CY1115600T1 - Πιπεραζινες ως ανθελονοσιακοι παραγοντες - Google Patents

Πιπεραζινες ως ανθελονοσιακοι παραγοντες

Info

Publication number
CY1115600T1
CY1115600T1 CY20141100780T CY141100780T CY1115600T1 CY 1115600 T1 CY1115600 T1 CY 1115600T1 CY 20141100780 T CY20141100780 T CY 20141100780T CY 141100780 T CY141100780 T CY 141100780T CY 1115600 T1 CY1115600 T1 CY 1115600T1
Authority
CY
Cyprus
Prior art keywords
piperazines
anthelmintic agents
pharmaceutical compositions
relates
medicaments
Prior art date
Application number
CY20141100780T
Other languages
English (en)
Inventor
Hamed Aissaoui
Christoph Boss
Olivier Corminboeuf
Bibia Heidmann
Romain Siegrist
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of CY1115600T1 publication Critical patent/CY1115600T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Η εφεύρεση αναφέρεται στα παράγωγα πιπεραζίνης του Χημικού τύπου Ι και στη χρήση τους ως δραστικά συστατικά στην παρασκευή φαρμακευτικών συνθέσεων. Η εφεύρεση αναφέρεται επίσης σε αντίστοιχες πτυχές συμπεριλαμβανομένων των φαρμακευτικών συνθέσεων που περιέχουν μια ή περισσότερες από τις ενώσεις αυτές καθώς επίσης και στη χρήση τους ως φάρμακα για την αντιμετώπιση ή την πρόληψη των πρωτοζωϊκών λοιμώξεων, και ειδικότερα της ελονοσίας.
CY20141100780T 2010-01-05 2014-09-24 Πιπεραζινες ως ανθελονοσιακοι παραγοντες CY1115600T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2010050022 2010-01-05
IB2010052045 2010-05-10
EP11702702.9A EP2521715B1 (en) 2010-01-05 2011-01-04 Piperazines as antimalarial agents

Publications (1)

Publication Number Publication Date
CY1115600T1 true CY1115600T1 (el) 2017-01-04

Family

ID=43706300

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100780T CY1115600T1 (el) 2010-01-05 2014-09-24 Πιπεραζινες ως ανθελονοσιακοι παραγοντες

Country Status (27)

Country Link
EP (1) EP2521715B1 (el)
JP (1) JP5165166B1 (el)
KR (1) KR101455484B1 (el)
CN (1) CN102666488B (el)
AR (1) AR079831A1 (el)
AU (1) AU2011204436B2 (el)
BR (1) BR112012016549A8 (el)
CA (1) CA2783882C (el)
CL (1) CL2012001641A1 (el)
CY (1) CY1115600T1 (el)
DK (1) DK2521715T3 (el)
ES (1) ES2523739T3 (el)
HK (1) HK1178529A1 (el)
HR (1) HRP20140890T1 (el)
IL (1) IL220698A (el)
MA (1) MA33979B1 (el)
MX (1) MX2012007172A (el)
MY (1) MY160904A (el)
NZ (1) NZ601607A (el)
PL (1) PL2521715T3 (el)
PT (1) PT2521715E (el)
RU (1) RU2555706C2 (el)
SG (1) SG181462A1 (el)
SI (1) SI2521715T1 (el)
TW (1) TWI402267B (el)
WO (1) WO2011083413A1 (el)
ZA (1) ZA201205879B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013018069A1 (en) 2011-08-04 2013-02-07 Actelion Pharmaceuticals Ltd Combination of antimalarial agents
WO2014072903A1 (en) * 2012-11-06 2014-05-15 Actelion Pharmaceuticals Ltd Novel aminomethyl-phenol derivatives as antimalarial agents
CA2901920A1 (en) * 2013-03-15 2014-09-18 Actelion Pharmaceuticals Ltd Novel acrylamide derivatives as antimalarial agents
EP4058147A4 (en) * 2020-01-21 2024-01-10 Eisai R&D Management Co., Ltd. NOVEL ANTIMALARIAL AGENT CONTAINING A HETEROCYCLIC COMPOUND

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9910079D0 (en) 1999-05-01 1999-06-30 Smithkline Beecham Plc Novel compounds
DE10008522A1 (de) * 2000-02-24 2001-09-06 Hassan Jomaa Verwendung von 2-PHenylendiaminderivaten zur Behandlung von Infektionen
KR20020084273A (ko) * 2000-03-31 2002-11-04 화이자 프로덕츠 인코포레이티드 신규한 피페라진 유도체
TWI382976B (zh) * 2005-10-21 2013-01-21 Actelion Pharmaceuticals Ltd 作為抗瘧疾劑之新穎哌
CN101544630B (zh) * 2009-05-13 2013-03-13 中国科学院广州生物医药与健康研究院 羟基化茚地那韦的制备方法

Also Published As

Publication number Publication date
TWI402267B (zh) 2013-07-21
RU2555706C2 (ru) 2015-07-10
AR079831A1 (es) 2012-02-22
EP2521715B1 (en) 2014-06-25
MY160904A (en) 2017-03-31
AU2011204436B2 (en) 2016-05-19
ZA201205879B (en) 2015-04-29
AU2011204436A1 (en) 2012-08-23
PL2521715T3 (pl) 2014-11-28
SI2521715T1 (sl) 2014-10-30
BR112012016549A8 (pt) 2017-12-26
MA33979B1 (fr) 2013-02-01
HRP20140890T1 (hr) 2014-11-07
NZ601607A (en) 2014-06-27
PT2521715E (pt) 2014-09-02
CN102666488A (zh) 2012-09-12
IL220698A (en) 2015-09-24
KR20120111740A (ko) 2012-10-10
KR101455484B1 (ko) 2014-10-27
BR112012016549A2 (pt) 2016-04-19
JP2013516453A (ja) 2013-05-13
TW201139416A (en) 2011-11-16
CL2012001641A1 (es) 2012-12-07
CN102666488B (zh) 2015-04-22
CA2783882A1 (en) 2011-07-14
CA2783882C (en) 2017-11-28
DK2521715T3 (da) 2014-08-11
JP5165166B1 (ja) 2013-03-21
WO2011083413A1 (en) 2011-07-14
HK1178529A1 (en) 2013-09-13
EP2521715A1 (en) 2012-11-14
RU2012133265A (ru) 2014-02-20
SG181462A1 (en) 2012-07-30
MX2012007172A (es) 2012-07-03
ES2523739T3 (es) 2014-12-01

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