SI2648520T1 - Formulation of dexmedetomidine pre-mixtures - Google Patents

Formulation of dexmedetomidine pre-mixtures Download PDF

Info

Publication number
SI2648520T1
SI2648520T1 SI201231312T SI201231312T SI2648520T1 SI 2648520 T1 SI2648520 T1 SI 2648520T1 SI 201231312 T SI201231312 T SI 201231312T SI 201231312 T SI201231312 T SI 201231312T SI 2648520 T1 SI2648520 T1 SI 2648520T1
Authority
SI
Slovenia
Prior art keywords
composition
dexmedetomidine
product
liquid pharmaceutical
formulated
Prior art date
Application number
SI201231312T
Other languages
English (en)
Slovenian (sl)
Inventor
Priyanka Roychowdhury
Robert A. Cedergren
Original Assignee
Hospira, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46613447&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2648520(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hospira, Inc. filed Critical Hospira, Inc.
Publication of SI2648520T1 publication Critical patent/SI2648520T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
SI201231312T 2012-01-04 2012-06-18 Formulation of dexmedetomidine pre-mixtures SI2648520T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/343,672 US8242158B1 (en) 2012-01-04 2012-01-04 Dexmedetomidine premix formulation
PCT/US2012/042940 WO2013103378A1 (en) 2012-01-04 2012-06-18 Dexmedetomidine premix formulation
EP12823234.5A EP2648520B1 (de) 2012-01-04 2012-06-18 Dexmedetomidin-vormischungsformulierung

Publications (1)

Publication Number Publication Date
SI2648520T1 true SI2648520T1 (en) 2018-08-31

Family

ID=46613447

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201231312T SI2648520T1 (en) 2012-01-04 2012-06-18 Formulation of dexmedetomidine pre-mixtures

Country Status (35)

