SK283883B6 - Použitie fumagillolu a jeho derivátov na prípravu liekov proti intestinálnym chorobám a farmaceutický prostriedok - Google Patents

Použitie fumagillolu a jeho derivátov na prípravu liekov proti intestinálnym chorobám a farmaceutický prostriedok Download PDF

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Publication number
SK283883B6
SK283883B6 SK1307-97A SK130797A SK283883B6 SK 283883 B6 SK283883 B6 SK 283883B6 SK 130797 A SK130797 A SK 130797A SK 283883 B6 SK283883 B6 SK 283883B6
Authority
SK
Slovakia
Prior art keywords
fumagillol
active ingredient
preparation
medicaments
milligrams
Prior art date
Application number
SK1307-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK130797A3 (en
Inventor
Jean-Michel Molina
Francis Derouin
Original Assignee
Sanofi-Synthelabo
Assistance Publique- Hopitaux De Paris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo, Assistance Publique- Hopitaux De Paris filed Critical Sanofi-Synthelabo
Publication of SK130797A3 publication Critical patent/SK130797A3/sk
Publication of SK283883B6 publication Critical patent/SK283883B6/sk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
SK1307-97A 1995-03-27 1996-03-26 Použitie fumagillolu a jeho derivátov na prípravu liekov proti intestinálnym chorobám a farmaceutický prostriedok SK283883B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9503549 1995-03-27
PCT/FR1996/000448 WO1996030010A2 (fr) 1995-03-27 1996-03-26 Utilisation du fumagillol et ses derives pour preparer les medicaments destines a combattre les infections intestinales

Publications (2)

Publication Number Publication Date
SK130797A3 SK130797A3 (en) 1998-03-04
SK283883B6 true SK283883B6 (sk) 2004-04-06

Family

ID=9477436

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1307-97A SK283883B6 (sk) 1995-03-27 1996-03-26 Použitie fumagillolu a jeho derivátov na prípravu liekov proti intestinálnym chorobám a farmaceutický prostriedok

Country Status (25)

