SI2857418T1 - Protitelesa proti toksinom clostridium difficile in njihova uporaba - Google Patents
Protitelesa proti toksinom clostridium difficile in njihova uporaba Download PDFInfo
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- SI2857418T1 SI2857418T1 SI200532173T SI200532173T SI2857418T1 SI 2857418 T1 SI2857418 T1 SI 2857418T1 SI 200532173 T SI200532173 T SI 200532173T SI 200532173 T SI200532173 T SI 200532173T SI 2857418 T1 SI2857418 T1 SI 2857418T1
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- antibody
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- 241000193163 Clostridioides difficile Species 0.000 title claims abstract 9
- 239000003053 toxin Substances 0.000 title abstract 2
- 231100000765 toxin Toxicity 0.000 title abstract 2
- 108700012359 toxins Proteins 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 claims abstract 15
- 102000036639 antigens Human genes 0.000 claims abstract 15
- 108091007433 antigens Proteins 0.000 claims abstract 15
- 238000000034 method Methods 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 101710182223 Toxin B Proteins 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 101100454807 Caenorhabditis elegans lgg-1 gene Proteins 0.000 claims 2
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 2
- 206010009657 Clostridium difficile colitis Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 208000003100 Pseudomembranous Enterocolitis Diseases 0.000 claims 2
- 206010037128 Pseudomembranous colitis Diseases 0.000 claims 2
- 108010059993 Vancomycin Proteins 0.000 claims 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 2
- 229960000282 metronidazole Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 2
- 229960003165 vancomycin Drugs 0.000 claims 2
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 2
- 108010001478 Bacitracin Proteins 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229960003071 bacitracin Drugs 0.000 claims 1
- 229930184125 bacitracin Natural products 0.000 claims 1
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108010074605 gamma-Globulins Proteins 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000006041 probiotic Substances 0.000 claims 1
- 230000000529 probiotic effect Effects 0.000 claims 1
- 235000018291 probiotics Nutrition 0.000 claims 1
- 229960002181 saccharomyces boulardii Drugs 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 229940031572 toxoid vaccine Drugs 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/809—Drug, bio-affecting and body treating compositions involving immunoglobulin or antibody fragment, e.g. fab', fv, fc, heavy chain or light chain
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Claims (14)
- PROTITELESA PROTI TOKSINOM CLOSTRIDIUM DIFFICILE IN NJIHOVA UPORABA PATENTNI ZAHTEVKI1. Izolirano monoklonsko humano protitelo ali njegov antigen vezavni del, ki se specifično veže na Clostridium difficile (C. difficile) toksin B, kjer protitelo ali njegov antigen vezavni del, obsega variabilno regijo težke verige, ki obsega aminokislinsko sekvenco, prikazano v SEQ ID NO: 54, in variabilno regijo lahke verige, ki obsega aminokislinsko sekvenco, prikazano v SEQ ID NO: 58.
- 2. . Izolirano protitelo po zahtevku 1, kjer je protitelo lgG1 izotip.
- 3. Farmacevtski sestavek, ki obsega terapevtsko ali profilaktično učinkovito količino protitelesa po zahtevku 1 ali 2 v farmacevtsko sprejemljivem nosilcu.
- 4. Farmacevtski sestavek, ki obsega protitelo ali njegov antigen vezavni del, ki se specifično veže na C. difficile toksin B s KD manj kot 10 χ 10"10 M, merjeno s površinsko plazmonsko resonanco in nevtralizira C. difficile toksin B, kjer protitelo vsebuje: (a) variabilno regijo težke verige, ki obsega CDR1, CDR2 in CDR3 aminokislinskih sekvenc SEQ ID NOs: 62, 64 in 66; in (b) variabilno regijo lahke verige, ki obsega CDR1, CDR2 in CDR3 sekvence SEQ ID NOs: 68, 70 in 72 formuliran za parenteralno dajanje.
- 5. Sestavek po zahtevku 4, kjer je protitelo humano protitelo.
- 6. Sestavek po zahtevku 4 ali 5, kjer je protitelo lgG1 izotip.
- 7. Monoklonsko protitelo ali njegov njegov antigen vezavni del po zahtevku 1 ali 2 ali sestavek po katerem koli izmed zahtevkov 3 do 6, za uporabo pri metodi zdravljenja človeškega ali živalskega telesa s terapijo ali pri izvedeni diagnostični metodi na človeškem ali živalskem telesu.
- 8. Monoklonsko protitelo ali njegov antigen vezavni del po zahtevku 1 ali 2 ali sestavek po katerem koli izmed zahtevkov 3 do 6, za uporabo pri metodi zdravljenja, s C. Difficile-posredovane bolezni, pri subjektu.
- 9. Monoklonsko protitelo ali njegov antigen vezavni del po zahtevku 1 ali 2 ali sestavek po katerem koli izmed zahtevkov 3 do 6, za uporabo pri metodi za preprečevanje ponovitve s C. D/7f/c/Ve-posredovane bolezni, pri subjektu.
- 10. Monoklonsko protitelo, antigen vezavni del ali sestavek za uporabo po zahtevku 8 ali 9, kjer: (a) subjekt je človek; in/ali (b) protitelo, antigen vezavni del ali sestavek, se daje subjektu intravensko, intramuskularno ali subkutano.
