SK285138B6 - Spôsob výroby farmaceuticky prijateľnej soli klavulanovej kyseliny - Google Patents

Spôsob výroby farmaceuticky prijateľnej soli klavulanovej kyseliny Download PDF

Info

Publication number
SK285138B6
SK285138B6 SK640-98A SK64098A SK285138B6 SK 285138 B6 SK285138 B6 SK 285138B6 SK 64098 A SK64098 A SK 64098A SK 285138 B6 SK285138 B6 SK 285138B6
Authority
SK
Slovakia
Prior art keywords
clavulanic acid
salt
butanol
isobutanol
amine
Prior art date
Application number
SK640-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK64098A3 (en
Inventor
Helmut Wagner
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of SK64098A3 publication Critical patent/SK64098A3/sk
Publication of SK285138B6 publication Critical patent/SK285138B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/02—Preparation
    • C07D503/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D503/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
SK640-98A 1995-11-15 1996-11-14 Spôsob výroby farmaceuticky prijateľnej soli klavulanovej kyseliny SK285138B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0186795A AT403375B (de) 1995-11-15 1995-11-15 Verfahren zur fällung von alkalisalzen der clavulansäure
PCT/EP1996/005015 WO1997018216A1 (en) 1995-11-15 1996-11-14 Production of a salt of clavulanic acid

Publications (2)

Publication Number Publication Date
SK64098A3 SK64098A3 (en) 1998-10-07
SK285138B6 true SK285138B6 (sk) 2006-07-07

Family

ID=3522721

Family Applications (1)

Application Number Title Priority Date Filing Date
SK640-98A SK285138B6 (sk) 1995-11-15 1996-11-14 Spôsob výroby farmaceuticky prijateľnej soli klavulanovej kyseliny

Country Status (25)

Country Link
US (1) US6133441A (zh)
EP (1) EP0874855B1 (zh)
JP (1) JP4319252B2 (zh)
KR (1) KR100537732B1 (zh)
CN (1) CN1090636C (zh)
AT (2) AT403375B (zh)
AU (1) AU714017B2 (zh)
BR (1) BR9611572A (zh)
CA (1) CA2237763C (zh)
CZ (1) CZ296567B6 (zh)
DE (1) DE69631608T2 (zh)
ES (1) ES2216073T3 (zh)
HK (1) HK1016971A1 (zh)
HU (1) HUP9903478A3 (zh)
IL (1) IL124353A (zh)
MX (1) MX9803887A (zh)
NO (1) NO982107L (zh)
NZ (1) NZ322485A (zh)
PL (1) PL188634B1 (zh)
RU (1) RU2179171C2 (zh)
SI (1) SI0874855T1 (zh)
SK (1) SK285138B6 (zh)
TR (1) TR199800860T2 (zh)
TW (1) TW427991B (zh)
WO (1) WO1997018216A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
JP2004511561A (ja) * 2000-10-20 2004-04-15 バイオケミ・ゲゼルシヤフト・エム・ベー・ハー 薬剤組成物
JP5733856B2 (ja) 2007-10-09 2015-06-10 ソファーミア，インコーポレイテッド 広帯域β−ラクタマーゼ阻害薬
US20100261700A1 (en) * 2009-04-09 2010-10-14 Larry Sutton Beta-lactamase inhibitors
US9975905B2 (en) 2013-03-12 2018-05-22 Gladius Pharmaceuticals Corporation Derivatized 3-styryl-cephalosporins
CN109535184B (zh) * 2017-09-21 2020-11-20 联邦制药(内蒙古)有限公司 一种克拉维酸叔辛胺制备克拉维酸钾的方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB2003863B (en) * 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
MX7417E (es) * 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
GB8618888D0 (en) * 1986-08-01 1986-09-10 Davy Mckee Ltd Process
US5679789A (en) * 1987-01-29 1997-10-21 Beecham Group, P.L.C. Pharmaceutical compositions comprising potassium clavulanate and methods of using them
CA1326486C (en) * 1987-01-29 1994-01-25 Dennis Edward Clark Potassium clavulanate
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
US5210296A (en) * 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
TR199700828T1 (xx) * 1995-02-25 1998-04-21 Spurcourt Limited .Klavulanik asit tuzlar�.
GB2298201B (en) * 1995-02-25 1997-05-28 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) * 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
TR199901631T2 (xx) * 1996-11-11 1999-09-21 Gist-Brocades B.V. Klavülanik asitin esterleri ve tuzlarının hazırlanması için işlem.

