SK278182B6 - Acylaminoindole derivatives as 5-ht1 agonists, method of their preparation and pharmaceutical compositions containing these matters their use and semifinished products of preparation proces - Google Patents

Acylaminoindole derivatives as 5-ht1 agonists, method of their preparation and pharmaceutical compositions containing these matters their use and semifinished products of preparation proces Download PDF

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Publication number
SK278182B6
SK278182B6 SK1207-94A SK120794A SK278182B6 SK 278182 B6 SK278182 B6 SK 278182B6 SK 120794 A SK120794 A SK 120794A SK 278182 B6 SK278182 B6 SK 278182B6
Authority
SK
Slovakia
Prior art keywords
compound
formula
alkyl
group
aryl
Prior art date
Application number
SK1207-94A
Other languages
English (en)
Slovak (sk)
Other versions
SK120794A3 (en
Inventor
John E Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SK120794A3 publication Critical patent/SK120794A3/sk
Publication of SK278182B6 publication Critical patent/SK278182B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
  • Materials For Photolithography (AREA)
  • Soft Magnetic Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pyrrole Compounds (AREA)
SK1207-94A 1992-04-10 1993-03-04 Acylaminoindole derivatives as 5-ht1 agonists, method of their preparation and pharmaceutical compositions containing these matters their use and semifinished products of preparation proces SK278182B6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86638292A 1992-04-10 1992-04-10
PCT/US1993/001807 WO1993021180A1 (en) 1992-04-10 1993-03-04 Acylaminoindole derivatives as 5-ht1 agonists

Publications (2)

Publication Number Publication Date
SK120794A3 SK120794A3 (en) 1995-05-10
SK278182B6 true SK278182B6 (en) 1996-03-06

Family

ID=25347493

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1207-94A SK278182B6 (en) 1992-04-10 1993-03-04 Acylaminoindole derivatives as 5-ht1 agonists, method of their preparation and pharmaceutical compositions containing these matters their use and semifinished products of preparation proces

Country Status (31)

Country Link
US (1) US5498626A (hu)
EP (1) EP0635015B1 (hu)
JP (1) JP2544704B2 (hu)
KR (1) KR0179074B1 (hu)
CN (1) CN1038506C (hu)
AT (1) ATE148465T1 (hu)
AU (1) AU670270B2 (hu)
BR (1) BR9306221A (hu)
CA (1) CA2132706C (hu)
CZ (1) CZ282653B6 (hu)
DE (1) DE69307875T2 (hu)
DK (1) DK0635015T3 (hu)
EG (1) EG20466A (hu)
ES (1) ES2097496T3 (hu)
FI (2) FI111256B (hu)
GR (1) GR3022767T3 (hu)
HR (1) HRP930753B1 (hu)
HU (1) HUT64060A (hu)
IL (1) IL105309A0 (hu)
MX (1) MX9301996A (hu)
MY (1) MY115278A (hu)
NO (1) NO309860B1 (hu)
NZ (1) NZ251047A (hu)
PL (1) PL172232B1 (hu)
RU (1) RU2110516C1 (hu)
SK (1) SK278182B6 (hu)
TW (1) TW394769B (hu)
UA (1) UA34452C2 (hu)
WO (1) WO1993021180A1 (hu)
YU (1) YU48916B (hu)
ZA (1) ZA932536B (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
AU670579B2 (en) 1992-04-07 1996-07-25 Pfizer Inc. Indole derivatives as 5-HT1 agonists
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
DE69413240T2 (de) * 1993-08-31 1999-02-04 Pfizer 5-arylindolderivate
GB9402016D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
GB9402011D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
US5965582A (en) * 1994-08-03 1999-10-12 Asta Medica Aktiengesellschaft N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420503D0 (en) * 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
WO1999053956A1 (fr) * 1998-04-16 1999-10-28 Yamanouchi Pharmaceutical Co., Ltd. Remedes contre l'obesite
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
AU2004206909A1 (en) * 2003-01-22 2004-08-05 Gtx Inc. Treating androgen deficiency in female (ADIF)-associated conditions with sarms
MX2010006162A (es) * 2007-12-07 2010-06-25 Pfizer Sal tosilato de una trans-n-isobutil-3-fluoro-3-[3-fluoro-4-(pirro lidin-1-il-metil)fenil]ciclobutanocarboxamida.
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
GB2083463B (en) * 1980-08-12 1984-05-10 Glaxo Group Ltd Heterocyclic compounds
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
HU219974B (hu) * 1990-06-07 2001-10-28 Astrazeneca Ab, Heterociklusos csoporttal helyettesített indolszármazék, előállítása és a vegyületet hatóanyagként tartalmazó gyógyszerkészítmények
HUT64326A (en) * 1990-10-15 1993-12-28 Pfizer Process for production indole derivatives and pharmaceutical preparations containing these compounds
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
DE69230803T2 (de) * 1991-11-25 2000-12-07 Pfizer 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten

Also Published As

Publication number Publication date
AU3782193A (en) 1993-11-18
NZ251047A (en) 1996-09-25
SK120794A3 (en) 1995-05-10
NO309860B1 (no) 2001-04-09
PL172232B1 (pl) 1997-08-29
UA34452C2 (uk) 2001-03-15
TW394769B (en) 2000-06-21
BR9306221A (pt) 1998-06-30
DE69307875T2 (de) 1997-05-22
JPH07501831A (ja) 1995-02-23
CN1038506C (zh) 1998-05-27
FI111256B (fi) 2003-06-30
HRP930753A2 (en) 1994-10-31
YU48916B (sh) 2002-11-15
RU2110516C1 (ru) 1998-05-10
EP0635015A1 (en) 1995-01-25
ATE148465T1 (de) 1997-02-15
ZA932536B (en) 1994-10-08
CZ282653B6 (cs) 1997-08-13
FI931613A0 (fi) 1993-04-08
HUT64060A (en) 1993-11-29
CA2132706A1 (en) 1993-10-28
GR3022767T3 (en) 1997-06-30
EP0635015B1 (en) 1997-01-29
YU25593A (sh) 1996-10-09
MX9301996A (es) 1994-03-31
CA2132706C (en) 1998-08-04
US5498626A (en) 1996-03-12
CZ247794A3 (en) 1995-07-12
JP2544704B2 (ja) 1996-10-16
KR950700903A (ko) 1995-02-20
CN1080288A (zh) 1994-01-05
HRP930753B1 (en) 2000-10-31
FI20010214A (fi) 2001-02-05
NO943803L (no) 1994-10-07
AU670270B2 (en) 1996-07-11
RU94045902A (ru) 1996-08-27
MY115278A (en) 2003-05-31
EG20466A (en) 1999-05-31
WO1993021180A1 (en) 1993-10-28
IL105309A0 (en) 1993-08-18
FI931613A (fi) 1993-10-11
DK0635015T3 (da) 1997-03-17
KR0179074B1 (ko) 1999-03-20
HU9301048D0 (en) 1993-06-28
NO943803D0 (no) 1994-10-07
ES2097496T3 (es) 1997-04-01
DE69307875D1 (de) 1997-03-13

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