JPH05504350A - 新規噴射ガス及び医薬製剤におけるそれらの使用 - Google Patents
新規噴射ガス及び医薬製剤におけるそれらの使用Info
- Publication number
- JPH05504350A JPH05504350A JP3503687A JP50368791A JPH05504350A JP H05504350 A JPH05504350 A JP H05504350A JP 3503687 A JP3503687 A JP 3503687A JP 50368791 A JP50368791 A JP 50368791A JP H05504350 A JPH05504350 A JP H05504350A
- Authority
- JP
- Japan
- Prior art keywords
- specified
- agonists
- propellant gas
- active ingredients
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K3/00—Materials not provided for elsewhere
- C09K3/30—Materials not provided for elsewhere for aerosols
Abstract
Description
Claims (11)
- 1.TG227を所望によりTG11、TG12、TG114、プロパン、ブタ ン、ペンタン及びDMEを含む群から選ばれる一つ又はそれ以上の噴射ガスとの 混合物として含むことを特徴とする噴射ガス。
- 2.少なくとも一つの界面活性剤を追加的に含むことを特徴とする、請求項1に 記載の噴射ガス。
- 3.界面活性剤がリン脂質、高級飽和又は不飽和脂肪酸のソルビタンエステル、 又は高級、好ましくは不飽和脂肪酸のポリエトキシソルビタンエステルであるこ とを特徴とする、請求項2に記載の噴射ガス。
- 4.界面活性剤がレシチン、オレイン酸ポリエトキシエチレンソルビタン又はト リオレイン酸ソルビタンであることを特徴とする、請求項2に記載の噴射ガス。
- 5.有効成分としてβ作用薬、抗コリン作用薬、ステロイド、抗アレルギ−薬又 はPAFアンタゴニスト、又はそのような化合物の組合せを含むことを特徴とす る、請求項1、2、3又は4のいずれか1項に記載の噴射ガスをベースとした粉 末エーロゾル製造用の医薬製剤。
- 6.使用されるβ作用薬がバンブテロール、ビトルテロール、ピルブテロール、 クレンブテロール、フェノテロール、ヘキソプレナリン、イブテロール、ピルブ テロール、プロカテロール、レブロテロール、サルブタモール、サルメテロール 、スルホンテロール、テルブタリン、ツロブテロール、1−(2−フルオロ−4 −ヒドロキシフェニル)−2−[4−(1−ベンゾイミダゾリル)−2−メチル −2−ブチルアミノ]エタノール、エリスロ−5′−ヒドロキシ−8′−(1− ヒドロキシ−2−イソプロピルアミノブチル)−2H−1,4−ベンゾオキサジ ン−3−(4H)−オン、1−(4−アミノ−3−クロロ−5−トリフルオロメ チルフェニル)−2−tert.−ブチルアミノ)エタノール、1−(4−エト キシカルボニルアミノ−3−シアノ−5−フルオロフェニル)−2−(tert .−ブチルアミノ)エタノールであり、使用される抗コリン作用薬が臭化イプラ トロピウム、臭化オキシトロピウム、塩化トロスピウム、ベンジル酸−N−β− フルオロエチルノルトロピンエステル、メトブロミドであり、使用されるステロ イドがプデソニド、ベクロメタゾン(又はその17,21−ジプロピオネート) 、デキサメタゾン−21−イソニコチネート、フルニソリドであり、抗アレルギ −薬がクロモグリク酸ニナトリウム、ネドクロミルであり、PAFアンタゴニス トかWEB2086、WEB2170、WEB2347であることを特徴とする 、請求項5に記載の医薬製剤。
- 7.有効成分の組合せが、請求項6に明記されたβ作用薬の一つ及び請求項6に 明記された抗コリン作用薬の一つを含むことを特徴とする、請求項5に記載の医 薬製剤。
- 8.有効成分の組み合わせが、請求項6に明記されたβ作用薬の一つ及びクロモ グリク酸ニナトリウムを含むことを特徴とする、請求項5に記載の医薬製剤。
- 9.有効成分の組合せが、請求項6に明記されたβ作用薬の一つ及び請求項6に 明記されたPAFアンタゴニストの一つを含むことを特徴とする、請求項5に記 載の医薬製剤。
- 10.有効成分の組合せが、クロモグリク酸ニナトリウム及び請求項6に明記さ れたPAFアンタゴニストの一つを含むことを特徴とする、請求項5に記載の医 薬製剤。
- 11.慣用の方法により医薬的に超微粉化された有効成分が、請求項1、2、3 又は4のいずれか1項に記載の液化噴射ガス混合物に、所望により界面活性剤を 添加して懸濁されることを特徴とする、請求項5〜10のいずれか1項に記載の 医薬製剤の製造方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4003270A DE4003270A1 (de) | 1990-02-03 | 1990-02-03 | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
DE4003270.1 | 1990-02-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH05504350A true JPH05504350A (ja) | 1993-07-08 |
JP3497162B2 JP3497162B2 (ja) | 2004-02-16 |
Family
ID=6399399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50368791A Expired - Lifetime JP3497162B2 (ja) | 1990-02-03 | 1991-01-31 | 新規噴射ガス及び医薬製剤におけるそれらの使用 |
Country Status (26)
Country | Link |
---|---|
US (7) | US6419899B1 (ja) |
EP (1) | EP0513099B1 (ja) |
JP (1) | JP3497162B2 (ja) |
KR (1) | KR920703034A (ja) |
AT (1) | ATE185587T1 (ja) |
AU (1) | AU656129B2 (ja) |
CA (1) | CA2075060C (ja) |
CZ (1) | CZ285209B6 (ja) |
DE (2) | DE4003270A1 (ja) |
DK (1) | DK0513099T3 (ja) |
