SK285228B6 - Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén - Google Patents

Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén Download PDF

Info

Publication number
SK285228B6
SK285228B6 SK53-2005A SK532005A SK285228B6 SK 285228 B6 SK285228 B6 SK 285228B6 SK 532005 A SK532005 A SK 532005A SK 285228 B6 SK285228 B6 SK 285228B6
Authority
SK
Slovakia
Prior art keywords
cyclopentene
hydroxymethyl
racemic
amino
optically active
Prior art date
Application number
SK53-2005A
Other languages
English (en)
Slovak (sk)
Inventor
Christine Bernegger
Eva Maria Urban
Olwen Mary Birch
Kurt Burgdorf
Frank Brux
Kay-Sara Etter
Pierre Bossard
Walter Brieden
Laurent Duc
John Gordon
Murchu Colm O'
Yves Guggisberg
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of SK285228B6 publication Critical patent/SK285228B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/23—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK53-2005A 1997-05-13 1998-05-04 Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén SK285228B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH111697 1997-05-13
CH274097 1997-11-27

Publications (1)

Publication Number Publication Date
SK285228B6 true SK285228B6 (sk) 2006-09-07

Family

ID=25686703

Family Applications (3)

Application Number Title Priority Date Filing Date
SK53-2005A SK285228B6 (sk) 1997-05-13 1998-05-04 Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén
SK54-2005A SK285229B6 (sk) 1997-05-13 1998-05-04 Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu
SK589-98A SK284810B6 (sk) 1997-05-13 1998-05-04 Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu

Family Applications After (2)

Application Number Title Priority Date Filing Date
SK54-2005A SK285229B6 (sk) 1997-05-13 1998-05-04 Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu
SK589-98A SK284810B6 (sk) 1997-05-13 1998-05-04 Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu

Country Status (17)

Country Link
US (4) US6156893A (hu)
EP (2) EP1502914A1 (hu)
JP (3) JP4540136B2 (hu)
KR (2) KR100577886B1 (hu)
CN (2) CN1302116C (hu)
AT (1) ATE275206T1 (hu)
CA (1) CA2237297C (hu)
CZ (3) CZ297887B6 (hu)
DE (1) DE59811884D1 (hu)
DK (1) DK0878548T3 (hu)
ES (1) ES2223095T3 (hu)
HK (1) HK1092782A1 (hu)
HU (1) HU226327B1 (hu)
NO (1) NO324679B1 (hu)
PL (1) PL197848B1 (hu)
PT (1) PT878548E (hu)
SK (3) SK285228B6 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0705263T3 (da) * 1993-06-21 1997-05-05 Merrell Pharma Inc Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner
GB9717928D0 (en) * 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams
GB9721780D0 (en) * 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
CZ299083B6 (cs) * 1997-11-27 2008-04-16 Lonza Ag Zpusob výroby aminoalkoholu
CN1189569C (zh) * 1998-12-23 2005-02-16 隆萨股份公司 光学活性的1－氨基－4－羟甲基－2－环戊烯衍生物的制备方法
ATE360607T1 (de) * 2003-07-25 2007-05-15 Prometic Biosciences Inc Herstellung von metallsalzen von fettsäuren mit mittlerer kettenlänge
DE102005061756B4 (de) * 2005-12-21 2008-01-03 Sanofi-Aventis Deutschland Gmbh Verbessertes Verfahren zur Herstellung von Ramipril
US8236853B1 (en) 2007-12-03 2012-08-07 University Of South Florida Formation of cyclopentene nitro-ester and derivatives
JP2014505059A (ja) 2011-01-18 2014-02-27 ジェネラル アトミクス ヒドロラーゼ酵素基質およびその使用
CN102557990B (zh) * 2011-04-25 2014-06-25 开原亨泰制药股份有限公司 (1s，4r)n-叔丁氧羰基-4-氨基-2-环戊烯-1-羧酸甲酯的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931559A (en) * 1988-01-20 1990-06-05 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
US4950758A (en) * 1988-01-20 1990-08-21 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
CA2055086A1 (en) * 1991-02-12 1992-08-13 Chikara Kaneko Cyclopentene derivatives and their use
US5200527A (en) * 1991-04-08 1993-04-06 Lonza Ltd. Process for the production of 2-azabicyclo [2.2.1] hept-5-en-3-one
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
GB9217823D0 (en) * 1992-08-21 1992-10-07 Glaxo Group Ltd Chemical process
JPH06116217A (ja) * 1992-10-02 1994-04-26 Kuraray Co Ltd （±）−シス−４−アミノシクロペント−２−エンカルボン酸誘導体の光学分割法
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
AU3170597A (en) * 1996-05-30 1998-01-05 Lonza A.G. Process for the preparation of amino alcohols and derivatives thereof
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers

