AR081026A1 - Analogos de quinolina y su uso en el tratamiento de enfermedades respiratorias - Google Patents
Analogos de quinolina y su uso en el tratamiento de enfermedades respiratoriasInfo
- Publication number
- AR081026A1 AR081026A1 ARP110101593A ARP110101593A AR081026A1 AR 081026 A1 AR081026 A1 AR 081026A1 AR P110101593 A ARP110101593 A AR P110101593A AR P110101593 A ARP110101593 A AR P110101593A AR 081026 A1 AR081026 A1 AR 081026A1
- Authority
- AR
- Argentina
- Prior art keywords
- het
- alkyl
- arylene
- arilen
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Su uso en el tratamiento de la inflamacion pulmonar o de la broncoconstriccion y composiciones que los comprenden y procesos para su preparacion. Reivindicacion 1: Un compuesto de Formula (1): donde X es un anillo de fenilo sustituido seleccionado entre: (2); Z es un enlace o una porcion seleccionada entre: (3); R1 es CH2OH, CH2CH2OH, N(H)C(O)H, o N(H)S(O2) alquilo C1-3, y R2 es H; o R1 y R2 junto con el fenilo al cual están unidos forman un anillo heterocíclico fusionado, bicíclico que tiene 9 o 10 átomos del anillo donde 1 o 2 átomos del anillo se seleccionan entre N, O y S, donde dicho anillo heterocíclico fusionado biciclico es opcionalmente sustituido con uno, dos o tres sustituyentes adicionales seleccionados independientemente entre alquilo, oxo y OH; R3 se selecciona entre alquileno C4-2, alquenileno C4-12, alquinileno C4-12, R8-O-R8, R8-N(R7)-R8, cicloalquileno C3-6, R8-cicloalquileno C3-6, R8-cicloalquilen C3-6-Het, cicloalquilen C3-6-R8, R8-cicloalquilen C3-6-R8, arileno C6-10, R8-arileno C6-10, arilen C6-10-R8, R8-arilen C6-10-R8, R8-arilen C6-10-O-R8, R8-arilen C6-10-N(R7)-R8, R8-arilen C6-10-ariIeno C6-10, Het, R8-Het, Het-R8, R8-Het-R8, R8-O-Het, R8-arilen C6-10-O-Het, R8-arilen C6-10-C(O)-Het, R8-arilen C6-10-N(R7)-Het, R8-Het-arileno C6-10, R8-arilen C6-10-Het, y R8-O-R8-arileno C6-10; donde dicho alquileno, alquenileno o alquinileno es cada uno opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados entre halo, oxo, y OR7; donde dichos grupos fenileno están cada uno opcionalmente sustituido con 1, 2, 3 o 4 sustituyentes seleccionados entre halo, alquilo, y OR7; Het es heterocicleno monocíclico, saturado o insaturado, de 5-6 miembros o un heterocicleno bicíclico, saturado o insaturado, de 8-10 miembros donde 1 o 2 átomos del anillo se seleccionan entre N, O y S, y donde dicho heterocicleno monocíclico o bicíclico está opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados entre halo, alquilo, alcoxi, oxo y OH; Y es C(O), OC(O), C(O)N(R7), C(O)N(R7)CH2, OC(O)NR7CH2, N(R7)C(O), o N(R7)C(O)N(R7); a es 0, 1, 2, 3, 4; R4 se selecciona entre halo, alquilo, y OR7; R5 es H o alquilo; b es 1, 2, 3, 4, o 5; R6 se selecciona entre halo, alquilo, haloalquilo, OR7, O-haloalquilo, R8-OR7, O-R8-OR7, C(O)alquilo, O-R8-C(O)alquilo, CON(R7)2, R8-CON(R7)2, R8-N(R7)2, N(R7)C(O)alquilo, N(R7)C(O)N(R7)2, N(R7)SO2alquilo, R8-SO2N(R7)2, y CN; o dos R6 en carbonos adyacentes, junto con el fenilo al cual están unidos forman un anillo heterocíclico bicíclico que tiene 9 o 10 átomos del anillo donde 1 o 2 átomos del anillo se seleccionan entre N, O y S; R7 es H o alquilo; y R8 es alquileno C1-10, alquenileno C2-10, o alquinileno C2-10 donde cada R8 es opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados entre halo, oxo, y OR7; con la condicion de que la cantidad total de átomos de carbono en las cadenas de alquileno C1-10, alquenileno C2-10, o alquinileno C2-10 de dos grupos R8 en cualquier definicion de R3 no sea superior a 12; R9 es H o alquilo C1-3; o su sal farmacéuticamente aceptable.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33302010P | 2010-05-10 | 2010-05-10 | |