- 11. Izolirano monoklonsko protitelo, antigen vezavni del ali pripravek za uporabo po katerem koli od zahtevkov 8 do 10, pri čemer se protitelo, antigen vezavni del ali sestavek, daje z drugim terapevtskim sredstvom.
- 12. Monoklonsko protitelo, antigen vezavni del ali pripravek za uporabo po zahtevku 11, kjer je terapevtski agent: (a) antibiotik, poliklonski gama-globulin, probiotično sredstvo ali cepivo C. difficile·, ali (b) vankomicin, metronidazol, bacitracin, Saccharomyces boulardii ali cepivo proti toksoidu C. difficile.
- 13. Monoklonsko protitelo, antigen vezavni del ali pripravek za uporabo po zahtevku 12, kjer je terapevtsko sredstvo je vankomicin ali metronidazol.
- 14. Monoklonsko protitelo, antigen vezavni del ali sestavek za uporabo po katerem koli izmed zahtevkov od 8 do 13, kjer je s C. D/fficZ/e-posredovana bolezen s C. D/fflc/te-podsredovani pseudomembranozni kolitis (PMC), driska ali ponovitev s C. D/Wc/7e-posredovane bolezni.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54235704P | 2004-02-06 | 2004-02-06 | |
| US61385404P | 2004-09-28 | 2004-09-28 | |
| EP14194551.9A EP2857418B1 (en) | 2004-02-06 | 2005-02-04 | Antibodies against Clostridium difficile toxins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2857418T1 true SI2857418T1 (sl) | 2018-01-31 |
Family
ID=36928722
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200531949T SI2270045T1 (sl) | 2004-02-06 | 2005-02-04 | Protitelesa proti Clostridium difficile toksinom in njihova uporaba |
| SI200531344T SI1766093T1 (sl) | 2004-02-06 | 2005-02-04 | Antitelesa proti toksinom clostridium difficile in njihova uporaba |
| SI200532173T SI2857418T1 (sl) | 2004-02-06 | 2005-02-04 | Protitelesa proti toksinom clostridium difficile in njihova uporaba |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200531949T SI2270045T1 (sl) | 2004-02-06 | 2005-02-04 | Protitelesa proti Clostridium difficile toksinom in njihova uporaba |
| SI200531344T SI1766093T1 (sl) | 2004-02-06 | 2005-02-04 | Antitelesa proti toksinom clostridium difficile in njihova uporaba |
Country Status (28)
| Country | Link |
|---|---|
| US (8) | US7625559B2 (sl) |
| EP (3) | EP1766093B1 (sl) |
| JP (3) | JP4588763B2 (sl) |
| KR (3) | KR101332927B1 (sl) |
| CN (1) | CN101014620B (sl) |
| AT (1) | ATE512986T1 (sl) |
| AU (1) | AU2005320349C1 (sl) |
| BE (1) | BE2017C023I2 (sl) |
| BR (1) | BRPI0507433C1 (sl) |
| CA (1) | CA2553946C (sl) |
| CY (3) | CY1111860T1 (sl) |
| DK (3) | DK1766093T3 (sl) |
| ES (3) | ES2643760T3 (sl) |
| HK (3) | HK1152048A1 (sl) |
| HR (1) | HRP20110599T1 (sl) |
| HU (3) | HUE024962T2 (sl) |
| LT (2) | LT2857418T (sl) |
| LU (1) | LUC00025I2 (sl) |
| MX (1) | MXPA06008839A (sl) |
| NL (1) | NL300881I2 (sl) |
| NO (2) | NO340300B1 (sl) |
| NZ (2) | NZ580828A (sl) |
| PL (3) | PL1766093T3 (sl) |
| PT (3) | PT1766093E (sl) |
| RS (1) | RS51908B (sl) |
| SI (3) | SI2270045T1 (sl) |
| WO (1) | WO2006121422A2 (sl) |
| ZA (1) | ZA200606516B (sl) |
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2011
- 2011-08-11 HR HR20110599T patent/HRP20110599T1/hr unknown
- 2011-09-13 CY CY20111100872T patent/CY1111860T1/el unknown
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2012
- 2012-06-07 US US13/490,757 patent/US8609111B2/en active Active
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2013
- 2013-02-27 JP JP2013036855A patent/JP5717300B2/ja active Active
- 2013-11-14 US US14/080,598 patent/US9217029B2/en active Active
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2015
- 2015-09-24 HK HK15109420.4A patent/HK1208873A1/xx unknown
- 2015-10-29 US US14/926,706 patent/US20160152694A1/en not_active Abandoned
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2017
- 2017-06-27 NL NL300881C patent/NL300881I2/nl unknown
- 2017-06-27 HU HUS1700028C patent/HUS1700028I1/hu unknown
- 2017-06-28 BE BE2017C023C patent/BE2017C023I2/fr unknown
- 2017-06-28 CY CY2017022C patent/CY2017022I1/el unknown
- 2017-07-04 LU LU00025C patent/LUC00025I2/en unknown
- 2017-07-07 NO NO2017032C patent/NO2017032I1/no unknown
- 2017-07-11 LT LTPA2017022 patent/LTC2270045I2/lt unknown
- 2017-09-21 CY CY20171101001T patent/CY1119416T1/el unknown
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2018
- 2018-03-19 US US15/924,703 patent/US20180208643A1/en not_active Abandoned
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2020
- 2020-09-16 US US17/022,766 patent/US20210269511A1/en not_active Abandoned
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