SK109198A3 - Sugar-modified gapped oligonucleotides - Google Patents
Sugar-modified gapped oligonucleotides Download PDFInfo
- Publication number
- SK109198A3 SK109198A3 SK1091-98A SK109198A SK109198A3 SK 109198 A3 SK109198 A3 SK 109198A3 SK 109198 A SK109198 A SK 109198A SK 109198 A3 SK109198 A3 SK 109198A3
- Authority
- SK
- Slovakia
- Prior art keywords
- oligonucleotide
- oligonucleotides
- seq
- deoxy
- nucleoside
- Prior art date
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- 108091034117 Oligonucleotide Proteins 0.000 title claims abstract description 372
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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US1162096P | 1996-02-14 | 1996-02-14 | |
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EP (1) | EP0882061B1 (zh) |
JP (1) | JP4293636B2 (zh) |
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CN (1) | CN1214688A (zh) |
AT (1) | ATE267207T1 (zh) |
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BR (1) | BR9707529A (zh) |
CA (2) | CA2246229C (zh) |
CZ (1) | CZ243498A3 (zh) |
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TR (1) | TR199801581T2 (zh) |
WO (1) | WO1997030067A1 (zh) |
ZA (1) | ZA971208B (zh) |
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IL144975A0 (en) | 1999-02-26 | 2002-06-30 | Univ British Columbia | A composition containing an antisense oligonucleotide |
US7569551B2 (en) | 2000-02-25 | 2009-08-04 | The University Of British Columbia | Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
IL151928A0 (en) | 2000-03-30 | 2003-04-10 | Whitehead Biomedical Inst | Rna sequence-specific mediators of rna interference |
EP1191097A1 (en) | 2000-09-21 | 2002-03-27 | Leids Universitair Medisch Centrum | Induction of exon skipping in eukaryotic cells |
JP4095895B2 (ja) | 2000-12-01 | 2008-06-04 | マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー.ヴェー. | Rna干渉を媒介する短鎖rna分子 |
JP4491240B2 (ja) * | 2002-01-17 | 2010-06-30 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | Igfbp−2およびigfbp−5を阻害する二重特異性アンチセンスオリゴヌクレオチド、並びにこれらの使用方法 |
AU2003225410A1 (en) | 2003-03-21 | 2004-10-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
EP1667731B1 (en) * | 2003-10-01 | 2013-05-22 | The University Of British Columbia | Bispecific oligonucleotide for the treatment of cns malignancies |
KR101147147B1 (ko) | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
WO2005094899A1 (en) | 2004-04-02 | 2005-10-13 | The University Of British Columbia | Clusterin antisense therapy for treatment of cancer |
US7807816B2 (en) | 2004-06-28 | 2010-10-05 | University Of Western Australia | Antisense oligonucleotides for inducing exon skipping and methods of use thereof |
USRE48960E1 (en) | 2004-06-28 | 2022-03-08 | The University Of Western Australia | Antisense oligonucleotides for inducing exon skipping and methods of use thereof |
US7923207B2 (en) | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Apparatus and system having dry gene silencing pools |
US7923206B2 (en) | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Method of determining a cellular response to a biological agent |
US7935811B2 (en) | 2004-11-22 | 2011-05-03 | Dharmacon, Inc. | Apparatus and system having dry gene silencing compositions |
DK1814595T3 (da) * | 2004-11-23 | 2014-03-31 | Univ British Columbia | Behandling af cancer med en kombination af et middel, som forstyrrer EGF-signalvejen og et oligonucleotid, som reducerer clusterinniveauerne |
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WO2007123391A1 (en) | 2006-04-20 | 2007-11-01 | Academisch Ziekenhuis Leiden | Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene. |
EP1857548A1 (en) | 2006-05-19 | 2007-11-21 | Academisch Ziekenhuis Leiden | Means and method for inducing exon-skipping |
US20070275029A1 (en) * | 2006-05-26 | 2007-11-29 | Ico Therapeutics Inc. | Therapeutic drug combinations and delivery systems comprising c-raf kinase antisense polynucleotides for treating ocular diseases and disorders |
