SI9620137B - Postopek za pripravo 2,4-dihidroksipiridina in 2,4-dihidroksi-3-nitropiridina - Google Patents
Postopek za pripravo 2,4-dihidroksipiridina in 2,4-dihidroksi-3-nitropiridina Download PDFInfo
- Publication number
- SI9620137B SI9620137B SI9620137A SI9620137A SI9620137B SI 9620137 B SI9620137 B SI 9620137B SI 9620137 A SI9620137 A SI 9620137A SI 9620137 A SI9620137 A SI 9620137A SI 9620137 B SI9620137 B SI 9620137B
- Authority
- SI
- Slovenia
- Prior art keywords
- dihydroxypyridine
- process according
- preparing
- acid
- nitropyridine
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Predlozeni izum se nanasa na postopek za pripravo 2,4-dihidroksipiridina, ki obsega segrevanje spojine s formulo A, kjer je R H, alkil ali aralkil, in fosforjeve kisline, pri cemer razmerje fosforjeve kisline proti vodi ni manjse od priblizno 27 do priblizno 1 mas.%. Izum se prav tako nanasa na postopek za pripravo 2,4-dihidroksi-3-nitropiridina, ki obsega reakcijo 2,4-dihidroksipiridina z dusikovo kislino. S postopki v smislu predlozenega izuma pripravimo intermediate, ki so uporabni pri pripravi spojin, ki so koristne za zdravljenje kardiovaskularne bolezni, oznacene kot hipertenzija ali miokardialna ishemija, za izboljsanje ishemicne poskodbe ali velikosti miokardialnega infarkta ali zdravljenje hiperlipidemije ali hiperholesterolemije.
Claims (10)
1 PATENTNI ZAHTEVKI 1. Postopek za pripravo 2,4-dihidroksipiridina, označen s tem, da obsega segrevanje spojine s formulo A: OH
kjer je R H, alkil ali aralkil, in fosfoijeve kisline, pri čemer razmerje fosforjeve kisline proti vodi ni manjše kot 27 mas. % proti 1 mas. %.
2. Postopek po zahtevku 1, označen s tem, da razmerje dobimo z odstranitvijo vode.
3. Postopek po zahtevku 2, označen s tem, da odstranitev izvedemo z destilacijo.
4. Postopek po zahtevku 1, označen s tem, da fosforjevo kislino in spojino s formulo A segrejemo na 210°C.
5. Postopek za pripravo 2,4-dihidroksi-3-nitropiridina, označen s tem, da obsega reakcijo 2,4-dihidroksipiridina, pripravljenega po zahtevku 1, z dušikovo kislino.
