SI9110156B - Nove zmesi poganjalnih plinov in njihova uporaba v pripravkih zdravil - Google Patents
Nove zmesi poganjalnih plinov in njihova uporaba v pripravkih zdravil Download PDFInfo
- Publication number
- SI9110156B SI9110156B SI9110156A SI9110156A SI9110156B SI 9110156 B SI9110156 B SI 9110156B SI 9110156 A SI9110156 A SI 9110156A SI 9110156 A SI9110156 A SI 9110156A SI 9110156 B SI9110156 B SI 9110156B
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- Slovenia
- Prior art keywords
- mentioned
- combination
- active ingredients
- betamimetics
- preparations
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract 7
- 238000002360 preparation method Methods 0.000 title claims 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 5
- 230000003454 betamimetic effect Effects 0.000 claims 5
- 239000007789 gas Substances 0.000 claims 5
- 239000003380 propellant Substances 0.000 claims 5
- -1 sorbitan ester Chemical class 0.000 claims 5
- 239000000808 adrenergic beta-agonist Substances 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 3
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 230000003266 anti-allergic effect Effects 0.000 claims 2
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 claims 2
- 239000000812 cholinergic antagonist Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229960000265 cromoglicic acid Drugs 0.000 claims 2
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 2
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims 1
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims 1
- 125000004173 1-benzimidazolyl group Chemical group [H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N1* 0.000 claims 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- YREYLAVBNPACJM-UHFFFAOYSA-N 2-(tert-butylamino)-1-(2-chlorophenyl)ethanol Chemical compound CC(C)(C)NCC(O)C1=CC=CC=C1Cl YREYLAVBNPACJM-UHFFFAOYSA-N 0.000 claims 1
- RTLJQOLVPIGICL-UHFFFAOYSA-N 4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(methylsulfonylmethyl)phenol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CS(C)(=O)=O)=C1 RTLJQOLVPIGICL-UHFFFAOYSA-N 0.000 claims 1
- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 claims 1
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 1
- BQTXJHAJMDGOFI-NJLPOHDGSA-N Dexamethasone 21-(4-Pyridinecarboxylate) Chemical compound O=C([C@]1(O)[C@@]2(C)C[C@H](O)[C@]3(F)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)COC(=O)C1=CC=NC=C1 BQTXJHAJMDGOFI-NJLPOHDGSA-N 0.000 claims 1
- VQDBNKDJNJQRDG-UHFFFAOYSA-N Pirbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=N1 VQDBNKDJNJQRDG-UHFFFAOYSA-N 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims 1
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims 1
- 239000004147 Sorbitan trioleate Substances 0.000 claims 1
- RVCSYOQWLPPAOA-CVPHZBIISA-M [(5s)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-hydroxy-2,2-diphenylacetate;chloride Chemical compound [Cl-].[N+]12([C@H]3CCC2CC(C3)OC(=O)C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 RVCSYOQWLPPAOA-CVPHZBIISA-M 0.000 claims 1
- WKHOPHIMYDJVSA-UHFFFAOYSA-N [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(2-methylpropanoyloxy)phenyl] 2-methylpropanoate Chemical compound CC(C)C(=O)OC1=CC(OC(=O)C(C)C)=CC(C(O)CNC(C)(C)C)=C1 WKHOPHIMYDJVSA-UHFFFAOYSA-N 0.000 claims 1
- SCSIRWUYQVAIRL-UHFFFAOYSA-N ac1miw90 Chemical compound C1=2CC(C(=O)N(CCC)CCC)CC=2SC(N2C(C)=NN=C2CN=2)=C1C=2C1=CC=CC=C1Cl SCSIRWUYQVAIRL-UHFFFAOYSA-N 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 1
- 230000001078 anti-cholinergic effect Effects 0.000 claims 1
- 229960003060 bambuterol Drugs 0.000 claims 1
- ANZXOIAKUNOVQU-UHFFFAOYSA-N bambuterol Chemical compound CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC(C(O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-UHFFFAOYSA-N 0.000 claims 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 1