AU2007282224B2 (en) | 2006-08-11 | 2013-08-29 | Vico Therapeutics B.V. | Methods and means for treating DNA repeat instability associated genetic disorders |
JP5352462B2 (ja) | 2006-09-22 | 2013-11-27 | ダーマコン, インコーポレイテッド | 二本鎖オリゴヌクレオチド複合体、rna干渉による遺伝子サイレンシング方法、および医薬品組成物 |
WO2009008727A2 (en) | 2007-07-12 | 2009-01-15 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs or tissues |
AU2008317566B2 (en) | 2007-10-26 | 2014-05-01 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
NZ587178A (en) | 2008-02-08 | 2011-11-25 | Prosensa Holding Bv | Methods and means for treating dna repeat instability associated genetic disorders |
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CA2739464C (en) | 2008-10-03 | 2020-03-31 | Opko Curna, Llc | Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1 |
AU2009308217B2 (en) * | 2008-10-24 | 2016-01-21 | Ionis Pharmaceuticals, Inc. | 5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom |
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CA2746003C (en) | 2008-12-04 | 2020-03-31 | Opko Curna, Llc | Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf |
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KR101682735B1 (ko) | 2009-02-12 | 2016-12-06 | 큐알엔에이, 인크. | 뇌 유래된 신경영양성 인자 (bdnf)에 대한 자연 안티센스 전사체의 저해에 의한 뇌 유래된 신경영양성 인자 (bdnf) 관련된 질환의 치료 |
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- 1997-02-07 SK SK1091-98A patent/SK109198A3/sk unknown
- 1997-02-07 AT AT97907581T patent/ATE267207T1/de active
- 1997-02-07 NZ NZ331217A patent/NZ331217A/en not_active IP Right Cessation
- 1997-02-07 CA CA2246229A patent/CA2246229C/en not_active Expired - Lifetime
- 1997-02-07 BR BR9707529-9A patent/BR9707529A/pt not_active Application Discontinuation
- 1997-02-07 AU AU19552/97A patent/AU725262B2/en not_active Ceased
- 1997-02-07 PL PL97328563A patent/PL328563A1/xx unknown
- 1997-02-07 JP JP52941297A patent/JP4293636B2/ja not_active Expired - Lifetime
- 1997-02-07 TR TR1998/01581T patent/TR199801581T2/xx unknown
- 1997-02-07 ES ES97907581T patent/ES2221039T3/es not_active Expired - Lifetime
- 1997-02-07 DK DK97907581T patent/DK0882061T3/da active
- 1997-02-07 DE DE69729179T patent/DE69729179T2/de not_active Expired - Lifetime
- 1997-02-07 CZ CZ982434A patent/CZ243498A3/cs unknown
- 1997-02-07 EP EP97907581A patent/EP0882061B1/en not_active Expired - Lifetime
- 1997-02-07 HU HU9901118A patent/HUP9901118A3/hu unknown
- 1997-02-07 CA CA2749312A patent/CA2749312A1/en not_active Abandoned
- 1997-02-07 WO PCT/US1997/002043 patent/WO1997030067A1/en active IP Right Grant
- 1997-02-07 IL IL12575997A patent/IL125759A0/xx unknown
- 1997-02-07 CN CN97193129A patent/CN1214688A/zh active Pending
- 1997-02-07 KR KR1019980706209A patent/KR19990082476A/ko not_active Application Discontinuation
- 1997-02-11 US US08/802,331 patent/US6451991B1/en not_active Expired - Lifetime
- 1997-02-13 ZA ZA9701208A patent/ZA971208B/xx unknown
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AU1955297A (en) | 1997-09-02 |
CZ243498A3 (cs) | 1999-09-15 |
ES2221039T3 (es) | 2004-12-16 |
NZ331217A (en) | 2000-02-28 |
WO1997030067A1 (en) | 1997-08-21 |
EP0882061A1 (en) | 1998-12-09 |
HUP9901118A2 (hu) | 1999-07-28 |
CN1214688A (zh) | 1999-04-21 |
DK0882061T3 (da) | 2004-09-27 |
ZA971208B (en) | 1997-10-23 |
EP0882061B1 (en) | 2004-05-19 |
AU725262B2 (en) | 2000-10-12 |
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CA2246229C (en) | 2011-08-23 |
IL125759A0 (en) | 1999-04-11 |
NO983718D0 (no) | 1998-08-13 |
HUP9901118A3 (en) | 2000-06-28 |
CA2246229A1 (en) | 1997-08-21 |
JP2000504725A (ja) | 2000-04-18 |
PL328563A1 (en) | 1999-02-01 |
DE69729179T2 (de) | 2004-12-30 |
DE69729179D1 (de) | 2004-06-24 |
EP0882061A4 (en) | 2000-12-13 |
BR9707529A (pt) | 2000-01-04 |
JP4293636B2 (ja) | 2009-07-08 |
KR19990082476A (ko) | 1999-11-25 |
TR199801581T2 (xx) | 1998-10-21 |
ATE267207T1 (de) | 2004-06-15 |
CA2749312A1 (en) | 1997-08-21 |
US6451991B1 (en) | 2002-09-17 |
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