SI3216459T1 - Farmacevtski sestavki za zdravljenje metabolnega sindroma - Google Patents
Farmacevtski sestavki za zdravljenje metabolnega sindromaInfo
- Publication number
- SI3216459T1 SI3216459T1 SI201131638T SI201131638T SI3216459T1 SI 3216459 T1 SI3216459 T1 SI 3216459T1 SI 201131638 T SI201131638 T SI 201131638T SI 201131638 T SI201131638 T SI 201131638T SI 3216459 T1 SI3216459 T1 SI 3216459T1
- Authority
- SI
- Slovenia
- Prior art keywords
- treating
- pharmaceutical composition
- metabolic syndrome
- metabolic
- syndrome
- Prior art date
Links
- 208000001145 Metabolic Syndrome Diseases 0.000 title 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10305070A EP2359843A1 (en) | 2010-01-21 | 2010-01-21 | Pharmaceutical composition for treating a metabolic syndrome |
| EP16205881.2A EP3216459B1 (en) | 2010-01-21 | 2011-01-21 | Pharmaceutical composition for treating a metabolic syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3216459T1 true SI3216459T1 (sl) | 2019-02-28 |
Family
ID=41718306
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201131638T SI3216459T1 (sl) | 2010-01-21 | 2011-01-21 | Farmacevtski sestavki za zdravljenje metabolnega sindroma |
| SI201130355T SI2525807T1 (sl) | 2010-01-21 | 2011-01-21 | Farmacevtski sestavek za zdravljenje metaboličnega sindroma |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201130355T SI2525807T1 (sl) | 2010-01-21 | 2011-01-21 | Farmacevtski sestavek za zdravljenje metaboličnega sindroma |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US20130203651A1 (sl) |
| EP (7) | EP2359843A1 (sl) |
| JP (3) | JP5925130B2 (sl) |
| KR (2) | KR20120123445A (sl) |
| CN (1) | CN102753192B (sl) |
| AR (1) | AR079939A1 (sl) |
| AU (2) | AU2011208650B2 (sl) |
| BR (1) | BR112012017949A2 (sl) |
| CA (1) | CA2787131A1 (sl) |
| CL (1) | CL2012002031A1 (sl) |
| CO (1) | CO6592082A2 (sl) |
| CY (2) | CY1116026T1 (sl) |
| DK (2) | DK3216459T3 (sl) |
| ES (3) | ES2703581T3 (sl) |
| HK (2) | HK1173073A1 (sl) |
| HR (2) | HRP20150029T1 (sl) |
| HU (1) | HUE041442T2 (sl) |
| IL (2) | IL220862A0 (sl) |
| LT (1) | LT3216459T (sl) |
| MA (1) | MA33931B1 (sl) |
| MX (2) | MX336751B (sl) |
| NZ (1) | NZ601306A (sl) |
| PL (2) | PL3216459T3 (sl) |
| PT (2) | PT2525807E (sl) |
| RS (1) | RS53742B1 (sl) |
| RU (2) | RU2593960C2 (sl) |
| SG (2) | SG182652A1 (sl) |
| SI (2) | SI3216459T1 (sl) |
| TR (1) | TR201820147T4 (sl) |
| TW (2) | TWI561241B (sl) |
| UY (1) | UY33194A (sl) |
| WO (1) | WO2011089203A1 (sl) |
| ZA (1) | ZA201204996B (sl) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2349324T3 (en) | 2008-10-17 | 2017-12-11 | Sanofi Aventis Deutschland | COMBINATION OF AN INSULIN AND A GLP-1 AGONIST |
| KR101836070B1 (ko) | 2009-11-13 | 2018-03-09 | 사노피-아벤티스 도이칠란트 게엠베하 | Ｇｌｐ－１ 작용제, 인슐린 및 메티오닌을 포함하는 약제학적 조성물 |
| JP5973918B2 (ja) | 2009-11-13 | 2016-08-23 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Ｇｌｐ−１アゴニスト及びメチオニンを含む薬学的組成物 |