ES (1) | ES2139574T3 (ja) |
FI (1) | FI103348B1 (ja) |
GR (1) | GR3032176T3 (ja) |
HK (1) | HK1010737A1 (ja) |
HR (1) | HRP940737B1 (ja) |
HU (1) | HU218664B (ja) |
IL (1) | IL97024A0 (ja) |
NO (1) | NO302420B1 (ja) |
NZ (1) | NZ236974A (ja) |
PT (1) | PT96635B (ja) |
RU (1) | RU2118170C1 (ja) |
SI (1) | SI9110155B (ja) |
SK (1) | SK281440B6 (ja) |
WO (1) | WO1991011496A1 (ja) |
YU (1) | YU48509B (ja) |
ZA (1) | ZA91756B (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004515528A (ja) * | 2000-12-15 | 2004-05-27 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 抗コリン作用薬及びシクレソニドをベースとする新規薬剤組成物 |
JP2005502608A (ja) * | 2001-06-23 | 2005-01-27 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 抗コリン作用剤とコルチコステロイドとβ刺激剤を含む新規な医薬組成物 |
JP2006514679A (ja) * | 2003-03-19 | 2006-05-11 | アドバンスト インハレーション リサーチ,インコーポレイテッド | トロスピウム含有組成物 |
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DE4003270A1 (de) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
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US5744123A (en) * | 1991-12-12 | 1998-04-28 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
US5674471A (en) * | 1991-12-12 | 1997-10-07 | Glaxo Group Limited | Aerosol formulations containing P134a and salbutamol |
JP3280974B2 (ja) * | 1991-12-12 | 2002-05-13 | グラクソ、グループ、リミテッド | 医 薬 |
CA2125666C (en) | 1991-12-12 | 2002-07-16 | Rachel Ann Akehurst | Medicaments |
US5916540A (en) | 1994-10-24 | 1999-06-29 | Glaxo Group Limited | Aerosol formulations containing P134A and/or P227 and particulate medicament |
US5683676A (en) * | 1991-12-12 | 1997-11-04 | Glaxo Group Limited | Canister containing aerosol formulations containing P134a and particulate medicaments |
US7105152B1 (en) | 1991-12-18 | 2006-09-12 | 3M Innovative Properties Company | Suspension aerosol formulations |
US7101534B1 (en) | 1991-12-18 | 2006-09-05 | 3M Innovative Properties Company | Suspension aerosol formulations |
NZ246421A (en) | 1991-12-18 | 1996-05-28 | Minnesota Mining & Mfg | Aerosol formulation containing a drug and a propellant and which is substantially free of surfactant |
US20030103907A1 (en) * | 1991-12-18 | 2003-06-05 | Schultz Robert K. | Suspension aerosol formulations |
AU3936293A (en) * | 1992-03-26 | 1993-10-21 | Great Lakes Chemical Corporation | Azeotrope-like compositions of 1,1,1,2,3,3,3-heptafluoropropane and 1,1-difluoroethane |
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JP5209963B2 (ja) * | 2004-07-02 | 2013-06-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 噴霧剤としてtg227ea又はtg134aを含有するエアロゾル懸濁製剤 |
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-
1990
- 1990-02-03 DE DE4003270A patent/DE4003270A1/de not_active Withdrawn
-
1991
- 1991-01-24 IL IL97024A patent/IL97024A0/xx not_active IP Right Cessation
- 1991-01-30 YU YU15591A patent/YU48509B/sh unknown
- 1991-01-30 SI SI9110155A patent/SI9110155B/sl unknown
- 1991-01-31 AU AU72116/91A patent/AU656129B2/en not_active Expired
