SK285344B6 - Použitie cis-N-cyklohexyl-N-etyl-[3-(3-chlór-4- cyklohexylfenyl)alyl]amínu na prípravu farmacetických kompozícií na liečbu proliferatívnych chorôb - Google Patents
Použitie cis-N-cyklohexyl-N-etyl-[3-(3-chlór-4- cyklohexylfenyl)alyl]amínu na prípravu farmacetických kompozícií na liečbu proliferatívnych chorôb Download PDFInfo
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9609531A FR2751645B1 (fr) | 1996-07-29 | 1996-07-29 | Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales |
| PCT/FR1997/001409 WO1998004251A1 (fr) | 1996-07-29 | 1997-07-28 | Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK7999A3 SK7999A3 (en) | 2000-01-18 |
| SK285344B6 true SK285344B6 (sk) | 2006-11-03 |
Family
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Family Applications (1)
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| SK79-99A SK285344B6 (sk) | 1996-07-29 | 1997-07-28 | Použitie cis-N-cyklohexyl-N-etyl-[3-(3-chlór-4- cyklohexylfenyl)alyl]amínu na prípravu farmacetických kompozícií na liečbu proliferatívnych chorôb |
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| EP (1) | EP0917464B1 (cs) |
| JP (1) | JP3538431B2 (cs) |
| KR (1) | KR100315559B1 (cs) |
| CN (1) | CN1154483C (cs) |
| AR (1) | AR008090A1 (cs) |
| AT (1) | ATE266392T1 (cs) |
| AU (1) | AU735948B2 (cs) |
| BR (1) | BR9711606A (cs) |
| CA (1) | CA2261827C (cs) |
| CZ (1) | CZ294266B6 (cs) |
| DE (1) | DE69729099T2 (cs) |
| DK (1) | DK0917464T3 (cs) |
| EE (1) | EE03851B1 (cs) |
| ES (1) | ES2221061T3 (cs) |
| FR (1) | FR2751645B1 (cs) |
| HU (1) | HU224346B1 (cs) |
| ID (1) | ID17707A (cs) |
| IL (1) | IL127922A (cs) |
| IS (1) | IS2049B (cs) |
| MY (1) | MY120426A (cs) |
| NO (1) | NO322897B1 (cs) |
| NZ (1) | NZ333957A (cs) |
| PT (1) | PT917464E (cs) |
| RU (1) | RU2176502C2 (cs) |
| SI (1) | SI0917464T1 (cs) |
| SK (1) | SK285344B6 (cs) |
| TR (1) | TR199900161T2 (cs) |
| UA (1) | UA61080C2 (cs) |
| WO (1) | WO1998004251A1 (cs) |
| ZA (1) | ZA976697B (cs) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2143403B1 (es) * | 1998-03-13 | 2001-01-01 | Consejo Superior Investigacion | Derivados de ciclopropenilaminas como agentes anticancerosos. |
| GB9814036D0 (en) | 1998-06-29 | 1998-08-26 | Univ Dundee | Materials and methods relating to the induction of apoptosis in target cells |
| FR2794742B1 (fr) * | 1999-06-11 | 2005-06-03 | Sanofi Synthelabo | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
| FR2795724B1 (fr) * | 1999-07-02 | 2002-12-13 | Sanofi Synthelabo | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
| FR2803593B1 (fr) * | 2000-01-06 | 2002-02-15 | Sanofi Synthelabo | Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| EP1420644B1 (de) * | 2001-08-23 | 2006-05-31 | Bayer CropScience S.A. | Substituierte propargylamine |
| FR2887454B1 (fr) * | 2005-06-28 | 2009-06-05 | Sanofi Aventis Sa | Combinaisons antitumorales contenant des derives du taxane et des sigma ligands |
| UA98772C2 (ru) | 2006-06-23 | 2012-06-25 | Эбботт Леборетриз | Производные циклопропиламина как модуляторы н3-гистаминового рецептора |
| US9108948B2 (en) * | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| WO2008112164A2 (en) | 2007-03-08 | 2008-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
| EP2337563B1 (en) | 2008-09-08 | 2014-04-09 | The Board of Trustees of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| WO2010062308A1 (en) | 2008-10-28 | 2010-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase and methods of use thereof |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| JP2015529651A (ja) * | 2012-08-01 | 2015-10-08 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | α７ニコチン性アセチルコリン受容体モジュレーターおよびそれらの使用−Ｉ |
| KR20150135332A (ko) | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법 |
| GEP20207149B (en) | 2016-03-22 | 2020-09-10 | Merck Sharp & Dohme | Allosteric modulators of nicotinic acetylcholine receptors |
| JP2023541960A (ja) * | 2020-09-17 | 2023-10-04 | メレティオス セラピューティクス | ウイルス感染を治療するための化合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3674832A (en) * | 1968-08-22 | 1972-07-04 | Schering Corp | Cyclopropane carboxylic acid derivatives |
| FR2132547A1 (en) * | 1971-04-08 | 1972-11-24 | Clin Byla Ets | Substd phenyl alkyl or alkenyl amides - useful as analgesics and antiinflammatories |