Country Link
US (1) US5900431A (zh)
EP (1) EP0817626B1 (zh)
JP (1) JP3260378B2 (zh)
KR (1) KR100286920B1 (zh)
CN (1) CN1072485C (zh)
AP (1) AP646A (zh)
AT (1) ATE172641T1 (zh)
AU (1) AU706161B2 (zh)
CA (1) CA2216623C (zh)
CZ (1) CZ286821B6 (zh)
DE (1) DE69600879T2 (zh)
DK (1) DK0817626T3 (zh)
EA (1) EA000150B1 (zh)
ES (1) ES2128846T3 (zh)
FR (1) FR06C0014I2 (zh)
HU (1) HU224028B1 (zh)
IS (1) IS2048B (zh)
NO (1) NO315968B1 (zh)
NZ (1) NZ304906A (zh)
OA (1) OA10515A (zh)
PL (1) PL183378B1 (zh)
SK (1) SK283883B6 (zh)
TR (1) TR199701048T1 (zh)
UA (1) UA41446C2 (zh)
WO (1) WO1996030010A2 (zh)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69600879T2 (de) * 1995-03-27 1999-06-02 Assistance Publique, Hopitaux De Paris, Paris Verwendung von fumagillol und seinen derivaten zur herstellung von arzneimitteln gegen darminfektionen
EP0799616A1 (en) * 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Oral composition comprising a fumagillol derivative
AU2811400A (en) * 1999-02-26 2000-09-14 Sanofi-Synthelabo Stable formulation containing fumagillin
JP3265394B1 (ja) * 2001-03-14 2002-03-11 泰三 矢野 アクリル系樹脂手袋
DE10341887A1 (de) * 2003-09-09 2005-03-31 Leopold Kostal Gmbh & Co. Kg Elektrisches Schaltermodul
FR2886855B1 (fr) * 2005-06-08 2009-07-17 Agronomique Inst Nat Rech Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques
US8399512B2 (en) * 2007-11-28 2013-03-19 Mersana Therapeutics, Inc. Biocompatible biodegradable fumagillin analog conjugates
CN102123586A (zh) * 2008-07-18 2011-07-13 法弗根股份有限公司 治疗超重或肥胖受试者的方法
US20120004162A1 (en) 2008-12-04 2012-01-05 Vath James E Methods of Treating an Overweight or Obese Subject
US8642650B2 (en) 2008-12-04 2014-02-04 Zafgen, Inc. Methods of treating an overweight or obese subject
WO2013055385A2 (en) 2011-10-03 2013-04-18 Zafgen Corporation Methods of treating age related disorders
CA2777108A1 (en) 2009-10-09 2011-04-14 Zafgen Corporation Sulphone compounds and methods of making and using same
WO2011085198A1 (en) 2010-01-08 2011-07-14 Zafgen Corporation Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph)
JP5827239B2 (ja) 2010-01-08 2015-12-02 ザフゲン，インコーポレイテッド フマギロール型化合物並びにその製造方法及び使用方法
WO2011127304A2 (en) 2010-04-07 2011-10-13 Zafgen Corporation Methods of treating an overweight subject
BR112013001613A2 (pt) 2010-07-22 2016-05-24 Zafgen Inc compostos tricíclicos e métodos para fazer e usar os mesmos.
UA111479C2 (uk) 2010-11-09 2016-05-10 Зафджен, Інк. Кристалічні форми інгібітору metap-2 та способи їх отримання і застосування
WO2012075020A1 (en) 2010-11-29 2012-06-07 Zafgen Corporation Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol
JP6058557B2 (ja) 2011-01-26 2017-01-11 ザフゲン，インコーポレイテッド テトラゾール化合物ならびにその作製方法および使用方法
WO2012122264A1 (en) 2011-03-08 2012-09-13 Zafgen Corporation Oxaspiro [2.5] octane derivatives and analogs
AU2012253760B2 (en) 2011-05-06 2016-02-04 Zafgen, Inc. Tricyclic pyrazole sulfonamide compounds and methods of making and using same
KR20140053013A (ko) 2011-05-06 2014-05-07 자프겐 인크. 삼환식 설폰아마이드 화합물 그리고 그의 제조방법 및 그를 이용하는 방법
EA025526B1 (ru) 2011-05-06 2017-01-30 Зафджен Инк. Частично насыщенные трициклические соединения и способы их получения и применения
AU2013209723B2 (en) 2012-01-18 2016-11-24 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
CA2861381A1 (en) 2012-01-18 2013-07-25 Zafgen, Inc. Tricyclic sulfone compounds and methods of making and using same
MX2014013525A (es) 2012-05-07 2015-10-22 Zafgen Inc Sal polimorfica de la sal de oxalato de 6-o-(4-dimetilaminoetoxi)c inamoil fumagilol y metodos para elaborarla y utilizarla.
WO2013169857A1 (en) 2012-05-08 2013-11-14 Zafgen, Inc. Treating hypothalamic obesity with metap2 inhibitors
WO2013169860A1 (en) 2012-05-09 2013-11-14 Zafgen, Inc. Fumigillol type compounds and methods of making and using same
BR112015010225A2 (pt) 2012-11-05 2017-07-11 Zafgen Inc compostos tricíclicos e seus métodos de produção e utilização
CN104918615B (zh) 2012-11-05 2018-10-12 扎夫根股份有限公司 治疗肝病的方法
EP2925737B1 (en) 2012-11-05 2017-06-14 Zafgen, Inc. Tricyclic compounds for use in the treatment and/or control of obesity
AU2014236528A1 (en) 2013-03-14 2015-09-24 Zafgen, Inc. Methods of treating renal disease and other disorders
AR105671A1 (es) 2015-08-11 2017-10-25 Zafgen Inc Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
CN106432255A (zh) 2015-08-11 2017-02-22 扎夫根公司 烟曲霉素醇螺环化合物和制备和使用其的方法
CN106591389B (zh) * 2015-10-15 2019-10-11 中国科学院微生物研究所 一种利用烟曲霉菌生产烟曲霉素的方法
CN105622593B (zh) * 2016-02-25 2018-06-26 中国农业科学院蜜蜂研究所 一种烟曲霉素的提取方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2791530A (en) * 1953-08-31 1957-05-07 Abbott Lab Stabilized fumagillin compositions
JPH0629278B2 (ja) * 1985-06-26 1994-04-20 藤沢薬品工業株式会社 オキサスピロオクタン化合物
US5135920A (en) * 1988-11-16 1992-08-04 Takeda Chemical Industries, Ltd. Angiostatic agents
EP0541716A1 (en) * 1990-07-27 1993-05-19 Repligen Corporation Novel methods and compositions for treatment of angiogenic diseases
US5328930A (en) * 1993-03-01 1994-07-12 Emory University Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin
DE69600879T2 (de) * 1995-03-27 1999-06-02 Assistance Publique, Hopitaux De Paris, Paris Verwendung von fumagillol und seinen derivaten zur herstellung von arzneimitteln gegen darminfektionen
EP0799616A1 (en) * 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Oral composition comprising a fumagillol derivative
CA2210600A1 (en) * 1996-07-17 1998-01-17 Takashi Houkan Inhibitor of tumor metastasis or recurrence
AU3968597A (en) * 1996-08-02 1998-02-25 Children's Medical Center Corporation Method of regulating the female reproductive system through angiogenesis inhibitors

