US6331543B1
(en)
|
1996-11-01 |
2001-12-18 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
|
DE19752952A1
(de)
*
|
1997-11-28 |
1999-06-02 |
Merck Patent Gmbh |
Thienopyrimidine
|
US6410584B1
(en)
|
1998-01-14 |
2002-06-25 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells with indole derivatives
|
US6248308B1
(en)
*
|
1998-04-14 |
2001-06-19 |
Sepracor Inc. |
Methods of using norastemizole in combination with leukotriene inhibitors to treat or prevent asthma
|
DE19819023A1
(de)
|
1998-04-29 |
1999-11-04 |
Merck Patent Gmbh |
Thienopyrimidine
|
US6200771B1
(en)
|
1998-10-15 |
2001-03-13 |
Cell Pathways, Inc. |
Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
|
US6133271A
(en)
*
|
1998-11-19 |
2000-10-17 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
|
US6187779B1
(en)
|
1998-11-20 |
2001-02-13 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
|
US6369092B1
(en)
|
1998-11-23 |
2002-04-09 |
Cell Pathways, Inc. |
Method for treating neoplasia by exposure to substituted benzimidazole derivatives
|
US6077842A
(en)
*
|
1998-11-24 |
2000-06-20 |
Cell Pathways, Inc. |
Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
|
US6034099A
(en)
*
|
1998-11-24 |
2000-03-07 |
Cell Pathways, Inc. |
Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
|
US6486155B1
(en)
|
1998-11-24 |
2002-11-26 |
Cell Pathways Inc |
Method of inhibiting neoplastic cells with isoquinoline derivatives
|
US6020379A
(en)
*
|
1999-02-19 |
2000-02-01 |
Cell Pathways, Inc. |
Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
|
US6482948B1
(en)
|
1999-03-30 |
2002-11-19 |
Nippon Soda Co., Ltd. |
Thienopyrimidine compounds and salts thereof and process for the preparation of the same
|
DE19928146A1
(de)
*
|
1999-06-19 |
2000-12-21 |
Merck Patent Gmbh |
Thienopyrimidine
|
DE19942474A1
(de)
*
|
1999-09-06 |
2001-03-15 |
Merck Patent Gmbh |
Pyrazolo[4,3-d]pyrimidine
|
DE19943815A1
(de)
*
|
1999-09-14 |
2001-03-15 |
Merck Patent Gmbh |
Verwendung von Thienopyrimidinen
|
DE19944604A1
(de)
*
|
1999-09-17 |
2001-03-22 |
Merck Patent Gmbh |
Aminderivate
|
DE10001021A1
(de)
*
|
2000-01-13 |
2001-07-19 |
Merck Patent Gmbh |
Pharmazeutische Zubereitung
|
DE10031584A1
(de)
*
|
2000-06-29 |
2002-01-10 |
Merck Patent Gmbh |
5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
|
DE10031585A1
(de)
*
|
2000-06-29 |
2002-01-10 |
Merck Patent Gmbh |
2-Aminoalkyl-thieno[2,3-d]pyrimidine
|
DE10042997A1
(de)
*
|
2000-09-01 |
2002-03-14 |
Merck Patent Gmbh |
Thienopyrimidine
|
KR20030034232A
(ko)
*
|
2000-09-29 |
2003-05-01 |
닛뽕소다 가부시키가이샤 |
티에노피리미딘 화합물 및 그 염 및 제조방법
|
DE10064994A1
(de)
*
|
2000-12-23 |
2002-07-04 |
Merck Patent Gmbh |
Sulfamidothienopyrimidine
|
DE10103647A1
(de)
*
|
2001-01-27 |
2002-08-01 |
Merck Patent Gmbh |
Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates
|
KR20030070149A
(ko)
*
|
2001-01-31 |
2003-08-27 |
메르크 파텐트 게엠베하 |
피라졸로[4,3-d]피리미딘 및 나이트레이트 또는티에노피리미딘 및 나이트레이트를 포함하여 이루어지는약제학적 조성물
|
HUP0303005A3
(en)
*
|
2001-02-02 |
2005-05-30 |
Merck Patent Gmbh |
Pharmaceutical compositions comprising pyrazolo[4,3-d]pyrimidines or thienopyrimidines and endothelin receptor antagonists
|
JP2005503345A
(ja)
*
|
2001-04-30 |
2005-02-03 |
バイエル・コーポレーシヨン |
新規な4−アミノ−5,6−置換チオフェノ[2,3−d]ピリミジン
|
DE10148883A1
(de)
|
2001-10-04 |
2003-04-10 |
Merck Patent Gmbh |
Pyrimidinderivate
|
JPWO2003035653A1
(ja)
*
|
2001-10-26 |
2005-02-10 |
日本曹達株式会社 |
ピリドチエノピリミジン化合物およびその塩
|
US6962940B2
(en)
|
2002-03-20 |
2005-11-08 |
Celgene Corporation |
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
|
US7276529B2
(en)
|
2002-03-20 |
2007-10-02 |
Celgene Corporation |
Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
US7208516B2
(en)
|
2002-03-20 |
2007-04-24 |
Celgene Corporation |
Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
|
US7893101B2
(en)
|
2002-03-20 |
2011-02-22 |
Celgene Corporation |
Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
|
DE10224462A1
(de)
*
|
2002-06-03 |
2003-12-11 |
Bayer Ag |
Verwendung von cGMP stimulierenden Verbindungen
|
AR044743A1
(es)
*
|
2002-09-26 |
2005-10-05 |
Nihon Nohyaku Co Ltd |
Herbicida, metodo de emplearlo, derivados de tienopirimidina sustituida,compuestos intermediarios, y procedimientos que se utilizan para producirlos,
|
JP2004137270A
(ja)
*
|
2002-09-26 |
2004-05-13 |
Nippon Nohyaku Co Ltd |
新規除草剤、その使用方法、新規置換チエノピリミジン誘導体及びその中間体並びにそれらの製造方法
|
ES2217956B1
(es)
*
|
2003-01-23 |
2006-04-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.
