SI9300556A - Method for the purification of clavulanic acid - Google Patents

Method for the purification of clavulanic acid Download PDF

Info

Publication number
SI9300556A
SI9300556A SI9300556A SI9300556A SI9300556A SI 9300556 A SI9300556 A SI 9300556A SI 9300556 A SI9300556 A SI 9300556A SI 9300556 A SI9300556 A SI 9300556A SI 9300556 A SI9300556 A SI 9300556A
Authority
SI
Slovenia
Prior art keywords
clavulanic acid
solution
salt
solvent
ethyl acetate
Prior art date
Application number
SI9300556A
Other languages
English (en)
Slovenian (sl)
Inventor
Ho Suk Yang
Nam Hee Choi
Sang Chul Lee
Yu Beom Ham
Kyeong Bok Min
Original Assignee
Pharma Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Dev Ltd filed Critical Pharma Dev Ltd
Publication of SI9300556A publication Critical patent/SI9300556A/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI9300556A 1992-10-21 1993-10-21 Method for the purification of clavulanic acid SI9300556A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR920019353 1992-10-21

Publications (1)

Publication Number Publication Date
SI9300556A true SI9300556A (en) 1994-06-30

Family

ID=19341504

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9300556A SI9300556A (en) 1992-10-21 1993-10-21 Method for the purification of clavulanic acid

Country Status (16)

Country Link
EP (1) EP0594099B1 (xx)
JP (1) JPH06197782A (xx)
KR (1) KR100200239B1 (xx)
AT (1) ATE167677T1 (xx)
AU (1) AU669212B2 (xx)
CA (1) CA2107928A1 (xx)
CZ (1) CZ221193A3 (xx)
DE (1) DE69319296T2 (xx)
DK (1) DK0594099T3 (xx)
ES (1) ES2118870T3 (xx)
GR (1) GR3027699T3 (xx)
HU (1) HUT66020A (xx)
NZ (1) NZ248917A (xx)
PL (1) PL300747A1 (xx)
SI (1) SI9300556A (xx)
ZA (1) ZA937638B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
GB2282810B (en) * 1992-06-11 1997-02-26 Smithkline Beecham Plc Preparation or purification of clavulanic acid
ATE198892T1 (de) 1993-11-17 2001-02-15 Biochemie Gmbh Trennung von cephalosporinisomeren
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
CN1238776A (zh) * 1996-11-11 1999-12-15 吉斯特-布罗卡迪斯有限公司 制备棒酸盐和酯的方法
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
CN1312814A (zh) * 1998-07-16 2001-09-12 Dsm公司 制备棒酸盐类及其酯类的改进方法
CA2408853C (en) * 2000-05-13 2012-01-10 Smithkline Beecham P.L.C. Process
CN108558909B (zh) * 2018-05-17 2019-09-17 国药集团威奇达药业有限公司 综合回收克拉维酸叔丁胺盐结晶母液中有效成分的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
BE862211A (fr) * 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline

Also Published As

Publication number Publication date
GR3027699T3 (en) 1998-11-30
DE69319296T2 (de) 1998-11-05
EP0594099A1 (en) 1994-04-27
DE69319296D1 (de) 1998-07-30
CA2107928A1 (en) 1994-04-22
CZ221193A3 (en) 1994-05-18
AU4900893A (en) 1994-05-05
HU9302876D0 (en) 1993-12-28
NZ248917A (en) 1995-08-28
AU669212B2 (en) 1996-05-30
HUT66020A (en) 1994-08-29
ZA937638B (en) 1994-05-05
ES2118870T3 (es) 1998-10-01
KR940009194A (ko) 1994-05-20
PL300747A1 (en) 1994-05-16
ATE167677T1 (de) 1998-07-15
KR100200239B1 (ko) 1999-06-15
DK0594099T3 (da) 1999-02-15
EP0594099B1 (en) 1998-06-24
JPH06197782A (ja) 1994-07-19

Similar Documents

Publication Publication Date Title
SI9300556A (en) Method for the purification of clavulanic acid
EP0672670B1 (en) Process for the preparation of clavulanic acid
US4978673A (en) Organic salts of physostigmine derivatives
CZ284695B6 (cs) Způsob přípravy trihydrátu (2R,3S)-4-acetoxy-2alfa-benzoyl-oxy-5beta,20-epoxy-1,7beta,10beta-trihydroxy-9-oxo-tax-11-en-13alfa-yl-3-terc.butoxykarbonylamino-2-hydroxy-3-fenylpropionátu
EP2407468B1 (en) Improved method for preparing meropenem using zinc powder
US2528267A (en) Eobeet j
US5571941A (en) Process for the purifying of iopamidol
EP0827504B1 (en) Process for manufacturing clavulanic acid salt
SI9500074A (en) Process for preparation of alkani salts of clavulanic acid.
MXPA97008774A (en) Procedure for the manufacture of acidoclavulan salt
EP0093511A1 (en) Method for producing and optically active 2,2-dimethylcyclopropanecarboxylic acid
CN113072491B (zh) 一种硫酸羟氯喹的制备方法
US5015763A (en) N-methyl-α-dialkylamioacetohydroxamic acid compound
KR20000017154A (ko) Ｏ,ｓ-디알킬 포스포로아미도티오에이트의 ｎ-아실 유도체의개선된 제조방법
EP0437567B1 (en) Phenyl-glycine derivatives
KR800000569B1 (ko) 세파로스포린 c의 유도체의 제법
US6235775B1 (en) Acetone adduct of fungicidal V-28-3M
SU331537A1 (ru) Способ получения адриамицина
CS197241B2 (en) Method of producing hydroxy-methyl pyridines from acetoxy-methyl pyridines
DE10047444A1 (de) Verfahren zur Trennung und hochreinen Isolierung von niedermolekularen, strukturell ähnlichen Verbindungen insbesondere von Tetrahydropyrimidinderivaten wie z.B. 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidincarbonsäuren (Ectoine) und deren Spaltprodukte
KR19980076017A (ko) 무정형 세팔로스포린에스테르 유도체의 제조방법
SI9500072A (sl) Postopek za pripravo in/ali čiščenje klavulanske kisline ali njenih farmacevtsko sprejemljivih soli ali estrov