SI9110155B - Novi poganjalni plini in njihova uporaba v pripravkih zdravil - Google Patents

Novi poganjalni plini in njihova uporaba v pripravkih zdravil Download PDF

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Publication number
SI9110155B
SI9110155B SI9110155A SI9110155A SI9110155B SI 9110155 B SI9110155 B SI 9110155B SI 9110155 A SI9110155 A SI 9110155A SI 9110155 A SI9110155 A SI 9110155A SI 9110155 B SI9110155 B SI 9110155B
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Slovenia
Prior art keywords
preparation according
pharmaceutical preparation
combination
pharmaceutical
propellant gas
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SI9110155A
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English (en)
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SI9110155A (sl
Inventor
Hans-Hermann Weil
Ottfried Daab
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Boehringer Ingelheim Kg
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Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of SI9110155A publication Critical patent/SI9110155A/sl
Publication of SI9110155B publication Critical patent/SI9110155B/sl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • C09K3/30—Materials not provided for elsewhere for aerosols

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (11)

1 PATENTNI ZAHTEVKI 1. Farmacevtski pripravek za izdelavo praškastih aerosolov, ki obsega poganjalni plin v zmesi s farmacevtsko učinkovito snovjo, označen s tem, da poganjalni plin obsega 1,1,1,2,3,3,3-heptafluoropropan, po izbiri v zmesi z enim ali več poganjalnih plinov, izbranih iz skupine triklorofluorometana, diklorodifluorometana, 1,2-dikloro-l, 1,2,2-tetrafluoroetana, propana, butana, pentana in dimetiletra, vendar v odsotnosti kakršnegakoli drugega delno fluoriranega C2-C4-alkana.
2. Farmacevtski pripravek po zahtevku 1, označen s tem, da poganjalni plin dodatno vsebuje vsaj eno površinsko aktivno snov.
3. Farmacevtski pripravek po zahtevku 2, označen s tem, da je površinsko aktivna snov fosfolipid sorbitan ester z višjo nasičeno ali nenasičeno maščobno kislino ali polietoksisorbitan ester višje nasičene ali nenasičene maščobne kisline.
4. Farmacevtski pripravek po zahtevku 2 ali 3, označen s tem, daje površinsko aktivna snov lecitin, polietoksietilensorbitan oleat ali sorbitan trioleat.
5. Farmacevtski pripravek po kateremkoli od zahtevkov 1 do 4, označen s tem, da kot učinkovino vsebuje betamimetik, antiholinergik, steroid, antialergik ali PAF-antagonist ali kombinacijo takih spojin.
6. Farmacevtski pripravek po zahtevku 5, označen s tem, da uporabimo kot betamimetik: bambuterol bitolterol karbuterol klenbuterol fenoterol heksoprenalin ibuterol 2 pirbuterol prokaterol reproterol salbutamol salmeterol sulfonterol terbutalin tulobuterol l-(2-fluor-4-hidroksifenil)-2-[4-(l-ben2imidazolil)-2-metil-2-butilamino]etaiiol eritro-5'-hidroksi-8'-(l-hidroksi-2-izopropilaminobutil)-2H-l,4-benzoksazin-3-(4H)-on l-(4-amino-3-klor-5-trifluorometilfenil)-2-(terc.-butilainino)etaiiol l-(4-etoksikarbonilamino-3-cian-5-fluorofenil)-2-(terc.-butilaimno)etanol kot antiholinergike: ipratropijev bromid oksitropijev bromid trospijev klorid Ν-β-fluoretilnortropinestermetobromid benzilne kisline kot steroide: budezonid bekometazon (oz. 17,21-dipropionat) deksametazon-21-izonikotinat flunizolid kot antialergike: dinatrijev kromoglikat nedokromil 3 kot PAF-antagoniste: WEB 2086, WEB 2170 WEB 2347.
7. Farmacevtski pripravek po zahtevku 5, označen s tem, da kombinacija aktivnih snovi obsega enega od betamimetikov, definiranih v zahtevku 6, in enega od antiholinergikov, definiranih v zahtevku 6.
8. Farmacevtski pripravek po zahtevku 5, označen s tem, da kombinacija učinkovin obsega enega od betamimetikov, definiranih v zahtevku 6, in dinatrijev kromoglikat.
9. Farmacevtski pripravek po zahtevku 5, označen s tem, da kombinacija učinkovin obsega enega od betamimetikov, definiranih v zahtevku 6, in enega od PAF-antagonistov, definiranih v zahtevku 6.
10. Farmacevtski pripravek po zahtevku 5, označen s tem, da kombinacija učinkovin obsega dinatrijev kromoglikat in enega od PAF-antagonistov, definiranih v zahtevku 6.
11. Postopek za pripravo farmacevtskega pripravka po kateremkoli od zahtevkov 1 do 10, označen s tem, da po običajnih metodah suspendiramo mikronizirane farmacevtske učinkovine, po izbiri ob dodatku površinsko aktivnih snovi, v zmesi utekočinjenega poganjalnega plina, kot je definirana v kateremkoli od zahtevkov 1 do 4. Za
BOEHRINGERINGELHEIM KG: PATENTNA PISARNA, «λα LJUBLJANA, ČOPOVA 14
SI9110155A 1990-02-03 1991-01-30 Novi poganjalni plini in njihova uporaba v pripravkih zdravil SI9110155B (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4003270A DE4003270A1 (de) 1990-02-03 1990-02-03 Neue treibgase und ihre verwendung in arzneimittelzubereitungen
YU15591A YU48509B (sh) 1990-02-03 1991-01-30 Suspenzije u kondenzovanim potisnim gasovima

