SI2817329T1 - Polipeptidi, ki se vežejo na človeški komplement c5 - Google Patents
Polipeptidi, ki se vežejo na človeški komplement c5Info
- Publication number
- SI2817329T1 SI2817329T1 SI201331358T SI201331358T SI2817329T1 SI 2817329 T1 SI2817329 T1 SI 2817329T1 SI 201331358 T SI201331358 T SI 201331358T SI 201331358 T SI201331358 T SI 201331358T SI 2817329 T1 SI2817329 T1 SI 2817329T1
- Authority
- SI
- Slovenia
- Prior art keywords
- human complement
- polypeptides binding
- polypeptides
- binding
- complement
- Prior art date
Links
- 101000941598 Homo sapiens Complement C5 Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE1250145 | 2012-02-20 | ||
PCT/SE2013/050139 WO2013126006A1 (en) | 2012-02-20 | 2013-02-19 | Polypeptides binding to human complement c5 |
EP13752233.0A EP2817329B1 (en) | 2012-02-20 | 2013-02-19 | Polypeptides binding to human complement c5 |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2817329T1 true SI2817329T1 (sl) | 2019-04-30 |
Family
ID=49006055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201331358T SI2817329T1 (sl) | 2012-02-20 | 2013-02-19 | Polipeptidi, ki se vežejo na človeški komplement c5 |
Country Status (31)
Country | Link |
---|---|
US (4) | US9808502B2 (sl) |
EP (2) | EP2817329B1 (sl) |
JP (2) | JP6276202B2 (sl) |
KR (2) | KR102149028B1 (sl) |
CN (1) | CN104114574B (sl) |
AU (3) | AU2013222836B2 (sl) |
BR (1) | BR112014020427B1 (sl) |
CA (1) | CA2863862C (sl) |
CY (1) | CY1121455T1 (sl) |
DK (1) | DK2817329T3 (sl) |
ES (1) | ES2715638T3 (sl) |
HK (1) | HK1204790A1 (sl) |
HR (1) | HRP20190522T1 (sl) |
HU (1) | HUE041996T2 (sl) |
IL (2) | IL234114B (sl) |
LT (1) | LT2817329T (sl) |
ME (1) | ME03640B (sl) |
MX (1) | MX359201B (sl) |
MY (1) | MY167232A (sl) |
NZ (1) | NZ628625A (sl) |
PH (1) | PH12014501604A1 (sl) |
PL (1) | PL2817329T3 (sl) |
PT (1) | PT2817329T (sl) |
RS (1) | RS58503B1 (sl) |
RU (1) | RU2654668C2 (sl) |
SG (1) | SG11201404942UA (sl) |
SI (1) | SI2817329T1 (sl) |
TR (1) | TR201903840T4 (sl) |
UA (1) | UA117096C2 (sl) |
WO (1) | WO2013126006A1 (sl) |
ZA (1) | ZA201406773B (sl) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ628625A (en) | 2012-02-20 | 2016-03-31 | Swedish Orphan Biovitrum Ab Publ | Polypeptides binding to human complement c5 |
CN104854127B (zh) | 2012-10-25 | 2020-12-25 | 阿菲博迪公司 | 白蛋白结合多肽 |
US9745340B2 (en) | 2012-10-25 | 2017-08-29 | Affibody Ab | Method for the separation of proteins containing an albumin-binding |
CN117964710A (zh) | 2013-08-28 | 2024-05-03 | 阿菲博迪公司 | 具有突变的支架的结合多肽 |
US9994626B2 (en) | 2013-08-28 | 2018-06-12 | Swedish Orphan Biovitrum Ab (Publ) | Stable polypeptides binding to human complement C5 |
BR122023024819A2 (pt) | 2014-06-12 | 2023-12-26 | Ra Pharmaceuticals, Inc. | Uso de um polipeptídeo para inibir a clivagem de c5 em um sistema celular |
JP7028557B2 (ja) * | 2014-06-13 | 2022-03-02 | アフィボディ アクティエボラーグ | 新規ポリペプチド |
EP3154564B1 (en) | 2014-06-13 | 2019-08-21 | Affibody AB | New polypeptide |
DE102014225439A1 (de) * | 2014-12-10 | 2016-06-16 | Zf Friedrichshafen Ag | Stufenplanet |
MX2017008660A (es) | 2015-01-12 | 2017-11-17 | Affibody Ab | Polipeptidos enlazados a il-17a. |
EP3250230B9 (en) * | 2015-01-28 | 2022-02-23 | RA Pharmaceuticals, Inc. | Modulators of complement activity |
RU2769701C2 (ru) | 2015-12-16 | 2022-04-05 | Ра Фармасьютикалз, Инк. | Модуляторы активности комплемента |
EP3551210A1 (en) | 2016-12-07 | 2019-10-16 | RA Pharmaceuticals, Inc. | Modulators of complement activity |
UY37651A (es) * | 2017-03-31 | 2018-10-31 | Swedish Orphan Biovitrum Ab Publ | Polipéptido de unión al il-1r-i |