Country Link
US (10) US8242158B1 (de)
EP (2) EP2648520B1 (de)
JP (4) JP5892177B2 (de)
KR (1) KR101632103B1 (de)
CN (2) CN107802624A (de)
AR (2) AR089673A1 (de)
AU (1) AU2013201069B1 (de)
BR (1) BR112013008005A8 (de)
CA (1) CA2806706C (de)
CL (1) CL2013000815A1 (de)
CO (1) CO6680698A2 (de)
CY (1) CY1120521T1 (de)
DK (1) DK2648520T3 (de)
EC (1) ECSP13012569A (de)
ES (1) ES2671749T3 (de)
GT (1) GT201300055A (de)
HK (1) HK1249429A1 (de)
HR (1) HRP20180838T1 (de)
HU (1) HUE038128T2 (de)
IL (1) IL224867B (de)
LT (1) LT2648520T (de)
MX (1) MX2013003629A (de)
MY (2) MY161022A (de)
PE (2) PE20160681A1 (de)
PL (1) PL2648520T3 (de)
PT (1) PT2648520T (de)
RS (1) RS57346B1 (de)
SA (2) SA115360458B1 (de)
SG (1) SG191706A1 (de)
SI (1) SI2648520T1 (de)
TR (1) TR201809123T4 (de)
TW (2) TWI574688B (de)
UY (1) UY34562A (de)
WO (1) WO2013103378A1 (de)
ZA (1) ZA201301649B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130096170A1 (en) * 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
CN105764496B (zh) * 2013-10-07 2020-09-25 帝国制药美国公司 用于经皮递送非镇静量的右旋美托咪啶的方法和组合物
KR101831290B1 (ko) 2013-10-07 2018-02-22 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 조성물을 사용하여 주의력 결핍 과잉행동 장애, 불안 및 불면증을 치료하기 위한 방법 및 조성물
TWI704933B (zh) 2013-10-07 2020-09-21 美商帝國製藥美國股份有限公司 右美托咪啶經皮輸送裝置及使用其之方法
FI3054934T3 (fi) * 2013-10-07 2024-07-19 Teikoku Pharma Usa Inc Menetelmät ja koostumukset vieroitusoireyhtymien hoitoon käyttäen ei-sedatiivisia transdermaalisia deksmedetomidiinikoostumuksia
BR112016014404A2 (pt) * 2013-12-18 2017-08-08 Gnt Llc Composições e métodos para tratamento de glaucoma
FI127534B (en) * 2014-11-10 2018-08-31 Vetcare Oy Substituted benzoefuroquinolizine and ɑ2-adrenergic agonist comprising compositions
CN106038538A (zh) * 2015-04-17 2016-10-26 江苏恒瑞医药股份有限公司 一种右美托咪定的预混合制剂
CN105168122B (zh) * 2015-09-24 2018-11-27 辰欣药业股份有限公司 一种盐酸右美托咪定注射液及其制备工艺
US20170128421A1 (en) * 2015-11-11 2017-05-11 Siva Prasad Reddy Sura Premix formulation for parenteral use and packaging thereof
US10632043B2 (en) * 2015-11-11 2020-04-28 Aurobindo Pharma Ltd Premix formulation for parenteral use and packaging thereof
US9717796B1 (en) * 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
CN107412152B (zh) * 2016-05-24 2020-12-04 海南合瑞制药股份有限公司 一种盐酸右美托咪定注射液组合物
CN110114069B (zh) * 2016-12-26 2022-03-04 久光制药株式会社 微针装置
EP4371554A3 (de) 2016-12-31 2024-08-07 BioXcel Therapeutics, Inc. Verwendung von sublingualem dexmedetomidin zur behandlung von unruhe
CN107028880A (zh) * 2017-06-09 2017-08-11 安徽赛诺制药有限公司 一种盐酸右美托咪定注射液的生产工艺
US20190262314A1 (en) * 2018-02-26 2019-08-29 Slayback Pharma Llc Ready-to-use dexmedetomidine compositions
CN108956809B (zh) * 2018-06-04 2021-03-23 四川科伦药物研究院有限公司 一种检测1-(1-氯乙基)-2,3-二甲苯有关物质的方法
US20210267944A1 (en) 2018-06-27 2021-09-02 Bioxcel Therapeutics, Inc. Methods for treating agitation using dexmedetomidine hydrochloride
SG11202012772XA (en) 2018-06-27 2021-01-28 Bioxcel Therapeutics Inc Film formulations containing dexmedetomidine and methods of producing them
CN108872431B (zh) * 2018-07-09 2021-03-23 成都倍特药业股份有限公司 一种检测4-(1-(2,5-二甲基苯基)乙基)-1h-咪唑或/和其盐酸盐的方法
CN109081811A (zh) * 2018-09-19 2018-12-25 南京正大天晴制药有限公司 盐酸右美托咪定的有关物质及其制备方法
JP2019048091A (ja) * 2018-10-23 2019-03-28 ニプロ株式会社 デクスメデトミジン注射液を充填したプレフィルドシリンジ
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags
CN111481506B (zh) * 2019-01-25 2023-01-24 江苏恒瑞医药股份有限公司 一种包含经鼻给药的右美托咪定组合物的药物制品
CN116474218A (zh) * 2019-06-28 2023-07-25 四川普锐特药业有限公司 保持给药均一度的药物流体分配器及右美托咪定鼻喷器
WO2021016112A2 (en) 2019-07-19 2021-01-28 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
JP2023545372A (ja) * 2020-10-08 2023-10-30 バイオエクセル セラピューティクス，インコーポレイテッド デクスメデトミジン塩酸塩を用いた双極性障害及び精神病の治療
EP4085891A1 (de) 2021-05-05 2022-11-09 B. Braun Melsungen AG Dexmedetomidinlösung in einem polyethylenbehälter mit niedriger dichte
CN113041242A (zh) * 2021-05-18 2021-06-29 上海交通大学医学院附属仁济医院 右美托咪定在促进肝脏再生中的应用
CN113116815A (zh) * 2021-06-07 2021-07-16 辰欣药业股份有限公司 一种盐酸右美托咪定注射液的制备方法
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4407957A (en) 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
