ES2079176T3 - Agente de contraste para ecografia. - Google Patents

Agente de contraste para ecografia.

Info

Publication number
ES2079176T3
ES2079176T3 ES92901804T ES92901804T ES2079176T3 ES 2079176 T3 ES2079176 T3 ES 2079176T3 ES 92901804 T ES92901804 T ES 92901804T ES 92901804 T ES92901804 T ES 92901804T ES 2079176 T3 ES2079176 T3 ES 2079176T3
Authority
ES
Spain
Prior art keywords
ecography
contrast agent
stabilisation
demonstration
absorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92901804T
Other languages
English (en)
Other versions
ES2079176T5 (es
Inventor
Klaus-Dieter Beller
Rudolf Linder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6422745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2079176(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Application granted granted Critical
Publication of ES2079176T3 publication Critical patent/ES2079176T3/es
Publication of ES2079176T5 publication Critical patent/ES2079176T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Graft Or Block Polymers (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Fish Paste Products (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

SE DESCRIBE UNA PREPARACION ACUOSA QUE SE EMPLEA PARA LA ABSORCION Y ESTABILIZACION DE BURBUJAS DE MICROGAS, PARA LA UTILIZACION COMO MEDIO PARA CONTRASTAR ECOS, CONTENIENDO POLIMERO DE POLIOXIETILENOPOLIOXIPROPILENO Y FOSFOPOLIDA CARGADA NEGATIVAMENTE Y ES APROPIADO PARA LA REPRESENTACION DE LA ZONA IZQUIERDA DEL CORAZON.
ES92901804T 1991-01-09 1992-01-04 Agente de contraste para ecografia. Expired - Lifetime ES2079176T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4100470A DE4100470A1 (de) 1991-01-09 1991-01-09 Echokontrastmittel
DE4100470 1991-01-09

Publications (2)

Publication Number Publication Date
ES2079176T3 true ES2079176T3 (es) 1996-01-01
ES2079176T5 ES2079176T5 (es) 2007-10-16

Family

ID=6422745

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92901804T Expired - Lifetime ES2079176T5 (es) 1991-01-09 1992-01-04 Agente de contraste para ecografia.

Country Status (25)

Country Link
US (1) US5599523A (es)
EP (2) EP0494615A1 (es)
JP (1) JP3290655B2 (es)
KR (1) KR100203221B1 (es)
AT (1) ATE126708T1 (es)
AU (1) AU652803B2 (es)
BG (1) BG61667B2 (es)
CA (1) CA2098915C (es)
CZ (1) CZ280939B6 (es)
DE (3) DE4100470A1 (es)
DK (1) DK0566601T4 (es)
ES (1) ES2079176T5 (es)
FI (1) FI119913B (es)
GR (1) GR3017925T3 (es)
HK (1) HK1006147A1 (es)
HU (1) HU220763B1 (es)
IE (1) IE70131B1 (es)
IL (1) IL100607A (es)
NZ (1) NZ241246A (es)
PL (1) PL167253B1 (es)
RU (1) RU2091079C1 (es)
SK (1) SK278776B6 (es)
UA (1) UA27121C2 (es)
WO (1) WO1992011873A1 (es)
ZA (1) ZA92118B (es)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (es) 1990-04-02 1993-05-01 Sint Sa
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
DK0605477T4 (da) * 1991-09-17 2007-10-01 Ge Healthcare As Gasformige ultralydskontrastmidler
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
PL176116B1 (pl) * 1993-01-25 1999-04-30 Sonus Pharma Inc Środek kontrastowy do ultrasonografii i sposób wytwarzania środka kontrastowego do ultrasonografii
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
CA2164813C (en) * 1993-07-30 2009-11-24 Ernest G. Schutt Stabilized microbubble compositions for ultrasound
DE4328642A1 (de) * 1993-08-26 1995-03-02 Byk Gulden Lomberg Chem Fab Ultraschallkontrastmittel
GB9318288D0 (en) * 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
HU225495B1 (en) * 1993-12-15 2007-01-29 Bracco Research Sa Gas mixtures useful as ultrasound contrast media
GB9417941D0 (en) * 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
US5540909A (en) 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
WO2004073750A1 (en) 1995-06-07 2004-09-02 Harald Dugstad Improvements in or relating to contrast agents
CA2246779C (en) 1996-02-19 2008-04-29 Nycomed Imaging A/S Improvements in or relating to contrast agents
CZ281298A3 (cs) * 1996-03-05 1999-01-13 Acusphere, Inc. Fluorované plyny v mikrokapslích jako zobrazující činidla pro ultrazvukové vyšetření
DE19626530A1 (de) * 1996-07-02 1998-01-15 Byk Gulden Lomberg Chem Fab MR-Kontrastmittelzubereitungen
NZ334365A (en) * 1996-08-02 1999-10-28 Nycomed Imaging As Use of a contrast agent comprising microbubbles of biocompatible gas stabilised by opsonisable amphiphilic material for ultrasound imaging of the liver
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6054118A (en) * 1997-01-22 2000-04-25 Nycomed Imaging As Contrast agents comprising two types of gas-containing microparticles
GB9701237D0 (en) * 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE19805012A1 (de) * 1998-02-07 1999-08-12 Thomas Gieselmann Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung
GB9912356D0 (en) 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
US8048439B2 (en) 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
PL223344B1 (pl) 2003-11-17 2016-10-31 Btg Int Ltd Pakiet do skleroterapii
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
GB0509824D0 (en) 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam
WO2007070827A2 (en) * 2005-12-15 2007-06-21 Bristol-Myers Squibb Pharma Company Contrast agents for myocardium perfusion imaging

