SK139799A3 - Isolated nucleic acid, a polypeptide, a nucleic acid construct, a host cell, process for the production of arachidonic acid, pharmaceutical composition, cosmetic composition and nutritive preparation containing nucleic acid and the use thereof - Google Patents
Isolated nucleic acid, a polypeptide, a nucleic acid construct, a host cell, process for the production of arachidonic acid, pharmaceutical composition, cosmetic composition and nutritive preparation containing nucleic acid and the use thereof Download PDFInfo
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- SK139799A3 SK139799A3 SK1397-99A SK139799A SK139799A3 SK 139799 A3 SK139799 A3 SK 139799A3 SK 139799 A SK139799 A SK 139799A SK 139799 A3 SK139799 A3 SK 139799A3
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- seq
- acid
- cell
- host cell
- desaturase
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- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 title claims abstract description 158
- 238000000034 method Methods 0.000 title claims abstract description 90
- 235000021342 arachidonic acid Nutrition 0.000 title claims abstract description 79
- 229940114079 arachidonic acid Drugs 0.000 title claims abstract description 79
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- 239000000203 mixture Substances 0.000 title claims description 98
- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 88
- 102000004196 processed proteins & peptides Human genes 0.000 title claims description 81
- 229920001184 polypeptide Polymers 0.000 title claims description 80
- 102000039446 nucleic acids Human genes 0.000 title claims description 38
- 108020004707 nucleic acids Proteins 0.000 title claims description 38
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
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- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A23L33/12—Fatty acids or derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Animal Husbandry (AREA)
- Pediatric Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/833,610 US5972664A (en) | 1997-04-11 | 1997-04-11 | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
PCT/US1998/007422 WO1998046765A1 (en) | 1997-04-11 | 1998-04-10 | Methods and compositions for synthesis of long chain polyunsaturated fatty acids |
Publications (1)
Publication Number | Publication Date |
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SK139799A3 true SK139799A3 (en) | 2000-05-16 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1397-99A SK139799A3 (en) | 1997-04-11 | 1998-04-10 | Isolated nucleic acid, a polypeptide, a nucleic acid construct, a host cell, process for the production of arachidonic acid, pharmaceutical composition, cosmetic composition and nutritive preparation containing nucleic acid and the use thereof |
Country Status (24)
Country | Link |
---|---|
US (2) | US5972664A (hu) |
EP (1) | EP1007691B1 (hu) |
JP (1) | JP4453881B2 (hu) |
KR (2) | KR20010006255A (hu) |
CN (1) | CN1253587A (hu) |
AT (1) | ATE277188T1 (hu) |
AU (1) | AU720725B2 (hu) |
BG (1) | BG103796A (hu) |
BR (1) | BR9809083A (hu) |
CA (1) | CA2286263A1 (hu) |
DE (1) | DE69826494T2 (hu) |
DK (1) | DK1007691T3 (hu) |
ES (1) | ES2229491T3 (hu) |
HU (1) | HUP0001295A3 (hu) |
IL (1) | IL132149A0 (hu) |
IN (1) | IN1998KO00639A (hu) |
NO (1) | NO994924L (hu) |
NZ (1) | NZ337458A (hu) |
PL (1) | PL336067A1 (hu) |
PT (1) | PT1007691E (hu) |
SI (1) | SI1007691T1 (hu) |
SK (1) | SK139799A3 (hu) |
TR (1) | TR199902466T2 (hu) |
WO (1) | WO1998046765A1 (hu) |
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US6483008B1 (en) * | 1990-08-15 | 2002-11-19 | Calgene Llc | Methods for producing plants with elevated oleic acid content |
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US7745694B1 (en) | 1997-04-11 | 2010-06-29 | Monsanto Technology Llc | Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants |
US6432684B1 (en) | 1997-04-11 | 2002-08-13 | Abbott Laboratories | Human desaturase gene and uses thereof |
US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