Also Published As

Publication number Publication date
AT403375B (de) 1998-01-26
KR100537732B1 (ko) 2006-04-14
JP4319252B2 (ja) 2009-08-26
RU2179171C2 (ru) 2002-02-10
CZ296567B6 (cs) 2006-04-12
KR19990067480A (ko) 1999-08-25
TR199800860T2 (xx) 2000-07-21
IL124353A0 (en) 1998-12-06
HUP9903478A2 (hu) 2000-03-28
ES2216073T3 (es) 2004-10-16
DE69631608D1 (de) 2004-03-25
NO982107D0 (no) 1998-05-08
SK64098A3 (en) 1998-10-07
CA2237763C (en) 2008-05-06
AU7625096A (en) 1997-06-05
ATA186795A (de) 1997-06-15
DE69631608T2 (de) 2004-12-23
CN1090636C (zh) 2002-09-11
ATE259817T1 (de) 2004-03-15
IL124353A (en) 2005-06-19
HUP9903478A3 (en) 2000-05-29
US6133441A (en) 2000-10-17
BR9611572A (pt) 1999-03-30
CZ149198A3 (cs) 1998-08-12
PL326696A1 (en) 1998-10-26
EP0874855A1 (en) 1998-11-04
EP0874855B1 (en) 2004-02-18
CN1204337A (zh) 1999-01-06
AU714017B2 (en) 1999-12-16
MX9803887A (es) 1998-09-30
JP2000500149A (ja) 2000-01-11
WO1997018216A1 (en) 1997-05-22
NO982107L (no) 1998-05-08
CA2237763A1 (en) 1997-05-22
NZ322485A (en) 2000-01-28
PL188634B1 (pl) 2005-03-31
HK1016971A1 (en) 1999-11-12
TW427991B (en) 2001-04-01
SI0874855T1 (en) 2004-06-30

Similar Documents

Publication Publication Date Title
EP0672670B1 (en) Process for the preparation of clavulanic acid
KR950014004B1 (ko) 신규한 알킬렌디암모늄디클라부라네이트 유도체 그들의 제조방법 및 그 용도
EP0594099B1 (en) Process for the purification of crude clavulanic acid
FI101965B (fi) Klavulaanihapon 2-amino-2,4,4-trimetyylipentaanisuolan käyttö klavulaa nihapon alkali- tai maa-alkalimetallisuolojen valmistuksessa
EP0178980B1 (fr) Dérivés de céphalosporines, procédé d'obtention et leur application à titre d'antibiotiques
EP0827504B1 (en) Process for manufacturing clavulanic acid salt
SK285138B6 (sk) Spôsob výroby farmaceuticky prijateľnej soli klavulanovej kyseliny
US5726170A (en) Clavulanic acid salts
SI9500134A1 (en) Preparation procedure of pure alkali salts of clavulanic acid
SI21236A (sl) Postopek kristalizacije losartan kalija
HUT77090A (hu) Diamino-éterrel képzett diklavulanátsó, eljárás annak előállítására és ezt tartalmazó gyógyászati készítmények
EP0099297A1 (fr) Nouveaux dérivés des céphalosporines, leur procédé de préparation et médicaments antibiotiques contenant lesdits dérivés
EP0941229A1 (en) Purification of fermented clavulanic acid
US20010029038A1 (en) Purification of fermented clavulanic acid
US3062811A (en) Process for the preparation of salts of penicillin
BE858670A (fr) Procede de preparation de d(-)alpha-aminobenzylpenicillines a faible teneur de n,n-dimethylaniline