BR9612341A - Processo para preparar 2,4-diidróxipiridina. - Google Patents
Processo para preparar 2,4-diidróxipiridina.Info
- Publication number
- BR9612341A BR9612341A BR9612341-9A BR9612341A BR9612341A BR 9612341 A BR9612341 A BR 9612341A BR 9612341 A BR9612341 A BR 9612341A BR 9612341 A BR9612341 A BR 9612341A
- Authority
- BR
- Brazil
- Prior art keywords
- dihydroxypyridine
- preparing
- directed
- phosphoric acid
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
"PROCESSO PARA PREPARAR 2,4-DIIDRóXIPIRIDINA". A presente invenção é dirigida a um processo para preparar 2,4-diidroxipiridina, compreendendo aquecer um composto de fórmula A: (A) em que R é H, alquila ou aralquila e ácido fosfórico, onde a relação de ácido fosfórico para água não é menor do que cerca de 27 para 1% em peso. A invenção também é dirigida a um processo para preparar 2,4-diidróxi-3-nitropiridina, compreendendo reagir 2,4-diidroxipiridina com ácido nítrico. Os processos da presente invenção preparam intermediários que são úteis no preparo de compostos que são utilizáveis para tratar doenças cardiovasculares caracterizadas por hipertensão ou isquemia do miocárdio, melhorando a lesão isquêmica ou a extensão do infarto do miocárdio, ou tratar hiperlipidemia ou hipercolesterolemia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US949296P | 1996-01-02 | 1996-01-02 | |
PCT/US1996/020768 WO1997024327A1 (en) | 1996-01-02 | 1996-12-23 | Process for preparing 2,4-dihydroxypyridine and 2,4-dihydroxy-3-nitropyridine |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9612341A true BR9612341A (pt) | 1999-12-28 |
Family
ID=21737998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9612341-9A BR9612341A (pt) | 1996-01-02 | 1996-12-23 | Processo para preparar 2,4-diidróxipiridina. |
Country Status (22)
Country | Link |
---|---|
US (2) | US6307054B1 (pt) |
EP (1) | EP0909270B1 (pt) |
JP (1) | JP2000502709A (pt) |
KR (1) | KR19990076966A (pt) |
AP (1) | AP772A (pt) |
AT (1) | ATE219767T1 (pt) |
AU (1) | AU722894B2 (pt) |
BR (1) | BR9612341A (pt) |
CA (1) | CA2241887C (pt) |
CZ (1) | CZ203998A3 (pt) |
DE (1) | DE69622051T2 (pt) |
DK (1) | DK0909270T3 (pt) |
EA (1) | EA000884B1 (pt) |
ES (1) | ES2178725T3 (pt) |
HK (1) | HK1019590A1 (pt) |
HU (1) | HUP9900969A3 (pt) |
IL (1) | IL125164A (pt) |
OA (1) | OA10803A (pt) |
PT (1) | PT909270E (pt) |
SI (1) | SI9620137B (pt) |
SK (1) | SK283625B6 (pt) |
WO (1) | WO1997024327A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2228163T3 (es) | 1998-12-31 | 2005-04-01 | Aventis Pharmaceuticals Inc. | Procedimiento para preparar derivados de desaza-adenosina n6-sustituidos. |
US7018365B2 (en) | 1999-05-21 | 2006-03-28 | Micro Therapeutics, Inc. | Threaded syringe with quick stop |
US6784165B1 (en) * | 1999-11-23 | 2004-08-31 | Aderis Pharmaceuticals, Inc. | Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines |
US7291603B2 (en) * | 2002-07-24 | 2007-11-06 | Ptc Therapeutics, Inc. | Nucleoside compounds and their use for treating cancer and diseases associated with somatic mutations |
WO2004100964A1 (en) * | 2003-04-24 | 2004-11-25 | Aderis Pharmaceuticals, Inc. | Method of treating atrial fibrillation or atrial flutter |
WO2005025545A2 (en) * | 2003-09-17 | 2005-03-24 | Aderis Pharmaceuticals, Inc. | Pharmaceutical formulation for controlled release of selodenoson |
GT200500281A (es) * | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0607944D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
GB0607950D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
PL2013211T3 (pl) | 2006-04-21 | 2012-08-31 | Novartis Ag | Pochodne puryny do zastosowania jako agoniści receptora adenozyny A2A |
GB0607953D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
GB0607948D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
EP1889846A1 (en) | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
