SK278776B6 - Echokontrastný prostriedok - Google Patents
Echokontrastný prostriedok Download PDFInfo
- Publication number
- SK278776B6 SK278776B6 SK729-93A SK72993A SK278776B6 SK 278776 B6 SK278776 B6 SK 278776B6 SK 72993 A SK72993 A SK 72993A SK 278776 B6 SK278776 B6 SK 278776B6
- Authority
- SK
- Slovakia
- Prior art keywords
- contrast agent
- echo
- contrast
- negatively charged
- polyoxyethylene polyoxypropylene
- Prior art date
Links
- 239000002961 echo contrast media Substances 0.000 title claims abstract description 12
- 229920000642 polymer Polymers 0.000 claims abstract description 15
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims abstract description 13
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 230000006641 stabilisation Effects 0.000 claims abstract description 4
- FVJZSBGHRPJMMA-IOLBBIBUSA-N PG(18:0/18:0) Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-IOLBBIBUSA-N 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000011105 stabilization Methods 0.000 claims description 3
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims description 2
- 229940067605 phosphatidylethanolamines Drugs 0.000 claims description 2
- 150000003905 phosphatidylinositols Chemical class 0.000 claims description 2
- 229940067626 phosphatidylinositols Drugs 0.000 claims description 2
- 150000008106 phosphatidylserines Chemical class 0.000 claims description 2
- -1 polyoxyethylene Polymers 0.000 claims 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 abstract description 5
- 238000011835 investigation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 35
- 239000002872 contrast media Substances 0.000 description 19
- 238000003384 imaging method Methods 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- BIABMEZBCHDPBV-MPQUPPDSSA-N 1,2-palmitoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-MPQUPPDSSA-N 0.000 description 7
- 229920001983 poloxamer Polymers 0.000 description 7
- 241000282472 Canis lupus familiaris Species 0.000 description 6
- 210000001174 endocardium Anatomy 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 239000000080 wetting agent Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 229940039231 contrast media Drugs 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 229960000502 poloxamer Drugs 0.000 description 2
- 229920001993 poloxamer 188 Polymers 0.000 description 2
- 229940044519 poloxamer 188 Drugs 0.000 description 2
- 230000002618 waking effect Effects 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108010002885 Polygeline Proteins 0.000 description 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Graft Or Block Polymers (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fish Paste Products (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Radiation-Therapy Devices (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4100470A DE4100470A1 (de) | 1991-01-09 | 1991-01-09 | Echokontrastmittel |
| PCT/EP1992/000012 WO1992011873A1 (de) | 1991-01-09 | 1992-01-04 | Echokontrastmittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK72993A3 SK72993A3 (en) | 1994-04-06 |
| SK278776B6 true SK278776B6 (sk) | 1998-02-04 |
Family
ID=6422745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK729-93A SK278776B6 (sk) | 1991-01-09 | 1992-01-04 | Echokontrastný prostriedok |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5599523A (ru) |
| EP (2) | EP0566601B2 (ru) |
| JP (1) | JP3290655B2 (ru) |
| KR (1) | KR100203221B1 (ru) |
| AT (1) | ATE126708T1 (ru) |
| AU (1) | AU652803B2 (ru) |
| BG (1) | BG61667B2 (ru) |
| CA (1) | CA2098915C (ru) |
| CZ (1) | CZ280939B6 (ru) |
| DE (3) | DE4100470A1 (ru) |
| DK (1) | DK0566601T4 (ru) |
