SK282222B6 - Deriváty 2(1h)-chinolónu, spôsob ich prípravy a ich použitie ako liečiv - Google Patents

Deriváty 2(1h)-chinolónu, spôsob ich prípravy a ich použitie ako liečiv Download PDF

Info

Publication number
SK282222B6
SK282222B6 SK346-98A SK34698A SK282222B6 SK 282222 B6 SK282222 B6 SK 282222B6 SK 34698 A SK34698 A SK 34698A SK 282222 B6 SK282222 B6 SK 282222B6
Authority
SK
Slovakia
Prior art keywords
quinolone
ethyl
thieno
piperazinyl
methyl
Prior art date
Application number
SK346-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK34698A3 (en
Inventor
Cort Gary Mc
Christian Hoornaert
Genevi�Ve Dellac
Michel Aletru
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9510815A external-priority patent/FR2738822B1/fr
Priority claimed from FR9511083A external-priority patent/FR2739100B1/fr
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of SK34698A3 publication Critical patent/SK34698A3/sk
Publication of SK282222B6 publication Critical patent/SK282222B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SK346-98A 1995-09-15 1996-09-12 Deriváty 2(1h)-chinolónu, spôsob ich prípravy a ich použitie ako liečiv SK282222B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9510815A FR2738822B1 (fr) 1995-09-15 1995-09-15 Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique
FR9511083A FR2739100B1 (fr) 1995-09-21 1995-09-21 Derives de 4-(omega-(4-(4-fluorobenzoyl)piperidin-1-yl)- alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique
PCT/FR1996/001401 WO1997010238A1 (fr) 1995-09-15 1996-09-12 Derives de quinolein-2(1h)-one comme antagonistes de la serotonine

Publications (2)

Publication Number Publication Date
SK34698A3 SK34698A3 (en) 1998-08-05
SK282222B6 true SK282222B6 (sk) 2001-12-03

Family

ID=26232206

Family Applications (1)

Application Number Title Priority Date Filing Date
SK346-98A SK282222B6 (sk) 1995-09-15 1996-09-12 Deriváty 2(1h)-chinolónu, spôsob ich prípravy a ich použitie ako liečiv

Country Status (30)

