SK283707B6 - 4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínová zlúčenina, spôsob jej prípravy, medziprodukty a farmaceutický prostriedok obsahujúci túto zlúčeninu - Google Patents

4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínová zlúčenina, spôsob jej prípravy, medziprodukty a farmaceutický prostriedok obsahujúci túto zlúčeninu Download PDF

Info

Publication number
SK283707B6
SK283707B6 SK1781-97A SK178197A SK283707B6 SK 283707 B6 SK283707 B6 SK 283707B6 SK 178197 A SK178197 A SK 178197A SK 283707 B6 SK283707 B6 SK 283707B6
Authority
SK
Slovakia
Prior art keywords
group
formula
compound
carbon atoms
tetrahydropyridine
Prior art date
Application number
SK1781-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK178197A3 (en
Inventor
Domenico Badone
Marco Baroni
Rosanna Cardamone
Jacqueline Fournier
Umberto Guzzi
Alessandra Ielmini
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of SK178197A3 publication Critical patent/SK178197A3/sk
Publication of SK283707B6 publication Critical patent/SK283707B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
SK1781-97A 1995-06-28 1996-06-26 4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínová zlúčenina, spôsob jej prípravy, medziprodukty a farmaceutický prostriedok obsahujúci túto zlúčeninu SK283707B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9507760A FR2736053B1 (fr) 1995-06-28 1995-06-28 Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
PCT/FR1996/000995 WO1997001536A1 (fr) 1995-06-28 1996-06-26 4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines ayant une activite neurotrophique et neuroprotectrice

Publications (2)

Publication Number Publication Date
SK178197A3 SK178197A3 (en) 1998-07-08
SK283707B6 true SK283707B6 (sk) 2003-12-02

Family

ID=9480466

Family Applications (2)

Application Number Title Priority Date Filing Date
SK1781-97A SK283707B6 (sk) 1995-06-28 1996-06-26 4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínová zlúčenina, spôsob jej prípravy, medziprodukty a farmaceutický prostriedok obsahujúci túto zlúčeninu
SK593-2003A SK285433B6 (sk) 1995-06-28 1996-06-26 Spôsob prípravy bifenylových derivátov vhodných na prípravu 4-aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínov

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK593-2003A SK285433B6 (sk) 1995-06-28 1996-06-26 Spôsob prípravy bifenylových derivátov vhodných na prípravu 4-aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínov

Country Status (29)