| ES (1) | ES2079176T5 (ru) |
| FI (1) | FI119913B (ru) |
| GR (1) | GR3017925T3 (ru) |
| HK (1) | HK1006147A1 (ru) |
| HU (1) | HU220763B1 (ru) |
| IE (1) | IE70131B1 (ru) |
| IL (1) | IL100607A (ru) |
| NZ (1) | NZ241246A (ru) |
| PL (1) | PL167253B1 (ru) |
| RU (1) | RU2091079C1 (ru) |
| SK (1) | SK278776B6 (ru) |
| UA (1) | UA27121C2 (ru) |
| WO (1) | WO1992011873A1 (ru) |
| ZA (1) | ZA92118B (ru) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922304A (en) * | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| IN172208B (ru) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| US20010024638A1 (en) * | 1992-11-02 | 2001-09-27 | Michel Schneider | Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof |
| US7083778B2 (en) * | 1991-05-03 | 2006-08-01 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US6989141B2 (en) * | 1990-05-18 | 2006-01-24 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US20040208826A1 (en) * | 1990-04-02 | 2004-10-21 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US6613306B1 (en) | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US20030194376A1 (en) * | 1990-05-18 | 2003-10-16 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
| GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
| US5993805A (en) * | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
| US6875420B1 (en) | 1991-09-17 | 2005-04-05 | Amersham Health As | Method of ultrasound imaging |
| US6723303B1 (en) | 1991-09-17 | 2004-04-20 | Amersham Health, As | Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane |
| JP3231768B2 (ja) * | 1991-09-17 | 2001-11-26 | ソーナス ファーマシューティカルス，インコーポレイテッド | 気体状超音波造影剤及び超音波造影剤として使用する気体の選定方法 |
| US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
| GB9200388D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
| US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
| IL108416A (en) | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Colloids with phase difference as contrast ultrasound agents |
| PL176116B1 (pl) * | 1993-01-25 | 1999-04-30 | Sonus Pharma Inc | Środek kontrastowy do ultrasonografii i sposób wytwarzania środka kontrastowego do ultrasonografii |
| US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
| US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
| US5798091A (en) | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
| WO1995003835A1 (en) | 1993-07-30 | 1995-02-09 | Alliance Pharmaceutical Corp. | Stabilized microbubble compositions for ultrasound |
| DE4328642A1 (de) * | 1993-08-26 | 1995-03-02 | Byk Gulden Lomberg Chem Fab | Ultraschallkontrastmittel |
| GB9318288D0 (en) * | 1993-09-03 | 1993-10-20 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| RU2138293C1 (ru) * | 1993-12-15 | 1999-09-27 | Бракко Рисерч С.А. | Контрастные вещества для ультразвуковой эхографии, контрастные средства, содержащие эти вещества, и способы их приготовления |
| GB9417941D0 (en) * | 1994-09-06 | 1994-10-26 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
| GB9423419D0 (en) * | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
| US5804162A (en) | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| WO2004073750A1 (en) * | 1995-06-07 | 2004-09-02 | Harald Dugstad | Improvements in or relating to contrast agents |
| KR100500334B1 (ko) | 1996-02-19 | 2005-09-09 | 아머샴 헬스 에이에스 | 조영제또는그와관련된개선 |
| PT904113E (pt) * | 1996-03-05 | 2004-09-30 | Acusphere Inc | Gases fluorados microencapsulados para utilizacao como agentes de aquisicao de imagem |
| DE19626530A1 (de) * | 1996-07-02 | 1998-01-15 | Byk Gulden Lomberg Chem Fab | MR-Kontrastmittelzubereitungen |
| CZ28999A3 (cs) * | 1996-08-02 | 1999-07-14 | Nycomed Imaging As | Použití kontrastního prostředku |