US40693010P | 2010-10-26 | 2010-10-26 | |
US201161477263P | 2011-04-20 | 2011-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR081026A1 true AR081026A1 (es) | 2012-05-30 |
Family
ID=44072535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110101593A AR081026A1 (es) | 2010-05-10 | 2011-05-09 | Analogos de quinolina y su uso en el tratamiento de enfermedades respiratorias |
Country Status (9)
Country | Link |
---|---|
US (2) | US8394829B2 (es) |
EP (1) | EP2569285A1 (es) |
JP (2) | JP5807058B2 (es) |
AR (1) | AR081026A1 (es) |
AU (1) | AU2011253203A1 (es) |
CA (1) | CA2796826A1 (es) |
NZ (1) | NZ603136A (es) |
UY (1) | UY33372A (es) |
WO (1) | WO2011143105A1 (es) |
Families Citing this family (11)
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UY33372A (es) * | 2010-05-10 | 2011-12-30 | Gilead Sciences Inc | ?análogos de quinolina bi?funcionales, su uso en la manufactura de medicamentos,composiciones que los comprenden y procesos de preparacion?. |
MX2015010714A (es) | 2013-02-19 | 2016-06-14 | Pfizer | Compuestos de azabencimidazol. |
WO2015119998A1 (en) * | 2014-02-06 | 2015-08-13 | Abbvie, Inc. | 6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof |
JP6125467B2 (ja) * | 2014-06-16 | 2017-05-10 | 富士フイルム株式会社 | プリント注文受付機とその作動方法および作動プログラム |
EP3172210B1 (en) | 2014-07-24 | 2020-01-15 | Pfizer Inc | Pyrazolopyrimidine compounds |
DK3177624T3 (da) | 2014-08-06 | 2019-07-01 | Pfizer | Imidazopyridazinforbindelser |
CA2972259A1 (en) | 2014-12-26 | 2016-06-30 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
CN106554350B (zh) * | 2015-09-29 | 2019-12-20 | 四川海思科制药有限公司 | 具有β2激动活性的苯并杂环衍生物及其制法和应用 |
WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
KR102626210B1 (ko) | 2017-12-07 | 2024-01-18 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
CN112250557A (zh) * | 2020-10-23 | 2021-01-22 | 徐州工程学院 | 一种高效合成1,6-二烯-3-酮衍生物的方法 |
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2011
- 2011-05-09 UY UY0001033372A patent/UY33372A/es not_active Application Discontinuation
- 2011-05-09 NZ NZ603136A patent/NZ603136A/en not_active IP Right Cessation
- 2011-05-09 WO PCT/US2011/035738 patent/WO2011143105A1/en active Application Filing
- 2011-05-09 CA CA2796826A patent/CA2796826A1/en not_active Abandoned
- 2011-05-09 US US13/103,577 patent/US8394829B2/en not_active Expired - Fee Related
- 2011-05-09 EP EP11719748A patent/EP2569285A1/en not_active Withdrawn
- 2011-05-09 JP JP2013510204A patent/JP5807058B2/ja not_active Expired - Fee Related
- 2011-05-09 AR ARP110101593A patent/AR081026A1/es unknown
- 2011-05-09 AU AU2011253203A patent/AU2011253203A1/en not_active Abandoned
-
2012
- 2012-09-14 US US13/619,636 patent/US20130012504A1/en not_active Abandoned
-
2015
- 2015-03-09 JP JP2015045538A patent/JP2015131833A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2011253203A1 (en) | 2012-11-22 |
US8394829B2 (en) | 2013-03-12 |
JP5807058B2 (ja) | 2015-11-10 |
UY33372A (es) | 2011-12-30 |
WO2011143105A1 (en) | 2011-11-17 |
US20130012504A1 (en) | 2013-01-10 |
JP2015131833A (ja) | 2015-07-23 |
JP2013526520A (ja) | 2013-06-24 |
NZ603136A (en) | 2014-11-28 |
CA2796826A1 (en) | 2011-11-17 |
EP2569285A1 (en) | 2013-03-20 |
US20110275622A1 (en) | 2011-11-10 |
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