SK1942003A3 - Novel heteroaryl derivatives and use thereof as anti-tumour agents - Google Patents
Novel heteroaryl derivatives and use thereof as anti-tumour agents Download PDFInfo
- Publication number
- SK1942003A3 SK1942003A3 SK194-2003A SK1942003A SK1942003A3 SK 1942003 A3 SK1942003 A3 SK 1942003A3 SK 1942003 A SK1942003 A SK 1942003A SK 1942003 A3 SK1942003 A3 SK 1942003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- alkyl
- mono
- group
- radical
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10035908A DE10035908A1 (de) | 2000-07-21 | 2000-07-21 | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
PCT/EP2001/008262 WO2002008190A2 (de) | 2000-07-21 | 2001-07-18 | Neue heteroaryl-derivate und deren verwendung als antitumormittel |
Publications (1)
Publication Number | Publication Date |
---|---|
SK1942003A3 true SK1942003A3 (en) | 2003-12-02 |
Family
ID=7649970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK194-2003A SK1942003A3 (en) | 2000-07-21 | 2001-07-18 | Novel heteroaryl derivatives and use thereof as anti-tumour agents |
Country Status (21)
Country | Link |
---|---|
US (1) | US6638935B2 (no) |
EP (1) | EP1305289A2 (no) |
JP (1) | JP2004516243A (no) |
KR (1) | KR20030015894A (no) |
CN (1) | CN1447796A (no) |
AR (1) | AR032467A1 (no) |
AU (2) | AU8198901A (no) |
BG (1) | BG107506A (no) |
BR (1) | BR0112711A (no) |
CA (1) | CA2353353A1 (no) |
DE (1) | DE10035908A1 (no) |
HU (1) | HUP0300743A2 (no) |
IL (1) | IL153931A0 (no) |
MX (1) | MXPA03000596A (no) |
NO (1) | NO20030302L (no) |
NZ (1) | NZ524156A (no) |
PL (1) | PL361354A1 (no) |
RU (1) | RU2003105238A (no) |
SK (1) | SK1942003A3 (no) |
WO (1) | WO2002008190A2 (no) |
ZA (1) | ZA200300545B (no) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040014744A1 (en) * | 2002-04-05 | 2004-01-22 | Fortuna Haviv | Substituted pyridines having antiangiogenic activity |
AU2003246571B2 (en) * | 2002-06-29 | 2008-06-26 | Zentaris Gmbh | Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases |
JP2006516656A (ja) * | 2003-01-28 | 2006-07-06 | アヴェンティス ファーマ エス.エー. | N−アリールヘテロ芳香族物質、それを含む組成物およびその用途 |
AR044586A1 (es) * | 2003-06-04 | 2005-09-21 | Aventis Pharma Sa | Productos aril - heteroaromaticos, composiciones que los contienen y su utilizacion |
FR2855825B1 (fr) * | 2003-06-04 | 2008-08-22 | Aventis Pharma Sa | Produits aryl-heteroaromatiques, compositions les contenant et utilisation |
US7592466B2 (en) | 2003-10-09 | 2009-09-22 | Abbott Laboratories | Ureas having antiangiogenic activity |
FR2871157A1 (fr) * | 2004-06-04 | 2005-12-09 | Aventis Pharma Sa | Produits biaryl aromatiques, compositions les contenant et utilisation |
EP1645556A1 (en) * | 2004-10-07 | 2006-04-12 | Boehringer Ingelheim International GmbH | Arylpiperazine-benzoylamide derivatives useful as pharmaceutical agents |
AU2008210455A1 (en) * | 2007-01-31 | 2008-08-07 | Vertex Pharmaceuticals Incorporated | 2-aminopyridine derivatives useful as kinase inhibitors |
EP2125750B1 (en) * | 2007-02-26 | 2014-05-21 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
WO2009017671A1 (en) * | 2007-07-26 | 2009-02-05 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
CN101903384A (zh) | 2007-11-02 | 2010-12-01 | 沃泰克斯药物股份有限公司 | 作为蛋白激酶Cθ抑制剂的[1H-吡唑并[3,4-B]吡啶-4-基]-苯基或-吡啶-2-基衍生物 |
AR069207A1 (es) * | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
