HRP20180838T1 - Formuliranje deksmedetomidina u obliku predsmjese - Google Patents

Formuliranje deksmedetomidina u obliku predsmjese

Info

Publication number
HRP20180838T1
HRP20180838T1 HRP20180838TT HRP20180838T HRP20180838T1 HR P20180838 T1 HRP20180838 T1 HR P20180838T1 HR P20180838T T HRP20180838T T HR P20180838TT HR P20180838 T HRP20180838 T HR P20180838T HR P20180838 T1 HRP20180838 T1 HR P20180838T1
Authority
HR
Croatia
Prior art keywords
premix formulation
dexmedetomidine
dexmedetomidine premix
formulation
premix
Prior art date
Application number
HRP20180838TT
Other languages
English (en)
Inventor
Priyanka Roychowdhury
Robert A. CEDERGREN
Original Assignee
Hospira, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46613447&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20180838(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hospira, Inc. filed Critical Hospira, Inc.
Publication of HRP20180838T1 publication Critical patent/HRP20180838T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
HRP20180838TT 2012-01-04 2018-05-25 Formuliranje deksmedetomidina u obliku predsmjese HRP20180838T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/343,672 US8242158B1 (en) 2012-01-04 2012-01-04 Dexmedetomidine premix formulation
EP12823234.5A EP2648520B1 (en) 2012-01-04 2012-06-18 Dexmedetomidine premix formulation
PCT/US2012/042940 WO2013103378A1 (en) 2012-01-04 2012-06-18 Dexmedetomidine premix formulation

Publications (1)

Publication Number Publication Date
HRP20180838T1 true HRP20180838T1 (hr) 2018-06-29

Family

ID=46613447

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20180838TT HRP20180838T1 (hr) 2012-01-04 2018-05-25 Formuliranje deksmedetomidina u obliku predsmjese

Country Status (35)

Country Link
US (10) US8242158B1 (hr)
EP (2) EP3345599A1 (hr)
JP (4) JP5892177B2 (hr)
KR (1) KR101632103B1 (hr)
CN (2) CN103281902A (hr)
AR (2) AR089673A1 (hr)
AU (1) AU2013201069B1 (hr)
BR (1) BR112013008005A8 (hr)
CA (1) CA2806706C (hr)
CL (1) CL2013000815A1 (hr)
CO (1) CO6680698A2 (hr)
CY (1) CY1120521T1 (hr)
DK (1) DK2648520T3 (hr)
EC (1) ECSP13012569A (hr)
ES (1) ES2671749T3 (hr)
GT (1) GT201300055A (hr)
HK (1) HK1249429A1 (hr)
HR (1) HRP20180838T1 (hr)
HU (1) HUE038128T2 (hr)
IL (1) IL224867B (hr)
LT (1) LT2648520T (hr)
MX (1) MX2013003629A (hr)
MY (2) MY161022A (hr)
PE (2) PE20131166A1 (hr)
PL (1) PL2648520T3 (hr)
PT (1) PT2648520T (hr)
RS (1) RS57346B1 (hr)
SA (2) SA115360458B1 (hr)
SG (1) SG191706A1 (hr)
SI (1) SI2648520T1 (hr)
TR (1) TR201809123T4 (hr)
TW (2) TWI574688B (hr)
UY (1) UY34562A (hr)
WO (1) WO2013103378A1 (hr)
ZA (1) ZA201301649B (hr)