AU2018301412A1 (en) * | 2017-07-11 | 2020-01-30 | Alexion Pharmaceuticals, Inc. | Polypeptides that bind complement component C5 or serum albumin and fusion proteins thereof |
AU2020251706A1 (en) | 2019-04-03 | 2021-11-25 | Clean Earth Technology Pty Ltd | Materials and processes for recovering precious metals |
WO2021089695A1 (en) * | 2019-11-05 | 2021-05-14 | Affibody Ab | Polypeptides |
EP4225372A1 (en) * | 2020-10-05 | 2023-08-16 | Alexion Pharmaceuticals, Inc. | Methods of treating dermatomyositis |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5135916A (en) | 1989-06-12 | 1992-08-04 | Oklahoma Medical Research Foundation | Inhibition of complement mediated inflammatory response |
SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
US6267964B1 (en) | 1989-08-01 | 2001-07-31 | Affibody Technology Sweden Ab | Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives |
US6395888B1 (en) | 1996-02-01 | 2002-05-28 | Gilead Sciences, Inc. | High affinity nucleic acid ligands of complement system proteins |
SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
JPH09510088A (ja) | 1994-03-03 | 1997-10-14 | アレクション・ファーマシューティカル・インク | 最終補体インヒビター融合遺伝子およびタンパク質 |
US5627264A (en) | 1994-03-03 | 1997-05-06 | Alexion Pharmaceuticals, Inc. | Chimeric complement inhibitor proteins |
EP0751787B1 (en) | 1994-03-23 | 2005-01-12 | Alexion Pharmaceuticals, Inc. | Method for reducing immune and hemostatic dysfunctions during extracorporeal circulation |
US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
DE69534701T2 (de) | 1994-09-23 | 2006-10-19 | Alexion Pharmaceuticals, Inc., Cheshire | Verfahren zur behandlung von entzündlichen gelenkerkrankungen |
US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
EP2281840A3 (en) | 2000-10-10 | 2012-05-23 | Genentech, Inc. | Inhibition of complement C5 activation for the treatment and prevention of delayed xenograft or acute vascular rejection |
AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
CA2457461C (en) | 2001-08-17 | 2013-12-24 | Tanox, Inc. | Complement pathway inhibitors binding to c5 and c5a without preventing the formation of c5b |
US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
ITMI20021527A1 (it) | 2002-07-11 | 2004-01-12 | Consiglio Nazionale Ricerche | Anticorpi anti componente c5 del complemento e loro uso |
US9415102B2 (en) | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
WO2004050111A2 (en) | 2002-12-02 | 2004-06-17 | Resistentia Pharmaceuticals Ab | Methods and materials for treating inflammatory conditions using a polypeptide comprising a self-c5 amino acid segment and a non-self amino acid segment |
US7361339B2 (en) | 2003-01-09 | 2008-04-22 | Alexion Pharmaceuticals, Inc. | Methods for reducing morality associated with acute myocardial infarction |
ATE427356T1 (de) | 2003-06-02 | 2009-04-15 | Varleigh Ltd | Komplementinhibitoren aus zecken |
EP1667702A2 (en) * | 2003-09-10 | 2006-06-14 | Baxter International Inc., Baxter Healthcare Corp. | Peptides that inhibit complement activation |
SE0400274D0 (sv) | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
US7803931B2 (en) | 2004-02-12 | 2010-09-28 | Archemix Corp. | Aptamer therapeutics useful in the treatment of complement-related disorders |
US7838244B2 (en) | 2004-03-24 | 2010-11-23 | Auckland Uniservices Limited | SET1 proteins and uses thereof |
JP5634008B2 (ja) | 2004-04-06 | 2014-12-03 | アフィボディ・アーベー | 新規の使用および方法 |
GB0518443D0 (en) * | 2005-09-09 | 2005-10-19 | Evolutec Ltd | Method of treating myasthenia gravis |