WO2009075835A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceutical, Inc | CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1 |
TW200934490A (en) * | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
US8592409B2 (en) | 2008-01-24 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
CA2714532A1 (en) * | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
CA2715290A1 (en) * | 2008-02-15 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
JP5538356B2 (ja) * | 2008-03-18 | 2014-07-02 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1型の阻害剤 |
US8569292B2 (en) | 2008-05-01 | 2013-10-29 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
WO2009134387A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
TW200946520A (en) * | 2008-05-01 | 2009-11-16 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
JP5451752B2 (ja) * | 2008-05-01 | 2014-03-26 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター |
KR20110039563A (ko) | 2008-07-23 | 2011-04-19 | 버텍스 파마슈티칼스 인코포레이티드 | 피라졸로피리딘 키나제 억제제 |
AU2009274023A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
CA2730499A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
MX2011001319A (es) * | 2008-08-06 | 2011-04-05 | Vertex Pharma | Inhibidores de aminopiridina cinasa. |
WO2010089303A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1 |
TW201039034A (en) * | 2009-04-27 | 2010-11-01 | Chunghwa Picture Tubes Ltd | Pixel structure and the method of forming the same |
US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
GEP20156309B (en) * | 2009-04-30 | 2015-07-10 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
JP5627675B2 (ja) | 2009-05-06 | 2014-11-19 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | ピラゾロピリジン |
EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
EP2448928B1 (en) | 2009-07-01 | 2014-08-13 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
AU2011209649A1 (en) | 2010-01-27 | 2012-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
CN102858769A (zh) | 2010-01-27 | 2013-01-02 | 沃泰克斯药物股份有限公司 | 吡唑并吡啶激酶抑制剂 |
WO2011094290A1 (en) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrimidine kinase inhibitors |
EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための11−β−HSD1のインヒビターとしてのアザスピロヘキサノン |
BR112013010021A2 (pt) | 2010-11-02 | 2019-09-24 | Boehringer Ingelheim Int | combinações farmacêuticas para o tratamento de distúrbios metabólicos. |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE791501A (fr) * | 1971-11-19 | 1973-05-17 | Albert Ag Chem Werke | Diamines cycliques n,n'-disubstituees et leur procede de preparation |
JPS50151886A (no) * | 1974-05-29 | 1975-12-06 | ||
HU175075B (hu) * | 1977-06-30 | 1980-05-28 | Egyt Gyogyszervegyeszeti Gyar | Sposob poluchenija piperazidov piridin-karbonovoj kisloty |
DE3172006D1 (en) * | 1980-05-22 | 1985-10-03 | Masayuki Ishikawa | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof |
US4937246A (en) * | 1987-11-25 | 1990-06-26 | Takeda Chemical Industries, Ltd. | PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof |
MX16687A (es) * | 1988-07-07 | 1994-01-31 | Ciba Geigy Ag | Compuestos de biarilo y procedimiento para su preparacion. |
AU675145B2 (en) * | 1993-06-18 | 1997-01-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
CZ288002B6 (cs) * | 1995-01-11 | 2001-03-14 | Samjin Pharmaceutical Co., Ltd. | Piperazinové deriváty a farmaceutický prostředek s protinádorovou aktivitou je obsahující |
