DE69631608D1 - Herstellung von einem clavulansäuresalz - Google Patents

Herstellung von einem clavulansäuresalz

Info

Publication number
DE69631608D1
DE69631608D1 DE69631608T DE69631608T DE69631608D1 DE 69631608 D1 DE69631608 D1 DE 69631608D1 DE 69631608 T DE69631608 T DE 69631608T DE 69631608 T DE69631608 T DE 69631608T DE 69631608 D1 DE69631608 D1 DE 69631608D1
Authority
DE
Germany
Prior art keywords
clavulanic acid
pct
butanol
production
date
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69631608T
Other languages
English (en)
Other versions
DE69631608T2 (de
Inventor
Helmut Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Biochemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie GmbH filed Critical Biochemie GmbH
Publication of DE69631608D1 publication Critical patent/DE69631608D1/de
Application granted granted Critical
Publication of DE69631608T2 publication Critical patent/DE69631608T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/02—Preparation
    • C07D503/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D503/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69631608T 1995-11-15 1996-11-14 Herstellung von einem clavulansäuresalz Expired - Lifetime DE69631608T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT0186795A AT403375B (de) 1995-11-15 1995-11-15 Verfahren zur fällung von alkalisalzen der clavulansäure
AT186795 1995-11-15
PCT/EP1996/005015 WO1997018216A1 (en) 1995-11-15 1996-11-14 Production of a salt of clavulanic acid

Publications (2)

Publication Number Publication Date
DE69631608D1 true DE69631608D1 (de) 2004-03-25
DE69631608T2 DE69631608T2 (de) 2004-12-23

Family

ID=3522721

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69631608T Expired - Lifetime DE69631608T2 (de) 1995-11-15 1996-11-14 Herstellung von einem clavulansäuresalz

Country Status (25)

Country Link
US (1) US6133441A (de)
EP (1) EP0874855B1 (de)
JP (1) JP4319252B2 (de)
KR (1) KR100537732B1 (de)
CN (1) CN1090636C (de)
AT (2) AT403375B (de)
AU (1) AU714017B2 (de)
BR (1) BR9611572A (de)
CA (1) CA2237763C (de)
CZ (1) CZ296567B6 (de)
DE (1) DE69631608T2 (de)
ES (1) ES2216073T3 (de)
HK (1) HK1016971A1 (de)
HU (1) HUP9903478A3 (de)
IL (1) IL124353A (de)
MX (1) MX9803887A (de)
NO (1) NO982107D0 (de)
NZ (1) NZ322485A (de)
PL (1) PL188634B1 (de)
RU (1) RU2179171C2 (de)
SI (1) SI0874855T1 (de)
SK (1) SK285138B6 (de)
TR (1) TR199800860T2 (de)
TW (1) TW427991B (de)
WO (1) WO1997018216A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
ATE286057T1 (de) * 2000-10-20 2005-01-15 Sandoz Ag Pharmazeutische zubereitungen enthaltend clavulansäure
WO2009049086A1 (en) 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
US20100261700A1 (en) * 2009-04-09 2010-10-14 Larry Sutton Beta-lactamase inhibitors
JP6403289B2 (ja) 2013-03-12 2018-10-10 グラディウス ファーマシューティカルズ コーポレーションＧｌａｄｉｕｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ 誘導体化３−スチリル−セファロスポリン
CN109535184B (zh) * 2017-09-21 2020-11-20 联邦制药(内蒙古)有限公司 一种克拉维酸叔辛胺制备克拉维酸钾的方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB2003863B (en) * 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
AU600655B2 (en) * 1984-10-27 1990-08-23 Beecham Group Plc Preparation of clavulanic acid and its salts and esters
GB8618888D0 (en) * 1986-08-01 1986-09-10 Davy Mckee Ltd Process
NZ223316A (en) * 1987-01-29 1989-10-27 Beecham Group Plc Crystalline potassium clavulanate and pharmaceutical compositions
US5679789A (en) * 1987-01-29 1997-10-21 Beecham Group, P.L.C. Pharmaceutical compositions comprising potassium clavulanate and methods of using them
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
US5210296A (en) * 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9401969D0 (en) * 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB2298201B (en) * 1995-02-25 1997-05-28 Spurcourt Ltd Clavulanic acid salts
EP0729961B1 (de) * 1995-02-25 2001-12-19 Spurcourt Limited Clavulansäure Salz
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) * 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
PL333247A1 (en) * 1996-11-11 1999-11-22 Gist Brocades Bv Method of manufacturing of salts and esters of clavulan acid

Also Published As

Publication number Publication date
ATA186795A (de) 1997-06-15
JP2000500149A (ja) 2000-01-11
NO982107L (no) 1998-05-08
EP0874855A1 (de) 1998-11-04
AU714017B2 (en) 1999-12-16
MX9803887A (es) 1998-09-30
IL124353A0 (en) 1998-12-06
IL124353A (en) 2005-06-19
EP0874855B1 (de) 2004-02-18
TR199800860T2 (xx) 2000-07-21
SK64098A3 (en) 1998-10-07
BR9611572A (pt) 1999-03-30
NZ322485A (en) 2000-01-28
PL326696A1 (en) 1998-10-26
CN1204337A (zh) 1999-01-06
ATE259817T1 (de) 2004-03-15
AU7625096A (en) 1997-06-05
AT403375B (de) 1998-01-26
ES2216073T3 (es) 2004-10-16
CA2237763A1 (en) 1997-05-22
PL188634B1 (pl) 2005-03-31
HK1016971A1 (en) 1999-11-12
KR100537732B1 (ko) 2006-04-14
RU2179171C2 (ru) 2002-02-10
NO982107D0 (no) 1998-05-08
HUP9903478A2 (hu) 2000-03-28
DE69631608T2 (de) 2004-12-23
CN1090636C (zh) 2002-09-11
JP4319252B2 (ja) 2009-08-26
CZ296567B6 (cs) 2006-04-12
SK285138B6 (sk) 2006-07-07
TW427991B (en) 2001-04-01
HUP9903478A3 (en) 2000-05-29
SI0874855T1 (en) 2004-06-30
WO1997018216A1 (en) 1997-05-22
US6133441A (en) 2000-10-17
CA2237763C (en) 2008-05-06
KR19990067480A (ko) 1999-08-25
CZ149198A3 (cs) 1998-08-12

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SANDOZ AG, BASEL, CH

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC