UA27121C2 - Водhий розчиh для одержаhhя коhтрастhого середовища, застосовуваhого в ультразвуковій діагhостиці, та спосіб його одержаhhя - Google Patents

Водhий розчиh для одержаhhя коhтрастhого середовища, застосовуваhого в ультразвуковій діагhостиці, та спосіб його одержаhhя

Info

Publication number
UA27121C2
UA27121C2 UA94040995A UA94040995A UA27121C2 UA 27121 C2 UA27121 C2 UA 27121C2 UA 94040995 A UA94040995 A UA 94040995A UA 94040995 A UA94040995 A UA 94040995A UA 27121 C2 UA27121 C2 UA 27121C2
Authority
UA
Ukraine
Prior art keywords
preparing
aqueous solution
medium used
ultrasonic diagnosis
contrasting medium
Prior art date
Application number
UA94040995A
Other languages
English (en)
Russian (ru)
Inventor
Клаус-Дітер Беллер
Рудольф Ліндер
Original Assignee
Бік Гулден Ломберг Кеміше Фабрік Гмбх
Бик Гулден Ломберг Кемише Фабрик Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6422745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA27121(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бік Гулден Ломберг Кеміше Фабрік Гмбх, Бик Гулден Ломберг Кемише Фабрик Гмбх filed Critical Бік Гулден Ломберг Кеміше Фабрік Гмбх
Publication of UA27121C2 publication Critical patent/UA27121C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Abstract

Водний розчин для одержання контрастного середовища, застосовуваного в ультразвуковій діагностиці, містить 0,1 - 10мас.% на об’єм поліоксіетиленполіоксипропіленового полімеру та ,01 - 5мас.% на об’єм негативно заряджених фосфоліпідів.
UA94040995A 1991-01-09 1992-01-04 Водhий розчиh для одержаhhя коhтрастhого середовища, застосовуваhого в ультразвуковій діагhостиці, та спосіб його одержаhhя UA27121C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4100470A DE4100470A1 (de) 1991-01-09 1991-01-09 Echokontrastmittel
PCT/EP1992/000012 WO1992011873A1 (de) 1991-01-09 1992-01-04 Echokontrastmittel

Publications (1)

Publication Number Publication Date
UA27121C2 true UA27121C2 (uk) 2000-02-28

Family

ID=6422745

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94040995A UA27121C2 (uk) 1991-01-09 1992-01-04 Водhий розчиh для одержаhhя коhтрастhого середовища, застосовуваhого в ультразвуковій діагhостиці, та спосіб його одержаhhя

Country Status (25)

Country Link
US (1) US5599523A (uk)
EP (2) EP0566601B2 (uk)
JP (1) JP3290655B2 (uk)
KR (1) KR100203221B1 (uk)
AT (1) ATE126708T1 (uk)
AU (1) AU652803B2 (uk)
BG (1) BG61667B2 (uk)
CA (1) CA2098915C (uk)
CZ (1) CZ280939B6 (uk)
DE (3) DE4100470A1 (uk)
DK (1) DK0566601T4 (uk)
ES (1) ES2079176T5 (uk)
FI (1) FI119913B (uk)
GR (1) GR3017925T3 (uk)
HK (1) HK1006147A1 (uk)
HU (1) HU220763B1 (uk)
IE (1) IE70131B1 (uk)
IL (1) IL100607A (uk)
NZ (1) NZ241246A (uk)
PL (1) PL167253B1 (uk)
RU (1) RU2091079C1 (uk)
SK (1) SK278776B6 (uk)
UA (1) UA27121C2 (uk)
WO (1) WO1992011873A1 (uk)
ZA (1) ZA92118B (uk)

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US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5993805A (en) * 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
ATE191346T1 (de) * 1991-09-17 2000-04-15 Sonus Pharma Inc Gasförmige ultraschallkontrastmittel
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
CZ191695A3 (en) * 1993-01-25 1996-05-15 Sonus Pharma Inc Biologically compatible contrast agent, process of its preparation and representation method by ultrasound
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
CA2164813C (en) * 1993-07-30 2009-11-24 Ernest G. Schutt Stabilized microbubble compositions for ultrasound
DE4328642A1 (de) * 1993-08-26 1995-03-02 Byk Gulden Lomberg Chem Fab Ultraschallkontrastmittel
GB9318288D0 (en) * 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
DE69432295T2 (de) * 1993-12-15 2003-08-14 Bracco Research Sa Gas-mischungen verwendbar als ultraschallkontrastmittel
GB9417941D0 (en) * 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
WO2004073750A1 (en) * 1995-06-07 2004-09-02 Harald Dugstad Improvements in or relating to contrast agents
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
WO1997029783A1 (en) * 1996-02-19 1997-08-21 Nycomed Imaging A/S Improvements in or relating to contrast agents
EP0904113B1 (en) * 1996-03-05 2004-05-12 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
DE19626530A1 (de) * 1996-07-02 1998-01-15 Byk Gulden Lomberg Chem Fab MR-Kontrastmittelzubereitungen
CZ28999A3 (cs) * 1996-08-02 1999-07-14 Nycomed Imaging As Použití kontrastního prostředku
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6054118A (en) * 1997-01-22 2000-04-25 Nycomed Imaging As Contrast agents comprising two types of gas-containing microparticles
GB9701237D0 (en) * 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE19805012A1 (de) * 1998-02-07 1999-08-12 Thomas Gieselmann Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung
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US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
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IN172208B (uk) * 1990-04-02 1993-05-01 Sint Sa

Also Published As

Publication number Publication date
DK0566601T3 (da) 1995-12-18
KR930703023A (ko) 1993-11-29
WO1992011873A1 (de) 1992-07-23
KR100203221B1 (ko) 1999-06-15
BG61667B2 (bg) 1998-02-27
SK72993A3 (en) 1994-04-06
AU1154792A (en) 1992-08-17
SK278776B6 (sk) 1998-02-04
ES2079176T5 (es) 2007-10-16
IL100607A0 (en) 1992-09-06
IE70131B1 (en) 1996-10-30
EP0566601A1 (de) 1993-10-27
CZ178093A3 (en) 1994-04-13
EP0566601B2 (de) 2007-02-21
CZ280939B6 (cs) 1996-05-15
CA2098915A1 (en) 1992-07-10
GR3017925T3 (en) 1996-01-31
DE4100470A1 (de) 1992-07-16
HK1006147A1 (en) 1999-02-12
RU2091079C1 (ru) 1997-09-27
EP0494615A1 (de) 1992-07-15
IL100607A (en) 1996-07-23
NZ241246A (en) 1994-01-26
JP2000509363A (ja) 2000-07-25
AU652803B2 (en) 1994-09-08
DE59203392D1 (de) 1995-09-28
DK0566601T4 (da) 2007-05-29
ES2079176T3 (es) 1996-01-01
FI119913B (fi) 2009-05-15
US5599523A (en) 1997-02-04
IE920038A1 (en) 1992-07-15
HU220763B1 (hu) 2002-05-28
FI933137A (fi) 1993-07-08
JP3290655B2 (ja) 2002-06-10
HUT64239A (en) 1993-12-28
EP0566601B1 (de) 1995-08-23
HU9301703D0 (en) 1993-09-28
DE4290068D2 (de) 1993-10-07
FI933137A0 (fi) 1993-07-08
PL167253B1 (pl) 1995-08-31
CA2098915C (en) 2005-05-17
ZA92118B (en) 1992-08-26
ATE126708T1 (de) 1995-09-15

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