SK17612001A3 - Hyaluronidáza z Hirudinaria manillensis, jej izolácia, čistenie a rekombinantné spôsoby jej výroby - Google Patents

Hyaluronidáza z Hirudinaria manillensis, jej izolácia, čistenie a rekombinantné spôsoby jej výroby Download PDF

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Publication number
SK17612001A3
SK17612001A3 SK1761-2001A SK17612001A SK17612001A3 SK 17612001 A3 SK17612001 A3 SK 17612001A3 SK 17612001 A SK17612001 A SK 17612001A SK 17612001 A3 SK17612001 A3 SK 17612001A3
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SK
Slovakia
Prior art keywords
lys
leu
protein
ser
gly
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SK1761-2001A
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English (en)
Slovak (sk)
Inventor
Maria Kordowicz
Detlef G�Ssow
Uwe Hofmann
Tadeusz Pacuszka
Andrzej Gardas
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Merck Patent Gmbh
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Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SK17612001A3 publication Critical patent/SK17612001A3/sk

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • C12N9/2408Glucanases acting on alpha -1,4-glucosidic bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK1761-2001A 1999-06-12 2000-06-06 Hyaluronidáza z Hirudinaria manillensis, jej izolácia, čistenie a rekombinantné spôsoby jej výroby SK17612001A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99111468 1999-06-12
PCT/EP2000/005181 WO2000077221A1 (en) 1999-06-12 2000-06-06 Hyaluronidase from the hirudinaria manillensis, isolation, purification and recombinant method of production

Publications (1)

Publication Number Publication Date
SK17612001A3 true SK17612001A3 (sk) 2002-04-04

Family

ID=8238352

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1761-2001A SK17612001A3 (sk) 1999-06-12 2000-06-06 Hyaluronidáza z Hirudinaria manillensis, jej izolácia, čistenie a rekombinantné spôsoby jej výroby

Country Status (23)

Country Link
US (1) US7049124B1 (zh)
EP (1) EP1185666B1 (zh)
JP (1) JP2003502045A (zh)
KR (1) KR20020011138A (zh)
CN (1) CN1355850A (zh)
AR (1) AR024335A1 (zh)
AT (1) ATE324452T1 (zh)
AU (1) AU6149300A (zh)
BR (1) BR0011500A (zh)
CA (1) CA2376467A1 (zh)
CZ (1) CZ20014383A3 (zh)
DE (1) DE60027562T2 (zh)
DK (1) DK1185666T3 (zh)
ES (1) ES2258976T3 (zh)
HK (1) HK1046297A1 (zh)
HU (1) HUP0201452A2 (zh)
MX (1) MXPA01012806A (zh)
NO (1) NO20016047L (zh)
PL (1) PL352060A1 (zh)
PT (1) PT1185666E (zh)
SK (1) SK17612001A3 (zh)
WO (1) WO2000077221A1 (zh)
ZA (1) ZA200200233B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103060291A (zh) * 2012-12-28 2013-04-24 青岛九龙生物医药有限公司 一种玻璃酸酶的提取方法

