SK278182B6 - Acylaminoindole derivatives as 5-ht1 agonists, method of their preparation and pharmaceutical compositions containing these matters their use and semifinished products of preparation proces - Google Patents

Acylaminoindole derivatives as 5-ht1 agonists, method of their preparation and pharmaceutical compositions containing these matters their use and semifinished products of preparation proces Download PDF

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Publication number
SK278182B6
SK278182B6 SK1207-94A SK120794A SK278182B6 SK 278182 B6 SK278182 B6 SK 278182B6 SK 120794 A SK120794 A SK 120794A SK 278182 B6 SK278182 B6 SK 278182B6
Authority
SK
Slovakia
Prior art keywords
compound
formula
alkyl
group
aryl
Prior art date
Application number
SK1207-94A
Other languages
English (en)
Slovak (sk)
Other versions
SK120794A3 (en
Inventor
John E Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SK120794A3 publication Critical patent/SK120794A3/sk
Publication of SK278182B6 publication Critical patent/SK278182B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Soft Magnetic Materials (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
SK1207-94A 1992-04-10 1993-03-04 Acylaminoindole derivatives as 5-ht1 agonists, method of their preparation and pharmaceutical compositions containing these matters their use and semifinished products of preparation proces SK278182B6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86638292A 1992-04-10 1992-04-10
PCT/US1993/001807 WO1993021180A1 (en) 1992-04-10 1993-03-04 Acylaminoindole derivatives as 5-ht1 agonists

Publications (2)

Publication Number Publication Date
SK120794A3 SK120794A3 (en) 1995-05-10
SK278182B6 true SK278182B6 (en) 1996-03-06

Family

ID=25347493

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1207-94A SK278182B6 (en) 1992-04-10 1993-03-04 Acylaminoindole derivatives as 5-ht1 agonists, method of their preparation and pharmaceutical compositions containing these matters their use and semifinished products of preparation proces

Country Status (31)

Country Link
US (1) US5498626A (fi)
EP (1) EP0635015B1 (fi)
JP (1) JP2544704B2 (fi)
KR (1) KR0179074B1 (fi)
CN (1) CN1038506C (fi)
AT (1) ATE148465T1 (fi)
AU (1) AU670270B2 (fi)
BR (1) BR9306221A (fi)
CA (1) CA2132706C (fi)
CZ (1) CZ282653B6 (fi)
DE (1) DE69307875T2 (fi)
DK (1) DK0635015T3 (fi)
EG (1) EG20466A (fi)
ES (1) ES2097496T3 (fi)
FI (2) FI111256B (fi)
GR (1) GR3022767T3 (fi)
HR (1) HRP930753B1 (fi)
HU (1) HUT64060A (fi)
IL (1) IL105309A0 (fi)
MX (1) MX9301996A (fi)
MY (1) MY115278A (fi)
NO (1) NO309860B1 (fi)
NZ (1) NZ251047A (fi)
PL (1) PL172232B1 (fi)
RU (1) RU2110516C1 (fi)
SK (1) SK278182B6 (fi)
TW (1) TW394769B (fi)
UA (1) UA34452C2 (fi)
WO (1) WO1993021180A1 (fi)
YU (1) YU48916B (fi)
ZA (1) ZA932536B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
EP0635017A1 (en) 1992-04-07 1995-01-25 Pfizer Inc. Indole derivatives as 5-ht1 agonists
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
CA2169179C (en) * 1993-08-31 2000-02-29 John E. Macor 5-arylindole derivatives
GB9402016D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
GB9402011D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
EP0775131A2 (de) * 1994-08-03 1997-05-28 ASTA Medica Aktiengesellschaft Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420503D0 (en) * 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
AU3170099A (en) * 1998-04-16 1999-11-08 Yamanouchi Pharmaceutical Co., Ltd. Remedies for obesity
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
JP2006516286A (ja) * 2003-01-22 2006-06-29 ジーティーエックス・インコーポレイテッド Ｓａｒｍによる女性のアンドロゲン減少に関連する病気の治療
WO2009071988A1 (en) * 2007-12-07 2009-06-11 Pfizer Inc. Tosylate salt of trans-n-isobutyl-3-fluoro-3- [3-flu0r0-4- (pyrrolidin-1-yl-methyl) -phenyl] cyclobut anecarboxamide
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
FR2488606A1 (fr) * 1980-08-12 1982-02-19 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
BE889931A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
EP0636623B1 (en) * 1990-06-07 2001-08-16 AstraZeneca AB Indole derivatives as 5-HT1- like agonists
PL168919B1 (pl) * 1990-10-15 1996-05-31 Pfizer Sposób wytwarzania nowych pochodnych indolu PL PL PL PL
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
HUT69705A (en) * 1991-11-25 1995-09-28 Pfizer Indole derivatives

Also Published As

Publication number Publication date
CZ282653B6 (cs) 1997-08-13
DE69307875D1 (de) 1997-03-13
RU2110516C1 (ru) 1998-05-10
EP0635015B1 (en) 1997-01-29
HRP930753B1 (en) 2000-10-31
AU3782193A (en) 1993-11-18
SK120794A3 (en) 1995-05-10
FI20010214A (fi) 2001-02-05
KR950700903A (ko) 1995-02-20
US5498626A (en) 1996-03-12
EP0635015A1 (en) 1995-01-25
UA34452C2 (uk) 2001-03-15
CN1038506C (zh) 1998-05-27
WO1993021180A1 (en) 1993-10-28
GR3022767T3 (en) 1997-06-30
MX9301996A (es) 1994-03-31
ATE148465T1 (de) 1997-02-15
NZ251047A (en) 1996-09-25
NO943803L (no) 1994-10-07
BR9306221A (pt) 1998-06-30
CA2132706A1 (en) 1993-10-28
JPH07501831A (ja) 1995-02-23
JP2544704B2 (ja) 1996-10-16
ZA932536B (en) 1994-10-08
FI931613A (fi) 1993-10-11
ES2097496T3 (es) 1997-04-01
FI111256B (fi) 2003-06-30
EG20466A (en) 1999-05-31
CA2132706C (en) 1998-08-04
HUT64060A (en) 1993-11-29
NO943803D0 (no) 1994-10-07
KR0179074B1 (ko) 1999-03-20
CN1080288A (zh) 1994-01-05
DK0635015T3 (da) 1997-03-17
AU670270B2 (en) 1996-07-11
NO309860B1 (no) 2001-04-09
DE69307875T2 (de) 1997-05-22
MY115278A (en) 2003-05-31
YU48916B (sh) 2002-11-15
PL172232B1 (pl) 1997-08-29
HRP930753A2 (en) 1994-10-31
TW394769B (en) 2000-06-21
IL105309A0 (en) 1993-08-18
YU25593A (sh) 1996-10-09
FI931613A0 (fi) 1993-04-08
HU9301048D0 (en) 1993-06-28
RU94045902A (ru) 1996-08-27
CZ247794A3 (en) 1995-07-12

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