| US4104383A (en) | 1973-11-02 | 1978-08-01 | C M Industries | Derivatives of phenylpropenylamine |
| GB1475314A (en) * | 1973-11-02 | 1977-06-01 | Cm Ind | Phenyl-propylamine derivatives |
| IT1113391B (it) * | 1979-05-09 | 1986-01-20 | Maggioni Farma | Derivati fenilcicloesanici ad attivita' antidepressiva |
| US4537902A (en) | 1979-06-11 | 1985-08-27 | Merck & Co., Inc. | 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase |
| FR2641276B1 (fr) * | 1988-12-30 | 1991-07-12 | Sanofi Sa | Derives du benzene, leur preparation et les compositions pharmaceutiques en contenant |
| JP2814694B2 (ja) | 1989-07-21 | 1998-10-27 | セイコーエプソン株式会社 | 識別コード読み書き構造及びその装置及びその方法 |
| FR2663328B1 (fr) * | 1990-06-14 | 1994-08-05 | Sanofi Sa | Derives d'hexahydroazepines, un procede pour leur preparation et compositions pharmaceutiques les contenant. |
| FR2694287B1 (fr) * | 1992-07-31 | 1994-09-16 | Jouveinal Inst Rech | Nouvelles cycloalkylalkylamines ligands aux récepteurs sigma, leur procédé de préparation et leur application en thérapeutique. |
| FR2713639B1 (fr) * | 1993-12-09 | 1996-08-30 | Irj | Nouveaux dérivés de 2-arylalkényl-azacycloalkanes ligands aux récepteurs sigma, leur procédé de préparation et leur application en thérapeutique. |
| FR2724656B1 (fr) * | 1994-09-15 | 1996-12-13 | Adir | Nouveaux derives du benzopyranne, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2725445B1 (fr) * | 1994-10-10 | 1996-10-31 | Adir | Nouveaux derives a structure 1-arylalkenyl 4-aryl alkyl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5919934A (en) * | 1997-02-19 | 1999-07-06 | The George Washington University | Compounds, compositions, and methods for cancer imaging and therapy |
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1996
- 1996-07-29 FR FR9609531A patent/FR2751645B1/fr not_active Expired - Fee Related
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1997
- 1997-07-28 AT AT97935643T patent/ATE266392T1/de not_active IP Right Cessation
- 1997-07-28 AU AU38551/97A patent/AU735948B2/en not_active Ceased
- 1997-07-28 TR TR1999/00161T patent/TR199900161T2/xx unknown
- 1997-07-28 AR ARP970103405A patent/AR008090A1/es unknown
- 1997-07-28 SI SI9730649T patent/SI0917464T1/xx unknown
- 1997-07-28 KR KR1019997000698A patent/KR100315559B1/ko not_active Expired - Fee Related
- 1997-07-28 DK DK97935643T patent/DK0917464T3/da active
- 1997-07-28 US US09/230,643 patent/US6235791B1/en not_active Expired - Fee Related
- 1997-07-28 CA CA002261827A patent/CA2261827C/fr not_active Expired - Fee Related
- 1997-07-28 BR BR9711606A patent/BR9711606A/pt not_active Application Discontinuation
- 1997-07-28 CN CNB971968853A patent/CN1154483C/zh not_active Expired - Fee Related
- 1997-07-28 CZ CZ1999242A patent/CZ294266B6/cs not_active IP Right Cessation
- 1997-07-28 UA UA99021083A patent/UA61080C2/uk unknown
- 1997-07-28 JP JP50856798A patent/JP3538431B2/ja not_active Expired - Fee Related
- 1997-07-28 NZ NZ333957A patent/NZ333957A/xx unknown
- 1997-07-28 ES ES97935643T patent/ES2221061T3/es not_active Expired - Lifetime
- 1997-07-28 ID IDP972614A patent/ID17707A/id unknown
- 1997-07-28 DE DE69729099T patent/DE69729099T2/de not_active Expired - Fee Related
- 1997-07-28 HU HU9902806A patent/HU224346B1/hu not_active IP Right Cessation
- 1997-07-28 EE EEP199900029A patent/EE03851B1/xx not_active IP Right Cessation
- 1997-07-28 WO PCT/FR1997/001409 patent/WO1998004251A1/fr active IP Right Grant
- 1997-07-28 IL IL12792297A patent/IL127922A/xx not_active IP Right Cessation
- 1997-07-28 SK SK79-99A patent/SK285344B6/sk not_active IP Right Cessation
- 1997-07-28 PT PT97935643T patent/PT917464E/pt unknown
- 1997-07-28 ZA ZA9706697A patent/ZA976697B/xx unknown
- 1997-07-28 EP EP97935643A patent/EP0917464B1/fr not_active Expired - Lifetime
- 1997-07-28 RU RU99104150/14A patent/RU2176502C2/ru not_active IP Right Cessation
- 1997-07-29 MY MYPI97003451A patent/MY120426A/en unknown
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1999
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- 1999-01-28 NO NO19990401A patent/NO322897B1/no not_active IP Right Cessation
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| Date | Code | Title | Description |
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| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20090728 |