- 229940092705 beclomethasone Drugs 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- FWYVRZOREBYLCY-UHFFFAOYSA-N bepafant Chemical compound C1C=2SC=3N4C(C)=NN=C4CN=C(C=4C(=CC=CC=4)Cl)C=3C=2CC1C(=O)N1CCOCC1 FWYVRZOREBYLCY-UHFFFAOYSA-N 0.000 claims 1
- 229960004620 bitolterol Drugs 0.000 claims 1
- FZGVEKPRDOIXJY-UHFFFAOYSA-N bitolterol Chemical compound C1=CC(C)=CC=C1C(=O)OC1=CC=C(C(O)CNC(C)(C)C)C=C1OC(=O)C1=CC=C(C)C=C1 FZGVEKPRDOIXJY-UHFFFAOYSA-N 0.000 claims 1
- 229960004436 budesonide Drugs 0.000 claims 1
- 229960001386 carbuterol Drugs 0.000 claims 1
- KEMXXQOFIRIICG-UHFFFAOYSA-N carbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(NC(N)=O)=C1 KEMXXQOFIRIICG-UHFFFAOYSA-N 0.000 claims 1
- 229960001117 clenbuterol Drugs 0.000 claims 1
- STJMRWALKKWQGH-UHFFFAOYSA-N clenbuterol Chemical compound CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1 STJMRWALKKWQGH-UHFFFAOYSA-N 0.000 claims 1
- 229960001022 fenoterol Drugs 0.000 claims 1
- 229960000708 hexoprenaline Drugs 0.000 claims 1
- OXLZNBCNGJWPRV-UHFFFAOYSA-N hexoprenaline Chemical compound C=1C=C(O)C(O)=CC=1C(O)CNCCCCCCNCC(O)C1=CC=C(O)C(O)=C1 OXLZNBCNGJWPRV-UHFFFAOYSA-N 0.000 claims 1
- 229950002451 ibuterol Drugs 0.000 claims 1
- 229960001361 ipratropium bromide Drugs 0.000 claims 1
- KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 claims 1
- 229940067606 lecithin Drugs 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940102396 methyl bromide Drugs 0.000 claims 1
- GZUXJHMPEANEGY-UHFFFAOYSA-N methyl bromide Substances BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 claims 1
- NVOYVOBDTVTBDX-PMEUIYRNSA-N oxitropium Chemical compound CC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)C1=CC=CC=C1 NVOYVOBDTVTBDX-PMEUIYRNSA-N 0.000 claims 1
- 229960000797 oxitropium Drugs 0.000 claims 1
- GTLACDSXYULKMZ-UHFFFAOYSA-N pentafluoroethane Chemical compound FC(F)C(F)(F)F GTLACDSXYULKMZ-UHFFFAOYSA-N 0.000 claims 1
- 150000003904 phospholipids Chemical group 0.000 claims 1
- 229960005414 pirbuterol Drugs 0.000 claims 1
- 229960002288 procaterol Drugs 0.000 claims 1
- FKNXQNWAXFXVNW-BLLLJJGKSA-N procaterol Chemical compound N1C(=O)C=CC2=C1C(O)=CC=C2[C@@H](O)[C@@H](NC(C)C)CC FKNXQNWAXFXVNW-BLLLJJGKSA-N 0.000 claims 1
- 229960002720 reproterol Drugs 0.000 claims 1
- WVLAAKXASPCBGT-UHFFFAOYSA-N reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 claims 1
- 229960002052 salbutamol Drugs 0.000 claims 1
- 229960004017 salmeterol Drugs 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 150000004671 saturated fatty acids Chemical class 0.000 claims 1
- 229950004959 sorbitan oleate Drugs 0.000 claims 1
- 235000019337 sorbitan trioleate Nutrition 0.000 claims 1
- 229960000391 sorbitan trioleate Drugs 0.000 claims 1
- 229950007862 sulfonterol Drugs 0.000 claims 1
- 229960000195 terbutaline Drugs 0.000 claims 1
- 239000003848 thrombocyte activating factor antagonist Substances 0.000 claims 1
- 229960001530 trospium chloride Drugs 0.000 claims 1
- 229960000859 tulobuterol Drugs 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K3/00—Materials not provided for elsewhere
- C09K3/30—Materials not provided for elsewhere for aerosols
Claims (10)
1 PATENTNI ZAHTEVKI 1. Zmesi poganjalnih plinov iz dveh ali več komponent za inhalativne farmacevtske pripravke, označene s tem, da vsebujejo 1,1,1,2,3,3,3-heptafluorpropan in poleg tega eno ali več spojin iz skupine 1,1,1,2-tetrafluoretana, pentafluoretana, TG 11, TG 12 ali TG 114, pri čemer je vsebnost 1,1,1,2,3,3,3-heptafluorpropana med 30 in 95 mas.%.
2. Zmesi poganjalnih plinov po zahtevku 1, označene s tem, da dodatno vsebujejo vsaj eno površinsko aktivno snov.
3. Zmesi poganjalnih plinov po zahtevku 2, označene s tem, da je površinsko aktivna snov fosfolipid, sorbitanester z višjo nasičeno ali nenasičeno maščobno kislino ali polietoksisorbitanester višje, prednostno nenasičene maščobne kisline.
4. Zmes poganjalnih plinov po zahtevku 2, označena s tem, da je površinsko aktivna snov lecitin, polioksietilensorbitan oleat ali sorbitan trioleat.
