SK283897B6 - 4-[2-Etoxy-5-(4-metylpiperazin-1-ylsulfonyl)benzamido]-1-metyl-3- n-propylpyrazol-5-karboxamid - Google Patents

4-[2-Etoxy-5-(4-metylpiperazin-1-ylsulfonyl)benzamido]-1-metyl-3- n-propylpyrazol-5-karboxamid Download PDF

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Publication number
SK283897B6
SK283897B6 SK1787-2001A SK17872001A SK283897B6 SK 283897 B6 SK283897 B6 SK 283897B6 SK 17872001 A SK17872001 A SK 17872001A SK 283897 B6 SK283897 B6 SK 283897B6
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Slovakia
Prior art keywords
compound
formula
mol
preparation
stirred
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SK1787-2001A
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English (en)
Slovak (sk)
Inventor
Peter James Dunn
Albert Shaw Wood
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Pfizer Research And Development Company N. V./S. A.
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Application filed by Pfizer Research And Development Company N. V./S. A. filed Critical Pfizer Research And Development Company N. V./S. A.
Publication of SK283897B6 publication Critical patent/SK283897B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SK1787-2001A 1996-06-14 1997-06-10 4-[2-Etoxy-5-(4-metylpiperazin-1-ylsulfonyl)benzamido]-1-metyl-3- n-propylpyrazol-5-karboxamid SK283897B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9612514.1A GB9612514D0 (en) 1996-06-14 1996-06-14 Novel process

Publications (1)

Publication Number Publication Date
SK283897B6 true SK283897B6 (sk) 2004-04-06

Family

ID=10795332

Family Applications (5)

Application Number Title Priority Date Filing Date
SK743-97A SK283893B6 (sk) 1996-06-14 1997-06-10 Spôsob výroby 5-[2-etoxy-5-(4-metylpiperazin-1-ylsulfonyl)- fenyl]-1-metyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]- pyrimidin-7-ónu a medziprodukty tohto spôsobu
SK1784-2001A SK283895B6 (sk) 1996-06-14 1997-06-10 Spôsob výroby 5[2-etoxy-5-(4-metylpiperazinu-1-ylsulfonyl)- fenyl]-1-metyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3- d]pyrimidin-7-ónu
SK1787-2001A SK283897B6 (sk) 1996-06-14 1997-06-10 4-[2-Etoxy-5-(4-metylpiperazin-1-ylsulfonyl)benzamido]-1-metyl-3- n-propylpyrazol-5-karboxamid
SK1783-2001A SK283894B6 (sk) 1996-06-14 1997-06-10 Spôsob výroby 5-[2-etoxy-5-(4-metylpiperazin-1-ylsulfonyl)- fenyl]-1-metyl-3-n-propyl-1,6-dihydro-7H-pyrazolo [4,3-d]pyrimidin-7-ónu
SK1786-2001A SK283896B6 (sk) 1996-06-14 1997-06-10 Kyselina 2-etoxy-5-(4-metylpiperazin-1-ylsulfonyl) benzoová

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SK743-97A SK283893B6 (sk) 1996-06-14 1997-06-10 Spôsob výroby 5-[2-etoxy-5-(4-metylpiperazin-1-ylsulfonyl)- fenyl]-1-metyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]- pyrimidin-7-ónu a medziprodukty tohto spôsobu
SK1784-2001A SK283895B6 (sk) 1996-06-14 1997-06-10 Spôsob výroby 5[2-etoxy-5-(4-metylpiperazinu-1-ylsulfonyl)- fenyl]-1-metyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3- d]pyrimidin-7-ónu

Family Applications After (2)

Application Number Title Priority Date Filing Date
SK1783-2001A SK283894B6 (sk) 1996-06-14 1997-06-10 Spôsob výroby 5-[2-etoxy-5-(4-metylpiperazin-1-ylsulfonyl)- fenyl]-1-metyl-3-n-propyl-1,6-dihydro-7H-pyrazolo [4,3-d]pyrimidin-7-ónu
SK1786-2001A SK283896B6 (sk) 1996-06-14 1997-06-10 Kyselina 2-etoxy-5-(4-metylpiperazin-1-ylsulfonyl) benzoová