Country Link
US (1) US5981754A (cs)
EP (2) EP1216996A3 (cs)
JP (2) JP3147906B2 (cs)
KR (1) KR100460581B1 (cs)
CN (1) CN1153765C (cs)
AT (1) ATE223897T1 (cs)
AU (1) AU715090B2 (cs)
BR (1) BR9608662A (cs)
CA (1) CA2225746C (cs)
CY (1) CY2312B1 (cs)
CZ (1) CZ291075B6 (cs)
DE (1) DE69623631T2 (cs)
DK (1) DK0837848T3 (cs)
EE (1) EE03870B1 (cs)
ES (1) ES2183965T3 (cs)
FR (1) FR2736053B1 (cs)
HU (1) HUP9900055A3 (cs)
IL (1) IL122159A (cs)
IS (1) IS1999B (cs)
NO (1) NO310144B1 (cs)
NZ (1) NZ312723A (cs)
PL (2) PL187087B1 (cs)
PT (1) PT837848E (cs)
RU (1) RU2163237C2 (cs)
SK (2) SK283707B6 (cs)
TR (1) TR199701710T1 (cs)
UA (1) UA62914C2 (cs)
WO (1) WO1997001536A1 (cs)
ZA (1) ZA965527B (cs)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2762514B1 (fr) * 1997-04-29 1999-10-22 Sanofi Sa Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
FR2763847B1 (fr) 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
FR2771007B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
CO4980891A1 (es) * 1997-11-14 2000-11-27 Sanofi Sa Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer
FR2771006B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
JP2002518386A (ja) * 1998-06-19 2002-06-25 イーライ・リリー・アンド・カンパニー ヘテロアリール化合物の製造
FR2803593B1 (fr) * 2000-01-06 2002-02-15 Sanofi Synthelabo Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2823748B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
ATE365162T1 (de) * 2001-04-20 2007-07-15 Sanofi Aventis Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten
FR2840896B1 (fr) * 2002-06-18 2005-04-08 Sanofi Synthelabo Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant
CN1726209B (zh) * 2002-12-16 2011-04-13 三菱制药株式会社 3-取代的-4-嘧啶酮衍生物
EP2426120A1 (en) 2003-08-18 2012-03-07 Fujifilm Finechemicals Co., Ltd. Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them
TWI350168B (en) * 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
WO2006002361A2 (en) 2004-06-24 2006-01-05 Incyte Corporation 2-methylpropanamides and their use as pharmaceuticals
EA200700117A1 (ru) * 2004-06-24 2007-06-29 Инсайт Корпорейшн N-замещенные пиперидины и их применение в качестве фармацевтических препаратов
WO2006012173A1 (en) * 2004-06-24 2006-02-02 Incyte Corporation Amido compounds and their use as pharmaceuticals
WO2006002350A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
KR20070024639A (ko) * 2004-06-24 2007-03-02 인사이트 산 디에고 인코포레이티드 아미도 화합물 및 약제로서의 이의 용도
JP2008509910A (ja) * 2004-08-10 2008-04-03 インサイト・コーポレイション アミド化合物およびその医薬としての使用
GEP20125565B (en) * 2004-11-10 2012-07-10 Incyte Corp Lactam compounds and their pharmaceutical use
US8110581B2 (en) * 2004-11-10 2012-02-07 Incyte Corporation Lactam compounds and their use as pharmaceuticals
CA2587153A1 (en) * 2004-11-18 2006-05-26 Incyte Corporation Inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1 and methods of using the same
FR2883285B1 (fr) * 2005-03-17 2007-05-18 Sanofi Aventis Sa Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique
JP4864342B2 (ja) * 2005-04-27 2012-02-01 北興化学工業株式会社 ビアリール化合物の製造方法
US20070066584A1 (en) * 2005-09-21 2007-03-22 Wenqing Yao Amido compounds and their use as pharmaceuticals
EA200870019A1 (ru) * 2005-12-05 2008-12-30 Инсайт Корпорейшн Лактамовые соединения и способы их применения
US7998959B2 (en) * 2006-01-12 2011-08-16 Incyte Corporation Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
JP2009525333A (ja) * 2006-01-31 2009-07-09 インサイト・コーポレイション アミド化合物およびその医薬としての使用
WO2007101270A1 (en) * 2006-03-02 2007-09-07 Incyte Corporation MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
US20070208001A1 (en) * 2006-03-03 2007-09-06 Jincong Zhuo Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
CA2649677A1 (en) * 2006-05-01 2007-11-15 Incyte Corporation Tetrasubstituted ureas as modulators of 11-.beta. hydroxyl steroid dehydrogenase type 1
JP2009537564A (ja) * 2006-05-17 2009-10-29 インサイト・コーポレイション １１−βヒドロキシルステロイドデヒドロゲナーゼタイプＩの複素環阻害剤およびそれを用いる方法
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
AU2008345573B2 (en) 2007-12-20 2013-12-19 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
IN2012DN06383A (cs) * 2010-01-19 2015-10-02 Bayer Ip Gmbh
WO2018195649A1 (en) * 2017-04-26 2018-11-01 Alberta Research Chemicals Inc. Substituted tetrahydropyridine derivatives as ido-1 inhibitors and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
FR2650505B1 (fr) * 1989-08-07 1994-06-03 Midy Spa Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
DE4325855A1 (de) * 1993-08-02 1995-02-09 Boehringer Ingelheim Kg Neue Benzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
HK1014952A1 (en) 1999-10-08
IL122159A0 (en) 1998-04-05
DE69623631D1 (en) 2002-10-17
EP0837848B1 (fr) 2002-09-11
MX9710472A (es) 1998-03-31
FR2736053A1 (fr) 1997-01-03
CA2225746C (en) 2004-05-18
UA62914C2 (en) 2004-01-15
PT837848E (pt) 2002-12-31
DK0837848T3 (da) 2003-01-06
BR9608662A (pt) 1999-05-04
KR100460581B1 (ko) 2005-04-14
PL192353B1 (pl) 2006-10-31
SK285433B6 (sk) 2007-01-04
NO310144B1 (no) 2001-05-28
JP2001114763A (ja) 2001-04-24
CZ291075B6 (cs) 2002-12-11
FR2736053B1 (fr) 1997-09-19
NZ312723A (en) 1999-10-28
IS1999B (is) 2005-04-15
CN1189154A (zh) 1998-07-29
ES2183965T3 (es) 2003-04-01
EP1216996A3 (fr) 2003-10-15
DE69623631T2 (de) 2003-08-07
EP1216996A2 (fr) 2002-06-26
AU6461996A (en) 1997-01-30
RU2163237C2 (ru) 2001-02-20
CZ422297A3 (cs) 1998-04-15
AU715090B2 (en) 2000-01-13
ZA965527B (en) 1997-01-24
US5981754A (en) 1999-11-09
SK178197A3 (en) 1998-07-08
EP0837848A1 (fr) 1998-04-29
JP3302351B2 (ja) 2002-07-15
PL187087B1 (pl) 2004-05-31
IL122159A (en) 2001-06-14
PL324216A1 (en) 1998-05-11
NO976079L (no) 1997-12-23
HUP9900055A3 (en) 1999-11-29
IS4641A (is) 1997-12-23
EE9700348A (et) 1998-06-15
JP3147906B2 (ja) 2001-03-19
CA2225746A1 (en) 1997-01-16
CN1153765C (zh) 2004-06-16
CY2312B1 (en) 2003-11-14
JPH11506118A (ja) 1999-06-02
EE03870B1 (et) 2002-10-15
HUP9900055A2 (hu) 1999-04-28
ATE223897T1 (de) 2002-09-15
TR199701710T1 (xx) 1998-05-21
WO1997001536A1 (fr) 1997-01-16
KR19990028431A (ko) 1999-04-15
NO976079D0 (no) 1997-12-23