EP1903044A1 (en) * | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
CN101553459A (zh) * | 2006-11-10 | 2009-10-07 | 诺瓦提斯公司 | 环戊烯二醇单乙酸酯衍生物 |
JP2012516843A (ja) | 2009-02-02 | 2012-07-26 | インドコ レメディーズ リミテッド | ニトロピリジン誘導体の調製方法 |
CN114349873B (zh) * | 2021-04-12 | 2023-03-17 | 杭州安誉科技有限公司 | 用于多孔模块辅助控制装置的高强度风扇支架 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3547935A (en) * | 1967-08-07 | 1970-12-15 | American Cyanamid Co | Certain nitro-4-pyridinols,n-oxides thereof and derivatives thereof |
GB1199699A (en) * | 1968-01-08 | 1970-07-22 | Glanzstoff Ag | Process for the Production of Condensed Aromatic Bis-(2,4-Dihydroxypyridine) Derivatives |
DE3308449A1 (de) * | 1982-08-19 | 1984-03-15 | Rütgerswerke AG, 6000 Frankfurt | Verfahren zur reindarstellung von 2-chlor-6-alkoxy-3-nitropyridinen |
JP3261190B2 (ja) * | 1993-01-27 | 2002-02-25 | 広栄化学工業株式会社 | 2−ヒドロキシ−3,5−ジニトロピリジン類の製造法 |
-
1996
- 1996-12-23 BR BR9612341-9A patent/BR9612341A/pt not_active Application Discontinuation
- 1996-12-23 WO PCT/US1996/020768 patent/WO1997024327A1/en not_active Application Discontinuation
- 1996-12-23 SI SI9620137A patent/SI9620137B/sl not_active IP Right Cessation
- 1996-12-23 SK SK906-98A patent/SK283625B6/sk unknown
- 1996-12-23 AU AU13546/97A patent/AU722894B2/en not_active Ceased
- 1996-12-23 CA CA002241887A patent/CA2241887C/en not_active Expired - Fee Related
- 1996-12-23 JP JP9524559A patent/JP2000502709A/ja not_active Ceased
- 1996-12-23 DK DK96945096T patent/DK0909270T3/da active
- 1996-12-23 EP EP96945096A patent/EP0909270B1/en not_active Expired - Lifetime
- 1996-12-23 HU HU9900969A patent/HUP9900969A3/hu not_active Application Discontinuation
- 1996-12-23 AP APAP/P/1998/001289A patent/AP772A/en active
- 1996-12-23 IL IL12516496A patent/IL125164A/xx not_active IP Right Cessation
- 1996-12-23 ES ES96945096T patent/ES2178725T3/es not_active Expired - Lifetime
- 1996-12-23 EA EA199800621A patent/EA000884B1/ru not_active IP Right Cessation
- 1996-12-23 KR KR1019980705094A patent/KR19990076966A/ko not_active Application Discontinuation
- 1996-12-23 CZ CZ982039A patent/CZ203998A3/cs unknown
- 1996-12-23 AT AT96945096T patent/ATE219767T1/de not_active IP Right Cessation
- 1996-12-23 DE DE69622051T patent/DE69622051T2/de not_active Expired - Fee Related
- 1996-12-23 PT PT96945096T patent/PT909270E/pt unknown
-
1998
- 1998-07-01 US US09/108,622 patent/US6307054B1/en not_active Expired - Fee Related
- 1998-07-01 OA OA9800099A patent/OA10803A/en unknown
-
1999
- 1999-10-21 HK HK99104682A patent/HK1019590A1/xx not_active IP Right Cessation
-
2001
- 2001-05-18 US US09/861,023 patent/US6392049B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0909270A1 (en) | 1999-04-21 |
EA000884B1 (ru) | 2000-06-26 |
EP0909270A4 (pt) | 1999-04-21 |
AU722894B2 (en) | 2000-08-10 |
EP0909270B1 (en) | 2002-06-26 |
AU1354697A (en) | 1997-07-28 |
HK1019590A1 (en) | 2000-02-18 |
HUP9900969A3 (en) | 2001-11-28 |
US6392049B1 (en) | 2002-05-21 |
CA2241887A1 (en) | 1997-07-10 |
IL125164A0 (en) | 1999-01-26 |
OA10803A (en) | 2003-01-28 |
PT909270E (pt) | 2002-11-29 |
IL125164A (en) | 2003-03-12 |
ES2178725T3 (es) | 2003-01-01 |
SI9620137A (sl) | 1999-02-28 |
US6307054B1 (en) | 2001-10-23 |
SK90698A3 (en) | 2000-12-11 |
EA199800621A1 (ru) | 1999-02-25 |
DE69622051D1 (de) | 2002-08-01 |
CA2241887C (en) | 2004-02-24 |
DE69622051T2 (de) | 2003-01-23 |
WO1997024327A1 (en) | 1997-07-10 |
JP2000502709A (ja) | 2000-03-07 |
SI9620137B (sl) | 2006-02-28 |
DK0909270T3 (da) | 2002-10-07 |
AP9801289A0 (en) | 1998-09-30 |
HUP9900969A2 (hu) | 1999-07-28 |
CZ203998A3 (cs) | 1999-11-17 |
AP772A (en) | 1999-10-15 |
KR19990076966A (ko) | 1999-10-25 |
ATE219767T1 (de) | 2002-07-15 |
SK283625B6 (sk) | 2003-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EG | Technical examination (opinion): publication of technical examination (opinion) | ||
FC | Decision: refusal |