HRP960230B1 - Fluorophenyl substituted alkenyl carboxylic acid guanidines, processes for their preparation, their use as medicinal or diagnostic agent as well as medicaments containing them - Google Patents

Fluorophenyl substituted alkenyl carboxylic acid guanidines, processes for their preparation, their use as medicinal or diagnostic agent as well as medicaments containing them

Info

Publication number
HRP960230B1
HRP960230B1 HR960230A HRP960230A HRP960230B1 HR P960230 B1 HRP960230 B1 HR P960230B1 HR 960230 A HR960230 A HR 960230A HR P960230 A HRP960230 A HR P960230A HR P960230 B1 HRP960230 B1 HR P960230B1
Authority
HR
Croatia
Prior art keywords
medicinal
processes
preparation
carboxylic acid
well
Prior art date
Application number
HR960230A
Other languages
English (en)
Inventor
Schwark Jan-Robert
Lang Hans-Jochen
Kleemann Heinz-Werner
Weichert Andreas
Scholz Wolfgang
Albus Udo
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of HRP960230A2 publication Critical patent/HRP960230A2/hr
Publication of HRP960230B1 publication Critical patent/HRP960230B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/10—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by doubly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR960230A 1995-05-22 1996-05-20 Fluorophenyl substituted alkenyl carboxylic acid guanidines, processes for their preparation, their use as medicinal or diagnostic agent as well as medicaments containing them HRP960230B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19518796A DE19518796A1 (de) 1995-05-22 1995-05-22 Fluorphenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (2)

Publication Number Publication Date
HRP960230A2 HRP960230A2 (en) 1997-12-31
HRP960230B1 true HRP960230B1 (en) 2000-12-31

Family

ID=7762597

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960230A HRP960230B1 (en) 1995-05-22 1996-05-20 Fluorophenyl substituted alkenyl carboxylic acid guanidines, processes for their preparation, their use as medicinal or diagnostic agent as well as medicaments containing them

Country Status (29)

Country Link
US (2) US20010020042A1 (tr)
EP (1) EP0744397B1 (tr)
JP (1) JP3924018B2 (tr)
KR (1) KR960041152A (tr)
CN (1) CN1063437C (tr)
AR (1) AR002744A1 (tr)
AT (1) ATE192431T1 (tr)
AU (1) AU701493B2 (tr)
BR (1) BR9602394A (tr)
CA (1) CA2177007C (tr)
CZ (1) CZ291622B6 (tr)
DE (2) DE19518796A1 (tr)
DK (1) DK0744397T3 (tr)
ES (1) ES2147629T3 (tr)
GR (1) GR3033416T3 (tr)
HR (1) HRP960230B1 (tr)
HU (1) HUP9601358A3 (tr)
IL (1) IL118327A (tr)
MY (1) MY113803A (tr)
NO (1) NO305552B1 (tr)
NZ (1) NZ286622A (tr)
PL (1) PL183431B1 (tr)
PT (1) PT744397E (tr)
RU (1) RU2164913C2 (tr)
SI (1) SI0744397T1 (tr)
SK (1) SK281527B6 (tr)
TR (1) TR199600421A2 (tr)
TW (1) TW415936B (tr)
ZA (1) ZA964035B (tr)

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DE10046993A1 (de) 2000-09-22 2002-04-11 Aventis Pharma Gmbh Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
EP1646371A4 (en) * 2003-06-26 2010-09-22 Biotron Ltd ANTIVIRAL COMPOSITIONS AND METHODS
CN101208297B (zh) * 2005-06-24 2013-04-24 拜伊特朗有限公司 抗病毒化合物和方法
AU2013205388B2 (en) * 2005-06-24 2016-05-05 Biotron Limited Antiviral compounds and methods
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
BRPI0923861B8 (pt) 2008-12-31 2021-05-25 Ardelyx Inc compostos e composições farmacêuticas para inibir o antiporte nhe-mediado no tratamento de distúrbios associados com a retenção de fluido ou com a sobrecarga de sal e distúrbios do trato gastrointestinal
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2014029983A1 (en) 2012-08-21 2014-02-27 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
JP6377132B2 (ja) 2013-04-12 2018-08-22 アーデリクス，インコーポレーテッド Ｎｈｅ３結合化合物およびリン酸輸送の阻害方法
UA126283C2 (uk) 2017-01-09 2022-09-14 Арделікс, Інк. Сполуки, придатні для лікування розладів шлунково-кишкового тракту
BR112019013963A2 (pt) 2017-01-09 2020-04-28 Ardelyx Inc inibidores de antiporte mediado por nhe
EP3661945B1 (en) 2017-08-04 2024-04-03 Ardelyx, Inc. Glycyrrhetinic acid derivatives for treating hyperkalemia
CA3129233A1 (en) 2019-02-07 2020-08-13 Ardelyx, Inc. Glycyrrhetinic acid derivatives for use in treating hyperkalemia
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

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Also Published As

Publication number Publication date
DE59605101D1 (de) 2000-06-08
GR3033416T3 (en) 2000-09-29
PL183431B1 (pl) 2002-06-28
ATE192431T1 (de) 2000-05-15
NZ286622A (en) 1997-08-22
CN1063437C (zh) 2001-03-21
CZ145096A3 (en) 1996-12-11
BR9602394A (pt) 1998-10-06
EP0744397B1 (de) 2000-05-03
IL118327A0 (en) 1996-09-12
NO962063D0 (no) 1996-05-21
US20010020042A1 (en) 2001-09-06
RU2164913C2 (ru) 2001-04-10
HRP960230A2 (en) 1997-12-31
PT744397E (pt) 2000-09-29
HUP9601358A3 (en) 1997-10-28
TW415936B (en) 2000-12-21
SK65196A3 (en) 1996-12-04
AU5237396A (en) 1996-12-05
US6504057B2 (en) 2003-01-07
HUP9601358A2 (en) 1997-05-28
DK0744397T3 (da) 2000-08-28
AR002744A1 (es) 1998-04-29
AU701493B2 (en) 1999-01-28
PL314252A1 (en) 1996-11-25
SI0744397T1 (en) 2000-08-31
IL118327A (en) 2002-12-01
US20020123529A1 (en) 2002-09-05
EP0744397A3 (de) 1997-03-26
KR960041152A (ko) 1996-12-19
CA2177007C (en) 2009-01-06
ES2147629T3 (es) 2000-09-16
NO305552B1 (no) 1999-06-21
HU9601358D0 (en) 1996-07-29
DE19518796A1 (de) 1996-11-28
MY113803A (en) 2002-05-31
CA2177007A1 (en) 1996-11-23
EP0744397A2 (de) 1996-11-27
CZ291622B6 (cs) 2003-04-16
JPH08319266A (ja) 1996-12-03
CN1138029A (zh) 1996-12-18
TR199600421A2 (tr) 1997-03-21
SK281527B6 (sk) 2001-04-09
NO962063L (no) 1996-11-25
JP3924018B2 (ja) 2007-06-06
ZA964035B (en) 1997-11-21

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