SK282836B6 - Spôsob chromatografického získavania veľmi čistého cyklosporínu A a príbuzných cyklosporínov - Google Patents
Spôsob chromatografického získavania veľmi čistého cyklosporínu A a príbuzných cyklosporínov Download PDFInfo
- Publication number
- SK282836B6 SK282836B6 SK1222-98A SK122298A SK282836B6 SK 282836 B6 SK282836 B6 SK 282836B6 SK 122298 A SK122298 A SK 122298A SK 282836 B6 SK282836 B6 SK 282836B6
- Authority
- SK
- Slovakia
- Prior art keywords
- smb
- cyclosporin
- acetonitrile
- extract
- chromatography
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1996111094 DE19611094C2 (de) | 1996-03-21 | 1996-03-21 | Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens |
| PCT/DE1997/000525 WO1997034918A1 (de) | 1996-03-21 | 1997-03-14 | Chromatographisches verfahren zur gewinnung von hochgereinigtem cyclosporin a und verwandten cyclosporinen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK122298A3 SK122298A3 (en) | 1999-08-06 |
| SK282836B6 true SK282836B6 (sk) | 2002-12-03 |
Family
ID=7788939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1222-98A SK282836B6 (sk) | 1996-03-21 | 1997-03-14 | Spôsob chromatografického získavania veľmi čistého cyklosporínu A a príbuzných cyklosporínov |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6306306B1 (ko) |
| EP (1) | EP0888382B1 (ko) |
| JP (1) | JP3408818B2 (ko) |
| KR (1) | KR100467127B1 (ko) |
| CN (1) | CN1196711C (ko) |
| AT (1) | ATE210146T1 (ko) |
| CZ (1) | CZ293243B6 (ko) |
| DE (3) | DE19611094C2 (ko) |
| DK (1) | DK0888382T3 (ko) |
| ES (1) | ES2169384T3 (ko) |
| HK (1) | HK1015382A1 (ko) |
| HU (1) | HU222200B1 (ko) |
| IL (1) | IL125807A (ko) |
| NO (1) | NO321570B1 (ko) |
| PL (1) | PL187763B1 (ko) |
| PT (1) | PT888382E (ko) |
| RU (1) | RU2163607C2 (ko) |
| SK (1) | SK282836B6 (ko) |
| WO (1) | WO1997034918A1 (ko) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19858892A1 (de) | 1998-12-19 | 2000-06-21 | Merck Patent Gmbh | Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße |
| DE69939335D1 (de) | 1998-12-30 | 2008-09-25 | Dexcel Ltd | Dispergierbares konzentrat zur verabreichung von cyclosporin |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| PL210841B1 (pl) | 2001-10-19 | 2012-03-30 | Isotechnika Inc | Sposób wytwarzania mieszaniny izomerów (E) i (Z) ISATX247 |
| US6843854B2 (en) | 2002-05-31 | 2005-01-18 | Purdue Research Foundation | Method and apparatus for separating a component from a mixture |
| CA2498725C (en) * | 2002-09-13 | 2014-07-08 | Biogen Idec Inc. | Method of purifying polypeptides by simulated moving bed chromatography |
| CN1763084B (zh) * | 2005-10-11 | 2010-04-21 | 山东新时代药业有限公司 | 高纯度环孢菌素a的制备方法 |
| EP2151450A1 (de) | 2008-07-29 | 2010-02-10 | Sandoz AG | Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden |
| CN102086226B (zh) * | 2009-12-04 | 2012-10-10 | 山东新时代药业有限公司 | 一种制备环孢菌素a的方法 |
| US9428711B2 (en) | 2013-05-07 | 2016-08-30 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
| US8802880B1 (en) | 2013-05-07 | 2014-08-12 | Group Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
| EP3118186B1 (fr) | 2013-12-11 | 2022-02-09 | Novasep Process | Installation chromatographique de production d acides gras polyinsatures |
| BR112016015718B1 (pt) | 2014-01-07 | 2021-12-07 | Novasep Process Solutions | Processo de purificação de aminoácidos aromáticos |
| HUP1500502A2 (en) * | 2015-10-26 | 2017-04-28 | Rotachrom Tech Kft | Process for the purification of cyclosporin-a |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB568698A (en) | 1943-05-26 | 1945-04-17 | M O Valve Co Ltd | Improvements in the capping of thermionic valves, electric lamps and like devices |
| US2985589A (en) * | 1957-05-22 | 1961-05-23 | Universal Oil Prod Co | Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets |
| US4117118A (en) | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
