-04-07 | Fairfield Clinical Trials, Llc | Combination antihistamine medication |
| US20100216863A1 (en) * | 2004-01-30 | 2010-08-26 | Decode Genetics Ehf. | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment |
| US8158362B2 (en) | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
| JP4819699B2 (ja) * | 2004-02-06 | 2011-11-24 | メダ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト | 喘息及びｃｏｐｄの長期間の治療のための抗コリン作用薬及びグルココルチコイドの組合せ剤 |
| DK1713471T3 (da) * | 2004-02-06 | 2012-05-14 | Meda Pharma Gmbh & Co Kg | Kombination af anticholinergika og inhibitorer af phosphodiesterase type 4 til behandling af respiratoriske sygdomme |
| PE20060484A1 (es) * | 2004-07-14 | 2006-07-06 | Ucb Farchim Sa | Preparaciones farmaceuticas liquidas que comprenden un compuesto de benzhidril piperizina |
| PL2486942T3 (pl) | 2004-11-24 | 2019-05-31 | Meda Pharmaceuticals Inc | Kompozycje zawierające azelastynę oraz sposoby ich stosowania |
| US8758816B2 (en) | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
| JP4991693B2 (ja) * | 2005-03-16 | 2012-08-01 | メダ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 呼吸器疾患の治療のための抗コリン作用薬及びロイコトリエン受容体アンタゴニストの組み合わせ剤 |
| US7405302B2 (en) * | 2005-10-11 | 2008-07-29 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| ES2330047T3 (es) * | 2005-12-21 | 2009-12-03 | MEDA PHARMA GMBH & CO. KG | Combinacion de r,r-glicopirrolato, rolipram y budesonida para el tratmiento de enfermedades inflamatorias. |
| WO2007126865A2 (en) * | 2006-03-30 | 2007-11-08 | Patrin Pharma | Leukotriene antagonists via nasal drug delivery |
| WO2008067566A1 (en) | 2006-11-30 | 2008-06-05 | Amira Pharmaceuticals, Inc. | Compositions and treatments comprising 5-lipoxygenase-activating protein inhibitors and nitric oxide modulators |
| EP2222299B1 (en) * | 2007-11-19 | 2011-11-23 | Bausch & Lomb Incorporated | Use of levocabastine for modulating generation of pro-inflammatory cytokines |
| EP2408302A4 (en) * | 2009-03-17 | 2012-08-15 | Aciex Therapeutics Inc | OPHTALMIC FORMULATIONS OF KTOTICENE AND METHODS OF USE |
| US8569273B2 (en) | 2009-03-17 | 2013-10-29 | Aciex Therapeutics, Inc. | Ophthalmic formulations of cetirizine and methods of use |
| ES2910374T3 (es) | 2009-03-17 | 2022-05-12 | Nicox Ophthalmics Inc | Formulaciones oftálmicas de cetirizina y procedimientos de uso |
| EP3791880A1 (en) | 2009-04-29 | 2021-03-17 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical compositions comprising epa |
| KR101418404B1 (ko) | 2012-01-06 | 2014-07-10 | 한미약품 주식회사 | 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제 |
| CA2906008C (en) | 2013-03-13 | 2019-07-09 | Flatley Discovery Lab, Llc | Pyridazinone compounds and methods for the treatment of cystic fibrosis |
| WO2014164299A1 (en) | 2013-03-13 | 2014-10-09 | Inflammatory Response Research, Inc. | Use of levocetirizine and montelukast in the treatment of autoimmune disorders |
| KR101555908B1 (ko) * | 2013-12-19 | 2015-09-25 | 한미약품 주식회사 | 몬테루카스트 또는 이의 약제학적으로 허용 가능한 염을 포함하는 액상 제제 및 이의 제조방법 |
| CN106456624B (zh) | 2014-02-04 | 2020-05-22 | 生物制药合伙公司 | Flap抑制剂的降低中枢神经系统内的神经炎症介导的损伤的应用 |
| JP2017526728A (ja) | 2014-09-15 | 2017-09-14 | インフラマトリー・レスポンス・リサーチ・インコーポレイテッド | 炎症介在性状態の治療におけるレボセチリジン及びモンテルカスト |
| MX2021007967A (es) | 2019-01-11 | 2021-09-21 | Naegis Pharmaceuticals Inc | Inhibidores de síntesis de leucotrienos. |
| CN110721189A (zh) * | 2019-11-19 | 2020-01-24 | 贵州云峰药业有限公司 | 一种皮肤消毒剂 |
| CA3166799A1 (en) * | 2020-02-03 | 2021-08-12 | Vered Rosenberger | Topical montelukast formulations |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3813384A (en) | 1972-01-17 | 1974-05-28 | Asta Werke Ag Chem Fab | Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof |
| ES2053678T3 (es) | 1987-11-13 | 1994-08-01 | Asta Medica Ag | Procedimiento para preparar un medicamento con contenido de azelastina para la aplicacion nasal y/u ocular. |
| WO1989010143A1 (en) | 1988-04-27 | 1989-11-02 | Schering Corporation | Certain paf antagonist antihistamine combinations and methods |
| CA2141572C (en) * | 1992-08-03 | 2001-02-06 | James W. Young | Terfenadine metabolites and their optically pure isomers for treating allergic disorders |
| TR199801511T2 (xx) * | 1996-02-08 | 1998-10-21 | Merck&Co.,Inc. | Farmas�tik bile�im. |
| DE19610882A1 (de) * | 1996-03-20 | 1997-09-25 | Dresden Arzneimittel | Neue 1,3,5-trisubstituierte Indazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US5900421A (en) * | 1997-02-11 | 1999-05-04 | Sepracor Inc. | Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine |
| CN1253508A (zh) * | 1997-04-30 | 2000-05-17 | 沃尼尔－朗伯公司 | 局部鼻用抗炎组合物 |
| US6242179B1 (en) | 1997-12-17 | 2001-06-05 | Incyte Pharmaceuticals, Inc. | Human phosphatases |
| IL136461A0 (en) * | 1997-12-23 | 2001-06-14 | Schering Corp | Composition for treating respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine |
| US6194431B1 (en) * | 1998-04-14 | 2001-02-27 | Paul D. Rubin | Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors |
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| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20170205 |