Also Published As

Publication number Publication date
DE59811884D1 (de) 2004-10-07
EP0878548A2 (de) 1998-11-18
HUP9801083A3 (en) 2001-09-28
CZ297894B6 (cs) 2007-04-25
ES2223095T3 (es) 2005-02-16
KR100577886B1 (ko) 2006-08-30
EP0878548A3 (de) 1999-10-13
CN1201794A (zh) 1998-12-16
KR19980086933A (ko) 1998-12-05
CZ297887B6 (cs) 2007-04-18
NO982149D0 (no) 1998-05-12
CN1515673A (zh) 2004-07-28
JP4540136B2 (ja) 2010-09-08
DK0878548T3 (da) 2004-12-06
JP2010106025A (ja) 2010-05-13
CZ145898A3 (cs) 1998-12-16
KR100601764B1 (ko) 2006-07-19
SK58998A3 (en) 1998-12-02
NO982149L (no) 1998-11-16
US6262295B1 (en) 2001-07-17
HU226327B1 (en) 2008-08-28
HK1092782A1 (en) 2007-02-16
CA2237297A1 (en) 1998-11-13
ATE275206T1 (de) 2004-09-15
JPH115793A (ja) 1999-01-12
US6137007A (en) 2000-10-24
SK284810B6 (sk) 2005-12-01
PL197848B1 (pl) 2008-05-30
NO324679B1 (no) 2007-12-03
CN1302116C (zh) 2007-02-28
JP2010116397A (ja) 2010-05-27
PT878548E (pt) 2005-01-31
SK285229B6 (sk) 2006-09-07
CA2237297C (en) 2008-03-11
PL326267A1 (en) 1998-11-23
CZ297888B6 (cs) 2007-04-18
US6156893A (en) 2000-12-05
EP1502914A1 (de) 2005-02-02
HUP9801083A2 (hu) 1999-11-29
CN1115343C (zh) 2003-07-23
EP0878548B1 (de) 2004-09-01
HU9801083D0 (en) 1998-07-28
US6252112B1 (en) 2001-06-26

Similar Documents

Publication Publication Date Title
CZ283003B6 (cs) Způsob syntézy (4R-cis)-1,1-dimethylethyl-6-kyanomethyl-2,2-dimethyl-1,3-dioxan-4-acetátu a meziprodukty pro tento způsob
KR20220084103A (ko) 부분입체이성질체 타르타르산 에스테르를 사용한 라세미체 분해에 의한 2-시아노에틸 (4s)-4-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복실레이트의 제조 방법
CA3158165A1 (en) Process for the preparation of (2-cyanoethyl (4s)-4-(4-cyano-2-methoxy-phenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxylate by racemate separation by means of diastereomeric tartaric acid esters
JP2008545683A (ja) （置換された）（ｒ）−又は（ｓ）−マンデル酸の動的分割のための方法
SK285228B6 (sk) Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén
US7812179B2 (en) Process for the preparation of atorvastatin and intermediates
US6700011B1 (en) Process for the preparation of naproxene nitroxyalkylesters
WO2008103016A1 (en) Atorvastatin intermediates and method for producing the same
KR100481570B1 (ko) 2-이미다졸린-5-온 제조용 중간체
JP4484525B2 (ja) ニューロテンシン活性２，３−ジアリール−ピラゾリジン誘導体
EP2755945A1 (en) ARYLATED beta-DICARBONYL COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF
Yamagata et al. Synthesis of 1‐acyl‐2‐oxo‐3‐pyrrolidinecarbonitriles by the reaction of 2‐acylamino‐4, 5‐dihydro‐3‐furancarbonitriles with sodium iodide
JP2582809B2 (ja) 新規ピロリジン誘導体およびその製法
PL197831B1 (pl) Sposób wytwarzania pochodnej 4-(hydroksymetylo)-2- cyklopentenu
KR100396011B1 (ko) 에난티오머상으로순수한페닐치환된1,4-디히드로피리딘-3,5-디카르복실산유도체류의고선택적제조방법
HU223138B1 (hu) Új eljárás racém alkil-4,6,7,8,9,9a-hexahidro-2H, 3H-pirido-[1,2-a] pirazin-1-on-7-karbonsavészterek előállítására
FI68830C (fi) Dl- eller d-trans-8-fluor-5-(p-fluorfenyl)-2,3,4,4a,5,9b-heksahydro-1h-pyrido(4,3-b)indol som anvaends som mellanprodukt vid framstaellning av terapeutiskt anvaendbara 2-substituerade dl- och d-trans-8-fluor-5-(p-fluorfenyl)-2,3,4,4a,5,9b-heksahydro-1h-pyrido(4,3-b)indoler
KR0173036B1 (ko) 2-술파닐티아졸 카르복사미드 유도체 및 그의 제조방법
JP2013129642A (ja) 光学活性３，４−ビス（アルキルオキシカルボニル）−１，６−ヘキサン二酸誘導体の製造法
JP2009536938A (ja) Ａｃｅ阻害薬の合成における新規な医薬中間体及びその使用
JPH0363272A (ja) １―アザビシクロ〔２．２．１〕ヘプタン―３―カルボキシレートの分割方法
JPH02304090A (ja) 多環式化合物の製造方法
JPH02212474A (ja) 光学活性な１，４―ジヒドロピリジン誘導体の製造方法
JPS6321661B2 (hu)
JP2001288167A (ja) ピロール−２−カルボン酸誘導体の製造法

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20120504