SK284534B6 - Polypeptidový analóg natívneho keratinocytového rastového faktora, spôsob jeho výroby a použitie, farmaceutický prostriedok a kit, nukleová kyselina, vektor a hostiteľská bunka - Google Patents

Polypeptidový analóg natívneho keratinocytového rastového faktora, spôsob jeho výroby a použitie, farmaceutický prostriedok a kit, nukleová kyselina, vektor a hostiteľská bunka Download PDF

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Publication number
SK284534B6
SK284534B6 SK455-97A SK45597A SK284534B6 SK 284534 B6 SK284534 B6 SK 284534B6 SK 45597 A SK45597 A SK 45597A SK 284534 B6 SK284534 B6 SK 284534B6
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SK
Slovakia
Prior art keywords
kgf
amino acid
lys
analog
glu
Prior art date
Application number
SK455-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK45597A3 (en
Inventor
Charles F. Morris
William C. Kenney
Bao-Lu Chen
Eric W. Hsu
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of SK45597A3 publication Critical patent/SK45597A3/sk
Publication of SK284534B6 publication Critical patent/SK284534B6/sk

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SK455-97A 1994-10-13 1995-10-12 Polypeptidový analóg natívneho keratinocytového rastového faktora, spôsob jeho výroby a použitie, farmaceutický prostriedok a kit, nukleová kyselina, vektor a hostiteľská bunka SK284534B6 (sk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32347594A 1994-10-13 1994-10-13
US32334094A 1994-10-13 1994-10-13
US48782595A 1995-06-07 1995-06-07
PCT/IB1995/000971 WO1996011949A2 (fr) 1994-10-13 1995-10-12 Analogues du facteur de croissance de keratinocytes

Publications (2)

Publication Number Publication Date
SK45597A3 SK45597A3 (en) 1999-02-11
SK284534B6 true SK284534B6 (sk) 2005-06-02

Family

ID=27406268

Family Applications (2)

Application Number Title Priority Date Filing Date
SK455-97A SK284534B6 (sk) 1994-10-13 1995-10-12 Polypeptidový analóg natívneho keratinocytového rastového faktora, spôsob jeho výroby a použitie, farmaceutický prostriedok a kit, nukleová kyselina, vektor a hostiteľská bunka
SK431-97A SK43197A3 (en) 1994-10-13 1995-10-12 Method of treating diabetes mellitus using kgf

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK431-97A SK43197A3 (en) 1994-10-13 1995-10-12 Method of treating diabetes mellitus using kgf

Country Status (23)

Country Link
EP (2) EP0785948B1 (fr)
JP (2) JP4216329B2 (fr)
KR (1) KR100278597B1 (fr)
CN (1) CN1168678A (fr)
AT (2) ATE342278T1 (fr)
AU (1) AU3707795A (fr)
BG (2) BG101392A (fr)
BR (2) BR9509329A (fr)
CA (2) CA2201940C (fr)
CZ (3) CZ98197A3 (fr)
DE (2) DE69530403T2 (fr)
DK (2) DK0804479T3 (fr)
EE (2) EE9700225A (fr)
ES (2) ES2273338T3 (fr)
FI (2) FI971420A (fr)
HU (2) HU226168B1 (fr)
NO (2) NO318761B1 (fr)
NZ (2) NZ505502A (fr)
PL (2) PL320484A1 (fr)
PT (2) PT804479E (fr)
SI (2) SI0804479T1 (fr)
SK (2) SK284534B6 (fr)
WO (2) WO1996011949A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE197800T1 (de) 1989-01-31 2000-12-15 Jeffrey S Rubin Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor
ES2227527T3 (es) 1993-06-29 2005-04-01 Chiron Corp Un factor de crecimiento de queratinocitos (kgf) truncado que tiene actividad biologica aumentada.
US7084119B2 (en) 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
CZ98297A3 (cs) * 1994-10-13 1998-08-12 Amgen Inc. Způsob purifikace keratinocytových růstových faktorů
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
EP0822943B9 (fr) * 1995-04-27 2007-02-28 Coöperatie Cosun U.A. Derives d'inuline
EP1473366A1 (fr) * 1996-10-15 2004-11-03 Amgen Inc. Produits a base du facteur de croissance 2 des keratinocytes
DK0935652T3 (da) * 1996-10-15 2004-07-26 Amgen Inc Keratinocyt vækstfaktor-2 produkter
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
EP1012184B1 (fr) 1997-07-14 2007-10-10 Bolder Biotechnology, Inc. Derives d'hormone de croissance et proteines associees
US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
EP1041996A4 (fr) 1997-12-22 2003-05-14 Human Genome Sciences Inc Formulations du facteur-2 de croissance des keratinocytes
US6242666B1 (en) 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
BR122013003013B8 (pt) * 1999-01-14 2021-07-06 Bolder Biotechnology Inc proteína isolada monopeguilada do hormônio do crescimento e método para sua obtenção
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US6248725B1 (en) 1999-02-23 2001-06-19 Amgen, Inc. Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
WO2002062842A1 (fr) * 2001-02-06 2002-08-15 Merck Patent Gmbh Facteur de croissance des keratinocytes modifie (kgf) a immunogenicite reduite
MXPA04001526A (es) * 2001-08-21 2004-05-31 Chiron Corp Composiciones de polipetidos kgf.
AU2007214362B2 (en) * 2001-08-21 2009-11-26 Novartis Vaccines And Diagnostics, Inc. KGF polypeptide compositions
BRPI0519070A2 (pt) 2004-12-15 2008-12-23 Amgen Inc composiÇço de fator de crescimento de queratinàcito liofilizada, mÉtodos para preparar um fator de crescimento de queratinàcito liofilizado, e para tratar uma doenÇa, e, kit para preparar uma composiÇço farmacÊutica aquosa
CN102242124B (zh) * 2010-05-10 2013-05-22 齐鲁制药有限公司 改造的角化细胞生长因子基因及其在酵母中的表达
KR102440312B1 (ko) * 2020-08-28 2022-09-05 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
JPH01137994A (ja) * 1987-08-10 1989-05-30 Shionogi & Co Ltd reg蛋白質
WO1990000877A1 (fr) * 1988-07-27 1990-02-08 Marjan International Pty Ltd Machine a tendre les tapis
ATE197800T1 (de) * 1989-01-31 2000-12-15 Jeffrey S Rubin Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 bFGFムテインおよびその製造法
KR100390340B1 (ko) * 1993-03-26 2003-09-26 암겐 인코포레이티드 케라티노사이트성장인자산물을함유하는제약학적조성물
ES2227527T3 (es) * 1993-06-29 2005-04-01 Chiron Corp Un factor de crecimiento de queratinocitos (kgf) truncado que tiene actividad biologica aumentada.
US5348563A (en) * 1993-06-29 1994-09-20 Honeywell Inc. Air purifying apparatus
GB9315501D0 (en) * 1993-07-27 1993-09-08 Ici Plc Surfactant compositions
JPH09503751A (ja) * 1993-08-02 1997-04-15 プリズム ファーマシュティカルズ,インコーポレイティド 細胞毒性抱合体の単一起源性製剤

