SI3532459T1 - Zaviralci LSD1 in njihove medicinske uporabe - Google Patents

Zaviralci LSD1 in njihove medicinske uporabe

Info

Publication number
SI3532459T1
SI3532459T1 SI201731432T SI201731432T SI3532459T1 SI 3532459 T1 SI3532459 T1 SI 3532459T1 SI 201731432 T SI201731432 T SI 201731432T SI 201731432 T SI201731432 T SI 201731432T SI 3532459 T1 SI3532459 T1 SI 3532459T1
Authority
SI
Slovenia
Prior art keywords
medical uses
lsd1 inhibitors
lsd1
inhibitors
medical
Prior art date
Application number
SI201731432T
Other languages
English (en)
Inventor
Francois Brucelle
Victor S. Gehling
Avinash Khanna
Original Assignee
Constellation Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals, Inc. filed Critical Constellation Pharmaceuticals, Inc.
Publication of SI3532459T1 publication Critical patent/SI3532459T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI201731432T 2016-10-26 2017-10-26 Zaviralci LSD1 in njihove medicinske uporabe SI3532459T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662413166P 2016-10-26 2016-10-26
US201662413162P 2016-10-26 2016-10-26
PCT/US2017/058405 WO2018081343A1 (en) 2016-10-26 2017-10-26 Lsd1 inhibitors and medical uses thereof
EP17797805.3A EP3532459B1 (en) 2016-10-26 2017-10-26 Lsd1 inhibitors and medical uses thereof

Publications (1)

Publication Number Publication Date
SI3532459T1 true SI3532459T1 (sl) 2024-03-29

Family

ID=60320993

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201731432T SI3532459T1 (sl) 2016-10-26 2017-10-26 Zaviralci LSD1 in njihove medicinske uporabe

Country Status (19)

Country Link
US (3) US10517849B2 (sl)
EP (1) EP3532459B1 (sl)
JP (1) JP7142633B2 (sl)
CN (1) CN109863137B (sl)
AU (1) AU2017348100B2 (sl)
CA (1) CA3039793A1 (sl)
DK (1) DK3532459T3 (sl)
ES (1) ES2961499T3 (sl)
FI (1) FI3532459T3 (sl)
HR (1) HRP20231369T1 (sl)
HU (1) HUE063848T2 (sl)
LT (1) LT3532459T (sl)
MD (1) MD3532459T2 (sl)
PL (1) PL3532459T3 (sl)
PT (1) PT3532459T (sl)
RS (1) RS64889B1 (sl)
SI (1) SI3532459T1 (sl)
TW (1) TWI753037B (sl)
WO (1) WO2018081343A1 (sl)

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FI3532459T3 (fi) 2016-10-26 2023-10-23 Constellation Pharmaceuticals Inc Lsd1-estäjiä ja niiden lääkinnällisiä käyttöjä
SG11202000077RA (en) 2017-08-03 2020-02-27 Oryzon Genomics Sa Methods of treating behavior alterations
WO2020052649A1 (zh) * 2018-09-13 2020-03-19 南京明德新药研发有限公司 作为lsd1抑制剂的环丙胺类化合物及其应用
WO2020188089A1 (en) 2019-03-20 2020-09-24 Oryzon Genomics, S.A. Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat
AU2020242302A1 (en) 2019-03-20 2021-09-16 Oryzon Genomics, S.A. Methods of treating borderline personality disorder
EP3994280A1 (en) 2019-07-05 2022-05-11 Oryzon Genomics, S.A. Biomarkers and methods for personalized treatment of small cell lung cancer using kdm1a inhibitors
MX2023011779A (es) 2021-04-08 2023-11-22 Oryzon Genomics Sa Combinaciones de inhibidores de lsd1 para el tratamiento de canceres mieloides.
WO2023217758A1 (en) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors
WO2023217784A1 (en) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Methods of treating nf1-mutant tumors using lsd1 inhibitors
WO2024110649A1 (en) 2022-11-24 2024-05-30 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors and menin inhibitors for treating cancer

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US20190274998A1 (en) 2019-09-12
CN109863137A (zh) 2019-06-07
JP2019537584A (ja) 2019-12-26
FI3532459T3 (fi) 2023-10-23
JP7142633B2 (ja) 2022-09-27
US11013718B2 (en) 2021-05-25
CN109863137B (zh) 2022-12-16
AU2017348100B2 (en) 2021-08-26
AU2017348100A1 (en) 2019-05-02
RS64889B1 (sr) 2023-12-29
US20220079917A1 (en) 2022-03-17
CA3039793A1 (en) 2018-05-03
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US20200306223A1 (en) 2020-10-01
US10517849B2 (en) 2019-12-31
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EP3532459A1 (en) 2019-09-04
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