BR9814434A (pt) * | 1997-12-23 | 2001-10-23 | Univ Bristol | Desaturase |
US20030152983A1 (en) * | 1997-12-23 | 2003-08-14 | University Of Bristol | Desaturase |
WO1999061602A1 (en) * | 1998-05-29 | 1999-12-02 | Ohio University | Compositions and methods for the synthesis of fatty acids, their derivatives and downstream products |
PT1086236E (pt) | 1998-06-12 | 2007-12-12 | Calgene Llc | Ácidos gordos poliinsaturados em plantas |
US20030163845A1 (en) | 1998-09-02 | 2003-08-28 | Pradip Mukerji | Elongase genes and uses thereof |
US6677145B2 (en) * | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
US6913916B1 (en) | 1998-09-02 | 2005-07-05 | Abbott Laboratories | Elongase genes and uses thereof |
WO2000020603A1 (en) * | 1998-10-05 | 2000-04-13 | Abbott Laboratories | Altered fatty acid biosynthesis in insect cells using delta five desaturase |
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US6140081A (en) * | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
DE10030976A1 (de) | 2000-06-30 | 2002-01-10 | Basf Ag | DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren |
WO2001004636A1 (en) * | 1999-07-12 | 2001-01-18 | Ohio University | Mammalian cells expressing desaturases and elongases |
US7070970B2 (en) | 1999-08-23 | 2006-07-04 | Abbott Laboratories | Elongase genes and uses thereof |
CA2399349C (en) | 2000-02-09 | 2017-04-04 | Basf Aktiengesellschaft | Novel elongase gene and method for producing multiple-unsaturated fatty acids |
ES2343106T3 (es) | 2000-09-28 | 2010-07-23 | BIORIGINAL FOOD & SCIENCE CORP. | Fad4, fad5, fad5-2 y fad6, miembros de la familia de desaturasas de acidos grasos y usos de los mismos. |
DE10102337A1 (de) | 2001-01-19 | 2002-07-25 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren, neue Biosynthesegene sowie neue pflanzliche Expressionskonstrukte |
MXPA03006663A (es) * | 2001-01-25 | 2004-05-31 | Abbott Lab | Genes de desaturasa y usos de los mismos. |
US6635451B2 (en) * | 2001-01-25 | 2003-10-21 | Abbott Laboratories | Desaturase genes and uses thereof |
GB0107510D0 (en) | 2001-03-26 | 2001-05-16 | Univ Bristol | New elongase gene and a process for the production of -9-polyunsaturated fatty acids |
US7179647B2 (en) * | 2002-01-30 | 2007-02-20 | Basf Plant Science Gmbh | Elongase gene and method for producing polyunsaturated fatty acids |
GB2385852A (en) | 2002-02-27 | 2003-09-03 | Rothamsted Ex Station | Delta 6-desaturases from Primulaceae |
DE10219203A1 (de) | 2002-04-29 | 2003-11-13 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen |
BR0311324A (pt) | 2002-05-22 | 2005-06-28 | Monsanto Technology Llc | Dessaturases de ácidos graxos de fungos |
CA2510462A1 (en) | 2002-12-19 | 2004-07-08 | University Of Bristol | Method for producing polyunsaturated fatty acids in a transgenic plant or microorganism comprising an introduced delta-9-elongase and a delta-8-desaturase |
US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
US8084074B2 (en) * | 2003-02-12 | 2011-12-27 | E. I. Du Pont De Nemours And Company | Production of very long chain polyunsaturated fatty acids in oil seed plants |
AU2004215705B2 (en) | 2003-02-27 | 2009-11-12 | Basf Plant Science Gmbh | Method for the production of polyunsaturated fatty acids |
WO2004087902A2 (de) | 2003-03-31 | 2004-10-14 | University Of Bristol | Neue pflanzliche acyltransferasen spezifisch für langkettige mehrfach ungesättigte fettsäuren |
MXPA05010571A (es) | 2003-04-08 | 2005-11-23 | Basf Plant Science Gmbh | Delta-4-desaturasas a partir de euglena gracilis, que expresan plantas y aceites que comprenden pufa |
US7125672B2 (en) * | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
US7238482B2 (en) * | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
CA3037924A1 (en) | 2003-08-01 | 2005-02-10 | Basf Plant Science Gmbh | Method for the production of polyunsaturated fatty acids in transgenic organisms |
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EP1656449B1 (en) | 2003-08-21 | 2009-05-06 | Monsanto Technology LLC | Fatty acid desaturases from primula |