| US4215199A (en) | 1978-06-05 | 1980-07-29 | Sandoz Ltd. | Antibiotic production |
| SE448386B (sv) | 1978-10-18 | 1987-02-16 | Sandoz Ag | Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem |
| US4402832A (en) * | 1982-08-12 | 1983-09-06 | Uop Inc. | High efficiency continuous separation process |
| US4923616A (en) * | 1987-09-24 | 1990-05-08 | Mitsubishi Petrochemical Company, Ltd. | Method of separating chemical components in simulated moving bed |
| HU201577B (en) | 1988-12-20 | 1990-11-28 | Gyogyszerkutato Intezet | Process for producing cyclosporin antibiotics |
| WO1992013094A1 (fr) | 1991-01-25 | 1992-08-06 | Fujisawa Pharmaceutical Co., Ltd. | Procede pour produire de la cyclosporine a et/ou c |
| HU213553B (en) | 1992-05-25 | 1997-07-28 | Biogal Gyogyszergyar | Process for isolating of cyclosporin-a |
| US5709797A (en) * | 1996-06-05 | 1998-01-20 | Poli Industria Chimica S.P.A. | Method of isolating cyclosporins |
-
1996
- 1996-03-21 DE DE1996111094 patent/DE19611094C2/de not_active Expired - Lifetime
-
1997
- 1997-03-14 DK DK97920517T patent/DK0888382T3/da active
- 1997-03-14 EP EP97920517A patent/EP0888382B1/de not_active Expired - Lifetime
- 1997-03-14 ES ES97920517T patent/ES2169384T3/es not_active Expired - Lifetime
- 1997-03-14 RU RU98119067/12A patent/RU2163607C2/ru active
- 1997-03-14 JP JP53303697A patent/JP3408818B2/ja not_active Expired - Lifetime
- 1997-03-14 AT AT97920517T patent/ATE210146T1/de active
- 1997-03-14 PT PT97920517T patent/PT888382E/pt unknown
- 1997-03-14 WO PCT/DE1997/000525 patent/WO1997034918A1/de active IP Right Grant
- 1997-03-14 HU HU9901801A patent/HU222200B1/hu active IP Right Grant
- 1997-03-14 CZ CZ19982999A patent/CZ293243B6/cs not_active IP Right Cessation
- 1997-03-14 IL IL12580797A patent/IL125807A/xx not_active IP Right Cessation
- 1997-03-14 SK SK1222-98A patent/SK282836B6/sk not_active IP Right Cessation
- 1997-03-14 DE DE59705670T patent/DE59705670D1/de not_active Expired - Lifetime
- 1997-03-14 KR KR10-1998-0707580A patent/KR100467127B1/ko active IP Right Grant
- 1997-03-14 PL PL32911397A patent/PL187763B1/pl unknown
- 1997-03-14 CN CNB971927049A patent/CN1196711C/zh not_active Expired - Lifetime
- 1997-03-21 US US08/821,823 patent/US6306306B1/en not_active Expired - Fee Related
- 1997-04-18 DE DE19716167A patent/DE19716167C2/de not_active Expired - Lifetime
-
1998
- 1998-09-08 NO NO19984133A patent/NO321570B1/no not_active IP Right Cessation
-
1999
- 1999-02-10 HK HK99100547A patent/HK1015382A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0888382A1 (de) | 1999-01-07 |
| DE19611094A1 (de) | 1997-09-25 |
| EP0888382B1 (de) | 2001-12-05 |
| ES2169384T3 (es) | 2002-07-01 |
| JP2000507237A (ja) | 2000-06-13 |
| IL125807A0 (en) | 1999-04-11 |
| CN1212703A (zh) | 1999-03-31 |
| NO984133L (no) | 1998-09-08 |
| DE19611094C2 (de) | 1999-06-17 |
| DE19716167C2 (de) | 2000-06-29 |
| KR100467127B1 (ko) | 2005-05-27 |
| ATE210146T1 (de) | 2001-12-15 |
| CZ293243B6 (cs) | 2004-03-17 |
| PT888382E (pt) | 2002-05-31 |
| JP3408818B2 (ja) | 2003-05-19 |
| US6306306B1 (en) | 2001-10-23 |
| HK1015382A1 (en) | 1999-10-15 |
| IL125807A (en) | 2003-10-31 |
| DE19716167A1 (de) | 1998-10-22 |
| WO1997034918A1 (de) | 1997-09-25 |
| RU2163607C2 (ru) | 2001-02-27 |
| HUP9901801A2 (hu) | 1999-09-28 |
| DK0888382T3 (da) | 2002-04-02 |
| CN1196711C (zh) | 2005-04-13 |
| NO321570B1 (no) | 2006-06-06 |
| DE59705670D1 (de) | 2002-01-17 |
| HUP9901801A3 (en) | 2001-01-29 |
| CZ299998A3 (cs) | 1999-10-13 |
| HU222200B1 (hu) | 2003-05-28 |
| NO984133D0 (no) | 1998-09-08 |
| SK122298A3 (en) | 1999-08-06 |
| PL187763B1 (pl) | 2004-10-29 |
| KR20000064784A (ko) | 2000-11-06 |
| PL329113A1 (en) | 1999-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Patent expired |
Expiry date: 20170314 |