- 1991-01-31 WO PCT/EP1991/000178 patent/WO1991011496A1/de not_active Application Discontinuation
- 1991-01-31 CA CA002075060A patent/CA2075060C/en not_active Expired - Lifetime
- 1991-01-31 RU SU5052884A patent/RU2118170C1/ru active
- 1991-01-31 DK DK91903267T patent/DK0513099T3/da active
- 1991-01-31 ES ES91903267T patent/ES2139574T3/es not_active Expired - Lifetime
- 1991-01-31 DE DE59109161T patent/DE59109161D1/de not_active Revoked
- 1991-01-31 HU HU9202508A patent/HU218664B/hu unknown
- 1991-01-31 EP EP91903267A patent/EP0513099B1/de not_active Revoked
- 1991-01-31 AT AT91903267T patent/ATE185587T1/de not_active IP Right Cessation
- 1991-01-31 NZ NZ236974A patent/NZ236974A/en unknown
- 1991-01-31 JP JP50368791A patent/JP3497162B2/ja not_active Expired - Lifetime
- 1991-01-31 KR KR1019920701826A patent/KR920703034A/ko not_active Application Discontinuation
- 1991-02-01 PT PT96635A patent/PT96635B/pt not_active IP Right Cessation
- 1991-02-01 ZA ZA91756A patent/ZA91756B/xx unknown
- 1991-02-04 SK SK265-91A patent/SK281440B6/sk not_active IP Right Cessation
- 1991-02-04 CZ CS91265A patent/CZ285209B6/cs not_active IP Right Cessation
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1992
- 1992-07-31 NO NO923040A patent/NO302420B1/no not_active IP Right Cessation
- 1992-08-03 FI FI923491A patent/FI103348B1/fi active
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1994
- 1994-10-24 HR HR940737A patent/HRP940737B1/xx not_active IP Right Cessation
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1998
- 1998-10-21 HK HK98111443A patent/HK1010737A1/xx not_active IP Right Cessation
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1999
- 1999-12-17 GR GR990403262T patent/GR3032176T3/el unknown
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2000
- 2000-03-14 US US09/525,431 patent/US6419899B1/en not_active Expired - Fee Related
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2002
- 2002-02-06 US US10/072,400 patent/US20020071812A1/en not_active Abandoned
-
2003
- 2003-08-12 US US10/638,987 patent/US20040028618A1/en not_active Abandoned
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2004
- 2004-09-03 US US10/934,611 patent/US7160538B2/en not_active Expired - Lifetime
-
2006
- 2006-10-27 US US11/553,508 patent/US20070065370A1/en not_active Abandoned
-
2008
- 2008-07-25 US US12/179,785 patent/US20090104127A1/en not_active Abandoned
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2010
- 2010-09-27 US US12/891,076 patent/US20110014134A1/en not_active Abandoned
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004515528A (ja) * | 2000-12-15 | 2004-05-27 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 抗コリン作用薬及びシクレソニドをベースとする新規薬剤組成物 |
JP2005502608A (ja) * | 2001-06-23 | 2005-01-27 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 抗コリン作用剤とコルチコステロイドとβ刺激剤を含む新規な医薬組成物 |
JP2006514679A (ja) * | 2003-03-19 | 2006-05-11 | アドバンスト インハレーション リサーチ,インコーポレイテッド | トロスピウム含有組成物 |
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