Publications (2)

Publication Number Publication Date
SI9110155A SI9110155A (sl) 1998-04-30
SI9110155B true SI9110155B (sl) 1999-06-30

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SI9110155A SI9110155B (sl) 1990-02-03 1991-01-30 Novi poganjalni plini in njihova uporaba v pripravkih zdravil

Country Status (26)

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US (7) US6419899B1 (sl)
EP (1) EP0513099B1 (sl)
JP (1) JP3497162B2 (sl)
KR (1) KR920703034A (sl)
AT (1) ATE185587T1 (sl)
AU (1) AU656129B2 (sl)
CA (1) CA2075060C (sl)
CZ (1) CZ285209B6 (sl)
DE (2) DE4003270A1 (sl)
DK (1) DK0513099T3 (sl)
ES (1) ES2139574T3 (sl)
FI (1) FI103348B1 (sl)
GR (1) GR3032176T3 (sl)
HK (1) HK1010737A1 (sl)
HR (1) HRP940737B1 (sl)
HU (1) HU218664B (sl)
IL (1) IL97024A0 (sl)
NO (1) NO302420B1 (sl)
NZ (1) NZ236974A (sl)
PT (1) PT96635B (sl)
RU (1) RU2118170C1 (sl)
SI (1) SI9110155B (sl)
SK (1) SK281440B6 (sl)
WO (1) WO1991011496A1 (sl)
YU (1) YU48509B (sl)
ZA (1) ZA91756B (sl)

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Also Published As

Publication number Publication date
AU7211691A (en) 1991-08-21
EP0513099B1 (de) 1999-10-13
SI9110155A (sl) 1998-04-30
NO923040D0 (no) 1992-07-31
US20020071812A1 (en) 2002-06-13
YU15591A (sh) 1994-01-20
KR920703034A (ko) 1992-12-17
JPH05504350A (ja) 1993-07-08
ES2139574T3 (es) 2000-02-16
CS9100265A2 (en) 1991-09-15
FI923491A (fi) 1992-08-03
FI923491A0 (fi) 1992-08-03
HRP940737B1 (en) 2000-10-31
YU48509B (sh) 1998-09-18
US6419899B1 (en) 2002-07-16
FI103348B (fi) 1999-06-15
HU218664B (hu) 2000-10-28
CZ285209B6 (cs) 1999-06-16
DE4003270A1 (de) 1991-08-08
US20040028618A1 (en) 2004-02-12
PT96635B (pt) 1998-07-31
NO302420B1 (no) 1998-03-02
HUT62455A (en) 1993-05-28
SK281440B6 (sk) 2001-03-12
NZ236974A (en) 1993-07-27
WO1991011496A1 (de) 1991-08-08
HU9202508D0 (en) 1992-10-28
AU656129B2 (en) 1995-01-27
IL97024A0 (en) 1992-03-29
EP0513099A1 (de) 1992-11-19
RU2118170C1 (ru) 1998-08-27
JP3497162B2 (ja) 2004-02-16
US20070065370A1 (en) 2007-03-22
FI103348B1 (fi) 1999-06-15
CA2075060C (en) 2001-01-02
US20050031548A1 (en) 2005-02-10
HK1010737A1 (en) 1999-06-25
GR3032176T3 (en) 2000-04-27
DK0513099T3 (da) 2000-04-10
NO923040L (no) 1992-07-31
US20110014134A1 (en) 2011-01-20
DE59109161D1 (de) 1999-11-18
ZA91756B (en) 1992-10-28
US7160538B2 (en) 2007-01-09
ATE185587T1 (de) 1999-10-15
CA2075060A1 (en) 1991-08-04
HRP940737A2 (en) 1997-06-30
PT96635A (pt) 1991-10-31
US20090104127A1 (en) 2009-04-23

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