SK281527B6 - Guanididy alkenylkarboxylových kyselín substituovaných fluórfenylovými skupinami, spôsob ich prípravy, ich použitie a liečivo, ktoré ich obsahuje - Google Patents

Guanididy alkenylkarboxylových kyselín substituovaných fluórfenylovými skupinami, spôsob ich prípravy, ich použitie a liečivo, ktoré ich obsahuje Download PDF

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Publication number
SK281527B6
SK281527B6 SK651-96A SK65196A SK281527B6 SK 281527 B6 SK281527 B6 SK 281527B6 SK 65196 A SK65196 A SK 65196A SK 281527 B6 SK281527 B6 SK 281527B6
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SK
Slovakia
Prior art keywords
medicament
formula
carboxylic acid
manufacture
general formula
Prior art date
Application number
SK651-96A
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English (en)
Slovak (sk)
Other versions
SK65196A3 (en
Inventor
Jan-Robert Schwark
Hans Jochen Lang
Heinz-Werner Kleemann
Andreas Weichert
Wolfgang Scholz
Udo Albus
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of SK65196A3 publication Critical patent/SK65196A3/sk
Publication of SK281527B6 publication Critical patent/SK281527B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/10—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by doubly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK651-96A 1995-05-22 1996-05-17 Guanididy alkenylkarboxylových kyselín substituovaných fluórfenylovými skupinami, spôsob ich prípravy, ich použitie a liečivo, ktoré ich obsahuje SK281527B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19518796A DE19518796A1 (de) 1995-05-22 1995-05-22 Fluorphenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (2)

Publication Number Publication Date
SK65196A3 SK65196A3 (en) 1996-12-04
SK281527B6 true SK281527B6 (sk) 2001-04-09

Family

ID=7762597

Family Applications (1)

Application Number Title Priority Date Filing Date
SK651-96A SK281527B6 (sk) 1995-05-22 1996-05-17 Guanididy alkenylkarboxylových kyselín substituovaných fluórfenylovými skupinami, spôsob ich prípravy, ich použitie a liečivo, ktoré ich obsahuje

Country Status (29)

Country Link
US (2) US20010020042A1 (tr)
EP (1) EP0744397B1 (tr)
JP (1) JP3924018B2 (tr)
KR (1) KR960041152A (tr)
CN (1) CN1063437C (tr)
AR (1) AR002744A1 (tr)
AT (1) ATE192431T1 (tr)
AU (1) AU701493B2 (tr)
BR (1) BR9602394A (tr)
CA (1) CA2177007C (tr)
CZ (1) CZ291622B6 (tr)
DE (2) DE19518796A1 (tr)
DK (1) DK0744397T3 (tr)
ES (1) ES2147629T3 (tr)
GR (1) GR3033416T3 (tr)
HR (1) HRP960230B1 (tr)
HU (1) HUP9601358A3 (tr)
IL (1) IL118327A (tr)
MY (1) MY113803A (tr)
NO (1) NO305552B1 (tr)
NZ (1) NZ286622A (tr)
PL (1) PL183431B1 (tr)
PT (1) PT744397E (tr)
RU (1) RU2164913C2 (tr)
SI (1) SI0744397T1 (tr)
SK (1) SK281527B6 (tr)
TR (1) TR199600421A2 (tr)
TW (1) TW415936B (tr)
ZA (1) ZA964035B (tr)

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AU2013205388B2 (en) * 2005-06-24 2016-05-05 Biotron Limited Antiviral compounds and methods
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WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CN104902930A (zh) 2012-08-21 2015-09-09 阿德利克斯公司 在治疗与液体潴留或盐分过载相关的疾病和胃肠道疾病中用于抑制nhe-介导的反向转运的化合物和方法
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
HUE044550T2 (hu) 2013-04-12 2019-11-28 Ardelyx Inc NHE-3 megkötõ vegyületek és foszfát transzport gátlási módszerek
CN110267944B (zh) 2017-01-09 2024-03-08 阿德利克斯股份有限公司 可用于治疗胃肠道病症的化合物
JP2020505333A (ja) 2017-01-09 2020-02-20 アルデリックス， インコーポレイテッド Ｎｈｅ媒介性アンチポートの阻害薬
EP3661945B1 (en) 2017-08-04 2024-04-03 Ardelyx, Inc. Glycyrrhetinic acid derivatives for treating hyperkalemia
JP2022519714A (ja) 2019-02-07 2022-03-24 アルデリックス， インコーポレイテッド 高カリウム血症の治療で使用するためのグリチルレチン酸誘導体
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

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Also Published As

Publication number Publication date
TW415936B (en) 2000-12-21
US6504057B2 (en) 2003-01-07
US20020123529A1 (en) 2002-09-05
TR199600421A2 (tr) 1997-03-21
NO962063D0 (no) 1996-05-21
CA2177007A1 (en) 1996-11-23
HUP9601358A2 (en) 1997-05-28
ZA964035B (en) 1997-11-21
HRP960230A2 (en) 1997-12-31
EP0744397A2 (de) 1996-11-27
KR960041152A (ko) 1996-12-19
DK0744397T3 (da) 2000-08-28
NO962063L (no) 1996-11-25
IL118327A (en) 2002-12-01
SK65196A3 (en) 1996-12-04
DE19518796A1 (de) 1996-11-28
PL314252A1 (en) 1996-11-25
EP0744397A3 (de) 1997-03-26
AR002744A1 (es) 1998-04-29
AU5237396A (en) 1996-12-05
PT744397E (pt) 2000-09-29
CZ291622B6 (cs) 2003-04-16
CZ145096A3 (en) 1996-12-11
CN1063437C (zh) 2001-03-21
IL118327A0 (en) 1996-09-12
RU2164913C2 (ru) 2001-04-10
CN1138029A (zh) 1996-12-18
SI0744397T1 (en) 2000-08-31
MY113803A (en) 2002-05-31
JPH08319266A (ja) 1996-12-03
HU9601358D0 (en) 1996-07-29
EP0744397B1 (de) 2000-05-03
BR9602394A (pt) 1998-10-06
AU701493B2 (en) 1999-01-28
ES2147629T3 (es) 2000-09-16
PL183431B1 (pl) 2002-06-28
NO305552B1 (no) 1999-06-21
US20010020042A1 (en) 2001-09-06
JP3924018B2 (ja) 2007-06-06
NZ286622A (en) 1997-08-22
ATE192431T1 (de) 2000-05-15
HUP9601358A3 (en) 1997-10-28
HRP960230B1 (en) 2000-12-31
GR3033416T3 (en) 2000-09-29
CA2177007C (en) 2009-01-06
DE59605101D1 (de) 2000-06-08

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