Similar Documents

Publication Publication Date Title
SK283707B6 (sk) 4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínová zlúčenina, spôsob jej prípravy, medziprodukty a farmaceutický prostriedok obsahujúci túto zlúčeninu
EP0450761A1 (en) Spirocyclic oxytocin antagonists
EP0374801A2 (en) Novel N-sustituted azaheterocyclic carboxylic acids
RU2160731C2 (ru) Промежуточные продукты для получения 1-бензил-4-((5,6-диметокси-1-инданон)-2-ил)-метилпиперидина, способы их получения и способ получения 1-бензил-4-((5,6-диметокси-1-инданон)-2-ил)-метилпиперидина с их применением
CZ217495A3 (en) 2,3-cyclically condensed 1,4-dihydropyridines, process of their preparation, medicaments in which said substances are comprised and their use
PL196053B1 (pl) Pochodne etanosulfonylopiperydyny, środek farmaceutyczny, sposób wytwarzania pochodnych etanosulfonylopiperydyny i ich zastosowanie
PL190789B1 (pl) 1-Fenyloalkilo-1,2,3,6-tetrahydropirydyny, sposób ich wytwarzania i kompozycja farmaceutyczna je zawierająca
IL93814A (en) History of benzothiophyranilamines, their preparation and pharmaceutical preparations containing them
US5512584A (en) 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof
PL192926B1 (pl) Dwufenyloalkilo-czterohydropirydyny, sposób ich wytwarzania i kompozycje farmaceutyczne je zawierające
US7151107B2 (en) Use of benzoylalkyl-1,2,3,6-tetrahydropyridines
CA2420620A1 (en) 4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity
MXPA97010472A (en) 4-aril-phenylalkil-1,2,3,6-tetrahydropiridines that have a neuroprophic activity and neuroprotect
CZ291185B6 (cs) Způsob přípravy bifenylových derivátů vhodných pro přípravu 4-aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridinů
MXPA99005651A (es) Uso de benzoilalquil-1,2,3,6-tetrahidropiridinas