|
JP4015176B2
(ja)
|
2003-04-29 |
2007-11-28 |
ファイザー・インク |
高血圧症の治療に有用な5,7−ジアミノピラゾロ4,3−ジピリミジン類
|
DE10351436A1
(de)
*
|
2003-11-04 |
2005-06-09 |
Merck Patent Gmbh |
Verwendung von Thienopyrimidinen
|
GB0327323D0
(en)
*
|
2003-11-24 |
2003-12-31 |
Pfizer Ltd |
Novel pharmaceuticals
|
US7572799B2
(en)
*
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
US7569572B2
(en)
*
|
2004-04-07 |
2009-08-04 |
Pfizer Inc |
Pyrazolo[4,3-D]pyrimidines
|
GB0420722D0
(en)
|
2004-09-17 |
2004-10-20 |
Addex Pharmaceuticals Sa |
Novel allosteric modulators
|
ES2259892B1
(es)
*
|
2004-11-30 |
2007-11-01 |
Laboratorios Almirall S.A. |
Nuevos derivados de piridotienopirimidina.
|
ES2259891B1
(es)
*
|
2004-11-30 |
2007-11-01 |
Laboratorios Almirall S.A. |
Nuevos derivados de piridotienopirimidina.
|
US8506934B2
(en)
|
2005-04-29 |
2013-08-13 |
Robert I. Henkin |
Methods for detection of biological substances
|
AU2006258461B2
(en)
*
|
2005-06-14 |
2011-08-25 |
Aska Pharmaceutical Co., Ltd. |
Thienopyrimidine derivative
|
US20070213305A1
(en)
*
|
2005-11-02 |
2007-09-13 |
Cytovia, Inc. |
N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
US20070099941A1
(en)
*
|
2005-11-02 |
2007-05-03 |
Cytovia, Inc. |
N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
|
WO2007056215A2
(fr)
*
|
2005-11-02 |
2007-05-18 |
Cytovia, Inc. |
N-aryl-thienopyrimidin-4-amines et analogues en tant qu'activateurs de caspases et inducteurs d'apoptose et utilisation associee
|
KR20080065704A
(ko)
|
2005-11-09 |
2008-07-14 |
콤비네이토릭스, 인코포레이티드 |
의학적 이상의 치료 방법들, 조성물들, 및 키트들
|
WO2007063934A1
(fr)
*
|
2005-12-02 |
2007-06-07 |
Mitsubishi Tanabe Pharma Corporation |
Compose heterocyclique alicyclique
|
TWI417095B
(zh)
|
2006-03-15 |
2013-12-01 |
Janssen Pharmaceuticals Inc |
1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途
|
US8293489B2
(en)
|
2007-01-31 |
2012-10-23 |
Henkin Robert I |
Methods for detection of biological substances
|
TW200845978A
(en)
|
2007-03-07 |
2008-12-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
|
TW200900065A
(en)
|
2007-03-07 |
2009-01-01 |
Janssen Pharmaceutica Nv |
3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
|
PT2203439E
(pt)
|
2007-09-14 |
2011-02-11 |
Ortho Mcneil Janssen Pharm |
4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridinil-2'- onas 1',3'-dissubstituídas
|
ES2365966T3
(es)
|
2007-09-14 |
2011-10-14 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc. |
4-(aril-x-fenil)-1h-piridin-2-onas 1,3-disustituidas.