NZ567483A (en) * | 2005-11-04 | 2012-04-27 | Genentech Inc | Use of complement pathway inhibitors to treat ocular diseases |
GB0524788D0 (en) | 2005-12-05 | 2006-01-11 | Affibody Ab | Polypeptides |
CA3009854A1 (en) | 2006-03-08 | 2007-09-13 | Archemix Llc | Complement binding aptamers and anti-c5 agents useful in the treatment of ocular disorders |
IL302157A (en) | 2006-03-15 | 2023-06-01 | Alexion Pharma Inc | Treatment of patients with paroxysmal nocturnal hemoglobinuria by a complement inhibitor |
WO2008010902A2 (en) | 2006-07-06 | 2008-01-24 | The Trustees Of The University Of Pennsylvania | Regulation of tlr signaling by complement |
PL2061810T3 (pl) | 2006-09-05 | 2015-05-29 | Alexion Pharma Inc | Sposoby i kompozycje do leczenia neuropatii zależnych od przeciwciał |
GB0617734D0 (en) | 2006-09-08 | 2006-10-18 | Evolutec Ltd | Method of treating peripheral nerve disorders |
TW200819463A (en) * | 2006-09-08 | 2008-05-01 | Genentech Inc | Wnt antagonists and their use in the diagnosis and treatment of Wnt-mediated disorders |
BRPI0809105A2 (pt) * | 2007-03-22 | 2019-09-10 | Novartis Ag | antígenos c5 e uso destes |
WO2008154018A2 (en) | 2007-06-11 | 2008-12-18 | The Trustees Of The University Of Pennsylvania | Properdin modulation of alternative pathway and uses thereof |
AU2008281913B2 (en) | 2007-07-31 | 2013-11-07 | Affibody Ab | New albumin binding compositions, methods and uses |
WO2009030240A2 (en) | 2007-09-05 | 2009-03-12 | Immunobond Aps | Method of determining functional deficiencies in the complement system |
EP2231860B1 (en) | 2007-12-19 | 2011-10-05 | Affibody AB | Polypeptide derived from protein a and able to bind pdgf |
EP2077272A1 (en) | 2007-12-21 | 2009-07-08 | Affibody AB | Polypeptide libraries with a predetermined scaffold |
US9187535B2 (en) * | 2007-12-19 | 2015-11-17 | Affibody Ab | Polypeptide derived from protein A and able to bind PDGF |
EP2072525A1 (en) | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
NZ600622A (en) * | 2008-08-05 | 2013-12-20 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c5 |
HRP20230167T1 (hr) | 2008-11-10 | 2023-03-31 | Alexion Pharmaceuticals, Inc. | Postupci i pripravci za liječenje poremećaja povezanih s komplementom |
EP2327725A1 (en) * | 2009-11-26 | 2011-06-01 | InflaRx GmbH | Anti-C5a binding moieties with high blocking activity |
CA2791962A1 (en) | 2010-03-01 | 2011-09-09 | Alexion Pharmaceuticals, Inc. | Methods and compositions for treating degos' disease |
US20110245469A1 (en) * | 2010-04-02 | 2011-10-06 | Athena Discovery, Inc. | Intermediates formed in biosynthesis of relaxin-fusion proteins with extended in vivo half-lives |
ES2552954T3 (es) | 2010-04-30 | 2015-12-03 | Alexion Pharmaceuticals, Inc. | Anticuerpos anti-C5a y métodos para el uso de los anticuerpos |
CN110437321A (zh) | 2010-07-09 | 2019-11-12 | 阿菲博迪公司 | 多肽 |
WO2013006449A2 (en) | 2011-07-01 | 2013-01-10 | The Trustees Of The University Of Pennsylvania | Anti-properdin antibodies and uses thereof |
NZ628625A (en) * | 2012-02-20 | 2016-03-31 | Swedish Orphan Biovitrum Ab Publ | Polypeptides binding to human complement c5 |
WO2013172954A1 (en) | 2012-05-17 | 2013-11-21 | Ra Pharmaceuticals, Inc | Peptide and peptidomimetic inhibitors |
JP5980104B2 (ja) | 2012-11-22 | 2016-08-31 | 三菱電機株式会社 | 液晶表示装置の製造方法および液晶表示装置の製造システム |
JP6577868B2 (ja) | 2012-12-19 | 2019-09-18 | アフィボディ・アーベー | 新規ポリペプチド |
CN105209482B (zh) | 2013-03-15 | 2022-04-29 | 阿菲博迪公司 | 新的多肽 |
CN117964710A (zh) | 2013-08-28 | 2024-05-03 | 阿菲博迪公司 | 具有突变的支架的结合多肽 |
US9994626B2 (en) | 2013-08-28 | 2018-06-12 | Swedish Orphan Biovitrum Ab (Publ) | Stable polypeptides binding to human complement C5 |