| PT2611458T (pt) | 2010-08-30 | 2016-12-16 | Sanofi Aventis Deutschland | Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| US8951966B2 (en) | 2011-07-01 | 2015-02-10 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases |
| EP2548570A1 (en) * | 2011-07-19 | 2013-01-23 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| US9458214B2 (en) * | 2011-09-26 | 2016-10-04 | Novartis Ag | Dual function fibroblast growth factor 21 proteins |
| KR20150043505A (ko) * | 2012-09-07 | 2015-04-22 | 사노피 | 대사 증후군의 치료용 융합 단백질 |
| ES2828505T3 (es) | 2012-11-28 | 2021-05-26 | Ngm Biopharmaceuticals Inc | Composiciones y métodos para el tratamiento de trastornos y enfermedades metabólicos |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| IL292303A (en) | 2012-12-27 | 2022-06-01 | Ngm Biopharmaceuticals Inc | Methods of regulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| EP3062881B1 (en) | 2013-10-28 | 2019-10-02 | NGM Biopharmaceuticals, Inc. | Cancer models and associated methods |
| JP6837840B2 (ja) | 2014-01-24 | 2021-03-10 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 結合タンパク質及びその使用方法 |
| WO2015121457A1 (en) * | 2014-02-13 | 2015-08-20 | Westphal Sören | Fgf-8 for use in treating diseases or disorders of energy homeostasis |
| US20170065678A1 (en) | 2014-03-11 | 2017-03-09 | Novartis Ag | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
| PL3139948T3 (pl) * | 2014-05-07 | 2020-08-10 | Novo Nordisk A/S | Leczenie cukrzycy z zastosowaniem glp-1 i anty-il-21 |
| US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
| EP3155005A4 (en) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| CN104383523A (zh) * | 2014-10-22 | 2015-03-04 | 山西医科大学 | Cjc-1131降糖药物在治疗阿尔茨海默病的用途 |
| US10517929B2 (en) | 2014-10-23 | 2019-12-31 | Ngm Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising FGF19 variants |
| WO2016073855A1 (en) | 2014-11-07 | 2016-05-12 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| CN107206058A (zh) | 2014-12-12 | 2017-09-26 | 赛诺菲-安万特德国有限公司 | 甘精胰岛素/利西拉来固定比率配制剂 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| JP6728352B2 (ja) | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
| US11370841B2 (en) | 2016-08-26 | 2022-06-28 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| WO2018115401A1 (en) * | 2016-12-22 | 2018-06-28 | Sanofi | Fgf21 compound / glp-1r agonist combinations with optimized activity ratio |
| JP2018110304A (ja) | 2016-12-28 | 2018-07-12 | パナソニックＩｐマネジメント株式会社 | 監視システム、監視方法、及びプログラム |
| CN108570109B (zh) * | 2017-03-14 | 2022-04-26 | 广东东阳光药业有限公司 | 包含免疫球蛋白Fc部分的双靶点融合蛋白 |
| CA3089657A1 (en) * | 2018-01-31 | 2019-08-08 | Sanofi | Modified lipidated relaxin b chain peptides and their therapeutic use |
| WO2019154189A1 (en) | 2018-02-08 | 2019-08-15 | Sunshine Lake Pharma Co., Ltd. | Fgf21 variant, fusion protein and application thereof |
| EP3810183A1 (en) * | 2018-06-21 | 2021-04-28 | Sanofi | Fgf21 compound / glp-1r agonist combinations with optimized activity ratio |