|
KR20100075930A
(ko)
*
|
2007-10-19 |
2010-07-05 |
베링거 인겔하임 인터내셔날 게엠베하 |
헤테로사이클-치환된 피페라지노-디하이드로티에노피리미딘
|
US8580801B2
(en)
|
2008-07-23 |
2013-11-12 |
Robert I. Henkin |
Phosphodiesterase inhibitor treatment
|
CA2735764C
(fr)
|
2008-09-02 |
2016-06-14 |
Ortho-Mcneil-Janssen Pharmaceuticals, Inc. |
Derives de 3-azabicyclo[3.1.0]hexyle comme modulateurs des recepteurs metabotropiques du glutamate
|
MX2011005242A
(es)
|
2008-11-28 |
2011-09-06 |
Ortho Mcneil Janssen Pharm |
Derivados de indol y benzoxazina como moduladores de los receptores de glutamato metabotropicos.
|
MY153913A
(en)
|
2009-05-12 |
2015-04-15 |
Janssen Pharmaceuticals Inc |
7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
|
AR076859A1
(es)
|
2009-05-12 |
2011-07-13 |
Ortho Mcneil Janssen Pharm |
Derivados de 1,2,4-triazolo[4,3-a]piridina moduladores alostericos positivos de receptores mglur2 , composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de trastornos neurologicos y siquiatricos.
|
MX2011011964A
(es)
|
2009-05-12 |
2012-02-23 |
Janssen Pharmaceuticals Inc |
Derivados de 1,2,3-triazolo[4,3-a]piridina y su uso para el tratamiento o prevencion de trastornos neurologicos y psiquiatricos.
|
KR101147550B1
(ko)
*
|
2009-10-22 |
2012-05-17 |
한국과학기술연구원 |
단백질 키나아제 저해활성을 가지는 2,7-치환된 티에노[3,2-d]피리미딘 화합물
|
PE20130184A1
(es)
*
|
2010-02-17 |
2013-03-09 |
Takeda Pharmaceutical |
Compuesto heterociclico
|
CN103298809B
(zh)
|
2010-11-08 |
2016-08-31 |
杨森制药公司 |
1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
|
CA2814998C
(fr)
|
2010-11-08 |
2019-10-29 |
Janssen Pharmaceuticals, Inc. |
Derives de 1,2,4-triazolo[4,3-a]pyridine et leur utilisation en tant que modulateurs allosteriques positifs des recepteurs mglur2
|
PL2649069T3
(pl)
|
2010-11-08 |
2016-01-29 |
Janssen Pharmaceuticals Inc |
Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
|
CA2842190A1
(fr)
|
2011-07-19 |
2013-01-24 |
Infinity Pharmaceuticals Inc. |
Composes heterocycliques et leurs utilisations
|
US20150119399A1
(en)
|
2012-01-10 |
2015-04-30 |
President And Fellows Of Harvard College |
Beta-cell replication promoting compounds and methods of their use
|
WO2014055801A1
(fr)
|
2012-10-05 |
2014-04-10 |
Henkin Robert I |
Inhibiteurs de la phosphodiestérase destinés à traiter des troubles du goût et de l'odorat
|
JO3368B1
(ar)
|
2013-06-04 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
|
JO3367B1
(ar)
|
2013-09-06 |
2019-03-13 |
Janssen Pharmaceutica Nv |
مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
|
AU2015208233B2
(en)
|
2014-01-21 |
2019-08-29 |
Janssen Pharmaceutica Nv |
Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
|
PT3096790T
(pt)
|
2014-01-21 |
2019-10-15 |
Janssen Pharmaceutica Nv |
Combinações compreendendo moduladores alostéricos positivos ou agonistas ortostéricos do recetor glutamatérgico metabotrópico do subtipo 2 e seu uso
|
CN106233141B
(zh)
|
2014-02-18 |
2018-08-21 |
罗伯特·I·汉金 |
用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物
|
EP3157520B1
(fr)
|
2014-06-23 |
2019-09-04 |
Celgene Corporation |
Utilisation d'aprémilast pour le traitement d'une maladie hépatique ou d'une anomalie de la fonction hépatique
|
SG11201804901WA
(en)
|
2015-12-22 |
2018-07-30 |
SHY Therapeutics LLC |
Compounds for the treatment of cancer and inflammatory disease
|
AU2018209006B2
(en)
|
2017-01-22 |
2021-04-22 |
Sunshine Lake Pharma Co., Ltd. |
Thienopyrimidine derivative and use thereof in medicine
|
JP2020524703A
(ja)
*
|
2017-06-21 |
2020-08-20 |
シャイ・セラピューティクス・エルエルシーShy Therapeutics Llc |
がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのrasスーパーファミリーと相互作用する化合物
|