EA201492292A1 - Препарат антител - Google Patents

Препарат антител

Info

Publication number
EA201492292A1
EA201492292A1 EA201492292A EA201492292A EA201492292A1 EA 201492292 A1 EA201492292 A1 EA 201492292A1 EA 201492292 A EA201492292 A EA 201492292A EA 201492292 A EA201492292 A EA 201492292A EA 201492292 A1 EA201492292 A1 EA 201492292A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
preparation antibodies
sugars
antibodies
surfactant
Prior art date
Application number
EA201492292A
Other languages
English (en)
Other versions
EA033373B1 (ru
Inventor
Марта Косенза
Кристоф Штарк
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48914378&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201492292(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201492292A1 publication Critical patent/EA201492292A1/ru
Publication of EA033373B1 publication Critical patent/EA033373B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Антитела против BAFFR готовят в виде жидкого лекарственного препарата, включающего активный ингредиент антитело в высокой концентрации, для доставки пациенту без высоких уровней агрегации антитела. Фармацевтическая композиция на водной основе может включать один или более сахаров, буферный агент, поверхностно-активное вещество и/или свободную аминокислоту.
EA201492292A 2012-06-12 2013-06-11 Композиции на водной основе, предварительно наполненный шприц, их применения и способ доставки гипофукозилированного или нефукозилированного антитела против baffr млекопитающему EA033373B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261658472P 2012-06-12 2012-06-12
PCT/IB2013/054777 WO2013186700A1 (en) 2012-06-12 2013-06-11 Antibody formulation

Publications (2)

Publication Number Publication Date
EA201492292A1 true EA201492292A1 (ru) 2015-04-30
EA033373B1 EA033373B1 (ru) 2019-10-31

Family

ID=48914378

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201492292A EA033373B1 (ru) 2012-06-12 2013-06-11 Композиции на водной основе, предварительно наполненный шприц, их применения и способ доставки гипофукозилированного или нефукозилированного антитела против baffr млекопитающему

Country Status (36)

Country Link
US (4) US9216219B2 (ru)
EP (2) EP3593814A1 (ru)
JP (1) JP6265978B2 (ru)
KR (1) KR102124820B1 (ru)
CN (1) CN104363920B (ru)
AR (1) AR091413A1 (ru)
AU (1) AU2013276112B2 (ru)
BR (1) BR112014030820B1 (ru)
CA (1) CA2875386C (ru)
CL (1) CL2014003370A1 (ru)
CO (1) CO7151487A2 (ru)
CY (1) CY1122181T1 (ru)
DK (1) DK2858671T3 (ru)
EA (1) EA033373B1 (ru)
EC (1) ECSP15017314A (ru)
ES (1) ES2751659T3 (ru)
GT (1) GT201400285A (ru)
HK (1) HK1203146A1 (ru)
HR (1) HRP20191827T1 (ru)
HU (1) HUE045523T2 (ru)
IL (1) IL235966B (ru)
LT (1) LT2858671T (ru)
MA (1) MA37616A1 (ru)
MX (1) MX363380B (ru)
MY (1) MY179818A (ru)
NZ (1) NZ630885A (ru)
PE (1) PE20150200A1 (ru)
PH (1) PH12014502778A1 (ru)
PL (1) PL2858671T3 (ru)
PT (1) PT2858671T (ru)
SG (1) SG11201408174UA (ru)
SI (1) SI2858671T1 (ru)
TN (1) TN2014000488A1 (ru)
TW (1) TWI653983B (ru)
WO (1) WO2013186700A1 (ru)
ZA (1) ZA201408547B (ru)

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US9216219B2 (en) * 2012-06-12 2015-12-22 Novartis Ag Anti-BAFFR antibody formulation
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Also Published As

Publication number Publication date
MX363380B (es) 2019-03-21
US20130344088A1 (en) 2013-12-26
SI2858671T1 (sl) 2019-11-29
ES2751659T3 (es) 2020-04-01
WO2013186700A1 (en) 2013-12-19
EP2858671B1 (en) 2019-07-24
HRP20191827T1 (hr) 2019-12-27
JP2015521593A (ja) 2015-07-30
HK1203146A1 (en) 2015-10-23
IL235966A0 (en) 2015-01-29
JP6265978B2 (ja) 2018-01-24
LT2858671T (lt) 2019-10-25
PH12014502778B1 (en) 2015-02-02
KR20150029683A (ko) 2015-03-18
BR112014030820A2 (pt) 2017-07-25
TN2014000488A1 (en) 2016-03-30
MY179818A (en) 2020-11-16
DK2858671T3 (da) 2019-10-21
PH12014502778A1 (en) 2015-02-02
EP3593814A1 (en) 2020-01-15
EA033373B1 (ru) 2019-10-31
TW201402144A (zh) 2014-01-16
TWI653983B (zh) 2019-03-21
CN104363920B (zh) 2018-05-04
NZ630885A (en) 2016-01-29
EP2858671A1 (en) 2015-04-15
US20160145341A1 (en) 2016-05-26
CA2875386C (en) 2022-09-13
HUE045523T2 (hu) 2020-01-28
US9751951B2 (en) 2017-09-05
PE20150200A1 (es) 2015-02-08
IL235966B (en) 2020-05-31
MX2014015262A (es) 2015-06-23
CO7151487A2 (es) 2014-12-29
CL2014003370A1 (es) 2015-02-06
MA37616A1 (fr) 2017-08-31
KR102124820B1 (ko) 2020-06-22
US20180051092A1 (en) 2018-02-22
BR112014030820B1 (pt) 2023-02-07
GT201400285A (es) 2015-10-15
ECSP15017314A (es) 2018-06-30
US9216219B2 (en) 2015-12-22
US20180251564A1 (en) 2018-09-06
CY1122181T1 (el) 2020-11-25
ZA201408547B (en) 2015-12-23
AR091413A1 (es) 2015-02-04
PL2858671T3 (pl) 2020-01-31
US10689451B2 (en) 2020-06-23
CN104363920A (zh) 2015-02-18
AU2013276112A1 (en) 2014-12-18
AU2013276112B2 (en) 2015-07-09
PT2858671T (pt) 2019-10-28
SG11201408174UA (en) 2015-01-29
CA2875386A1 (en) 2013-12-19

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