| CN115322794A (zh) | 2020-01-11 | 2022-11-11 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
| KR20210149366A (ko) * | 2020-06-02 | 2021-12-09 | 주식회사 고바이오랩 | Icam-2에 결합하는 물질을 유효성분으로 포함하는 대사질환 예방 또는 치료용 약학 조성물 |
| US12054551B2 (en) | 2020-07-02 | 2024-08-06 | Sanofi | FGFR1/KLB targeting agonistic antigen-binding proteins and conjugates thereof with GLP-1R agonistic peptides |
| WO2022144021A1 (zh) * | 2021-01-04 | 2022-07-07 | 华领医药技术（上海）有限公司 | Dorzagliatin和胰高血糖素样肽-1类似物的药物组合物 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK347086D0 (da) | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| EP0280534B1 (en) | 1987-02-25 | 1993-04-21 | Novo Nordisk A/S | Novel insulin derivatives |
| US6011007A (en) | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
| KR100310122B1 (ko) | 1993-09-17 | 2002-04-24 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 아실화된인슐린 |
| UA65549C2 (uk) * | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| JP2002112772A (ja) * | 2000-07-10 | 2002-04-16 | Takeda Chem Ind Ltd | 新規ポリペプチドおよびそのｄｎａ |
| US6689385B2 (en) * | 2000-11-03 | 2004-02-10 | Chronorx Llc | Formulations for the treatment of insulin resistance and type 2 diabetes mellitus |
| AU2002322394A1 (en) | 2001-07-30 | 2003-02-17 | Eli Lilly And Company | Method for treating diabetes and obesity |
| AR036711A1 (es) | 2001-10-05 | 2004-09-29 | Bayer Corp | Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico |
| AU2003273300A1 (en) * | 2002-09-06 | 2004-03-29 | Bayer Pharmaceuticals Corporation | Modified glp-1 receptor agonists and their pharmacological methods of use |
| MXPA05013564A (es) | 2003-06-12 | 2006-03-09 | Lilly Co Eli | Proteinas de fusion. |
| KR20060135648A (ko) | 2003-12-10 | 2006-12-29 | 일라이 릴리 앤드 캄파니 | 섬유모세포 성장인자 21의 뮤테인 |
| EP1727559A1 (en) | 2004-01-26 | 2006-12-06 | Eli Lilly And Company | Use of fgf-21 and a thiazolidinedione for treating type 2 diabetes |
| WO2005091944A2 (en) | 2004-03-17 | 2005-10-06 | Eli Lilly And Company | Glycol linked fgf-21 compounds |
| WO2005113606A2 (en) | 2004-05-13 | 2005-12-01 | Eli Lilly And Company | Fgf-21 fusion proteins |
| US7622445B2 (en) | 2004-09-02 | 2009-11-24 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| KR100854198B1 (ko) | 2004-09-02 | 2008-08-26 | 일라이 릴리 앤드 캄파니 | 섬유아세포 성장 인자 21의 뮤테인 |
| JP5948627B2 (ja) | 2004-10-29 | 2016-07-20 | レイショファーム ゲーエムベーハー | 線維芽細胞成長因子（ｆｇｆ）のリモデリングと糖質ペグ化 |
| WO2006065582A2 (en) | 2004-12-14 | 2006-06-22 | Eli Lilly And Company | Muteins of fibroblast growth factor 21 |
| EP2068910A2 (en) * | 2006-08-04 | 2009-06-17 | Amylin Pharmaceuticals, Inc. | Use of exendins and exendin agonists and glp-1 receptor agonists for altering lipoprotein particle size and subclass composition |
| AR064623A1 (es) * | 2006-12-21 | 2009-04-15 | Centocor Inc | Uso de agonistas del receptor de glp -1 de accion prolongada para mejorar la sensibilidad a la insulina y los perfiles lipidicos |
| CN104163864B (zh) * | 2007-03-30 | 2017-08-01 | Ambrx公司 | 经修饰fgf‑21多肽和其用途 |