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US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
US8242158B1 (en) * 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
US20150098983A1 (en) * 2013-10-07 2015-04-09 Teikoku Pharma Usa, Inc. Methods and Compositions for Treating Withdrawal Syndromes Using Non-Sedative Dexmedetomidine Transdermal Compositions
KR101831290B1 (ko) 2013-10-07 2018-02-22 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 조성물을 사용하여 주의력 결핍 과잉행동 장애, 불안 및 불면증을 치료하기 위한 방법 및 조성물
CA2924236C (en) 2013-10-07 2020-01-07 Teikoku Pharma Usa, Inc. Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
KR101948779B1 (ko) 2013-10-07 2019-05-21 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
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CN105168122B (zh) * 2015-09-24 2018-11-27 辰欣药业股份有限公司 一种盐酸右美托咪定注射液及其制备工艺
US10632043B2 (en) * 2015-11-11 2020-04-28 Aurobindo Pharma Ltd Premix formulation for parenteral use and packaging thereof
US20170128421A1 (en) * 2015-11-11 2017-05-11 Siva Prasad Reddy Sura Premix formulation for parenteral use and packaging thereof
US9717796B1 (en) * 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
CN107412152B (zh) * 2016-05-24 2020-12-04 海南合瑞制药股份有限公司 一种盐酸右美托咪定注射液组合物
CN110114069B (zh) * 2016-12-26 2022-03-04 久光制药株式会社 微针装置
EP3562486B1 (en) 2016-12-31 2024-03-13 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
CN107028880A (zh) * 2017-06-09 2017-08-11 安徽赛诺制药有限公司 一种盐酸右美托咪定注射液的生产工艺
WO2019164765A1 (en) * 2018-02-26 2019-08-29 Slayback Pharma Llc Ready-to-use dexmedetomidine compositions
CN108956809B (zh) * 2018-06-04 2021-03-23 四川科伦药物研究院有限公司 一种检测1-(1-氯乙基)-2,3-二甲苯有关物质的方法
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BR112020026672A2 (pt) 2018-06-27 2021-03-30 Bioxcel Therapeutics, Inc. Formulações de filme contendo dexmedetomidina e métodos para produzi-las
CN108872431B (zh) * 2018-07-09 2021-03-23 成都倍特药业股份有限公司 一种检测4-(1-(2,5-二甲基苯基)乙基)-1h-咪唑或/和其盐酸盐的方法
CN109081811A (zh) * 2018-09-19 2018-12-25 南京正大天晴制药有限公司 盐酸右美托咪定的有关物质及其制备方法
JP2019048091A (ja) * 2018-10-23 2019-03-28 ニプロ株式会社 デクスメデトミジン注射液を充填したプレフィルドシリンジ
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags
CN111481506B (zh) * 2019-01-25 2023-01-24 江苏恒瑞医药股份有限公司 一种包含经鼻给药的右美托咪定组合物的药物制品
CN116474219A (zh) * 2019-06-28 2023-07-25 四川普锐特药业有限公司 保持给药均一度的药物流体分配器及右美托咪定鼻喷器
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CA3195133A1 (en) * 2020-10-08 2022-04-14 Frank Yocca Treatment of bipolar disorders and psychosis using dexmedetomidine hydrochloride
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Also Published As

Publication number Publication date
JP2014088433A (ja) 2014-05-15
SG191706A1 (en) 2013-08-30
KR20140096238A (ko) 2014-08-05
EP3345599A1 (en) 2018-07-11
UY34562A (es) 2014-07-31
IL224867A0 (en) 2013-06-27
SI2648520T1 (en) 2018-08-31
ECSP13012569A (es) 2015-04-30
HK1249429A1 (zh) 2018-11-02
PE20131166A1 (es) 2013-10-05
JP5927680B2 (ja) 2016-06-01
EP2648520B1 (en) 2018-04-11
TW201630603A (zh) 2016-09-01
JP5990832B2 (ja) 2016-09-14
US20180289674A1 (en) 2018-10-11
SA113340176B1 (ar) 2015-07-26
TR201809123T4 (tr) 2018-07-23
SA115360458B1 (ar) 2016-01-27
AR117001A2 (es) 2021-06-30
RS57346B1 (sr) 2018-08-31
EP2648520A1 (en) 2013-10-16
AU2013201069B1 (en) 2013-08-15
TWI593409B (zh) 2017-08-01
NZ607555A (en) 2015-08-28
MY188598A (en) 2021-12-22
CO6680698A2 (es) 2013-05-31
US9320712B2 (en) 2016-04-26
TW201332546A (zh) 2013-08-16
CY1120521T1 (el) 2019-07-10
US8455527B1 (en) 2013-06-04
DK2648520T3 (en) 2018-06-18
CA2806706C (en) 2015-07-14
ES2671749T3 (es) 2018-06-08
CN107802624A (zh) 2018-03-16
US9616049B2 (en) 2017-04-11
ZA201301649B (en) 2014-08-27
JP2014508746A (ja) 2014-04-10
US20180289673A1 (en) 2018-10-11
US8338470B1 (en) 2012-12-25
PT2648520T (pt) 2018-06-06
PL2648520T3 (pl) 2018-08-31
US8436033B1 (en) 2013-05-07
US8242158B1 (en) 2012-08-14
TWI574688B (zh) 2017-03-21
JP2015110639A (ja) 2015-06-18
MX2013003629A (es) 2013-11-05
LT2648520T (lt) 2018-07-10
US20130237576A1 (en) 2013-09-12
US8648106B2 (en) 2014-02-11
JP5892177B2 (ja) 2016-03-23
US10016396B2 (en) 2018-07-10
GT201300055A (es) 2014-08-26
IL224867B (en) 2018-01-31
CL2013000815A1 (es) 2013-09-06
US20140155446A1 (en) 2014-06-05
MY161022A (en) 2017-03-31
BR112013008005A2 (pt) 2016-06-14
CA2806706A1 (en) 2013-07-04
WO2013103378A1 (en) 2013-07-11
US20170165235A1 (en) 2017-06-15
US20160175285A1 (en) 2016-06-23
CN103281902A (zh) 2013-09-04
BR112013008005A8 (pt) 2018-01-09
KR101632103B1 (ko) 2016-06-20
PE20160681A1 (es) 2016-07-28
HUE038128T2 (hu) 2018-09-28
EP2648520A4 (en) 2014-05-21
JP2014058577A (ja) 2014-04-03
AR089673A1 (es) 2014-09-10

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