5. Pripravki zdravil za izdelavo praškastih aerosolov na osnovi zmesi poganjalnih plinov po zahtevkih 1, 2, 3 ali 4, označeni s tem, da vsebujejo kot učinkovino betamimetik, antiholinergik, steroid, antialergik ali PAF-antagonist ali kombinacijo takih spojin.
6. Pripravki zdravil po zahtevku 5, označeni s tem, da uporabimo kot betamimetik: bambuterol bitolterol karbuterol klenbuterol fenoterol heksoprenalin ibuterol pirbuterol prokaterol reproterol salbutamol salmeterol 2 sulfonterol terbutalin tulobuterol l-(2-fluor-4-hidroksifenil)-2-[4-(l-benzimidazolil)-2-metil-2-butilamino]etanol eritro-5’-hidroksi-8’-(l-hidroksi-2-izopropilamino-butil)-2H-l,4-benzoksazin- 3-(4H)-on l-(4-amino-3-klor-5-trifluormetilfenil)-2-terc.butilamino)etanol l-(4-etoksikarbonilamino-3-cian-5-fluorfenil)-2-(terc.butilamino)etanol kot antiholinergike: ipratropijev bromid oksitropijev bromid trospijev klorid metobromid N-/3-fluoretilnortropinestra benzilne kisline kot steroide: budesonid beklometazon (oz. 17,21-dipropionat) deksametazon-21-izonikotinat flunizolid kot antialergik: dinatrijev kromoglikat nedokromil kot PAF-antagoniste: WEB 2086 WEB 2170 WEB 2347. 3
7. Pripravki zdravil po zahtevku 5, označeni s tem, da obsega kombinacija učinkovin enega od betamimetikov, navedenih v zahtevku 6, in enega od antiholinergikov, navedenih v zahtevku 6.
8. Pripravek zdravila po zahtevku 5, označen s tem, da obsega kombinacija učinkovin enega od betamimetikov, navedenih v zahtevku 6, in dinatrijev kromoglikat.
9. Pripravek zdravila po zahtevku 5, označen s tem, da vsebuje kombinacija učinkovin enega od betamimetikov, navedenih v zahtevku 6, in enega od PAF-antagonistov, navedenih v zahtevku 6.
10. Pripravek zdravila po zahtevku 5, označen s tem, da obsega kombinacija učinkovin dinatrijev kromoglikat in enega od PAF-antagonistov, navedenih v zahtevku 6. Za BOEHRINGERINGELHEIM KG:
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4003272A DE4003272A1 (de) | 1990-02-03 | 1990-02-03 | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
| YU15691A YU49203B (sh) | 1990-02-03 | 1991-01-30 | Nove smeše potisnih gasova za farmaceutske preparate za inhaliranje |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9110156A SI9110156A (sl) | 1998-04-30 |
| SI9110156B true SI9110156B (sl) | 1999-04-30 |
Family
ID=6399400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9110156A SI9110156B (sl) | 1990-02-03 | 1991-01-30 | Nove zmesi poganjalnih plinov in njihova uporaba v pripravkih zdravil |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6413497B1 (sl) |
| EP (1) | EP0514415B1 (sl) |
| JP (1) | JP3497161B2 (sl) |
| AT (1) | ATE165863T1 (sl) |
| AU (1) | AU650001B2 (sl) |
| CA (1) | CA2075058C (sl) |
| CZ (1) | CZ286691B6 (sl) |
| DE (2) | DE4003272A1 (sl) |
| DK (1) | DK0514415T3 (sl) |
| ES (1) | ES2117964T3 (sl) |
| FI (1) | FI102905B (sl) |
| HK (1) | HK1010786A1 (sl) |
| HR (1) | HRP940735B1 (sl) |
| HU (2) | HU9202509D0 (sl) |
| IE (2) | IE910350A1 (sl) |
| IL (1) | IL97028A (sl) |
| NO (1) | NO302419B1 (sl) |
| NZ (1) | NZ236973A (sl) |
| PT (1) | PT96634B (sl) |
| SI (1) | SI9110156B (sl) |
| SK (1) | SK280426B6 (sl) |
| WO (1) | WO1991011495A1 (sl) |
| YU (1) | YU49203B (sl) |
| ZA (1) | ZA91754B (sl) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766573A (en) | 1988-12-06 | 1998-06-16 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| US5225183A (en) * | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| DE4003270A1 (de) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
| WO1992000062A1 (en) * | 1990-06-27 | 1992-01-09 | Minnesota Mining And Manufacturing Company | The use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations |
| MX9203481A (es) | 1990-10-18 | 1992-07-01 | Minnesota Mining & Mfg | Formulaciones. |
| CA2094266C (en) * | 1990-10-18 | 1999-06-01 | Robert K. Schultz | Aerosol formulations of beclomethasone-17,21-dipropionate |
| HU205249B (en) * | 1990-11-09 | 1992-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing suspensive aerosole composition |
| GB9024366D0 (en) * | 1990-11-09 | 1991-01-02 | Glaxo Group Ltd | Medicaments |