JP4916886B2 (ja) | 2003-11-12 | 2012-04-18 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 油性植物および酵母中の多価不飽和脂肪酸レベルを変更するのに適したδ15デサチュラーゼ |
ATE516295T1 (de) | 2004-01-20 | 2011-07-15 | Monsanto Technology Llc | Chimäre promotoren zur verwendung in pflanzen |
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CN1930277B (zh) | 2004-02-27 | 2011-02-02 | 巴斯福植物科学有限公司 | 在转基因植物中产生多不饱和脂肪酸的方法 |
BRPI0509944A (pt) | 2004-04-16 | 2007-09-25 | Monsanto Technology Llc | expressão de dessaturases de ácido graxo em milho |
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US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
WO2006092449A2 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
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DE102005052551A1 (de) | 2005-11-02 | 2007-05-16 | Rothamsted Res Harpenden | Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae |
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GB0603160D0 (en) | 2006-02-16 | 2006-03-29 | Rothamsted Res Ltd | Nucleic acid |
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US8629195B2 (en) | 2006-04-08 | 2014-01-14 | Bayer Materialscience Ag | Production of polyurethane foams |
US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
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1997
- 1997-04-11 US US08/833,610 patent/US5972664A/en not_active Expired - Lifetime
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1998
- 1998-04-10 KR KR19997009339A patent/KR20010006255A/ko not_active Application Discontinuation
- 1998-04-10 CN CN98804090A patent/CN1253587A/zh active Pending
- 1998-04-10 EP EP98918175A patent/EP1007691B1/en not_active Expired - Lifetime
- 1998-04-10 JP JP54417698A patent/JP4453881B2/ja not_active Expired - Fee Related
- 1998-04-10 PL PL98336067A patent/PL336067A1/xx unknown
- 1998-04-10 HU HU0001295A patent/HUP0001295A3/hu unknown
- 1998-04-10 AT AT98918175T patent/ATE277188T1/de active
- 1998-04-10 SK SK1397-99A patent/SK139799A3/sk unknown
- 1998-04-10 DE DE69826494T patent/DE69826494T2/de not_active Expired - Lifetime
- 1998-04-10 DK DK98918175T patent/DK1007691T3/da active
- 1998-04-10 PT PT98918175T patent/PT1007691E/pt unknown
- 1998-04-10 NZ NZ337458A patent/NZ337458A/xx unknown
- 1998-04-10 ES ES98918175T patent/ES2229491T3/es not_active Expired - Lifetime
- 1998-04-10 WO PCT/US1998/007422 patent/WO1998046765A1/en active IP Right Grant
- 1998-04-10 AU AU71148/98A patent/AU720725B2/en not_active Ceased
- 1998-04-10 TR TR1999/02466T patent/TR199902466T2/xx unknown
- 1998-04-10 KR KR19997009342A patent/KR20010006258A/ko not_active Application Discontinuation
- 1998-04-10 BR BR9809083-6A patent/BR9809083A/pt not_active Application Discontinuation
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- 1998-04-10 SI SI9830714T patent/SI1007691T1/xx unknown
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1999
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HUP0001295A1 (en) | 2000-07-28 |
CN1253587A (zh) | 2000-05-17 |
SI1007691T1 (en) | 2005-02-28 |
CA2286263A1 (en) | 1998-10-22 |
PT1007691E (pt) | 2005-02-28 |
EP1007691B1 (en) | 2004-09-22 |
KR20010006258A (ko) | 2001-01-26 |
PL336067A1 (en) | 2000-06-05 |
NO994924L (no) | 1999-11-30 |
BG103796A (bg) | 2000-05-31 |
BR9809083A (pt) | 2000-08-01 |
IN1998KO00639A (hu) | 2005-03-18 |
KR20010006255A (ko) | 2001-01-26 |
ATE277188T1 (de) | 2004-10-15 |
HUP0001295A3 (en) | 2003-10-28 |
NO994924D0 (no) | 1999-10-08 |
EP1007691A1 (en) | 2000-06-14 |
AU720725B2 (en) | 2000-06-08 |
US5972664A (en) | 1999-10-26 |
AU7114898A (en) | 1998-11-11 |
MX9909327A (es) | 2000-04-30 |
NZ337458A (en) | 2000-07-28 |
JP2001523092A (ja) | 2001-11-20 |
IL132149A0 (en) | 2001-03-19 |
DE69826494D1 (de) | 2004-10-28 |
DE69826494T2 (de) | 2006-03-09 |
ES2229491T3 (es) | 2005-04-16 |
US6589767B1 (en) | 2003-07-08 |
JP4453881B2 (ja) | 2010-04-21 |
WO1998046765A1 (en) | 1998-10-22 |
DK1007691T3 (da) | 2004-12-20 |
TR199902466T2 (xx) | 2000-07-21 |
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