Country Link
US (1) US5958924A (ru)
EP (1) EP0850235B1 (ru)
JP (1) JP3335362B2 (ru)
KR (1) KR100422850B1 (ru)
CN (1) CN1094490C (ru)
AR (1) AR003996A1 (ru)
AT (1) ATE187172T1 (ru)
AU (1) AU715879B2 (ru)
BG (1) BG63779B1 (ru)
BR (1) BR9610579A (ru)
CA (1) CA2228038C (ru)
CO (1) CO4750663A1 (ru)
CZ (1) CZ288149B6 (ru)
DE (1) DE69605430T2 (ru)
DK (1) DK0850235T3 (ru)
EE (1) EE04116B1 (ru)
ES (1) ES2142089T3 (ru)
GR (1) GR3032618T3 (ru)
HK (1) HK1014868A1 (ru)
HU (1) HU222745B1 (ru)
IL (1) IL123600A (ru)
NO (1) NO323841B1 (ru)
NZ (1) NZ318436A (ru)
PL (1) PL184808B1 (ru)
RU (1) RU2167874C2 (ru)
SI (1) SI0850235T1 (ru)
SK (1) SK282222B6 (ru)
TR (1) TR199800464T1 (ru)
UA (1) UA44332C2 (ru)
WO (1) WO1997010238A1 (ru)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100422850B1 (ko) * 1995-09-15 2004-07-23 사노피-신델라보 세로토닌길항제로서의2(1h)-퀴놀론유도체
FR2761071B1 (fr) * 1997-03-20 1999-12-03 Synthelabo Derives de quinolein-2(1h)-one et de dihydroquinolein-2(1h)- one, leur preparation et leur application en therapeutique
FR2761067B1 (fr) * 1997-03-20 1999-04-23 Synthelabo Derives de quinolein-2-(1h)-one, leur preparation et leur application en therapeutique
FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NZ520041A (en) 2000-01-20 2004-11-26 Eisai Co Ltd Novel piperidine compounds and drugs containing the same
FR2812548B1 (fr) * 2000-08-01 2002-09-20 Sanofi Synthelabo Utilisation de derives de quinolein-2(1h)-one ou un de leurs sels pharmaceutiquement acceptable pour la preparation d'un medicament destine au traitement de l'insuffisance renale
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
FR2909670B1 (fr) * 2006-12-12 2010-07-30 Sanofi Aventis Derive fluore de quinoleine-2(1h)-one,son procede de preparation et son utilisation comme intermediaire de synthese
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200922566A (en) 2007-09-14 2009-06-01 Ortho Mcneil Janssen Pharm 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
MY152078A (en) 2007-09-14 2014-08-15 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
US8461182B2 (en) * 2008-10-02 2013-06-11 Taisho Pharmaceutical Co., Ltd. 7-piperidinoalkyl-3, 4-Dihydroquinolone derivative
RU2512283C2 (ru) 2008-11-28 2014-04-10 Янссен Фармасьютикалз, Инк. Производные индола и бензоксазина в качестве модуляторов метаботропных глутаматных рецепторов
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EA020671B1 (ru) 2009-05-12 2014-12-30 Янссен Фармасьютикалз, Инк. ПРОИЗВОДНЫЕ 1,2,4-ТРИАЗОЛО[4,3-a]ПИРИДИНА И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2
PT2430022E (pt) 2009-05-12 2013-12-26 Janssen Pharmaceuticals Inc Derivados de 1,2,3-triazolo[4,3-a]piridina e a sua utilização para o tratamento ou prevenção de doenças neurológicas e psiquiátricas
US9012448B2 (en) 2010-11-08 2015-04-21 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
ES2552455T3 (es) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
ME03518B (me) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena
WO2015110435A1 (en) 2014-01-21 2015-07-30 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
CR20180413A (es) 2016-02-05 2018-12-04 Denali Therapeutics Inc Inhibidores de la proteína quinasa 1 que interactua con el receptor
WO2018107060A1 (en) 2016-12-09 2018-06-14 Denali Therapeutics Inc. Compounds, compositions and methods
CN108707109A (zh) * 2018-08-29 2018-10-26 常州沃腾化工科技有限公司 一种2-甲氧基-4-三氟甲基吡啶-3-磺酰氯的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1278792C (en) * 1985-05-06 1991-01-08 Joseph P. Yevich Antipsychotic fused-ring pyridinylpiperazine derivatives
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
FR2644786B1 (fr) * 1989-03-21 1993-12-31 Adir Cie Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
KR100422850B1 (ko) * 1995-09-15 2004-07-23 사노피-신델라보 세로토닌길항제로서의2(1h)-퀴놀론유도체

Also Published As

Publication number Publication date
MX9802028A (es) 1998-09-30
IL123600A (en) 2001-05-20
HK1014868A1 (en) 1999-10-08
DE69605430T2 (de) 2000-07-13
CZ78698A3 (cs) 1998-06-17
PL184808B1 (pl) 2002-12-31
NO323841B1 (no) 2007-07-09
EE04116B1 (et) 2003-08-15
JPH11514982A (ja) 1999-12-21
EP0850235B1 (fr) 1999-12-01
AU6991996A (en) 1997-04-01
CA2228038A1 (en) 1997-03-20
NO981141D0 (no) 1998-03-13
NO981141L (no) 1998-05-15
GR3032618T3 (en) 2000-05-31
AU715879B2 (en) 2000-02-10
RU2167874C2 (ru) 2001-05-27
TR199800464T1 (xx) 1998-05-21
DE69605430D1 (de) 2000-01-05
WO1997010238A1 (fr) 1997-03-20
AR003996A1 (es) 1998-09-30
CN1094490C (zh) 2002-11-20
ATE187172T1 (de) 1999-12-15
CO4750663A1 (es) 1999-03-31
SI0850235T1 (en) 2000-04-30
PL325467A1 (en) 1998-07-20
ES2142089T3 (es) 2000-04-01
SK34698A3 (en) 1998-08-05
BG102316A (en) 1999-03-31
NZ318436A (en) 1999-02-25
CN1202168A (zh) 1998-12-16
EP0850235A1 (fr) 1998-07-01
EE9800089A (et) 1998-10-15
HU222745B1 (hu) 2003-09-29
DK0850235T3 (da) 2000-05-29
CZ288149B6 (en) 2001-05-16
CA2228038C (en) 2009-04-21
KR19990044666A (ko) 1999-06-25
HUP9802940A2 (hu) 1999-05-28
BR9610579A (pt) 1999-07-06
KR100422850B1 (ko) 2004-07-23
US5958924A (en) 1999-09-28
JP3335362B2 (ja) 2002-10-15
UA44332C2 (uk) 2002-02-15
HUP9802940A3 (en) 2001-11-28
IL123600A0 (en) 1998-10-30
BG63779B1 (bg) 2002-12-29