6. Postopek po zatevku 5, označen s tem, da 2,4-dihidroksipiridin ne izoliramo pred reakcijo z dušikovo kislino.
7. Postopek po zahtevku 5, označen s tem, da organsko kislino dodamo pred reakcijo z dušikovo kislino. 2
8. Postopek po zahtevku 7, označen s tem, daje organska kislina ocetna.
9. Postopek po zahtevku 6, označen s tem, da organsko kislino dodamo pred reakcijo z dušikovo kislino.
10. Postopek po zahtevku 9, označen s tem, daje organska kislina ocetna.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US949296P | 1996-01-02 | 1996-01-02 | |
| PCT/US1996/020768 WO1997024327A1 (en) | 1996-01-02 | 1996-12-23 | Process for preparing 2,4-dihydroxypyridine and 2,4-dihydroxy-3-nitropyridine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9620137A SI9620137A (sl) | 1999-02-28 |
| SI9620137B true SI9620137B (sl) | 2006-02-28 |
Family
ID=21737998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9620137A SI9620137B (sl) | 1996-01-02 | 1996-12-23 | Postopek za pripravo 2,4-dihidroksipiridina in 2,4-dihidroksi-3-nitropiridina |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6307054B1 (sl) |
| EP (1) | EP0909270B1 (sl) |
| JP (1) | JP2000502709A (sl) |
| KR (1) | KR19990076966A (sl) |
| AP (1) | AP772A (sl) |
| AT (1) | ATE219767T1 (sl) |
| AU (1) | AU722894B2 (sl) |
| BR (1) | BR9612341A (sl) |
| CA (1) | CA2241887C (sl) |
| CZ (1) | CZ203998A3 (sl) |
| DE (1) | DE69622051T2 (sl) |
| DK (1) | DK0909270T3 (sl) |
| EA (1) | EA000884B1 (sl) |
| ES (1) | ES2178725T3 (sl) |
| HK (1) | HK1019590A1 (sl) |
| HU (1) | HUP9900969A3 (sl) |
| IL (1) | IL125164A (sl) |
| OA (1) | OA10803A (sl) |
| PT (1) | PT909270E (sl) |
| SI (1) | SI9620137B (sl) |
| SK (1) | SK283625B6 (sl) |
| WO (1) | WO1997024327A1 (sl) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2187100A (en) | 1998-12-31 | 2000-07-24 | Aventis Pharmaceuticals Products Inc. | Process for preparing n6-substituted deaza-adenosine derivatives |
| US7018365B2 (en) | 1999-05-21 | 2006-03-28 | Micro Therapeutics, Inc. | Threaded syringe with quick stop |
| US6784165B1 (en) * | 1999-11-23 | 2004-08-31 | Aderis Pharmaceuticals, Inc. | Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines |
| US7291603B2 (en) * | 2002-07-24 | 2007-11-06 | Ptc Therapeutics, Inc. | Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations |
| US20050009776A1 (en) * | 2003-04-24 | 2005-01-13 | Aderis Pharmaceuticals, Inc. | Method of treating atrial fibrillation or atrial flutter |
| WO2005025545A2 (en) * | 2003-09-17 | 2005-03-24 | Aderis Pharmaceuticals, Inc. | Pharmaceutical formulation for controlled release of selodenoson |
| GT200500281A (es) * | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
| GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| GB0607944D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
| GB0607950D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
| GB0607948D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
| GB0607953D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
| PT2013211E (pt) | 2006-04-21 | 2012-06-21 | Novartis Ag | Derivados de purina para utilização como agonistas de receptores a2a de adenosina |
| EP1889846A1 (en) | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
| EP1903044A1 (en) * | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
| JP2010508835A (ja) * | 2006-11-10 | 2010-03-25 | ノバルティス アーゲー | シクロペンテンジオールモノアセテート誘導体 |
| JP2012516843A (ja) | 2009-02-02 | 2012-07-26 | インドコ レメディーズ リミテッド | ニトロピリジン誘導体の調製方法 |
| CN114349873B (zh) * | 2021-04-12 | 2023-03-17 | 杭州安誉科技有限公司 | 用于多孔模块辅助控制装置的高强度风扇支架 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3547935A (en) * | 1967-08-07 | 1970-12-15 | American Cyanamid Co | Certain nitro-4-pyridinols,n-oxides thereof and derivatives thereof |