Country Status (48)

Country Link
US (2) US5955611A (pl)
EP (2) EP0916675B1 (pl)
JP (2) JP2866841B2 (pl)
KR (1) KR100207352B1 (pl)
CN (2) CN1106399C (pl)
AP (1) AP717A (pl)
AR (1) AR003401A1 (pl)
AT (2) ATE246194T1 (pl)
AU (1) AU697684B2 (pl)
BG (1) BG62554B1 (pl)
BR (1) BR9703580A (pl)
CA (1) CA2207694C (pl)
CO (1) CO4780028A1 (pl)
CZ (1) CZ290942B6 (pl)
DE (2) DE69723846T2 (pl)
DK (2) DK0812845T3 (pl)
DZ (1) DZ2247A1 (pl)
EA (1) EA000102B1 (pl)
EG (1) EG24123A (pl)
ES (2) ES2134051T3 (pl)
GB (1) GB9612514D0 (pl)
GR (1) GR3031087T3 (pl)
HK (1) HK1033459A1 (pl)
HN (1) HN1997000072A (pl)
HR (1) HRP970326B1 (pl)
HU (1) HU224497B1 (pl)
ID (1) ID18745A (pl)
IL (3) IL125411A (pl)
IN (5) IN187350B (pl)
IS (2) IS1922B (pl)
MA (1) MA24205A1 (pl)
MX (1) MX9704433A (pl)
NO (2) NO304551B1 (pl)
NZ (1) NZ328084A (pl)
OA (1) OA10426A (pl)
PE (2) PE20011303A1 (pl)
PL (1) PL189333B1 (pl)
PT (1) PT916675E (pl)
RS (2) RS49924B (pl)
SA (1) SA97180124B1 (pl)
SG (1) SG50024A1 (pl)
SI (2) SI0812845T1 (pl)
SK (5) SK283893B6 (pl)
TN (1) TNSN97102A1 (pl)
TR (1) TR199700470A2 (pl)
UA (1) UA27085C2 (pl)
UY (2) UY24585A1 (pl)
ZA (1) ZA975259B (pl)

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CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
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CN102993205B (zh) * 2012-12-27 2015-04-15 华润赛科药业有限责任公司 一种高收率制备高纯度西地那非游离碱的纯化方法
CN103044330B (zh) * 2013-01-14 2018-11-13 常州亚邦制药有限公司 西地那非中间体4-氨基-1-甲基-3-正丙基吡唑-5-甲酰胺的绿色合成新工艺
CN105085526B (zh) * 2014-05-15 2017-08-01 重庆圣华曦药业股份有限公司 一种改进的西地那非制备方法
CN105753870B (zh) * 2016-04-01 2018-05-22 重庆康刻尔制药有限公司 一种西地那非杂质f及其制备方法和应用
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CN113493459B (zh) * 2020-04-07 2022-12-13 广州白云山医药集团股份有限公司白云山制药总厂 Pde5抑制剂化合物及其制备方法和应用
CN112961160A (zh) * 2021-03-05 2021-06-15 遂成药业股份有限公司 一种西地那非的改良合成工艺
CN113754612B (zh) * 2021-10-26 2023-09-26 山东安舜制药有限公司 一种西地那非中间体的制备方法