Also Published As

Publication number Publication date
CA2216623C (en) 2005-05-31
KR19980703271A (ko) 1998-10-15
JP3260378B2 (ja) 2002-02-25
CA2216623A1 (en) 1996-10-03
HUP9801220A2 (hu) 1999-09-28
PL183378B1 (pl) 2002-06-28
FR06C0014I1 (zh) 2006-11-17
MX9707150A (es) 1998-07-31
NZ304906A (en) 1999-06-29
IS4557A (is) 1997-09-11
ATE172641T1 (de) 1998-11-15
ES2128846T3 (es) 1999-05-16
FR06C0014I2 (zh) 2006-12-29
IS2048B (is) 2005-09-15
HU224028B1 (hu) 2005-05-30
AP9701092A0 (en) 1997-10-31
EP0817626B1 (fr) 1998-10-28
AU706161B2 (en) 1999-06-10
CZ286821B6 (en) 2000-07-12
UA41446C2 (uk) 2001-09-17
SK130797A3 (en) 1998-03-04
HUP9801220A3 (en) 2001-10-29
DE69600879D1 (de) 1998-12-03
US5900431A (en) 1999-05-04
CN1179715A (zh) 1998-04-22
CZ304997A3 (en) 1997-12-17
WO1996030010A3 (fr) 1996-11-28
PL322470A1 (en) 1998-02-02
EP0817626A2 (fr) 1998-01-14
DE69600879T2 (de) 1999-06-02
NO974466D0 (no) 1997-09-26
CN1072485C (zh) 2001-10-10
AP646A (en) 1998-04-27
NO974466L (no) 1997-09-26
OA10515A (fr) 2002-04-24
KR100286920B1 (ko) 2001-04-16
WO1996030010A2 (fr) 1996-10-03
TR199701048T1 (xx) 1998-01-21
NO315968B1 (no) 2003-11-24
AU5278696A (en) 1996-10-16
DK0817626T3 (da) 1999-07-12
EA199700267A1 (ru) 1998-04-30
EA000150B1 (ru) 1998-10-29
JPH11506421A (ja) 1999-06-08

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Legal Events

Date Code Title Description
MK4A Patent expired

Expiry date: 20160326