| GB1199699A (en) * | 1968-01-08 | 1970-07-22 | Glanzstoff Ag | Process for the Production of Condensed Aromatic Bis-(2,4-Dihydroxypyridine) Derivatives |
| DE3308449A1 (de) * | 1982-08-19 | 1984-03-15 | Rütgerswerke AG, 6000 Frankfurt | Verfahren zur reindarstellung von 2-chlor-6-alkoxy-3-nitropyridinen |
| JP3261190B2 (ja) * | 1993-01-27 | 2002-02-25 | 広栄化学工業株式会社 | ２−ヒドロキシ−３，５−ジニトロピリジン類の製造法 |
-
1996
- 1996-12-23 WO PCT/US1996/020768 patent/WO1997024327A1/en not_active Application Discontinuation
- 1996-12-23 JP JP9524559A patent/JP2000502709A/ja not_active Ceased
- 1996-12-23 DK DK96945096T patent/DK0909270T3/da active
- 1996-12-23 HU HU9900969A patent/HUP9900969A3/hu not_active Application Discontinuation
- 1996-12-23 EP EP96945096A patent/EP0909270B1/en not_active Expired - Lifetime
- 1996-12-23 EA EA199800621A patent/EA000884B1/ru not_active IP Right Cessation
- 1996-12-23 CA CA002241887A patent/CA2241887C/en not_active Expired - Fee Related
- 1996-12-23 AU AU13546/97A patent/AU722894B2/en not_active Ceased
- 1996-12-23 PT PT96945096T patent/PT909270E/pt unknown
- 1996-12-23 AP APAP/P/1998/001289A patent/AP772A/en active
- 1996-12-23 ES ES96945096T patent/ES2178725T3/es not_active Expired - Lifetime
- 1996-12-23 SI SI9620137A patent/SI9620137B/sl not_active IP Right Cessation
- 1996-12-23 BR BR9612341-9A patent/BR9612341A/pt not_active Application Discontinuation
- 1996-12-23 AT AT96945096T patent/ATE219767T1/de not_active IP Right Cessation
- 1996-12-23 IL IL12516496A patent/IL125164A/xx not_active IP Right Cessation
- 1996-12-23 KR KR1019980705094A patent/KR19990076966A/ko not_active Application Discontinuation
- 1996-12-23 SK SK906-98A patent/SK283625B6/sk unknown
- 1996-12-23 DE DE69622051T patent/DE69622051T2/de not_active Expired - Fee Related
- 1996-12-23 CZ CZ982039A patent/CZ203998A3/cs unknown
-
1998
- 1998-07-01 US US09/108,622 patent/US6307054B1/en not_active Expired - Fee Related
- 1998-07-01 OA OA9800099A patent/OA10803A/en unknown
-
1999
- 1999-10-21 HK HK99104682A patent/HK1019590A1/xx not_active IP Right Cessation
-
2001
- 2001-05-18 US US09/861,023 patent/US6392049B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EA000884B1 (ru) | 2000-06-26 |
| EP0909270A4 (sl) | 1999-04-21 |
| EA199800621A1 (ru) | 1999-02-25 |
| SI9620137A (sl) | 1999-02-28 |
| OA10803A (en) | 2003-01-28 |
| AU1354697A (en) | 1997-07-28 |
| IL125164A (en) | 2003-03-12 |
| CZ203998A3 (cs) | 1999-11-17 |
| DE69622051D1 (de) | 2002-08-01 |
| ES2178725T3 (es) | 2003-01-01 |
| AP772A (en) | 1999-10-15 |
| US6392049B1 (en) | 2002-05-21 |
| WO1997024327A1 (en) | 1997-07-10 |
| EP0909270A1 (en) | 1999-04-21 |
| AU722894B2 (en) | 2000-08-10 |
| JP2000502709A (ja) | 2000-03-07 |
| CA2241887C (en) | 2004-02-24 |
| US6307054B1 (en) | 2001-10-23 |
| KR19990076966A (ko) | 1999-10-25 |
| IL125164A0 (en) | 1999-01-26 |
| SK283625B6 (sk) | 2003-10-07 |
| DE69622051T2 (de) | 2003-01-23 |
| BR9612341A (pt) | 1999-12-28 |
| HUP9900969A2 (hu) | 1999-07-28 |
| PT909270E (pt) | 2002-11-29 |
| HUP9900969A3 (en) | 2001-11-28 |
| SK90698A3 (en) | 2000-12-11 |
| EP0909270B1 (en) | 2002-06-26 |
| DK0909270T3 (da) | 2002-10-07 |
| HK1019590A1 (en) | 2000-02-18 |
| ATE219767T1 (de) | 2002-07-15 |
| CA2241887A1 (en) | 1997-07-10 |
| AP9801289A0 (en) | 1998-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| SP73 | Change of data on owner |
Owner name: AVENTIS PHARMACEUTICALS INC.; US Effective date: 20050909 |
|
| OU02 | Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims |
Effective date: 20051214 |
|
| KO00 | Lapse of patent |
Effective date: 20070821 |