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Also Published As

Publication number Publication date
NO972481L (no) 1997-12-15
NO306115B1 (no) 1999-09-20
YU25497A (sh) 1998-12-23
IS6634A (is) 2002-11-25
SK283893B6 (sk) 2004-04-06
CA2207694A1 (en) 1997-12-14
BR9703580A (pt) 1998-11-10
HU9701048D0 (en) 1997-08-28
DZ2247A1 (fr) 2002-12-18
SK283894B6 (sk) 2004-04-06
UY24585A1 (es) 1997-12-02
GB9612514D0 (en) 1996-08-14
DK0916675T3 (da) 2003-10-27
SI0916675T1 (en) 2003-12-31
PL320555A1 (en) 1997-12-22
EP0916675A2 (en) 1999-05-19
EG24123A (en) 2008-07-06
AU697684B2 (en) 1998-10-15
EP0812845B1 (en) 1999-07-14
HUP9701048A3 (en) 2000-10-30
EP0916675A3 (en) 1999-07-14
TNSN97102A1 (fr) 2005-03-15
ID18745A (id) 1998-05-07
HRP970326B1 (en) 2000-10-31
PT916675E (pt) 2003-11-28
RS49924B (sr) 2008-09-29
PE20011303A1 (es) 2001-12-25
DE69700321D1 (de) 1999-08-19
IN187319B (pl) 2002-03-23
JP3058863B2 (ja) 2000-07-04
IN187318B (pl) 2002-03-23
EA199700061A1 (ru) 1997-12-30
IS4503A (is) 1997-12-15
CN1149206C (zh) 2004-05-12
CZ290942B6 (cs) 2002-11-13
IL125411A0 (en) 1999-03-12
AR003401A1 (es) 1998-08-05
JPH11171879A (ja) 1999-06-29
DK0812845T3 (da) 1999-11-29
DE69723846D1 (de) 2003-09-04
CA2207694C (en) 1999-11-23
BG62554B1 (bg) 2000-02-29
CZ181197A3 (cs) 1998-03-18
KR100207352B1 (en) 1999-07-15
NO985064L (no) 1997-12-15
RS20060484A (en) 2007-04-10
MX9704433A (es) 1998-11-30
IS1922B (is) 2004-03-15
NZ328084A (en) 1998-08-26
PE1299A1 (es) 1999-01-13
IL125411A (en) 2000-02-29
AP9701009A0 (en) 1997-07-31
IS1923B (is) 2004-03-15
IL121000A0 (en) 1997-11-20
GR3031087T3 (en) 1999-12-31
MA24205A1 (fr) 1997-12-31
IN187317B (pl) 2002-03-23
ES2201397T3 (es) 2004-03-16
NO304551B1 (no) 1999-01-11
ATE182150T1 (de) 1999-07-15
SA97180124A (ar) 2005-12-03
PL189333B1 (pl) 2005-07-29
AP717A (en) 1999-01-04
CO4780028A1 (es) 1999-05-26
RS49653B (sr) 2007-09-21
SI0812845T1 (en) 1999-12-31
AU2487897A (en) 1997-12-18
IL121000A (en) 2000-02-29
UA27085C2 (uk) 2000-02-28
CN1168376A (zh) 1997-12-24
HK1033459A1 (en) 2001-08-31
ATE246194T1 (de) 2003-08-15
DE69700321T2 (de) 1999-11-04
SK74397A3 (en) 1998-06-03
CN1282740A (zh) 2001-02-07
SK283896B6 (sk) 2004-04-06
EP0916675B1 (en) 2003-07-30
JPH1081688A (ja) 1998-03-31
CN1106399C (zh) 2003-04-23
SA97180124B1 (ar) 2006-02-08
HRP970326A2 (en) 1998-06-30
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NO985064D0 (no) 1998-10-30
ZA975259B (en) 1997-12-15
HUP9701048A2 (hu) 1998-12-28
TR199700470A2 (xx) 1998-01-21
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JP2866841B2 (ja) 1999-03-08
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US6066735A (en) 2000-05-23
US5955611A (en) 1999-09-21
OA10426A (en) 2001-12-07
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ES2134051T3 (es) 1999-09-16
HU224497B1 (hu) 2005-10-28
BG101569A (en) 1998-01-30
EA000102B1 (ru) 1998-08-27
HN1997000072A (es) 1997-12-26
SK283895B6 (sk) 2004-04-06
UY24612A1 (es) 2000-09-29
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