Also Published As

Publication number Publication date
DE69530403T2 (de) 2003-10-30
CZ98197A3 (cs) 1998-11-11
EP0804479A1 (fr) 1997-11-05
WO1996011949A3 (fr) 1996-12-12
PL319784A1 (en) 1997-08-18
EE9700225A (et) 1998-02-16
AU681546B2 (en) 1997-08-28
FI971536A (fi) 1997-06-09
WO1996011950A1 (fr) 1996-04-25
KR100278597B1 (ko) 2001-01-15
NO971568L (no) 1997-06-12
FI971536A0 (fi) 1997-04-11
NZ505502A (en) 2005-01-28
PT804479E (pt) 2007-02-28
DE69535264D1 (de) 2006-11-23
AU3708395A (en) 1996-05-06
HUT78058A (hu) 1999-07-28
CZ297328B6 (cs) 2006-11-15
HUT78050A (hu) 1999-07-28
CA2202075A1 (fr) 1996-04-25
CN1168678A (zh) 1997-12-24
ES2196082T3 (es) 2003-12-16
DE69535264T2 (de) 2007-02-01
CA2202075C (fr) 2003-12-09
ATE237633T1 (de) 2003-05-15
ES2273338T3 (es) 2007-05-01
CA2201940C (fr) 2009-05-12
EP0804479B1 (fr) 2006-10-11
WO1996011949A2 (fr) 1996-04-25
HU226168B1 (en) 2008-05-28
EE03975B1 (et) 2003-02-17
NZ335109A (en) 2000-08-25
SK45597A3 (en) 1999-02-11
EP0785948B1 (fr) 2003-04-16
CA2201940A1 (fr) 1996-04-25
DE69530403D1 (de) 2003-05-22
FI971420A0 (fi) 1997-04-04
JP4426646B2 (ja) 2010-03-03
PL320484A1 (en) 1997-09-29
CZ297329B6 (cs) 2006-11-15
BG63167B1 (bg) 2001-05-31
NO971568D0 (no) 1997-04-04
SK43197A3 (en) 1999-03-12
JP4216329B2 (ja) 2009-01-28
SI0785948T1 (en) 2003-08-31
PT785948E (pt) 2003-09-30
ATE342278T1 (de) 2006-11-15
JPH10507193A (ja) 1998-07-14
FI971420A (fi) 1997-04-04
BG101392A (en) 1997-10-31
CZ105097A3 (cs) 1998-10-14
DK0804479T3 (da) 2007-01-29
SI0804479T1 (sl) 2006-12-31
NO971566L (no) 1997-04-14
EP0785948A1 (fr) 1997-07-30
NO318761B1 (no) 2005-05-02
JPH10507080A (ja) 1998-07-14
PL182888B1 (pl) 2002-03-29
BR9509269A (pt) 1997-12-23
DK0785948T3 (da) 2003-08-04
AU3707795A (en) 1996-05-06
EE9700081A (et) 1997-10-15
NO971566D0 (no) 1997-04-04
BG101408A (en) 1997-12-30
FI120040B (fi) 2009-06-15
BR9509329A (pt) 1997-10-14

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PC4A Assignment and transfer of rights

Owner name: BIOVITRUM AB (PUBL), SE-112 76 STOCKHOLM, SE

Free format text: FORMER OWNER: AMGEN INC., THOUSAND OAKS, CA, US

Effective date: 20090616

MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20111012