Similar Documents

Publication Publication Date Title
SK282222B6 (sk) Deriváty 2(1h)-chinolónu, spôsob ich prípravy a ich použitie ako liečiv
JP5198256B2 (ja) 縮合複素環式化合物、並びにそれらの組成物及び使用
PL188908B1 (pl) Nowe pochodne benzimidazolu i ich zastosowanie dowytwarzania leków do leczenia stanów alergicznych
SK280717B6 (sk) Bis-benzo alebo benzopyrido-cyklohepta zlúčeniny,
JPH0687856A (ja) ８‐クロロ‐１１‐〔１‐〔（５‐メチル‐３‐ピリジル）メチル〕‐４‐ピペリジリデン〕‐６，１１‐ジヒドロ‐５Ｈ‐ベンゾ〔５，６〕シクロヘプタ〔１，２‐ｂ〕ピリジン
KR19990028757A (ko) 벤조[ｇ]퀴놀린 유도체
CZ292092A3 (en) Tricyclic heterocyclic compounds
JP3014001B2 (ja) 興奮性アミノ酸拮抗剤
US4668682A (en) 2-Phenylalkyl-3-aminoalkyl-4(3H)-quinazolinone compound
EP0750614B1 (en) Quinazolinyl-amino derivatives having alpha-antagonist activity
NZ229144A (en) Substituted pyrimidinedione derivatives and pharmaceutical compositions, and 1-(1-piperazinyl) isoquinoline as an intermediate reagent
PL186885B1 (pl) Pochodne indoliny użyteczne jako antagoniści receptora 5-HT-2C
CZ114099A3 (cs) 1,4-Disubstituované piperaziny
JP2000512306A (ja) ５―ｈｔ―２ｃ受容体アンタゴニストとして有用なインドリン誘導体
JPH07267951A (ja) アンジオテンシンｉｉ拮抗剤としての新規イミダゾピリジン誘導体
US6593324B2 (en) Dervatives of quinoline as alpha-2 antagonists
JPS62169783A (ja) イミダゾ〔１，２−ａ〕キノリン誘導体、その製造法およびその医薬への応用
JPH064637B2 (ja) 新規なインドール誘導体
JP3269658B2 (ja) フェノール誘導体
MXPA98002028A (en) Quinolein-2 (1h) -ona derivatives as seroton antagonists
GB2088874A (en) Substituted Quinazolines for the Treatment of Hypertension and Bradycardia and as Cardiotonic Agents
KR20230121827A (ko) Nav1.8 전압-게이팅 나트륨 채널의 억제 및 Nav1.8매개 질환의 치료에 유용한 화학적 화합물
IE49470B1 (en) Substituted quinazolines for the treatment of hypertension and bradycardia and as cardiotonic agents
FR2739100A1 (fr) Derives de 4-(omega-(4-(4-fluorobenzoyl)piperidin-1-yl)- alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique
FR2738822A1 (fr) Derives de 4-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)quinolein-2(1h)-one, leur preparation et leur application en therapeutique

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20120912