SK11992002A3 - Derivát aminosulfonylbifenylu, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje - Google Patents

Derivát aminosulfonylbifenylu, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje Download PDF

Info

Publication number
SK11992002A3
SK11992002A3 SK1199-2002A SK11992002A SK11992002A3 SK 11992002 A3 SK11992002 A3 SK 11992002A3 SK 11992002 A SK11992002 A SK 11992002A SK 11992002 A3 SK11992002 A3 SK 11992002A3
Authority
SK
Slovakia
Prior art keywords
sulfamoylbiphenyl
amide
carbamimidoylphenoxy
acid
biphenyl
Prior art date
Application number
SK1199-2002A
Other languages
English (en)
Slovak (sk)
Inventor
Dieter Dorsch
Horst Juraszyk
Werner Mederski
Christos Tsaklakidis
Sabine Bernotat-Danielowski
Guido Melzer
Johannes Gleitz
Christopher Barnes
James Vickers
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SK11992002A3 publication Critical patent/SK11992002A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SK1199-2002A 2000-02-23 2001-02-22 Derivát aminosulfonylbifenylu, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje SK11992002A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10008329A DE10008329A1 (de) 2000-02-23 2000-02-23 Aminosulfonylbiphenylderivate
PCT/EP2001/002034 WO2001062717A1 (de) 2000-02-23 2001-02-22 Aminosulfonylbiphenylderivate

Publications (1)

Publication Number Publication Date
SK11992002A3 true SK11992002A3 (sk) 2003-01-09

Family

ID=7632028

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1199-2002A SK11992002A3 (sk) 2000-02-23 2001-02-22 Derivát aminosulfonylbifenylu, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje

Country Status (19)

Country Link
US (1) US20030135055A1 (es)
EP (1) EP1257530A1 (es)
JP (1) JP2003524651A (es)
KR (1) KR20020091092A (es)
CN (1) CN1404467A (es)
AU (1) AU2001254661A1 (es)
BR (1) BR0108607A (es)
CA (1) CA2399018A1 (es)
CZ (1) CZ20022783A3 (es)
DE (1) DE10008329A1 (es)
HK (1) HK1052499A1 (es)
HU (1) HUP0300008A2 (es)
MX (1) MXPA02008207A (es)
NO (1) NO20023998D0 (es)
PL (1) PL356565A1 (es)
RU (1) RU2002123337A (es)
SK (1) SK11992002A3 (es)
WO (1) WO2001062717A1 (es)
ZA (1) ZA200205482B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7030141B2 (en) 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
DE10204072A1 (de) * 2002-01-31 2003-08-14 Morphochem Ag Komb Chemie Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
WO2005063690A1 (en) * 2003-12-22 2005-07-14 Merck & Co., Inc. Alpha-hydroxy amides as bradykinin antagonists or inverse agonists
NZ556546A (en) 2005-01-07 2011-02-25 Synta Pharmaceuticals Corp Compounds for inflammation and immune-related uses
AU2007208239B2 (en) 2006-01-25 2013-04-18 Synta Pharmaceuticals Corp. Substituted aromatic compounds for inflammation and immune-related uses
EP1984337B1 (en) 2006-01-25 2014-04-30 Synta Pharmaceuticals Corp. Vinyl-phenyl derivatives for inflammation and immune-related uses
WO2007103996A1 (en) 2006-03-09 2007-09-13 Bristol-Myers Squibb Company 2-(aryloxy)acetamide factor viia inhibitors useful as anticoagulants
KR20090064478A (ko) 2006-11-13 2009-06-18 화이자 프로덕츠 인크. 디아릴, 디피리디닐 및 아릴-피리디닐 유도체, 및 이들의 용도
KR20180099916A (ko) 2007-02-09 2018-09-05 메타베이시스 테라퓨틱스, 인크. 글루카곤 수용체의 길항제
CA2966273C (en) 2008-08-13 2019-08-27 Metabasis Therapeutics, Inc. Glucagon antagonists
WO2015191900A1 (en) 2014-06-12 2015-12-17 Ligand Pharmaceuticals, Inc. Glucagon antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69720773T2 (de) * 1996-12-23 2004-01-29 Bristol Myers Squibb Pharma Co SAUERSTOFF ODER SCHWEFEL ENTHALTENDE 5-GLIEDRIGE HETEROAROMATISHE DERIVATIVE ALS FACTOR Xa HEMMER
AU2300699A (en) * 1998-02-17 1999-08-30 Ono Pharmaceutical Co. Ltd. Amidino derivatives and drugs containing the same as the active ingredient
WO2000071510A2 (en) * 1999-05-24 2000-11-30 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
EP1189879A1 (en) * 1999-05-24 2002-03-27 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa

Also Published As

Publication number Publication date
PL356565A1 (en) 2004-06-28
KR20020091092A (ko) 2002-12-05
ZA200205482B (en) 2003-12-31
HK1052499A1 (zh) 2003-09-19
MXPA02008207A (es) 2002-11-29
CZ20022783A3 (cs) 2002-11-13
US20030135055A1 (en) 2003-07-17
HUP0300008A2 (hu) 2003-06-28
CN1404467A (zh) 2003-03-19
AU2001254661A1 (en) 2001-09-03
CA2399018A1 (en) 2001-08-30
EP1257530A1 (de) 2002-11-20
JP2003524651A (ja) 2003-08-19
BR0108607A (pt) 2002-11-19
DE10008329A1 (de) 2001-08-30
RU2002123337A (ru) 2004-01-10
NO20023998L (no) 2002-08-22
NO20023998D0 (no) 2002-08-22
WO2001062717A1 (de) 2001-08-30

Similar Documents

Publication Publication Date Title
US6545055B1 (en) Inhibitors of factor Xa
JP3626366B2 (ja) シクロブチル−アリールオキシアリールスルホニルアミノヒドロキサム酸誘導体
WO2002026712A2 (en) Quaternary amines and related inhibitors of factor xa
HUT77533A (hu) Mátrix metalloproteáz gátlók, ezeket tartalmazó gyógyászati készítmények és eljárás előállításukra
NO177852B (no) Bifenylderivater, legemidler inneholdende disse, og anvendelse av dem for fremstilling av legemidler
SK172098A3 (en) New amidino derivatives and their use as thrombin inhibitors
SK11992002A3 (sk) Derivát aminosulfonylbifenylu, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje
US6946489B2 (en) Substituted biphenyl derivatives
AU776797B2 (en) N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them
US9708265B2 (en) Urethanes, ureas, amidines and related inhibitors of factor Xa
EP0703216A1 (en) Amidinophenol derivatives as protease inhibitors
JP2004517811A (ja) アザ−アミノ酸誘導体（第Ｘａ因子阻害剤１５）
AU2002363366B2 (en) Derivatives of phenoxy-N- 4-(isothiazolidin-1,1-dioxid-2YL)pheny!-valerian- acid amide and other compounds as inhibitors of the coagulation factor XA in the treatment of thromboembolic diseases and tumors
SK13382003A3 (sk) Derivát kyseliny šťaveľovej, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje
JP2004531494A (ja) ビウレタン誘導体
JP2005501075A (ja) 第Ｘａ因子阻害剤としてのフェニル誘導体
EP1322637A2 (en) Quaternary amidino based inhibitors of factor xa
JP2005530754A (ja) 血栓塞栓症に有効なセミカルバジド誘導体
JP2004525119A (ja) フェニル誘導体および血栓塞栓性疾患または腫瘍の処置におけるこれらの使用
US7285547B2 (en) Amidinophenylalanine derivatives as thrombin inhibitors
EP1539686A1 (en) Inhibitors of factor xa and other serine proteases involved in the coagulation cascade
WO2000008005A2 (de) Piperazinonderivate
AU706145B2 (en) Amidino protease inhibitors
JP2006519188A (ja) 第Ｘａ因子阻害剤としてのエチニル誘導体
CZ2003452A3 (en) Data processing system, with an Internet connection facility has a structured program loaded in memory for use in assigning predetermined data from a multiplicity of data to hierarchical memory addresses