GB2101114B (en) 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
JPS6058890A (ja) 1983-09-13 1985-04-05 Mizusawa Ind Chem Ltd 感熱記録紙用填剤
FI844786A0 (fi) 1984-12-04 1984-12-04 Farmos Oy Terapeutiskt utnyttjbar foerening.
GB2206880B (en) 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
US5344840A (en) 1988-02-29 1994-09-06 Orion-Yhtyma Oy 4-substituted imidazole derivatives useful in perioperative care
US5124157A (en) 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5217718A (en) 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
FI894911A0 (fi) 1989-10-17 1989-10-17 Farmos Oy En terapeutiskt vaerdefull foerening.
US5304569A (en) 1989-11-13 1994-04-19 Orion-Yhtyma Oy Compositions and their use in lowering intraocular pressure
WO1992019195A1 (en) 1991-04-25 1992-11-12 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
ATE220327T1 (de) 1992-09-29 2002-07-15 Inhale Therapeutic Syst Pulmonale abgabe von aktiven fragmenten des parathormons
GB2281206A (en) 1993-08-25 1995-03-01 Orion Yhtymae Oy Use of dexmedetomidine
FR2718357B1 (fr) 1994-04-06 1997-10-03 Defarges Alain Moreau Perfectionnements apportés à un dispositif d'injection par jet sans aiguille.
KR100365171B1 (ko) * 1994-08-08 2003-02-19 드바이오팜 에스.아. 약학적으로안정한옥살리플라티늄제제
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5654007A (en) 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
DE19749724A1 (de) 1997-11-11 1999-06-10 Gruenenthal Gmbh Verwendung einer Kombination aus Opioid und alpha-adrenergem Agonisten in Schmerzmitteln
US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
PE20001396A1 (es) 1999-01-18 2000-12-23 Gruenenthal Chemie Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista
EP1121933A1 (de) 2000-02-02 2001-08-08 Pfizer Products Inc. Alatrofloxacinhaltige vorgemischte injizierbare Arzneizusammenstetzungen
US6310094B1 (en) 2001-01-12 2001-10-30 Baxter International Inc. Ready-to-use esmolol solution
MXPA03008857A (es) 2001-03-29 2004-05-24 Baxter Int Solucion parenteral de amiodarona premezclada y metodo para elaboracion de la misma.
US6806291B1 (en) * 2003-10-09 2004-10-19 The Foundation For The Lsu Health Sciences Center Analgesic compounds, their synthesis and pharmaceutical compositions containing them
BRPI0604377A (pt) 2006-10-27 2008-06-24 Cristalia Prod Quimicos Farm microemulsão óleo/água de propofol estável e pronta-para-uso
US20080308444A1 (en) * 2007-06-13 2008-12-18 Baxter International Inc. Packaging system and method of alerting a practitioner
WO2010000020A1 (en) 2008-06-30 2010-01-07 Cathrx Ltd A catheter
US20100197694A1 (en) 2008-08-01 2010-08-05 Gerald Horn Compositions and methods for treatment of diseases and conditions with increased vascular permeability
EP2165706A1 (de) 2008-09-18 2010-03-24 BioAlliance Pharma Behandlung von Entzündungsschmerzen der Mundhöhlenschleimhäute unter Verwendung von therapeutischen mukosalen, bioadhäsiven Trägern mit verlängerter Abgabe
US8100890B2 (en) * 2008-10-15 2012-01-24 Bioquiddity, Inc. Special purpose fluid dispenser with pre-filled reservoir
JP5536661B2 (ja) * 2008-10-30 2014-07-02 国立大学法人 岡山大学 局所麻酔用組成物
AU2010248776B2 (en) 2009-05-15 2013-06-06 Baudax Bio, Inc. Sublingual dexmedetomidine compositions and methods of use thereof
US8410140B2 (en) * 2009-06-01 2013-04-02 The Regents Of The University Of Michigan Anesthetic methods and compositions
EP2459170A2 (de) 2009-07-31 2012-06-06 Astron Research Limited Stabile zusammensetzung für gebrauchsfertige gemcitabininjektion
CA2782872A1 (en) 2009-12-17 2011-06-23 Alpha Synergy Development, Inc. Compositions and methods for ophthalmic delivery of nasal decongestants
FR2959414B1 (fr) * 2010-04-30 2016-01-08 Luc Quintin Combinaison de molecules aux fins de traitement d'hypotension survenant au cours du choc septique, cardiogenique, ou anaphylactique refractaire, ou hemorragique terminal, apres correction de la volemie et de l'etat de mal asthmatique refractaire
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation