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866120A (en) 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US6610292B2 (en) 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
CN1200698C (zh) 1998-03-09 2005-05-11 伊斯塔药品公司 角膜硬化剂在制备治疗眼睛屈光不正的药物中的用途
WO2004092361A1 (en) * 2003-04-15 2004-10-28 Ista Pharmaceuticals, Inc. Process for isolating and purifing ovine hyaluronidase
WO2004110479A1 (de) * 2003-05-27 2004-12-23 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Hyaluronatlyase enthaltendes mittel zur behandlung des akuten myokardinfarktes bzw. symptomen darauf sowie zur behandlung von postinfarktioneller myokarditis und myokardischämie
JP2007506416A (ja) * 2003-09-26 2007-03-22 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー 合成ヘパラナーゼ分子及びその使用
RU2471867C2 (ru) * 2007-06-19 2013-01-10 Тамара П. Уваркина Гиалуронидаза и способ ее применения
GB0717166D0 (en) * 2007-09-04 2007-10-17 Univ Brighton Method for stabilisation of purified P-Glycoprotein
CA2717383C (en) * 2008-03-06 2017-01-03 Halozyme, Inc. Large-scale production of soluble hyaluronidase
ES2413492T3 (es) * 2008-10-14 2013-07-16 Burgard, Gunther, Dr. Uso de hialuronidasa para la prevención o el tratamiento de la hipertensión arterial
CA2851057A1 (en) * 2011-10-18 2013-04-25 Csl Behring Gmbh Combined use of a sulfated glycosaminoglycan and a hyaluronidase for improving the bioavailability of factor viii
EP2698636A1 (en) * 2012-08-13 2014-02-19 Fundació Institut d'Investigació Biomèdica de Bellvitge Methods and reagents for prevention and/or treatment of transplant rejection
US8501241B1 (en) 2012-09-17 2013-08-06 Biopep Solutions, Inc. Treating cancer with a whole, leech saliva extract
KR101454646B1 (ko) 2012-11-05 2014-10-27 (주)한국비엠아이 히알루로니다아제의 안정화 제제 및 이를 포함하는 액상제제
CN103695448B (zh) * 2013-07-29 2016-08-17 江南大学 一种透明质酸酶编码基因及其发酵生产和纯化方法
US9279111B2 (en) * 2013-07-29 2016-03-08 Jiangnan University Leech hyaluronidase and its application
CN104263666B (zh) * 2014-09-12 2017-07-14 江南大学 一种产小分子透明质酸的重组毕赤酵母及其构建方法
CN106148302A (zh) * 2016-07-08 2016-11-23 中国人民解放军军事医学科学院生物工程研究所 一种重组蛋白质的纯化方法
CN106520728B (zh) * 2016-11-08 2019-06-21 江南大学 一种提高水蛭透明质酸酶酶活的方法
CN109298113B (zh) * 2018-12-11 2021-06-18 华熙生物科技股份有限公司 一种测定包含有柠檬酸的溶液中的透明质酸含量的方法
CN115702242A (zh) * 2020-04-20 2023-02-14 医药控股公司 一种改性的细菌透明质酸酶多肽、生产方法、药物组合物及其用途
CN112915106A (zh) * 2021-02-05 2021-06-08 张虎山 一种肿瘤免疫微环境调控剂的制备及其应用
WO2023067008A1 (en) * 2021-10-19 2023-04-27 Pharmact Holding Ag A production of a purified modified bacterial hyaluronidase polypeptide, pharmaceutical compositions and their uses
CN116640745B (zh) * 2023-06-29 2023-12-08 江南大学 透明质酸酶突变体及其在水解硫酸软骨素中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8504025D0 (en) 1985-02-16 1985-03-20 Biopharm Ltd Hyaluronidase
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
US5747027A (en) * 1995-04-07 1998-05-05 The Regents Of The University Of California BH55 hyaluronidase

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103060291A (zh) * 2012-12-28 2013-04-24 青岛九龙生物医药有限公司 一种玻璃酸酶的提取方法
CN103060291B (zh) * 2012-12-28 2014-10-08 青岛九龙生物医药有限公司 一种玻璃酸酶的提取方法

Also Published As

Publication number Publication date
MXPA01012806A (es) 2002-09-02
EP1185666B1 (en) 2006-04-26
HUP0201452A2 (en) 2002-08-28
PL352060A1 (en) 2003-07-28
JP2003502045A (ja) 2003-01-21
DK1185666T3 (da) 2006-07-03
ES2258976T3 (es) 2006-09-16
PT1185666E (pt) 2006-09-29
CA2376467A1 (en) 2000-12-21
DE60027562D1 (de) 2006-06-01
ATE324452T1 (de) 2006-05-15
CN1355850A (zh) 2002-06-26
NO20016047D0 (no) 2001-12-11
DE60027562T2 (de) 2006-11-02
BR0011500A (pt) 2002-03-12
CZ20014383A3 (cs) 2002-03-13
NO20016047L (no) 2001-12-11
KR20020011138A (ko) 2002-02-07
EP1185666A1 (en) 2002-03-13
AR024335A1 (es) 2002-10-02
AU6149300A (en) 2001-01-02
ZA200200233B (en) 2003-06-25
HK1046297A1 (zh) 2003-01-03
WO2000077221A1 (en) 2000-12-21
US7049124B1 (en) 2006-05-23

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