| JP2010535781A (ja) * | 2007-08-03 | 2010-11-25 | イーライ リリー アンド カンパニー | 肥満に対する処置 |
| GB0716385D0 (en) * | 2007-08-22 | 2007-10-03 | Camurus Ab | Formulations |
| US20100286067A1 (en) | 2008-01-08 | 2010-11-11 | Biogenerix Ag | Glycoconjugation of polypeptides using oligosaccharyltransferases |
| WO2010006214A1 (en) * | 2008-07-09 | 2010-01-14 | Ambrx, Inc. | Fgf-21 neutralizing antibodies and their uses |
| MX2011011815A (es) * | 2009-05-05 | 2012-01-27 | Amgen Inc | Mutantes fgf21 y usos de los mismos. |
| JP2012529463A (ja) * | 2009-06-11 | 2012-11-22 | ノヴォ ノルディスク アー／エス | ２型糖尿病を治療するための、ｇｌｐ−１とｆｇｆ２１との組合せ |
| EP2548570A1 (en) * | 2011-07-19 | 2013-01-23 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
-
2010
- 2010-01-21 EP EP10305070A patent/EP2359843A1/en not_active Withdrawn
- 2010-01-21 EP EP11174543A patent/EP2460527A1/en not_active Withdrawn
-
2011
- 2011-01-19 TW TW100101879A patent/TWI561241B/zh active
- 2011-01-19 TW TW105119851A patent/TWI623320B/zh active
- 2011-01-19 AR ARP110100174A patent/AR079939A1/es unknown
- 2011-01-19 UY UY0001033194A patent/UY33194A/es not_active Application Discontinuation
- 2011-01-21 TR TR2018/20147T patent/TR201820147T4/tr unknown
- 2011-01-21 SG SG2012054045A patent/SG182652A1/en unknown
- 2011-01-21 WO PCT/EP2011/050793 patent/WO2011089203A1/en active Application Filing
- 2011-01-21 MA MA35075A patent/MA33931B1/fr unknown
- 2011-01-21 JP JP2012549361A patent/JP5925130B2/ja not_active Expired - Fee Related
- 2011-01-21 EP EP18162214.3A patent/EP3357503B1/en active Active
- 2011-01-21 HU HUE16205881A patent/HUE041442T2/hu unknown
- 2011-01-21 CN CN201180006759.5A patent/CN102753192B/zh not_active Expired - Fee Related
- 2011-01-21 PL PL16205881T patent/PL3216459T3/pl unknown
- 2011-01-21 SI SI201131638T patent/SI3216459T1/sl unknown
- 2011-01-21 ES ES16205881T patent/ES2703581T3/es active Active
- 2011-01-21 NZ NZ601306A patent/NZ601306A/xx not_active IP Right Cessation
- 2011-01-21 RU RU2012135686/15A patent/RU2593960C2/ru not_active IP Right Cessation
- 2011-01-21 ES ES11700669.2T patent/ES2529612T3/es active Active
- 2011-01-21 CA CA2787131A patent/CA2787131A1/en not_active Abandoned
- 2011-01-21 MX MX2012008092A patent/MX336751B/es unknown
- 2011-01-21 BR BR112012017949A patent/BR112012017949A2/pt not_active Application Discontinuation
- 2011-01-21 RS RS20150004A patent/RS53742B1/en unknown
- 2011-01-21 EP EP11700669.2A patent/EP2525807B1/en active Active
- 2011-01-21 KR KR1020127021708A patent/KR20120123445A/ko active Search and Examination
- 2011-01-21 DK DK16205881.2T patent/DK3216459T3/en active
- 2011-01-21 LT LTEP16205881.2T patent/LT3216459T/lt unknown
- 2011-01-21 RU RU2016124562A patent/RU2732703C2/ru active
- 2011-01-21 US US13/521,275 patent/US20130203651A1/en not_active Abandoned
- 2011-01-21 DK DK11700669.2T patent/DK2525807T3/en active
- 2011-01-21 PT PT117006692T patent/PT2525807E/pt unknown
- 2011-01-21 EP EP20140163127 patent/EP2754449A1/en not_active Withdrawn