NZ631007A (en) | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
-
2013
- 2013-02-19 NZ NZ628625A patent/NZ628625A/en unknown
- 2013-02-19 RS RS20190369A patent/RS58503B1/sr unknown
- 2013-02-19 AU AU2013222836A patent/AU2013222836B2/en active Active
- 2013-02-19 TR TR2019/03840T patent/TR201903840T4/tr unknown
- 2013-02-19 KR KR1020147025537A patent/KR102149028B1/ko active IP Right Grant
- 2013-02-19 MX MX2014009879A patent/MX359201B/es active IP Right Grant
- 2013-02-19 KR KR1020207024244A patent/KR102336895B1/ko active IP Right Grant
- 2013-02-19 HU HUE13752233A patent/HUE041996T2/hu unknown
- 2013-02-19 CN CN201380009789.0A patent/CN104114574B/zh active Active
- 2013-02-19 RU RU2014137303A patent/RU2654668C2/ru active
- 2013-02-19 ES ES13752233T patent/ES2715638T3/es active Active
- 2013-02-19 SI SI201331358T patent/SI2817329T1/sl unknown
- 2013-02-19 PL PL13752233T patent/PL2817329T3/pl unknown
- 2013-02-19 ME MEP-2019-84A patent/ME03640B/me unknown
- 2013-02-19 PT PT13752233T patent/PT2817329T/pt unknown
- 2013-02-19 WO PCT/SE2013/050139 patent/WO2013126006A1/en active Application Filing
- 2013-02-19 CA CA2863862A patent/CA2863862C/en active Active
- 2013-02-19 UA UAA201409807A patent/UA117096C2/uk unknown
- 2013-02-19 EP EP13752233.0A patent/EP2817329B1/en active Active
- 2013-02-19 MY MYPI2014702257A patent/MY167232A/en unknown
- 2013-02-19 LT LTEP13752233.0T patent/LT2817329T/lt unknown
- 2013-02-19 EP EP18213025.2A patent/EP3511339A1/en active Pending
- 2013-02-19 SG SG11201404942UA patent/SG11201404942UA/en unknown
- 2013-02-19 US US14/378,522 patent/US9808502B2/en active Active
- 2013-02-19 DK DK13752233.0T patent/DK2817329T3/en active
- 2013-02-19 JP JP2014557602A patent/JP6276202B2/ja active Active
- 2013-02-19 BR BR112014020427-6A patent/BR112014020427B1/pt active IP Right Grant
-
2014
- 2014-07-11 PH PH12014501604A patent/PH12014501604A1/en unknown
- 2014-08-13 IL IL234114A patent/IL234114B/en active IP Right Grant
- 2014-09-16 ZA ZA2014/06773A patent/ZA201406773B/en unknown
-
2015
- 2015-06-02 HK HK15105247.3A patent/HK1204790A1/xx unknown
-
2017
- 2017-09-29 US US15/721,507 patent/US10206975B2/en active Active
- 2017-10-12 AU AU2017245376A patent/AU2017245376B2/en active Active
- 2017-10-18 JP JP2017201509A patent/JP6719438B2/ja active Active
-
2018
- 2018-12-20 US US16/228,181 patent/US11123401B2/en active Active
-
2019
- 2019-03-18 HR HRP20190522TT patent/HRP20190522T1/hr unknown
- 2019-03-20 CY CY20191100331T patent/CY1121455T1/el unknown
- 2019-06-30 IL IL267724A patent/IL267724B/en unknown
- 2019-10-18 AU AU2019250239A patent/AU2019250239B2/en active Active
-
2021
- 2021-09-20 US US17/479,101 patent/US20210401930A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL267724B (en) | Human c5 complement-binding polypeptides | |
IL291571A (en) | cx3cr1 binding polypeptides | |
IL225439A0 (en) | Polypeptides that bind to component 5c of the human complement system | |
IL233793B (en) | mica binders | |
PL2900827T3 (pl) | 3-epimeraza | |
GB201220474D0 (en) | Polypeptides | |
HK1225656A1 (zh) | 結合人類補體c5的穩定多肽 | |
GB2506114B (en) | Boot | |
EP2871213A4 (en) | BELLY COMPOSITION | |
GB201420971D0 (en) | Therapeutic composition | |
HK1204948A1 (en) | Radiation-sterilization-resistant protein composition | |
GB201203944D0 (en) | Binding polypeptides | |
GB201218322D0 (en) | Herbal composition | |
GB201213124D0 (en) | Herbal composition | |
GB201214293D0 (en) | Binding surfaces | |
AU2012195V (en) | DC3000 Dianella caerulea | |
GB201103961D0 (en) | Binding polypeptides |