Also Published As

Publication number Publication date
GT201300055A (es) 2014-08-26
PT2648520T (pt) 2018-06-06
US20180289673A1 (en) 2018-10-11
JP5990832B2 (ja) 2016-09-14
HUE038128T2 (hu) 2018-09-28
KR20140096238A (ko) 2014-08-05
US8242158B1 (en) 2012-08-14
EP3345599A1 (de) 2018-07-11
JP5927680B2 (ja) 2016-06-01
JP5892177B2 (ja) 2016-03-23
IL224867B (en) 2018-01-31
CN103281902A (zh) 2013-09-04
MY188598A (en) 2021-12-22
WO2013103378A1 (en) 2013-07-11
US8455527B1 (en) 2013-06-04
ZA201301649B (en) 2014-08-27
HK1249429A1 (zh) 2018-11-02
SA113340176B1 (ar) 2015-07-26
US20180289674A1 (en) 2018-10-11
LT2648520T (lt) 2018-07-10
TWI593409B (zh) 2017-08-01
US8338470B1 (en) 2012-12-25
JP2015110639A (ja) 2015-06-18
PL2648520T3 (pl) 2018-08-31
UY34562A (es) 2014-07-31
HRP20180838T1 (hr) 2018-06-29
US10016396B2 (en) 2018-07-10
AU2013201069B1 (en) 2013-08-15
CO6680698A2 (es) 2013-05-31
JP2014088433A (ja) 2014-05-15
US20140155446A1 (en) 2014-06-05
CL2013000815A1 (es) 2013-09-06
ES2671749T3 (es) 2018-06-08
PE20131166A1 (es) 2013-10-05
RS57346B1 (sr) 2018-08-31
EP2648520A4 (de) 2014-05-21
TW201332546A (zh) 2013-08-16
NZ607555A (en) 2015-08-28
PE20160681A1 (es) 2016-07-28
IL224867A0 (en) 2013-06-27
CA2806706C (en) 2015-07-14
JP2014508746A (ja) 2014-04-10
SG191706A1 (en) 2013-08-30
AR117001A2 (es) 2021-06-30
CY1120521T1 (el) 2019-07-10
TWI574688B (zh) 2017-03-21
US9320712B2 (en) 2016-04-26
TW201630603A (zh) 2016-09-01
SA115360458B1 (ar) 2016-01-27
TR201809123T4 (tr) 2018-07-23
CA2806706A1 (en) 2013-07-04
DK2648520T3 (en) 2018-06-18
US20170165235A1 (en) 2017-06-15
EP2648520A1 (de) 2013-10-16
US20160175285A1 (en) 2016-06-23
MY161022A (en) 2017-03-31
KR101632103B1 (ko) 2016-06-20
ECSP13012569A (es) 2015-04-30
US9616049B2 (en) 2017-04-11
US8648106B2 (en) 2014-02-11
EP2648520B1 (de) 2018-04-11
BR112013008005A2 (pt) 2016-06-14
CN107802624A (zh) 2018-03-16
US8436033B1 (en) 2013-05-07
MX2013003629A (es) 2013-11-05
US20130237576A1 (en) 2013-09-12
JP2014058577A (ja) 2014-04-03
BR112013008005A8 (pt) 2018-01-09
AR089673A1 (es) 2014-09-10

Similar Documents

Publication Publication Date Title
SI2648520T1 (en) Formulation of dexmedetomidine pre-mixtures
PH12017500844B1 (en) Stable protein solution formulation containing high concentration of an anti-vegf antibody
AU2016204371A1 (en) Lyophilised and aqueous anti-CD40 antibody formulations
EA201492292A1 (ru) Препарат антител
BR112013003045A2 (pt) composto e composição farmacêutica e respectivos usos, recipiente estéril e método para preparar composição farmacêutica para administração
BR112012018695A2 (pt) compostos pirazol como antagonistas crth2
BR112015001207A8 (pt) derivados de carbamato/ureia, seus usos, composição farmacêutica, forma livre e seu método de preparação
HRP20211734T1 (hr) Dozni oblici dugodjelujućeg hormona rasta
RS54632B1 (en) LIQUID PHARMACEUTICAL COMPOSITION CONTAINING NITIZINON
ECSP13012399A (es) Un nuevo conjugado de granulocito colonia-estimulante factor (g-csf) con polietileno
PH12018501531A1 (en) Pyrazole compounds as crth2 antagonists
HRP20140622T4 (hr) Farmaceutski pripravak ibuprofena za injekciju
EA201591653A1 (ru) Композиции для лечения глазных расстройств с применением дипиридамола
BR112017018569A2 (pt) formulação estável para administração parentérica de tapentadol
CY1115600T1 (el) Πιπεραζινες ως ανθελονοσιακοι παραγοντες
EA201500128A1 (ru) Педиатрические жидкие композиции для перорального введения, содержащие непадутант
SA112340153B1 (ar) ايبوبروفين للحقن التسريبي في الوريد
TH136433A (th) สูตรผสมและเกลือลิพอฟิลิคของเมทิลแนลเทร็กโซนที่ให้ทางปาก
TH134237A (th) อนุพันธ์ n-(อิมมิดาโซไพริมิดิน-7-อิล)-เฮตเทอโรอัลริลเอไมด์และการใช้เหล่านี้ในรูปตัวยับยั้ง pde10a
PL399880A1 (pl) 8-(oktadecylosulfanylo)chinolina do zastosowania jako lek, zwlaszcza do stosowania w leczeniu i profilaktyce rozwoju insulinoopornosci, kompozycja farmaceutyczna zawierajaca 8-(oktadecylosulfanylo)chinoline oraz zastosowanie 8-(oktadecylosulfanylo)chinoliny do wytwarzania leku do stosowania w leczeniu i profilaktyce rozwoju insulinoopornosci