- 2011-01-21 AU AU2011208650A patent/AU2011208650B2/en not_active Ceased
- 2011-01-21 EP EP19195239.9A patent/EP3607964B1/en active Active
- 2011-01-21 KR KR1020187012112A patent/KR20180049194A/ko not_active Application Discontinuation
- 2011-01-21 ES ES19195239T patent/ES2930750T3/es active Active
- 2011-01-21 MX MX2015007689A patent/MX361922B/es unknown
- 2011-01-21 EP EP16205881.2A patent/EP3216459B1/en active Active
- 2011-01-21 SG SG10201500465XA patent/SG10201500465XA/en unknown
- 2011-01-21 PL PL11700669T patent/PL2525807T3/pl unknown
- 2011-01-21 PT PT16205881T patent/PT3216459T/pt unknown
- 2011-01-21 SI SI201130355T patent/SI2525807T1/sl unknown
-
2012
- 2012-07-04 ZA ZA2012/04996A patent/ZA201204996B/en unknown
- 2012-07-10 IL IL220862A patent/IL220862A0/en unknown
- 2012-07-20 CL CL2012002031A patent/CL2012002031A1/es unknown
- 2012-08-15 CO CO12138126A patent/CO6592082A2/es not_active Application Discontinuation
-
2013
- 2013-01-08 HK HK13100270.6A patent/HK1173073A1/xx not_active IP Right Cessation
-
2015
- 2015-01-12 HR HRP20150029AT patent/HRP20150029T1/hr unknown
- 2015-02-12 CY CY20151100146T patent/CY1116026T1/el unknown
- 2015-02-20 US US14/628,037 patent/US20150231210A1/en not_active Abandoned
-
2016
- 2016-01-29 JP JP2016015359A patent/JP6521880B2/ja active Active
- 2016-03-02 US US15/059,001 patent/US20160279199A1/en not_active Abandoned
- 2016-10-11 AU AU2016244202A patent/AU2016244202B2/en not_active Ceased
-
2018
- 2018-01-11 US US15/868,688 patent/US20180236033A1/en not_active Abandoned
- 2018-02-09 JP JP2018021608A patent/JP2018095659A/ja active Pending
- 2018-03-09 HK HK19101914.0A patent/HK1259492A1/zh unknown
- 2018-12-19 HR HRP20182158TT patent/HRP20182158T1/hr unknown
- 2018-12-21 CY CY20181101387T patent/CY1121423T1/el unknown
-
2019
- 2019-07-10 IL IL267980A patent/IL267980B/en active IP Right Grant
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL267980B (en) | A pharmaceutical preparation for the treatment of metabolic syndrome | |
| HK1246170A1 (zh) | 藥物組合物 | |
| AP3864A (en) | Pharmaceutical composition | |
| IL225457A0 (en) | Pharmaceutical composition | |
| LT2619182T (lt) | Farmacinė kompozicija | |
| GB201118232D0 (en) | Pharmaceutical composition | |
| ZA201304633B (en) | A pharmaceutical composition | |
| GB201010453D0 (en) | Pharmaceutical composition | |
| HK1189158A1 (en) | Pharmaceutical composition | |
| EP2774917A4 (en) | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIABETES | |
| ZA201302012B (en) | Low dose pharmaceutical composition | |
| EP2727593A4 (en) | PHARMACEUTICAL COMPOSITION CONTAINING NICORANDIL | |
| EP2711010A4 (en) | PHARMACEUTICAL COMPOSITION | |
| HUP1100444A2 (en) | Pharmaceutical composition | |
| GB201001911D0 (en) | Pharmaceutical composition | |
| ZA201201003B (en) | A pharmaceutical composition | |
| HUP1100445A2 (en) | Pharmaceutical composition | |
| GB201019775D0 (en) | Pharmaceutical composition |