AU707323B2 (en) * | 1995-03-10 | 1999-07-08 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
JP3032303B2 (ja) * | 1996-06-29 | 2000-04-17 | サムジン ファーマシューチカル カンパニー,リミテッド | ピペラジン誘導体及びその製造方法 |
ES2125206B1 (es) * | 1997-07-21 | 1999-11-16 | Esteve Labor Dr | Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
US6166203A (en) * | 1998-02-26 | 2000-12-26 | Neurogen Corporation | Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands |
EP1107758A2 (en) * | 1998-08-28 | 2001-06-20 | Scios Inc. | Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase |
KR100396738B1 (ko) * | 1999-03-03 | 2003-09-03 | 삼진제약주식회사 | 피페라진 유도체 및 그 제조방법 |
US6469006B1 (en) * | 1999-06-15 | 2002-10-22 | Bristol-Myers Squibb Company | Antiviral indoleoxoacetyl piperazine derivatives |
US6444687B1 (en) * | 1999-12-16 | 2002-09-03 | Schering Corporation | Substituted imidazole neuropeptide Y Y5 receptor antagonists |
-
2000
- 2000-07-21 DE DE10035908A patent/DE10035908A1/de not_active Withdrawn
-
2001
- 2001-07-18 NZ NZ524156A patent/NZ524156A/en unknown
- 2001-07-18 BR BR0112711-0A patent/BR0112711A/pt not_active IP Right Cessation
- 2001-07-18 EP EP01960509A patent/EP1305289A2/de not_active Withdrawn
- 2001-07-18 RU RU2003105238/04A patent/RU2003105238A/ru not_active Application Discontinuation
- 2001-07-18 IL IL15393101A patent/IL153931A0/xx unknown
- 2001-07-18 AU AU8198901A patent/AU8198901A/xx active Pending
- 2001-07-18 CN CN01814312A patent/CN1447796A/zh active Pending
- 2001-07-18 PL PL36135401A patent/PL361354A1/xx unknown
- 2001-07-18 MX MXPA03000596A patent/MXPA03000596A/es unknown
- 2001-07-18 KR KR10-2003-7000880A patent/KR20030015894A/ko not_active Application Discontinuation
- 2001-07-18 WO PCT/EP2001/008262 patent/WO2002008190A2/de active IP Right Grant
- 2001-07-18 JP JP2002514097A patent/JP2004516243A/ja not_active Withdrawn
- 2001-07-18 AU AU2001281989A patent/AU2001281989B2/en not_active Ceased
- 2001-07-18 SK SK194-2003A patent/SK1942003A3/sk not_active Application Discontinuation
- 2001-07-18 HU HU0300743A patent/HUP0300743A2/hu unknown
- 2001-07-20 AR ARP010103479A patent/AR032467A1/es unknown
- 2001-07-20 US US09/910,139 patent/US6638935B2/en not_active Expired - Fee Related
- 2001-07-20 CA CA002353353A patent/CA2353353A1/en not_active Abandoned
-
2002
- 2002-01-21 ZA ZA200300545A patent/ZA200300545B/xx unknown
-
2003
- 2003-01-20 NO NO20030302A patent/NO20030302L/no unknown
- 2003-01-30 BG BG107506A patent/BG107506A/bg unknown
Also Published As
Publication number | Publication date |
---|---|
IL153931A0 (en) | 2003-07-31 |
CN1447796A (zh) | 2003-10-08 |
HUP0300743A2 (hu) | 2003-10-28 |
RU2003105238A (ru) | 2004-08-10 |
MXPA03000596A (es) | 2003-05-14 |
WO2002008190A2 (de) | 2002-01-31 |
NO20030302L (no) | 2003-02-07 |
BR0112711A (pt) | 2003-05-20 |
ZA200300545B (en) | 2003-02-12 |
PL361354A1 (en) | 2004-10-04 |
BG107506A (bg) | 2003-09-30 |
NO20030302D0 (no) | 2003-01-20 |
WO2002008190A3 (de) | 2002-08-01 |
NZ524156A (en) | 2005-10-28 |
DE10035908A1 (de) | 2002-03-07 |
US6638935B2 (en) | 2003-10-28 |
KR20030015894A (ko) | 2003-02-25 |
AR032467A1 (es) | 2003-11-12 |
AU8198901A (en) | 2002-02-05 |
CA2353353A1 (en) | 2002-01-21 |
AU2001281989B2 (en) | 2005-05-12 |
EP1305289A2 (de) | 2003-05-02 |
US20020111354A1 (en) | 2002-08-15 |
JP2004516243A (ja) | 2004-06-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC9A | Refused patent application |