| US5182040A (en) * | 1991-03-28 | 1993-01-26 | E. I. Du Pont De Nemours And Company | Azeotropic and azeotrope-like compositions of 1,1,2,2-tetrafluoroethane |
| US5725791A (en) * | 1991-03-28 | 1998-03-10 | E. I. Du Pont De Nemours And Company | Azeotropic and azeotrope-like compositions of 1,1,2,2-tetrafluoroethane |
| EP1277467B1 (en) * | 1991-06-10 | 2006-09-20 | Schering Corporation | Non-chlorofluorocarbon aerosol formulations |
| ATE134509T1 (de) * | 1991-06-10 | 1996-03-15 | Schering Corp | Fluorchlorkohlenwasserstoffreie aerosolformulierungen |
| DE4123663A1 (de) * | 1991-07-17 | 1993-01-21 | Schwabe Willmar Gmbh & Co | Aerosol-zubereitung und verwendung eines treibmittels dafuer |
| IL104068A (en) † | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant |
| US5683676A (en) * | 1991-12-12 | 1997-11-04 | Glaxo Group Limited | Canister containing aerosol formulations containing P134a and particulate medicaments |
| US5744123A (en) * | 1991-12-12 | 1998-04-28 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
| US5674471A (en) * | 1991-12-12 | 1997-10-07 | Glaxo Group Limited | Aerosol formulations containing P134a and salbutamol |
| US5736124A (en) * | 1991-12-12 | 1998-04-07 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicament |
| US5916540A (en) | 1994-10-24 | 1999-06-29 | Glaxo Group Limited | Aerosol formulations containing P134A and/or P227 and particulate medicament |
| CA2455115C (en) | 1991-12-12 | 2008-05-27 | Glaxo Group Limited | Pharmaceutical aerosol formulation |
| AU663906B2 (en) * | 1991-12-12 | 1995-10-26 | Glaxo Group Limited | Medicaments |
| US5658549A (en) * | 1991-12-12 | 1997-08-19 | Glaxo Group Limited | Aerosol formulations containing propellant 134a and fluticasone propionate |
| US20030103907A1 (en) * | 1991-12-18 | 2003-06-05 | Schultz Robert K. | Suspension aerosol formulations |
| NZ246421A (en) * | 1991-12-18 | 1996-05-28 | Minnesota Mining & Mfg | Aerosol formulation containing a drug and a propellant and which is substantially free of surfactant |
| US7105152B1 (en) | 1991-12-18 | 2006-09-12 | 3M Innovative Properties Company | Suspension aerosol formulations |
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1990
- 1990-02-03 DE DE4003272A patent/DE4003272A1/de not_active Ceased
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1991
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- 1991-01-30 SI SI9110156A patent/SI9110156B/sl unknown
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- 1991-01-31 AT AT91903275T patent/ATE165863T1/de not_active IP Right Cessation
- 1991-01-31 CA CA002075058A patent/CA2075058C/en not_active Expired - Lifetime
- 1991-01-31 HU HU922509Q patent/HU9202509D0/hu unknown
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- 1991-01-31 NZ NZ236973A patent/NZ236973A/en unknown
- 1991-01-31 ES ES91903275T patent/ES2117964T3/es not_active Expired - Lifetime
- 1991-01-31 JP JP50368691A patent/JP3497161B2/ja not_active Expired - Lifetime
- 1991-01-31 DE DE59108979T patent/DE59108979D1/de not_active Revoked
- 1991-01-31 EP EP91903275A patent/EP0514415B1/de not_active Revoked
- 1991-01-31 HU HU9202509A patent/HU218784B/hu unknown
- 1991-01-31 WO PCT/EP1991/000177 patent/WO1991011495A1/de not_active Application Discontinuation
- 1991-01-31 DK DK91903275T patent/DK0514415T3/da active
- 1991-02-01 ZA ZA91754A patent/ZA91754B/xx unknown
- 1991-02-01 IE IE035091A patent/IE910350A1/en not_active IP Right Cessation
- 1991-02-01 PT PT96634A patent/PT96634B/pt not_active IP Right Cessation
- 1991-02-01 IE IE035191A patent/IE910351A1/en not_active IP Right Cessation
- 1991-02-04 SK SK264-91A patent/SK280426B6/sk not_active IP Right Cessation
- 1991-02-04 CZ CS1991264A patent/CZ286691B6/cs not_active IP Right Cessation
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1992
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1994
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1998
- 1998-11-05 HK HK98111767A patent/HK1010786A1/xx not_active IP Right Cessation
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