| US6017310A (en) * | 1996-09-07 | 2000-01-25 | Andaris Limited | Use of hollow microcapsules |
| US6068600A (en) * | 1996-12-06 | 2000-05-30 | Quadrant Healthcare (Uk) Limited | Use of hollow microcapsules |
| GB9701237D0 (en) * | 1997-01-22 | 1997-03-12 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US6054118A (en) * | 1997-01-22 | 2000-04-25 | Nycomed Imaging As | Contrast agents comprising two types of gas-containing microparticles |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| DE19805012A1 (de) * | 1998-02-07 | 1999-08-12 | Thomas Gieselmann | Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung |
| GB9912356D0 (en) | 1999-05-26 | 1999-07-28 | Btg Int Ltd | Generation of microfoam |
| US8512680B2 (en) | 2001-08-08 | 2013-08-20 | Btg International Ltd. | Injectables in foam, new pharmaceutical applications |
| JP2007511590A (ja) | 2003-11-17 | 2007-05-10 | ビーティージー・インターナショナル・リミテッド | 治療用フォーム |
| US8048439B2 (en) | 2003-11-17 | 2011-11-01 | Btg International Ltd. | Therapeutic foam |
| US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
| GB0509824D0 (en) | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Therapeutic foam |
| US20070140973A1 (en) * | 2005-12-15 | 2007-06-21 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardium perfusion imaging |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3141641A1 (de) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
| US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
| EP0318081B1 (en) * | 1987-11-27 | 1991-07-24 | Akzo N.V. | Stabilization of antibodies |
| IN172208B (ru) * | 1990-04-02 | 1993-05-01 | Sint Sa |
-
1991
- 1991-01-09 DE DE4100470A patent/DE4100470A1/de not_active Ceased
-
1992
- 1992-01-04 RU RU9293052889A patent/RU2091079C1/ru active
- 1992-01-04 HU HU9301703A patent/HU220763B1/hu unknown
- 1992-01-04 SK SK729-93A patent/SK278776B6/sk unknown
- 1992-01-04 ES ES92901804T patent/ES2079176T5/es not_active Expired - Lifetime
- 1992-01-04 EP EP92901804A patent/EP0566601B2/de not_active Expired - Lifetime
- 1992-01-04 PL PL92299987A patent/PL167253B1/pl unknown
- 1992-01-04 KR KR1019930702025A patent/KR100203221B1/ko not_active IP Right Cessation
- 1992-01-04 JP JP50166892A patent/JP3290655B2/ja not_active Expired - Lifetime
- 1992-01-04 UA UA94040995A patent/UA27121C2/ru unknown
- 1992-01-04 DK DK92901804T patent/DK0566601T4/da active
- 1992-01-04 DE DEEP9200012T patent/DE4290068D2/de not_active Expired - Lifetime
- 1992-01-04 DE DE59203392T patent/DE59203392D1/de not_active Expired - Lifetime
- 1992-01-04 CZ CS931780A patent/CZ280939B6/cs not_active IP Right Cessation
- 1992-01-04 AT AT92901804T patent/ATE126708T1/de not_active IP Right Cessation
- 1992-01-04 WO PCT/EP1992/000012 patent/WO1992011873A1/de active IP Right Grant
- 1992-01-04 EP EP92100093A patent/EP0494615A1/de active Pending
- 1992-01-04 CA CA002098915A patent/CA2098915C/en not_active Expired - Lifetime
- 1992-01-04 AU AU11547/92A patent/AU652803B2/en not_active Expired
- 1992-01-07 IE IE920038A patent/IE70131B1/en not_active IP Right Cessation
- 1992-01-07 IL IL10060792A patent/IL100607A/en not_active IP Right Cessation
- 1992-01-08 ZA ZA92118A patent/ZA92118B/xx unknown
- 1992-01-08 NZ NZ241246A patent/NZ241246A/en not_active IP Right Cessation
-
1993
- 1993-07-08 FI FI933137A patent/FI119913B/fi active IP Right Grant
-
1994
- 1994-02-28 BG BG98599A patent/BG61667B2/bg unknown
- 1994-11-22 US US08/347,206 patent/US5599523A/en not_active Expired - Lifetime
-
1995
- 1995-10-31 GR GR950403031T patent/GR3017925T3/el unknown
-
1998
- 1998-06-08 HK HK98105041A patent/HK1006147A1/xx not_active IP Right Cessation
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