GB1489980A - Reaction products of 3-amino-3,4-dihydro-4-hydroxy-4-phenylquinazolines - Google Patents

Reaction products of 3-amino-3,4-dihydro-4-hydroxy-4-phenylquinazolines

Info

Publication number
GB1489980A
GB1489980A GB46477A GB46477A GB1489980A GB 1489980 A GB1489980 A GB 1489980A GB 46477 A GB46477 A GB 46477A GB 46477 A GB46477 A GB 46477A GB 1489980 A GB1489980 A GB 1489980A
Authority
GB
United Kingdom
Prior art keywords
phenylquinazolines
dihydro
hydroxy
amino
reaction products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB46477A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1489980A publication Critical patent/GB1489980A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/92—Oxygen atoms with hetero atoms directly attached to nitrogen atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

1489980 Reaction products of 3-amino-3,4- dihydro - 4 - hydroxy - 4 - phenylquinazolines and #-phthalimido alkanoic acid derivatives UPJOHN CO 19 Dec 1975 [20 Jan 1975] 00464/77 Divided out of 1489979 Heading C2C The invention comprises compounds of Formulae IIIA and IIIB when R 1 and R 2 are independently H or C 1-3 alkyl; R 3 is H, Cl or F; R 4 is H, Cl or F provided that when R 3 is Cl, R 4 is not F and R 5 is H, Cl, Br, F, CF 3 or NO 2 which may be prepared by reacting a quinazoline of Formula I with a compound of Formula II wherein Y is Br, Cl, ethoxycarbonyloxy or 1- imidazolyl, the compound IIIA being obtained by using equimolar amounts of I and II and compound IIIB by the use of a molar excess of II.
GB46477A 1975-01-20 1975-12-19 Reaction products of 3-amino-3,4-dihydro-4-hydroxy-4-phenylquinazolines Expired GB1489980A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54239075A 1975-01-20 1975-01-20

Publications (1)

Publication Number Publication Date
GB1489980A true GB1489980A (en) 1977-10-26

Family

ID=24163623

Family Applications (3)

Application Number Title Priority Date Filing Date
GB46477A Expired GB1489980A (en) 1975-01-20 1975-12-19 Reaction products of 3-amino-3,4-dihydro-4-hydroxy-4-phenylquinazolines
GB5222175A Expired GB1489979A (en) 1975-01-20 1975-12-19 Triazolo benzo-diazepines and triazolo benzodiazocines
GB5226276A Expired GB1490060A (en) 1975-01-20 1975-12-19 2-(3-substituted-4h-1,2,4-triazol-4-yl)benzo-phenones

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB5222175A Expired GB1489979A (en) 1975-01-20 1975-12-19 Triazolo benzo-diazepines and triazolo benzodiazocines
GB5226276A Expired GB1490060A (en) 1975-01-20 1975-12-19 2-(3-substituted-4h-1,2,4-triazol-4-yl)benzo-phenones

Country Status (5)

Country Link
JP (1) JPS51115498A (en)
CH (2) CH622517A5 (en)
DE (1) DE2601400A1 (en)
FR (1) FR2297622A1 (en)
GB (3) GB1489980A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934940A1 (en) * 1996-06-12 1999-08-11 Japan Tobacco Inc. Cytokine production inhibitors, triazepine compounds, and intermediates thereof
CN107698522A (en) * 2017-11-09 2018-02-16 华中药业股份有限公司 The preparation method of the phenylquinazoline of 6 chlorine, 3 amino, 3,4 dihydro, 4 hydroxyl 4

Also Published As

Publication number Publication date
CH622517A5 (en) 1981-04-15
FR2297622A1 (en) 1976-08-13
JPS51115498A (en) 1976-10-12
FR2297622B1 (en) 1981-12-24
DE2601400A1 (en) 1976-07-22
GB1490060A (en) 1977-10-26
CH628047A5 (en) 1982-02-15
GB1489979A (en) 1977-10-26

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940610