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
DE3863908D1 (de) * 1987-11-27 1991-08-29 Akzo Nv Stabilisierung von antikoerpern.
IN172208B (es) † 1990-04-02 1993-05-01 Sint Sa

Also Published As

Publication number Publication date
SK72993A3 (en) 1994-04-06
CA2098915A1 (en) 1992-07-10
HU9301703D0 (en) 1993-09-28
CZ178093A3 (en) 1994-04-13
EP0566601B1 (de) 1995-08-23
AU1154792A (en) 1992-08-17
HU220763B1 (hu) 2002-05-28
DK0566601T4 (da) 2007-05-29
KR930703023A (ko) 1993-11-29
FI933137A0 (fi) 1993-07-08
EP0566601A1 (de) 1993-10-27
NZ241246A (en) 1994-01-26
EP0566601B2 (de) 2007-02-21
ATE126708T1 (de) 1995-09-15
US5599523A (en) 1997-02-04
ES2079176T5 (es) 2007-10-16
IE920038A1 (en) 1992-07-15
IL100607A (en) 1996-07-23
DE4290068D2 (de) 1993-10-07
CZ280939B6 (cs) 1996-05-15
HUT64239A (en) 1993-12-28
RU2091079C1 (ru) 1997-09-27
EP0494615A1 (de) 1992-07-15
GR3017925T3 (en) 1996-01-31
HK1006147A1 (en) 1999-02-12
FI933137A (fi) 1993-07-08
BG61667B2 (bg) 1998-02-27
AU652803B2 (en) 1994-09-08
KR100203221B1 (ko) 1999-06-15
PL167253B1 (pl) 1995-08-31
DE4100470A1 (de) 1992-07-16
WO1992011873A1 (de) 1992-07-23
CA2098915C (en) 2005-05-17
DK0566601T3 (da) 1995-12-18
FI119913B (fi) 2009-05-15
IE70131B1 (en) 1996-10-30
SK278776B6 (sk) 1998-02-04
JP2000509363A (ja) 2000-07-25
ZA92118B (en) 1992-08-26
DE59203392D1 (de) 1995-09-28
IL100607A0 (en) 1992-09-06
UA27121C2 (uk) 2000-02-28
JP3290655B2 (ja) 2002-06-10

Similar Documents

Publication Publication Date Title
ES2079176T3 (es) Agente de contraste para ecografia.
RU93052889A (ru) Эхоконтрастное вещество и способ его получения
GR3006630T3 (es)
FI900153A (fi) Administreringsanordningar baserade pao hydrogel.
ATE92931T1 (de) Fluor- und phosphorhaltige amphiphilische molekuele mit oberflaechenaktiven eigenschaften.
FI903153A0 (fi) 11b-aryl-4-estrener, foerfarande foer deras framstaellning samt deras anvaendning som laekemedel.
GR3019514T3 (en) Pharmaceutical preparation for the treatment of prolonged coagulation time
GR3001300T3 (en) Phospholipid-containing products, their preparation and use
ATE101798T1 (de) Kontrastmittel.
NO308510B1 (no) Anvendelse av mikrokapsler for fremstilling av et ultralydkontrastmiddel for kontrastering ved fargedopplersonografi
AU578783B2 (en) Pyridopyrimidines, several processes for their preparation and their use as medicaments
IT1147788B (it) Procedimento per la preparazione di attivatori di plasminogeni utili come agenti terapeutici e diagnostici
SE8102161L (sv) "3,7,11,15-tetrametyl-2,4,6,10,14-hexadekapentaensyra
FR2407717A1 (fr) Usage therapeutique nouveau de l'acetyl-1-carnitine
AU7252581A (en) Salt of furosemide or piretanide as acid component and penbutolol or (-)-3-(4-3-(3,4-dimethoxyphenylethylamino)-2- hydroxypropoxy)-phenyl)-crotonitrile as base component
EP0266559A3 (en) Therapeutic agent for the treatment of peptic ulcer disease
ATE59035T1 (de) Basisch substituierte benzofurancarbonsaeureamide, verfahren zu ihrer herstellung und sie enthaltende therapeutische mittel.
ES2077698T3 (es) Agente terapeutico para la gangrena diabetica.
ATE75938T1 (de) Enantiomere des propafenons enthaltende therapeutische mittel.
IT1237084B (it) Sensibilizzazione di composti metallorganici per la polimerizzazione radicalica fotocatalizzata e stabilizzazione dei preparati.
MX9200039A (es) Medio de contraste para ecografias.
ITMI921866A1 (it) Uso dell'oxatomide come agente antitosse
ES2085411T3 (es) Uso de heptastigmina en la terapia de ictus cerebral.
IT1156376B (it) Manipolo per la somministrazione localizzata di radiazioni laser particolarmente per uso medicale

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 566601

Country of ref document: ES